检索结果-南通市图书馆

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

引用

Translational Neurodegeneration 2020年第2期9卷 168-177页

作者： Nour K.Majbour Jan O.Aasly Eldbjørg Hustad mercy a.thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf Neurological Disorders Research Center Qatar Biomedical Research InstituteHamad Bin Khalifa UniversityQatar FoundationP.O.Box 5825DohaQatar Department of Neuroscience Norwegian University of Science and Technology(NTNU)TrondheimNorway Department of Neurology St.Olav’s HospitalUniversity Hospital of TrondheimTrondheimNorway Clinical Epidemiology Sidra Medical and Research CenterDohaQatar Department of Anatomy and Neurosciences Neuroscience Campus AmsterdamVU University Medical CentreAmsterdamthe Netherlands Department of Neurology Research Institute for GeriatricsKyoto Prefectural University of MedicineKyoto602-0841Japan Paracelsus-Elena-Klinik KlinikstraßeKasseland University Medical Center GöttingenDepartment of NeurologyGöttingenGermany Department of Neurology Amsterdam UMClocation VU University Medical CentreAmsterdamThe Netherlands

Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation *** We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the *** that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal *** Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy *** the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was *** The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal *** findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD.

关键词： Parkinson's disease LRRK2 mutation carriers Alpha-synuclein oligomers Biomarkers Inflammatory markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

OCCURRENCE OF EARLIEST CYCADS IN THE PERMIAN OF CHINA AND ITS BEARING ON THEIR EVOLUTION

引用

Chinese Science Bulletin 1989年第9期34卷 766-769页

作者：高志峰 BARRY a.thomas Department of Plant Science University College Cardiff Cardiff CF1 1XL UK Department of Botany National Museum of Wales Cardiff CF1 3NP UK

Living cycads show a range of archaic features which suggest that they are primitive plants. They have a long fossil record, but this unfortunately consists largely of vegetative leaves. Very few reproductive organs a... 详细信息

关键词： Cycas the Permian.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

引用

Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microglia:a promising therapeutic target in spinal cord injury

引用

Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

引用

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HIGH-INTENSITY SWEETENERS:OVERVIEW OF SAFETY AND TOXICOLOGY

HIGH-INTENSITY SWEETENERS:OVERVIEW OF SAFETY AND TOXICOLOGY

引用

纽特健康糖（阿斯巴甜）在健康饮食中的应用专题研讨会

作者： John a.thomas Department of Pharmacology Department of Radiology The University of Texas Health Science Center San Antonio Texas USA

Bulk sweeteners are generally carbohydrates, and they provide energy (calories) and bulk to food. On the other hand, high-intensity sweeteners possess a sweet taste, but are non-caloric and provide essentially no bulk to food. There are several different high-intensity, low-calorie sweeteners. Some of the sweeteners are naturally-occurring, while others are artificial or synthetic. The chemical formulas of the different sweeteners vary considerably, but generally they are relatively low molecular weight substances. They may range from simple dipeptides (e.g., aspartame) to complex organic molecules (e.g., stevioside). Most of the more commonly available high-intensity sweeteners and/or their metabolites are rapidly absorbed in the gastrointestinal tract. For example, acesulfame-K and saccharin are not metabolized and are excreted unchanged by the kidney. Sucralose, stevioside, and cyclamate undergo degrees of metabolism, and their metabolites are readily excreted. Gastrointestinal flora may, in part, assist in the metabolic breakdown depending on the parent compound. Unlike the other high-intensity sweeteners, aspartame is not absorbed intact but is metabolized in the gastrointestinal tract to naturally occurring dietary *** potential toxicity of a particular high-intensity sweetener varies. None of the more highly used high-intensity sweeteners are mutagenic, but large doses of cyclamate or saccharin in rodents have been associated with the production of bladder tumors. There is no evidence for the available high-intensity sweeteners being teratogenic or embryotoxic. High-intensity sweeteners are often non-cariogenic, i.e., they do not support growth of oral cavity microorganisms, and hence may be useful in preventive dentistry. Thus, the utilization of safe, high-intensity sweeteners in food products provides the Chinese people the opportunity to enjoy sweetness of sugar without the extra calories or cariogenic potential.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Optimal Combination of Stator and Rotor Pole Numbers in Flux-Switching PM Brushless AC Machines

Optimal Combination of Stator and Rotor Pole Numbers in Flux...

引用

11th International Conference on Electrical Machines and Systems

作者： a.thomas D.Howe Department of Electronic and Electrical Engineering University of SheffieldSheffield S1 3JDU.K.

＜正＞The combination of stator and rotor pole numbers in flux-switching PM machines is optimized analytically and by finite element *** influence on the optimal rotor pole width and split ratio is *** shows that the optimal rotor pole width for maximum torque varies with the stator and rotor pole number but its sum of total rotor pole width maintains constant which is～1/3 of the total rotor *** also shows that the 12/14 stator/rotor pole FSPM machine exhibits 10% larger electromagnetic torque than the conventional 12/10 stator/rotor pole FSPM machine.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Eco-environmental Impact of Bioenergy Production

引用

Journal of Resources and Ecology 2010年第2期1卷 110-116页

作者： John W.Bickham Mark a.thomas 普渡大学环境中心普渡大学农业与生物工程系

生物质能源生产是能源发展领域的重大挑战,在解决新的替代能源中扮演着重要角色。本文着重论述了美国生物能源生产的生态环境问题。从经济、环境和战略方面考虑,生物能源有望提高国家安全,因而受政策驱动的美国生物能源生产技术备受注... 详细信息

生物质能源生产是能源发展领域的重大挑战,在解决新的替代能源中扮演着重要角色。本文着重论述了美国生物能源生产的生态环境问题。从经济、环境和战略方面考虑,生物能源有望提高国家安全,因而受政策驱动的美国生物能源生产技术备受注目。尽管生物能源具有诸多潜在效益,但是在北美,生物原料供应、高强度经营的土地上农药使用及其对陆地野生动物的潜在影响等令人担忧,我们分析了其中的原因。通常认为,未来生物能源的环境、经济效应是正面的;然而,谨慎地审视和发展生物能源经济以保护生态系统的可持续性显得至关重要。

关键词： biodiversity biofuels wildlife terrestrial habitats conservation agricultural ecosystems

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

芯线:一种精炼钢的工艺方法

引用

兵器材料科学与工程 1989年第5期12卷 59-64页

作者： F.Villette a.thomas M.Douchy 周爱琪

本文介绍了Vallourec公司的Anzin和Saint-Saulve两个钢厂,在钢包处理中使用Affiva1芯线所取得良好的冶金效果。特别是成分微调与钙处理。目前加工厂和用户提出的越来越严格的质量标准和多样化的应用.对钢的生产提出更高的要求。因此,... 详细信息

本文介绍了Vallourec公司的Anzin和Saint-Saulve两个钢厂,在钢包处理中使用Affiva1芯线所取得良好的冶金效果。特别是成分微调与钙处理。目前加工厂和用户提出的越来越严格的质量标准和多样化的应用.对钢的生产提出更高的要求。因此,即使对于非关键产品,钢的组织、机械性能与化学成份的控制,以及夹杂物的类型、形状和数量都变得越来越重要。

关键词：钢包冶金芯线精炼钢

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

创新的移动业务满足低端用户的需求和预算

引用

网络电信 2006年第12期8卷 37-39页

作者： a.thomas

目前全球有20亿人使用移动电话来满足自己的沟通需要。然而地球上还有接近40亿人没有手机，无法使用通信手段进行沟通。在很多国家，移动网络的覆盖仍然远远未达到完善水平，一般来说，运营商会优先覆盖城市人口。但覆盖并非唯一理由：... 详细信息

目前全球有20亿人使用移动电话来满足自己的沟通需要。然而地球上还有接近40亿人没有手机，无法使用通信手段进行沟通。在很多国家，移动网络的覆盖仍然远远未达到完善水平，一般来说，运营商会优先覆盖城市人口。但覆盖并非唯一理由：实际上有75％的全球人口都在移动网络的覆盖范围之内，但是今天只有25％的人口是移动电话用户。

关键词：移动业务电话用户预算求和低端创新城市人口移动网络

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：