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Primary Care Practitioners’ Views on the Use of Proton Pump Inhibitors Associated with Alginate-Antacids for Better Gastroesophageal Reflux Disease Symptom Control: Results of a National Survey in Spain

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Open Journal of Gastroenterology 2014年第10期4卷 335-345页

作者： Carlos Martín de Argila mercedes Ricote Belinchón Agustín Albillos Martínez Gastroenterology and Hepatology Department Ramón y Cajal University Hospital Alcalá University Madrid Spain Mar Báltico Primary Care Center Madrid Spain

Background: Gastroesophageal reflux disease (GERD) is a prevalent disease in Western countries. Despite effective treatment modalities, in some patients total symptom control is not achieved in clinical practice. A cross-sectional study was designed to assess primary care practitioners’ views on the effectiveness of proton pump inhibitors (PPI) as monotherapy in the control of the most common symptoms of GERD (heartburn and regurgitation), as well as to determine the level of implementation of the “combined therapy” (PPI + alginate-antacids). Methods: A questionnaire on different aspects of the management of GERD was completed by 1491 primary care physicians. The questionnaire was composed of 11 close-ended questions with one-choice answer, with a total of 52 items, covering the main data from patients presenting with GERD. Results: Treatment with PPI alone was mostly considered insufficient for the control of GERD symptoms. The combined treatment of PPI + alginate-antacids was used for 37% and 21% of physicians for treating heart-burn and regurgitation, respectively. A better control of symptoms, an increase in the onset of action and to reduce nocturnal acid breakthrough were the most frequently argued reasons for the use of PPI + alginate-antacids. A high percentage of participants believed that treatment with PPI alone was insufficient for the control of symptoms and 39.8% of physicians reported the persistence of heartburn, 38.6% the persistence of regurgitation and 43.2% the persistence of epigastric discomfort in more than 25% of their patients treated with PPI as monotherapy. The most common schedule for the use of the antacid medication was on demand. Conclusions: Spanish primary care physicians consider that a high proportion of GERD patients continue to suffer from symptoms during PPI treatment alone. Ondemand “combined therapy” (PPI + antacid) is considered an efficient option to control reflux symptoms still troublesome in patients with PPI treatment al

关键词： Alginate-Antacids Cross-Sectional Study Gastroesophageal Reflux Disease Heartburn Primary Care Physicians Proton Pump Inhibitors Regurgitation Survey

Model for the Vaccination against the Poliomyelitis

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Journal of Mathematics and System Science 2013年第2期3卷 62-67页

作者： Irene Duarte Gandica Lina Marcela Ocampo Edwin Femando Duque Matin Maria mercedes Gonzáilez Escuela de Investigación en Biomatemótica Universidaddel Quindio Armenia Quindio 630001 Colombia Grupo GYMOL Universidaddel Quindlo Armenia Quindlo 630001 Colombia

The poliomyelitis is an acute infection produced by the polio virus that affects the human central nervous system. It is transmitted by fecal-oral and respiratory *** are two types of vaccine, OPV （live attenuated virus） and IPV （inactivated polio virus）. Currently, there is a plan of vaccination until the age of 5 with OPV. The children vaccinated expel a virus （derived from the vaccine） to the environment, and some of the people that have oral contact with them, get vaccinated by the herd behavior. Nevertheless, taking into account the lately observed facts about the reversion to virulence of the oral polio vaccine during its circulation in the environment, a change in the current vaccination schedule is being contemplated, where the oral polio vaccine can be replaced by the inactivated vaccine. Nowadays, In Colombia the inactivated oral polio vaccine is recommended for children presenting immune deficiency who are vaccinated with IPV. These children do not expel poliovirus to the environment. This work presents a mathematical model that describes the dynamics of the infection in a population where the two types of vaccination are carried out. The population is divided into two groups of age and Michaelis-Menten interactions. Different strategies of vaccination are simulated and analyzed.

关键词： Poliomyelitis vaccine OPV vaccine IPV vaccination mathematical model.

Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 673-681页

作者： Lin Zhang Anjaneya S.Ravipati Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente School of Science and Health University of Western SydneyLocked Bag 1797Penrith South DCNSW 1797Australia Fundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaParque Tecnológico de Ciencias de la SaludAvda.de Conocimiento 3E-18016 ArmillaGranadaSpain

Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic ***:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional *** antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/*** data was analysed using Gene data Screener ***:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial *** plant extracts have exhibited both anti-bacterial and anti-fungal *** instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of ***:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial *** is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the *** results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity *** in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use.

关键词： Anti-fungal activity Anti-bacterial activity Ethanol extract Chinese medicinal herb

Palm Forest Landscape in Castillos (Rocha, Uruguay): Contributions to the Design of a Conservation Area

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Open Journal of Forestry 2017年第2期7卷 97-120页

作者： mercedes Rivas José María Filippini Henrique Cunha Juan Hernández Yuri Resnichenko Rosa Lia Barbieri Faculty of Agronomy and Regional Eastern University Center University of the Republic Rocha Uruguay Embrapa Temperate Climate Pelotas Brazil Faculty of Science University of the Republic Montevideo Uruguay

Butia palm forests are considered unique due to their aesthetic value, high biodiversity level and historical, archaeological and cultural value. The lack of regeneration of butia palms caused by cattle overgrazing and natural grasslands replacement by agriculture endangers these palm forests. The aim of this work is to provide information for the proposal of a conservation area in this rural landscape within the framework of sustainable development. This work was developed within the context of a Geographic Information System with thematic information on palm forest density levels, soils, land use aptitude and rural registers. Field surveys were conducted to record the presence of plant species and genetic resources in different vegetation units. The main category of soil cover was natural grasslands, followed by native forests, wetlands and palm forests. Palm forests grow mainly on soil units with poor to rather poor drainage and on arable or non-arable lands under special conditions. We identified 212 farms where the palm forest is found, a high diversity of vegetation units, the presence of 302 native taxa of plants and a significant number of plant genetic resources for various uses. For the designation of a conservation area, we propose 20 priority farms that will ensure that palm forests are well represented regarding ecosystem diversity. We consider the creation of a Protected Landscape, a State Park or a GIAHS to be the best alternatives so as to protect this unique multifunctional landscape.

关键词： Butia odorata In Situ Conservation Geographic Information Systems Plant Genetic Resources

Morphologic changes due to human chorionic gonadotropin in the rat testis: Role of vascular endothelial growth factor

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Open Journal of Pediatrics 2013年第2期3卷 85-91页

作者： Alfonso Papparella Fabiano Nino Carmine Noviello mercedes Romano Serenella Papparella Orlando Paciello Antonio Agostino Sinisi Department of Endocrinology II University of Naples Naples Italy Department of Pathology and Animal Health Section of Pathologic Anatomy Faculty of Veterinary Medicine University of Naples Federico II Naples Italy Department of Pediatric Surgery II University of Naples Naples Italy Department of Pediatric Surgery Salesi Pediatric Hospital Ancona Italy

Introduction: Human chorionic gonadotropin (hCG) has an important role in the regulation of reproductive system and a high capacity to stimulate angiogenesis by secretion of vascular endothelial growth factor (VEGF). It could be also used for medical treatment of cryptorchidism, as it stimulates Leydig cells to produce testosterone, but its use has been discussed. Aim of the study was to evaluate the testicular morphological changes due to cyclic administration of hCG possibly related to VEGF effect. Methods: 80 pre-puberal male Sprague-Dawley rats were randomly divided in two groups hCG (50 U/I/ Kg) (n = 55/S) and placebo (n = 25/C) treated. The animals were sacrificed respectively after one (S1 n = 10;C1 n = 5), two (S2 n = 10;C2 n = 5) and three weeks of hCG or placebo treatment (S3 n = 35;C3 n = 15);a blood serum was obtained for evaluation of plasmatic testosterone. The testis, prostates, epididymides and seminal vesicles were drawn and weighted. Specimens were fixed in formalin and coloured by hematoxylin-eosin. Morphometric analysis of Leydig cell number, nuclear area and perimeter was carried out. Immunoistochemistry for VEGF has been performed with the avidin-biotin peroxidase technique. Statistical differences between groups, each of different age, were calculating using Student’s T-test. Results: After the first week of hCG treatment it has been observed an increased testicular weight and volume (+/﹣6%) in experimental respect to control group. This result was not observed after the second and third week of treatment. Significant variations were also observed in the mean prostate weight, whereas mean seminal vesicles weight was significant in the S2 and S3 groups respect to control. In the hCG treated rats it has been observed a poor differentiation of the seminiferous epithelium, with high Leydig cell evidence and increased intertubular eosinophilic material. An interstitial edema was demonstrated without inflammatory cell changes. Morphometric analysis

关键词： Cryptorchidism hCG VEGF Hormonal Treatment

街头时装现形记 The Sartorialist

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汽车生活 2008年第11期 120-129页

作者：张陆软 mercedes-BENZ

街上,人多,车多。我们谈车,已经谈了许多;今次,我们谈人。街头的人,各有等色的人,各有性格的人,各有不同路向的人。他们是什么人?不重要!走在街上的人的最重要功能,就是为街头添上灿烂的色彩。在SCOTT SCHUMAN眼中,他们变成了街头的符号。

关键词：时装表演街头时装性格设计师灵感美学照片杂志编辑巴黎美国

Current trends in access to treatment for hepatitis B in immigrants vs non-immigrants

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Gastroenterology Report 2020年第5期8卷 362-366,I0002页

作者： Mireia Miquel Albert Pardo Montse Forné Gemma Martínez-Alpin AdriàRodríguez-Castellano Meritxell Casas MercèRosinach MercèRoget Blai Dalmau Rocío Temiño Joan Carlos Quer Jordi Sanchez-Delgado Jordi Ortiz mercedes Vergara Liver Unit Gastroenterology DepartmentParc TaulíUniversity HospitalInstitut d’Investigacio i InnovacióParc TaulíI3PTAutonomous University of BarcelonaSabadellSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadridSpain Gastroenterology Department University Hospital Joan XXIIITarragonaSpain Liver Unit Gastroenterology DepartmentUniversity Hospital Mútua TerrassaBarcelonaSpain Liver Unit Gastroenterology DepartmentConsorci Sanitari de TerrassaTerrassaSpainó

Background:Universal vaccination for hepatitis B virus(HBV)and migratory movements have changed the demographic characteristics of this disease in Spain and in ***,we evaluated the characteristics of the disease and the possible differences according to origin(immigrants vs non-immigrants)and access to ***:This is a multicenter cross-sectional study(June 2014 to May 2015)in which outpatients with a positive HBsAg were seen and followed in four Hepatology *** and clinical data and indication and access to treatment were collected in two different regions of Catalonia(Spain)where there are no barriers to treatment due to a comprehensive coverage under the National Health ***:A total of 951 patients were evaluated(48.1%men).Of these,46.6%were immigrants(58.7%of them were born in Africa)and were significantly younger compared to *** proportions of patients with alcohol consumption,being overweight,and other indicators of metabolic co-morbidities were significantly higher in *** the 937 patients receiving HBeAg examination,91.7%were *** HBeAg-positive infection was significantly higher in immigrants(3.9%vs 0.6%,P=0.001)and chronic HBeAg-negative hepatitis was higher non-immigrants(31.7%vs 21.4%,P<0.001).Not only was the proportion of patients who met treatment criteria significantly higher among nonimmigrants(38.4%vs 29.2%,P=0.003),but also the proportion of those with indication of effectively receiving therapy at the time of data collection(83.2%vs 57.8%,P<0.001).Conclusions:The immigrant population with HBV is younger and has a lower prevalence of metabolic co-morbidities and a higher frequency of chronic HBeAg *** having access to care and an indication for treatment,some do not get adequately treated due to several factors including local adaptation that precludes access to treatment.

关键词： hepatitis B prevalence immigration access to treatment

Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2019年第9期14卷 1626-1634页

作者： Edwin E. Reza-Zaldivar mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre Unidad de Evaluation Preclinica Unidad de Biotecnologia Medica y FarmaceuticaCentro de Investigation y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Regenerative Medicine Unit Neuroscience InstituteDepartment of Neurosurgery and NeurologyIdlSSC Health Research Institute of the Hospital Clinico San CarlosMadridSpain

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive *** purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s ***’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus *** water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after ***,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM *** showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem *** findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s *** procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval *** 2016-011)on April 25,2016.

关键词： Alzheimer’s disease neurodegenerative disease cognitive impairment memory Alzheimer’s disease mouse model mesenchymal stem cell exosomes neurogenesis cognitive improvement cell-free therapy neural regeneration

Long-Term Prognostic Factors in Patients with Significant Left Main Coronary Artery Disease

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International Journal of Clinical Medicine 2014年第5期5卷 188-196页

作者： mercedes Camprubí Ramón de Castro Mohsen Mohandes Jordi Guarinos Miriam Garcia-Bermúdez Alfredo Bardají Servicio de Cardiología Hospital Universitario de Tar-ragona Joan XXIII Pere Virgili Institute for Health Re-search Universitat Rovira Virgili Tarragona Spain

Introduction and Objectives: The natural history of patients with left main coronary artery disease (LMCAD) is largely unknown. Our objective was to analyse the predictors of long-term mortality in these patients, both those that have had surgery and those that have not undergone surgery for various reasons, in a cohort treated at a university hospital. Methods: The study included patients with significant LMCAD diagnosed through consecutive coronary angiograms from 2001 to 2009. Clinical variables, the reasons for cardiac catheterisation, therapeutic decisions and clinical evolution in long-term follow-up were analysed. Results: Of the 163 patients included in the analysis, a total of 109 (66.9%) underwent revascularisation, while the remaining 54 (33.1%) received other medical treatment. We analysed the clinical events that took place with a mean follow-up period of 54 months (IQR: 25-95). The non-revascularised group had a lower survival rate than the revascularised group in unadjusted analysis (logrank test 0.005). Age (OR 1.04, CI 1.02-1.07, p = 0.001), ventricular dysfunction (OR 2.87, CI95% 1.71-4.81, p 0.0001), clinical instability (OR 2.11, CI95% 1.08 to 4.13, p = 0.028) and above 70% severity of LMCAD (OR 1.78, CI 1.09 to 2.91, p = 0.021) were independent predictors of mortality for the entire cohort, but revascularisation was not. Conclusions: Revascularisation is associated with improved survival in patients with LMCAD, but only age, ventricular dysfunction, clinical instability and the severity of the lesion are independent predictors of long-term mortality in the unselected population.

关键词： Left Main Coronary Artery Disease Surgical Revascularisation Percutaneous Coronary Intervention