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Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys

World Journal of Pediatrics 2023年第9期19卷 864-872页

作者： Francisco Javier ruiz‑Ojeda Augusto Anguita‑ruiz Maria C.rico rosaura Leis Gloria Bueno Luis A.Moreno mercedes Gil‑Campos Ángel Gil Concepción M.Aguilera Department of Biochemistry and Molecular Biology Ⅱ School of PharmacyUniversity of GranadaGranadaSpain Instituto de Investigación Biosanitaria Ibs.GrANADA 18012 GranadaSpain Institute of Nutrition and Food Technology“JoséMataix” Center of Biomedical ResearchUniversity of GranadaAvda.del Conocimiento S/N.18016 ArmillaGranadaSpain rG Adipocytes and Metabolism Institute for Diabetes and ObesityHelmholtz Center Munich85764 MunichGermany Barcelona Institute for Global Health ISGlobal08003 BarcelonaSpain CIBErOBN (Physiopathology of Obesity and Nutrition CB12/03/30038)Institute of Health Carlos Ⅲ(ISCⅢ)28029 MadridSpain Unit of Investigation in Human Nutrition Growth and Development of Galicia(GALINUT)University of Santiago de Compostela(USC)Santiago de CompostelaSpain Pediatric Nutrition research Group Institute of Sanitary Research of Santiago de Compostela(IDIS)CHUS-USC15706 Santiago de CompostelaSpain Unit of Pediatric Gastroenterology Hepatology and NutritioPediatric ServiceUniversity Clinical Hospital of Santiago(CHUS)15706 Santiago de CompostelaSpain GENUD research group Institute of Sanitary Research of Aragón(IIS Aragón)University of ZaragozaZaragozaSpain Instituto Agroalimentario de Aragón(IA2) Universidad de Zaragoza-CITAZaragozaSpain Unit of Pediatric Endocrinology University Clinical Hospital Lozano Blesa50009 ZaragozaSpain Metabolism and Investigation Unit Reina Sofa University HospitalMaimónides Institute of Biomedicine Research of Córdoba(IMIBIC)University of Córdoba14071 CórdobaSpain

Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with *** The study population is a sub-cohort of the PUBMEP research project,consisting of a cross-sectional population of 119 pubertal children with overweight(17 boys,19 girls),obesity(20 boys,25 girls),and normal weight(17 boys,21 girls).All subjects were classified into experimental groups according to their sex,obesity,and insulin resistance(Ir)*** were counted anthropometry,glucose and lipid metabolism,inflammation and cardiovascular biomarkers as well as isthmin-1(ISM1)serum *** population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in ***,the study population had blood whole-genome DNA methylation examined,allowing deepening into the obesity–ISM1 molecular *** Higher serum ISM1 levels were observed in boys with obesity than in normal weight(P=0.004)and overweight(P=0.007)***1 serum levels were positively associated with body mass index(BMI)Z-score(P=0.005)and fat mass(P=0.058)and negatively associated with myeloperoxidase(MPO)(P=0.043)in *** we did not find associations between ISM1 serum levels and metabolic outcomes in girls,which may indicate a putative sexual dimorphism,fat mass was positively associated in all children,including boys and girls(P=0.011).DNA methylation levels in two-enhancer-related CpG sites of ISM1(cg03304641 and cg14269097)were associated with serum levels of ISM1 in *** ISM1 is associated with obesity in boys at the pubertal stage,elucidating how this protein might be of special relevance as a new biomarker of obesity in *** studies including a longitudina

关键词： Children Epigenetics Isthmin-1 Obesity Puberty

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The Conditional Heterocedasticity on the Argentine Inflation. An Analysis for the Period from 1943 to 2013

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Journal of Mathematics and System Science 2017年第10期7卷 269-277页

作者： Juan Carlos Abril Maria De Las mercedes Abril Universidad Nacional de Tucumcin Facultad de Ciencias Economicas and Consejo Nacional de lnvestigaciones Cientificas y Tecnicas (CONICET). Tucuman. Argentina.

Numerous economic time series do not have a constant mean and in practical situations, we often see that the variance of observational error is subject to a substantial variability over time. This phenomenon is known as volatility. To take into account the presence of volatility in an economic series, it is necessary to resort to models known as conditional heteroscedastic models. In these models, the variance of a series at a given time point depends on past information and other data available up to that time point, so that a conditional variance must be defined, which is not constant and does not coincides with the overall variance of the observed series. There is a very large variety of nonlinear models in the literature, which are useful for the analysis of any economic time series with volatility, but we will focus in analyzing our series of interest using ArCH type models introduced by Engle （1982） and their extensions. These models are non-linear in terms of variance. Our objective will be the study of the monthly inflation data of Argentina for the period from January 1943 to December 2013. The data is officially published by the National Institute of Statistics and Censuses （or INDEC as it is known in Argentina）. Although it is a very long period in which various changes and interventions took place, it can be seen that certain general patterns of behavior have persisted over time, which allows us to admit that the study can be appropriately based on available information.

关键词： Inflation heterocedasticity volatility time series.

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Overcoming the barrier of nanoparticle production by femtosecond laser ablation in liquids using simultaneous spatial and temporal focusing

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Photonics research 2019年第11期7卷 1249-1257页

作者： CArLOS DO?ATE-BUENDíA mercedes FErNáNDEZ-ALONSO JESúS LANCIS GLADYS MíNGUEZ-VEGA GrOC·UJI Institute of New Imaging Technologies Universitat Jaume I

There exists an increasing demand of industrial-scale production of high-purity ligand-free nanoparticles due to the continuous development of biomedicine, catalysis, and energy applications. In this contribution, a simultaneous spatial and temporal focusing(SSTF) setup is first proposed for increasing nanoparticle productivity of the eco-friendly pulsed laser ablation in liquids(PLAL) technique. In spite of the fact that femtosecond pulses have proved to achieve higher ablation rates in air than picosecond pulses, in PLAL this is reversed due to the nonlinear energy losses in the liquid. However, thanks to the incorporation of SSTF, the energy delivered to the target is increased up to 70%, which leads to a nanoparticle production increase of a 2.4 factor. This breaks a barrier toward the employment of femtosecond lasers in high-efficiency PLAL.

关键词： barrier simultaneous liquids

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Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola rabelo Jose Tadeu Stefano Ana mercedes Cavaleiro rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa Departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P riglycerides(TGL)(TT vs XA; P re observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P re more obese(32.2 vs 29.0 kg/m2,P rum glucose and insulin levels increased significantly in the presence of ***: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

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DErMAOZONE品牌的品牌意识策略

DERMAOZONE品牌的品牌意识策略

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作者： JESSY mercedes QUINTErO MOrENO 上海外国语大学

学位级别：硕士

人们对外表的追求使得满足这些需求的市场不断发展,其中包括定价合理的医疗、有机产品、外科手术和技术先进的产品。皮肤护理品牌Dermaozone属于最后一类,该品牌使用臭氧成分及一种可持续方法取得了独特的竞争优势。然而,即便具备这些... 详细信息

人们对外表的追求使得满足这些需求的市场不断发展,其中包括定价合理的医疗、有机产品、外科手术和技术先进的产品。皮肤护理品牌Dermaozone属于最后一类,该品牌使用臭氧成分及一种可持续方法取得了独特的竞争优势。然而,即便具备这些竞争优势,该品牌也并未赢得客户的芳心。造成这种情况的一大原因是它们没有线上渠道。此外,由于分销渠道存在一些限制,客户无法享受全渠道体验。这些因素导致该品牌在厄瓜多尔客户当中缺乏知名度。因此,主要应解决的问题是如何改善品牌,使其从竞争者中获得市场份额。为解决这一问题,本专题研究将分析该公司,包括组织结构和环境,从而了解哪些因素可以用作业务机会。此外,为了解环境意识等新行为趋势对厄瓜多尔消费者的影响,作者制定了不同的定性和定量方法。这些信息有助于清晰了解厄瓜多尔人的需求和冲动,从而进一步了解新一代消费者的购买过程。作者为Dermaozone提出了合适的细分和定位,从而重塑其形象。建议包括品牌推广策略和额外的销售渠道。此外,本文还提出一项实施计划,其中涉及建立职务和KPI明确的营销部门,同时也对管理、财务、人力资源和研发部门提出了要求。总而言之,本研究将指导公司赢取新一代具备环保意识的厄瓜多尔消费者,并建议其他公司利用该国的技术发展优势,在化妆品市场建立全方位渠道。本文将在项目期间指出研究的局限性,提供未来研究方向。

关键词：品牌意识绿色营销消费者行为全渠道护肤市场

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Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

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Neural regeneration research 2022年第1期17卷 31-37页

作者： mercedes A.Hernández-Sapiéns Edwin E.reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu ricardo r.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de Neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics Department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,Notch-1,N-and E-cadherin,LrP,Syndecan,Delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSEN1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSEN1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex

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reshaping International Development Cooperation ——China’s Foreign Aid in Latin America

Reshaping International Development Cooperation ...

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作者： Melissa mercedes Alvarez Silva 华中师范大学

学位级别：硕士

巴西、俄罗斯、印度、中国和南非等新兴经济体的快速发展,既改变了国际秩序,也改变了国际发展格局。从历史上看,西方的援助活动一直由经合组织-发展援助委员会（OECD-DAC）主导,并且这种援助带有特定的意图和方向。由于中国等国在南南... 详细信息

巴西、俄罗斯、印度、中国和南非等新兴经济体的快速发展,既改变了国际秩序,也改变了国际发展格局。从历史上看,西方的援助活动一直由经合组织-发展援助委员会（OECD-DAC）主导,并且这种援助带有特定的意图和方向。由于中国等国在南南合作中一直发挥着重要作用,西方援助国和西方援助机构对如何提供发展合作产生了争论。显然,西方的对外援助概念和中国的对外援助概念在不同领域存在着差异。因此,本文希望根据自己国家的发展经验,研究作为21世纪国际发展合作的新塑造者中国的对外援助,尤其是其对拉丁美洲援助的重大贡献。本研究旨在更好地实现和平发展,构建人类命运共同体。

关键词：经合组织-发展援助委员会中国的对外援助拉丁美洲和平发展构建人类命运共同体

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Eco-friendly Leather： Chromium reduction in the Tanning Cycle

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Journal of Environmental Science and Engineering(A) 2017年第8期6卷 402-409页

作者： Elena Salernitano Alessandra Strafella mercedes roig Alice Dall'Ara Laboratory of TEMAF (Materials Technologies Faenza) Italian National Agency for New Technologies Energy and Sustainable Economic Development (ENEA) Faenza 48018 Italy INESCOP Centre for Technology and Innovation Elda 03600 Spain

The leather manufacturing is traditionally responsible for high environmental pollution. Tannery effluent contains, indeed, large amounts of lime sludge, sulfides, acids, toxic metals salts, in particular chromium salts, which are toxic, non-biodegradable and hardly disposable. For this reason, great research efforts are addressed to establish a significantly eco-sustainable and convenient business for companies and to produce high quality leather products. The replacement of current commercial chemical and toxic products with innovative natural/naturalized products and technologies in some crucial phases of the tanning cycle （mainly bating and defatting）, can induce an eco-friendly reduction of the needed chromium amount. Leather samples, treated with innovative bating and defatting products and tanned by several different Cr contents, were characterized by SEM-EDS （Scanning Electron Microscopy equipped with Energy Dispersive X-ray Spectroscopy） and TGA （Thermogravimetric Analysis）. SEM-EDS was used to observe the surface and cross-section morphology and to provide a semi-quantitative elemental analysis, while TGA to evaluate the thermal stability and decomposition phases. The compatibility of the innovative products was demonstrated and the environmental impact of the process, performed by the effluents characterization, was effectively improved as a result of a 20% Cr lowering. The use of innovative products and the chromium reduction did not affect the thermal stability, leather morphology and not involve significant differences in the composition.

关键词： Leather manufacturing tanning cycle Cr reduction natural/naturalized products.

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Evaluation of Ocimum basilicum *** Different Concentrations of K^(+)as an Inhibitor of Pathogenic Bacterial Strains

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 533-541页

作者： mercedes Georgina ramírez-Aragón Victoria Jared Borroel-García ramón Valenzuela-Soto ricardo David Valdez-Cepeda Francisco Javier Wong-Corral JoséLuis García-Hernández Universidad Politécnica de Gómez Palacio Gómez Palacio35120México Universidad Autónoma Chapingo Centro Regional Universitario Centro-NorteZacatecasZac.Universidad Autónoma de ZacatecasFacultad de MatemáticasZacatecas98053México Departamento de Investigación y Posgrado en Alimentos Universidad de SonoraHermosillo83000México Facultad de Agricultura y Zootecnia Universidad Juárez del Estado de DurangoGómez Palacio34000México

The extraction of bioactive compounds has become one of the most interesting areas of modern *** therapeutic reasons,it´s important to obtain antimicrobial agents from natural *** objective of the present study was to determine the inhibitory effect of ethanolic extract of basil(Ocimum basilicum *** rubin)subjected to different concentrations of potassium(K^(+))on the activity of three bacterial strains that are pathogens in *** was evaluated by inhibition surface and these results were compared to two antibiotics:Gentamicin(GE)and Ciprofloxacin(CPF)for their efficacy against each bacterial *** variables presented significant difference(p≤0.05).According to the results,basil extract evaluated showed positive antibacterial activity against the three strains of Pseudomonas aeruginosa,Listeria monocytogenes and Staphylococcus aureus on Mueller Hinton *** was observed highest inhibition areas of different diameters(15.3 mm,21.3 mm and 21.6 mm respectively)when the extract used was obtained from the plants with the highest concentration of potassium(13 mmol L-1).These values were even superior to the highest values showed on the treatments with the antibiotic gentamicin.

关键词： Basil inhibition potassium secondary metabolites antibiotics

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西班牙某医院波及黄斑的视网膜脱离患者手术时机与术后视力的关系（英文）

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国际眼科杂志 2017年第12期17卷 2203-2206页

作者： raquel Castro-Florez r Isabel Gese-Bordils mercedes Garcia-Torre Ignacio Jimenez-Alfaro Guillermo Fernandez-Sanz fundacion jimenez diaz 视网膜科西班牙马德里28040

目的:分析西班牙某三级医院视网膜科接受手术治疗的黄斑裂孔性视网膜脱离患者。着重强调诊断与手术之间的时间间隔,试图寻找术前时间与视力下降之间的关系。方法:回顾性研究。包括77例在Universitario Fundación Jiménez Díaz医院接... 详细信息

目的:分析西班牙某三级医院视网膜科接受手术治疗的黄斑裂孔性视网膜脱离患者。着重强调诊断与手术之间的时间间隔,试图寻找术前时间与视力下降之间的关系。方法:回顾性研究。包括77例在Universitario Fundación Jiménez Díaz医院接受手术治疗的黄斑裂孔性视网膜脱离患者。结果:77例患者中有72例(72眼)参与了该研究。初步手术成功率为94.44%(68/72),采取1或2次干预措施后,全部患者成功率为98.61%(71/72)。术前平均时间为5.3±2.26d。7(9.72%)例患者视力下降2行或更多。视力下降与患者年龄之间具有统计学意义(P=0.001)。研究表明进一步手术干预使视网膜再次附着与视力下降检测之间存在相关联系(P=0.045)。而研究未能发现视力下降与术前时间(P=0.100),手术类型(P=0.578)或晶状体状态(P=0.413)之间具有统计学意义。结论:每家医院都应该研究治疗此类型视网膜脱离治疗的方式,以优化利用现有资源,确保最佳的解剖结构复位和功能恢复。

关键词：视网膜脱离黄斑手术结果视力下降

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