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MAPK signaling： A key element in plant defense response to insects

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Insect Science 2015年第2期22卷 157-164页

作者： Christian Hettenhausen meredith C. Schuman Jianqiang Wu Kunming Institute of Botany Chinese Academy of Sciences Kunming China Max Planck Institute for Chemical Ecology Hans-Knoell Str. 8 07745 Jena Germany

Insects have long been the most abundant herbivores, and plants have evolved sophisticated mechanisms to defend against their attack, In particular, plants can perceive specific patterns of tissue damage associated with insect herbivory. Some plant species can perceive certain elicitors in insect oral secretions （OS） that enter wounds during feeding, and rapidly activate a series of intertwined signaling pathways to orchestrate the biosynthesis of various defensive metabolites. Mitogen-activated protein kinases （MAPKs）, common to all eukaryotes, are involved in the orchestration of many cellular processes, including development and stress responses. In plants, at least two MAPKs, salicylic acid-induced protein kinase （SIPK） and wound-induced protein kinase （WlPK）, are rapidly activated by wounding or insect 0S; importantly, genetic studies us- ing transgenic or mutant plants impaired in MAPK signaling indicated that MAPKs play critical roles in regulating the herbivory-induced dynamics of phytohormones, such as jasmonic acid, ethylene and salicylic acid, and MAPKs are also required for transcriptional activation of herbivore defense-related genes and accumulation of defensive metabolites. In this review, we summarize recent developments in understanding the functions of MAPKs in plant resistance to insect herbivores.

关键词： defense FAC insect jasmonate mitogen-activated protein kinase (MAPK) plant-insect interaction

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团队管理的两个关键要素

商学院 2024年第6期 14-14页

作者： meredith Somers 麻省理工学院斯隆管理学院

在成功团队的构建中,讲故事是一门艺术,它承载着文化的力量。麻省理工学院斯隆管理学院讲师、体育记者希拉·斯普林格(ShiraSpringer)提出,通过在团队内部讲故事,领导者可以与团队成员建立更为紧密的联系,增强团队凝聚力。他们不仅阐述... 详细信息

在成功团队的构建中,讲故事是一门艺术,它承载着文化的力量。麻省理工学院斯隆管理学院讲师、体育记者希拉·斯普林格(ShiraSpringer)提出,通过在团队内部讲故事,领导者可以与团队成员建立更为紧密的联系,增强团队凝聚力。他们不仅阐述自已的价值观,还通过分享个人职业生涯中的故事,包括成功和挫折,来传达自己的理念。同时,领导者还应该鼓励团队成员分享他们自己的故事。

关键词：麻省理工学院团队凝聚力讲故事斯普林斯隆管理学院 Springer 团队管理个人职业生涯

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如何招聘和留住财务人才

商学院 2024年第2期 16-16页

作者： meredith Somers 麻省理工学院斯隆管理学院

会计曾经是财务人员职业生涯的起点,随着技术的进步,财务工作需要体现更深入的数据分析能力,需要理解财务对业务的影响,这对财务团队提出了新的挑战。甫瀚咨询(Protiviti)首席顾问安德烈亚·斯皮内利强调了对于财务领域核心技能的需求... 详细信息

会计曾经是财务人员职业生涯的起点,随着技术的进步,财务工作需要体现更深入的数据分析能力,需要理解财务对业务的影响,这对财务团队提出了新的挑战。甫瀚咨询(Protiviti)首席顾问安德烈亚·斯皮内利强调了对于财务领域核心技能的需求。她表示:“人们仍然需要知道什么是资产和负债,借方和贷方是什么,但他们对它的运用和处理方式将会改变,人们必须适应这一变化。”

关键词：数据分析能力首席顾问财务团队财务人才财务人员核心技能处理方式招聘

COVID-19 and its effects upon orthopaedic surgery: The Trinidad and Tobago experience

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World Journal of Orthopedics 2021年第3期12卷 94-101页

作者： Marlon meredith Mencia Raakesh Goalan Department of Clinical Surgical Sciences University of the West IndiesSt.Joseph 0000Trinidad and Tobago Department of Surgery Sangre Grande HospitalSangre Grande 0000Trinidad and Tobago

The World Health Organisation(WHO)declared coronavirus disease 2019(COVID-19)a pandemic on March 11,***-19 is not the first infectious disease to affect Trinidad and *** country has faced outbreaks of both Chikungunya and Zika virus in 2014 and 2016 *** viral pandemic is predicted to have a significant impact upon all countries,but the healthcare services in a developing country are especially *** Government of Trinidad and Tobago swiftly established a parallel healthcare system to isolate and treat suspected and confirmed cases of ***‘lockdown’orders,office closures,social distancing and face mask usage recommendation were implemented following advice from the *** approach has seen Trinidad and Tobago emerge from the second wave of infections,with the most recent Oxford COVID-19 Government Response Tracker report indicating a favourable risk of openness index for the *** effects of the pandemic on the orthopaedic services in the public and private healthcare systems show significant *** by shortages in personal protective equipment and inadequate testing facilities,the public system moved into emergency mode prioritizing the care of urgent and critical *** healthcare driven more by economic considerations,quickly instituted widespread safety measures to ensure that the clinics remained open and elective surgery was not *** teaching at The University of the West Indies was quickly migrated to an online platform to facilitate both medical students and *** Caribbean Association of Orthopedic Surgeons through its frequent virtual meetings provided a forum for continuing education and social interaction amongst *** pandemic has disrupted our daily routines leading to unparalleled changes to our lives and *** of these changes will remain long after the pandemic is over,permanently transforming the practice of orthopaedics.

关键词： COVID-19 Coronavirus Orthopaedics Trinidad and Tobago University of the West Indies The Caribbean association of orthopaedic surgeons

Natural variation in linalool metabolites:One genetic locus,many functions?

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Journal of Integrative Plant Biology 2021年第8期63卷 1416-1421页

作者： Jun He Rayko Halitschke Ian T.Baldwin meredith C.Schuman National Citrus Engineering Research Center Citrus Research InstituteSouthwest UniversityChongqing400712 China Department of Molecular Ecology Max Planck Institute for Chemical EcologyJena07745 Germany Departments of Geography and Chemistry University of ZürichZürich8057 Switzerland

The ubiquitous volatile linalool is metabolized in plants to nonvolatile *** studied Nicotiana attenuata plants which naturally vary in(S)-(+)-linalool contents,and lines engineered to produce either(R)-(-)-or(S)-(+)-***(S)-(+)-linalool production was associated with slower growth of a generalist herbivore,and a large fraction was present as nonvolatile *** found that variation in volatile linalool and its nonvolatile glycosides mapped to the same genetic locus which harbored the biosynthetic gene,NaLIS,but that free linalool varied more in environmental *** study reveals how(S)-(+)-linalool and conjugates differ in their regulation and possible functions in resistance.

关键词： conjugated linalool Nicotiana attenuata Spodoptera littoralis

An overview of PCI in the very elderly

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Journal of Geriatric Cardiology 2015年第2期12卷 174-184页

作者： Vimalraj Bogana Shanmugam Richard Harper Ian meredith Yuvaraj Malaiapan Peter J Psaltis Cardiovascular Research Centre Monash University 246 Clayton Road Clayton Victoria 3168 Australia

Cardiovascular disease, and in particular ischemic heart disease （IHD）, is a major cause of morbidity and mortality in the very elderly （〉 80 years） worldwide. These patients represent a rapidly growing cohort presenting for percntaneous coronary intervention （PCI）, now constituting more than one in five patients treated with PCI in real-world practice. Furthermore, they often have greater ischemic burden than their younger counterparts, suggesting that they have greater scope of benefit from coronary revascularization therapy. Despite this, the very elderly are frequently under-represented in clinical revascularization trials and historically there has been a degree of physician reluctance in referring them for PCI procedures, with perceptions of disappointing outcomes, low success and high complication rates. Several issues have contributed to this, including the tendency for older patients with IHD to present late, with atypical symptoms or non-diagnostic ECGs, and reservations regarding their procedural risk-to-benefit ratio, due to shorter life expectancy, presence of comorbidities and increased bleeding risk from antiplatelet and anticoagulation medications. However, advances in PCI technology and techniques over the past decade have led to better outcomes and lower risk of complications and the existing body of evidence now indicates that the very elderly actually derive more relative benefit from PCI than younger populations. Importantly, this applies to all PCI settings： elective, urgent and emergency. This review discusses the role of PCI in the very elderly presenting with chronic stable IHD, non ST-elevation acute coronary syndrome, and ST-elevation myocardial infarction. It also addresses the clinical challenges met when considering PCI in this cohort and the ongoing need for research and development to further improve outcomes in these challenging patients.

关键词： Acute coronary syndrome Angina Antithrombotic therapy Myocardial infarction Octogenarians Percutaneous coronary intervention The elderly

On the unipolarity of charge transport in methanofullerene diodes

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npj Flexible Electronics 2017年第1期1卷 100-105页

作者： Ardalan Armin Safa Shoaee Qianqian Lin Paul L Burn Paul meredith Centre for Organic Photonics&Electronics The University of QueenslandSt Lucia CampusBrisbaneQLD 4072Australia Centre for Engineered Quantum Systems School of Mathematics and PhysicsThe University of QueenslandSt Lucia CampusBrisbaneQLD 4072Australia Institute of Physics and Astronomy University of PotsdamKarl-Liebknecht-Straße 24-25Potsdam-Golm D-14476Germany Clarendon Laboratory Department of PhysicsThe University of OxfordParks Road OxfordOxfordOX13PUUK Department of Physics Swansea UniversitySingleton ParkSwanseaWales SA28PPUK

Fullerenes are electron transporting organic semiconductors with a wide range of *** particular,methanofullerenes have been the preferred choice for solution-processed solar cells and *** wide applicability of fullerenes as both‘ntype’transport materials and electron acceptors is ***,what is still a matter of debate is whether the fullerenes can also support efficient transport of holes,particularly in diode *** this letter,we utilize a number of recently developed experimental methods for selective electron and hole mobility *** show for the two most widely used solution processable fullerenes,PC70-and-PC60BM,that whilst both exhibit electron mobilities as high as 10^(−3)cm^(2)/Vs,their hole mobilities are<10^(−9)cm^(2)/*** charge transport in these fullerenes can be considered predominantly unipolar in diode configurations.

关键词： charge utilize polarity

Chest complications in autologous breast reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 205-215页

作者： Candice M.Leach meredith S.Collins Department of Plastic and Reconstructive Surgery University of Kansas Medical CenterKansas CityKS 66160USA

Complications from autologous free flap reconstruction of the breast can present with both common surgical complications and unique complications at the chest recipient *** review covers complications at the chest recipient site,including chest wall deformity,chronic pain,mastectomy skin flap necrosis,infection,pyoderma gangrenosum,bleeding complications,pneumothorax,chyle leak,and positive internal mammary lymph node metastasis.

关键词： Autologous breast reconstruction complications chest wall deformity pneumothorax mastectomy skin flap necrosis chyle leak internal mammary node metastasis

Improving Cost Savings and Patient Outcomes with Hepatitis C Triple Therapy Treatment in the Medicaid Population

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Journal of Pharmacy and Pharmacology 2014年第8期2卷 470-481页

作者： Yongjie Chen Christine carter meredith Fish DanieUe Mayer Richard Algoo Sheena Cherian James Cavage Jamila Jorden PerformRx Philadelphia Pennsylvania 19113 USA School of Pharmacy University of Pittsburgh Pittsburgh Pennsylvania 15213 USA

One of the major infections that plague our world today, hepatitis C, has been causing liver disease in humans since early history. Over time, human ingenuity has allowed us to develop more effective treatments, but at traditionally massive monetary costs. In order to combat such costs, PerformRx came up with three ways to drive costs downward but also increase different outcomes for the Pennsylvania Medicaid population it serves. By restricting access to drugs via prior authorizations, tracking members within a DTM （drug therapy management） program, and giving members touchscreen tablet devices, there was an observed cost savings and a better ability to service members. Even though there was little impact on overall member outcomes, these initial interventions were the right steps to be innovative and create a beneficial scenario for both members and clients.

关键词： Hepatitis C tablet prior authorization triple therapy targeted medication review PerformRx.