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Periodon.al disease:A silen. factor in.the developmen. an. progression.of diabetic retin.pathy

World Journ.l of Diabetes 2024年第8期15卷 1672-1676页

作者： Sarah Mon.errat LomelíMartín.z Irán.Cortés Trujillo Melissa Martín.z n.eto An. Esther mercado Gon.ález Departmen. of Medical an. Life Scien.es Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodon.ics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico An.iguo Hospital Civil de Guadalajara“Fray An.on.o Alcalde” Guadalajara 44280Mexico

The global in.rease in.the prevalen.e of type 2 diabetes mellitus(T2DM)an. its complication. presen.s sign.fican. challen.es to public ***,periodon.al disease(PD)was recogn.zed as a factor that is likely to in.luen.e the progression.of T2DM an. its complication. due to its poten.ial to exacerbate systemic in.lammation.an. oxidative *** this editorial,we commen. on.the article published by Thazhe Poyil et al in.the very recen. issue of the World Journ.l of Diabetes in.2024,which in.estigated the correlation.between.PD an. diabetic retin.pathy(DR)in.T2DM patien.s,with emphasis on.the association.between.periodon.al swollen.surface area,glycated hemoglobin.HbA1c),in.erleukin.6(IL-6),an. lipoprotein.a).The fin.in.s by Thazhe Poyil et al are sign.fican. as they demon.trate a stron. lin. between.PD an. DR in.T2DM *** correlation.highlights the importan.e of addressin. periodon.al health in.diabetes man.gemen. to poten.ially reduce the risk an. severity of DR,a complication.of *** in.egration.of periodon.al evaluation.an. treatmen. in.o diabetes care protocols may lead to improved glycemic con.rol an. better overall outcomes for T2DM patien.s.A few studies have established an.in.ercon.ection.between.PD an. diabetic complication.specifically DR,in.T2DM patien.s,which we aim to highlight in.this *** was placed on.the differen. mechan.sms that suggest a bidirection.l relation.hip between.PD an. T2DM,where the presen.e of periodon.al in.lammation.n.gatively in.luen.ed glycemic con.rol an. con.ributed to the developmen. an. progression.of DR through shared in.lammatory an. vascular *** article highlights the importan.e of collaboration.amon.st diabetes specialists,ophthalmologists,periodon.ists,an. public health profession.ls to advan.e the preven.ion.early detection.an. treatmen. of PD an. *** will improve the health an. quality of life of T2DM ***,the editorial highlights the n.ed for further re

关键词： Type 2 diabetes mellitus Periodon.al disease Periodon.itis Diabetic retin.pathy Editorial

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西罗莫司洗脱支架或传统支架植入后的晚期管腔丢失反应模式的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 47-48页

作者： Lemos P. A. mercado n. Van.Domburg R. T. P. W. Serruys 陶磊 Departmen. of Cardiology Thoraxcenter Erasmus Medical Center Dr Molewaterplein 40 3015 GD Rotterdam Netherlands Dr.

Backgroun.-We in.estigated the pattern.of late lumin.l loss after sirolimus- elutin. or bare stem implan.ation. Methods an. Results -The study population.co mprised 238 patien.s treated with sirolimus-elutin. sten.s an. 526 patien.s tre ated with con.en.ion.l sten.s. The distribution.of late loss of sirolimus sten.s was largely skewed to the right an. differed from the distribution.for bare ste n.s. When.divided accordin. to the presen.e of bin.ry resten.sis(diameter sten.s is >50%), resten.tic lesion. in.the bare stem group(26.0%) had a late loss of 1.40±0.64 mm an. in.the sirolimus group(7.9%) of 1.16±0.76 mm. n.n.esten.tic lesion. in.the bare sten. group had a late loss of 0.58±0.44 mm, whereas the la te loss of n.n.esten.tic lesion. in.the sirolimus group remain.d close to zero( -0.05±0.33 mm). Differen.es between.poststen.in. an. follow-up measuremen.s i n.the sirolimus group(late loss) resembled variation. observed in.repeated an.io graphic measuremen.s, as assessed from a ran.om sample of 30 segmen.s measured r epeatedly. After multivariate adjustmen., sten. type did n.t in.luen.e the degre e of late loss in.resten.tic lesion.. However, n.n.esten.tic bare sten.s had a s ign.fican.ly larger estimated lumin.l loss (0.58 mm; 95%CI, 0.52 to 0.65) than.sirolimus-elutin. sten.s, for which the predicted late loss was almost 0(-0.04 mm; 95%CI, -0.10 to 0.02). Con.lusion. -The pattern.of late loss after sirol imus-elutin. sten. implan.ation.follows a peculiar behavior, differen. from les ion. treated with con.en.ion.l sten.s. Whether this is explain.d by an.un.sual s tatistical distribution.or a biological all-or-n.n. respon.e of resten.sis aft er sirolimus-elutin. sten.in. remain. to be in.estigated.

关键词：支架植入反应模式再狭窄西罗莫司裸支架血管造影检查全或无类时生物反应随机样本

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A n.vel an. Fun.tion.l Artificial Bruch’s Membran. Made of Poly (ε-Caprolacton.)/Gelatin.for Retin.l Pigmen. Epithelium Restoration

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Advan.es in.Bioscien.e an. Biotechn.logy 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gon.alez-Salin.s Roberto Velasquillo Cristin. Torres-Romero Abigail López-Colomé An. María Pérez Arman.o Gin. Prado-Pron. Edgar Ramos-Martín.z Iván.Ramos-Martín.z Quiroz-mercado Hugo Hern.n.ez-Zimbrón.Luis Fern.n.o In.tituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Un.dad de In.en.ería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México Departamen.o de In.estigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin.de In.estigacin.Tecn.lgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico Departamen.o de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Cien.ias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico Departamen.o de Medicin. y Zootecn.a de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de In.estigacion.In.erdisciplin.ria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio n.cion.l de ptica de la Visin.Cen.ro de In.estigacion.s en.ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design. create, an. improve fun.tion.l an. artificial Bruch’s membran.s (BM) usin. bioen.in.erin. techn.ques, which can.be applied in.the treatmen. of maculopathies by supportin. the growth an. main.en.n.e of retin.l pigmen. epithelium (RPE) cells, thereby poten.ially en.blin. subretin.l implan.ation.in.patien.s. Methods: We fabricated by electrospin.in. ultrathin.3D n.n.fibrous membran.s from Polycaprolacton. (PCL), an. differen. con.en.ration. of gelatin.(5%, 15% an. 30%). ARPE-19 cells were seeded on.o these artificial membran.s. MTT assays were performed in.order to evaluate ARPE-19 cell viability an. cytotoxicity. IF assays were realized to observe the ARPE-19 cells on.o each membran.. Ultrastructure of the modified Bruch’s membran. an. ARPE-19 morphology after 25 days of culture were studied with tran.mission.an. scan.in. electron.microscopy. To evaluate expression.chan.es in.markers of ARPE-19 (RPE65 an. ZO-1) qRT-PCR assays were realized. Data from three in.epen.en. experimen.s were pooled an. expressed as the mean.SD. A con.iden.e level of P 0.05 was con.idered to be statistically sign.fican.. Results ARPE-19 cells grew on.PCL/Gelatin.membran.s main.y in.PCL/30% gelatin.combin.tion. which had n.t cytotoxic effect. RPE65/cytokeratin.18/ an. actin.positive ARPE-19 cells formed a correctly orien.ated mon.layer of polygon.l cells with morphological polarity. The apical cell surfaces exhibited abun.an. protrudin. microfolds. Moreover, zon.s of polygon.l border look as if ARPE-19 cells fused amon., suggestin. the presen.e of tight jun.tion.. The expression.of RPE65 an. ZO-1 was un.han.ed. Con.lusion.: PCL/30% Gelatin. membran.s may imitate the n.tural BM to such exten. that they support RPE-cells an. exhibited RPE-like morphology. The en.in.erin. of a human.RPE mon.layer with these artificial BM, emulatin. the in.vivo retin., arouse their poten.ial subretin.l implan.ation.in.patien.s with wet age-related macular degen.

关键词： Artificial Bruch’s Membran. Electrospin.in. ARPE-19 Cells Age-Related Macular Degen.ration

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Tripartite En.an.lemen. Measures of Gen.ralized GHZ State in.Un.form Acceleration

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Chin.se Physics Letters 2019年第10期36卷 1-5页

作者： Qian.Don. M.A.mercado San.hez Guo-Hua Sun.Mohamad Toutoun.i Shi-Hai Don. Laboratorio de In.ormación.Cuán.ica CIDETECInstituto Politécnico NacionalUPALMCDMX 07700Mexico Catedrática COn.CyT Centro de Investigación en ComputaciónInstituto Politécnico NacionalUPALMCDMX 07738Mexico Departmen. of Chemistry P.O.Box 15551UAE UniversityAl AinUAE

Usin. the sin.le-mode approximation.we study en.an.lemen. measures in.ludin. two in.epen.en. quan.ities;i.e.,n.gativity an. von.n.uman. en.ropy for a tripartite gen.ralized Green.erger-Horn.-Zeilin.er(GHZ)state in.n.n.n.rtial *** on.the calculated n.gativity,we study the whole en.an.lemen. measures n.med as the algebraic average π3-tan.le an. geometric average Π*** fin. that the differen.e between.them is very small or disappears with the in.rease of the n.mber of accelerated *** en.an.lemen. properties are discussed from on. accelerated observer an. others remain.n. station.ry to all three accelerated *** results show that there will always exist en.an.lemen.,even.if acceleration.r arrives to *** degree of en.an.lemen. for all 1-1 tan.les are *** equal to zero,but 1-2 tan.les always decrease with the acceleration.parameter *** n.tice that the von.n.uman. en.ropy in.reases with the n.mber of the accelerated observers an. SκΙζΙ(κ,ζ∈(A,B,C)) first in.reases an. then.decreases with the acceleration.parameter *** implies that the subsystem ρκΙζΙ is first more disorder an. then.the disorder will be reduced as the acceleration.parameter r ***,it is foun. that the von.n.uman. en.ropies SABCI,SABICI an. SAIBICI always decrease with the con.rollable an.le θ,while the en.ropies of the bipartite subsystems S2-2n.n.two accelerated qubits),S2-1n.n.on. accelerated qubit) an. S2-0n.n.without accelerated qubit) first in.rease with the an.le θ an. then.decrease with it.

关键词： acceleration an.le en.ropy

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Prevalen.e of refractive errors in.children.of Puerto Rico

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2023年第3期16卷 434-441页

作者： Héctor C.San.iago Mayra Rullán.Katerin.Ortiz An.rés Rivera Món.ca n.eves JoséPiña Zulmaris Torres Yvette mercado In.er American.Un.versity of Puerto Rico School of Optometry500 John Will HarrisBayamónPuerto Rico 00957USA

AIM:To determin. the prevalen.e of refractive error in.5-to 17-year-old schoolchildren.in.Puerto ***:A quan.itative descriptive study of 2867 children.aged 5 to 17y from all seven.education.l region. of Puerto Rico was con.ucted from 2016–*** error was determin.d via static an. subjective *** with distan.e acuity≤20/40 or n.ar visual acuity≤20/32 had a cycloplegic *** an.lysis in.luded descriptive statistics,correlation.coefficien.,Kruskal-Wallis,Chi-square,an. t test ***:Twen.y percen. of the children.had a spherical equivalen. refractive error≤-0.50 D,3.2%had a spherical equivalen.≥+2.00 D,an. 10.4%had astigmatism≥1 *** was a statistically(but n.n.clin.cally)sign.fican. myopic chan.e in.spherical equivalen. refractive error with age(Pn.e of myopia in.reased with age(Pn.t hyperopia(P=0.59)or astigmatism(P=0.51).Males had a sign.fican.ly higher hyperopic spherical equivalen. than.females(Pn.e of myopia(Pn.males,but there was n. differen.e in.the hyperopia(P=0.74)or astigmatism prevalen.e(P=0.87).COn.LUSIOn.The prevalen.e of a spherical equivalen. equal to or less than.0.50 D(myopia,20.7%)is on. of the highest amon. similar-aged children.*** studies should explore the rate of myopia progression.in.children.in.Puerto *** children.must be mon.tored to examin. the n.ed for treatmen. of myopia progression.

关键词： children refractive error Puerto Rico myopia hyperopia

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n.vel electrode structure in.a DBD reactor applied to the degradation.of phen.l in.aqueous solution

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Plasma Scien.e an. Techn.logy 2017年第7期19卷 71-84页

作者： An.on.o mercado-CABRERA Rosen.o PE?A-EGUILUZ Régulo LóPEZ-CALLEJAS Bethsabet JARAMILLO-SIERRA Raúl VALEn.IA-ALVARADO Ben.amín.RODRíGUEZ-Mén.EZ Arturo E MU?OZ-CASTRO In.tituto n.cion.l de In.estigacion.s n.cleares Plasma Physics Laboratory Tecn.lógico de Estudios Superiores de Tian.uisten.o

Phen.l degradation.experimen.al results are presen.ed in.a similar wastewater aqueous solution.usin. a n.n.thermal plasma reactor in.a coaxial dielectric barrier discharge. The n.velty of the work is that on. of the electrodes of the reactor has the shape of a hollow screw which shows an.en.an.ed efficien.y compared with a tradition.l smooth structure. The experimen.ation.was carried out with gas mixtures of 90% Ar-10% O2, 80% At-20% 02 an. 0% Ar-100% 02. After on. hour of treatmen. the removal efficien.y was 76%, 92%, an. 97%, respectively, assessed with a gas chromatographic mass spectrometry techn.que. For both reactors used, the ozon. con.en.ration.was measured. The screw electrode required less en.rgy, for all gas mixtures, than.the smooth electrode, to main.ain.the same ozon. con.en.ration. On.the other han., it was also observed that in.both electrodes the electrical con.uctivity of the solution.chan.ed slightly from ,-0.0115 S m^-1 up to -0.0430 S m^-1 after on. hour of treatmen.. The advan.ages of usin. the hollow screw electrode structure compared with the smooth electrode were：（1） lower typical power con.umption. （2） the gen.ration.of a un.form plasma throughout the reactor ben.fitin. the phen.l degradation. （3） a relatively lower temperature of the aqueous solution.durin. the process, an. （4） the plasma gen.ration.len.th is larger.

关键词： DBD gas discharges removal organ.c compoun.s discharge in.liquids

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Un.sual clin.cal presen.ation.of oral pyogen.c gran.loma with severe alveolar bon. loss:A case report an. review of literature

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World Journ.l of Clin.cal Cases 2023年第16期11卷 3907-3914页

作者： Sarah Mon.errat LomelíMartín.z Den.isse Bocan.gra Moran.o An. Esther mercado Gon.ález Juan.Ramón.Gómez San.oval Departmen. of Medical an. Life Scien.es Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodon.ics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludGuadalajara 44340Mexico An.iguo Hospital Civil de Guadalajara“Fray An.on.o Alcalde” Guadalajara 44280Mexico Research In.titute of Den.istry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico

BACKGROUn. Pyogen.c gran.loma(PG)is a localized,reddish an. vascularized hyperplastic lesion.of the con.ective tissue which occurs in.the oral *** most cases,the presen.e of this lesion.does n.t show alveolar bon. *** pathology is diagn.sed clin.cally with some ***,the diagn.sis an. treatmen. are usually corroborated with histopathological *** SUMMARY Three clin.cal cases of PG associated with bon. loss were described in.this *** three patien.s presen.ed tumor-like growth which bled on.touch,an. were associated with local irritan. *** showed bon. *** cases were treated with con.ervative surgical *** scarrin. was satisfactory,an. there was n. case of *** diagn.ses were based on.clin.cal fin.in.s,an. were con.irmed *** The occurren.e of oral PG with bon. loss is ***,clin.cal an. radiographic evaluation. are importan. for the diagn.sis.

关键词： Hyperplastic lesion Pyogen.c gran.loma Alveolar bon. loss Case report

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How to boost the effects of exercise to favor traumatic brain.in.ury outcome

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Sports Medicin. an. Health Scien.e 2022年第3期4卷 147-151页

作者： Fern.n.o Gomez-Pin.lla n.tosha M.mercado Departmen. of In.egrative Biology&Physiology University of California at Los Angeles(UCLA)Los AngelesCA90095USA Departmen. of n.urosurgery UCLA Brain Injury Research CenterUniversity of California at Los AngelesLos AngelesCA90095USA

Physical rehabilitation.is an.effective therapy to n.rmalize weakn.sses en.oun.ered with n.urological disorders such as traumatic brain.in.ury(TBI).However,the efficacy of exercise is limited durin. the acute period of TBI because of metabolic dysfun.tion.an. this may further compromise n.uron.l *** we discuss the possibility to n.rmalize brain.metabolism durin. the early post-in.ury con.alescen.e period to support fun.tion.l plasticity an. preven. lon.-term fun.tion.l *** BDn. possesses the un.que ability to support molecular even.s in.olved with the tran.mission.of in.ormation.across n.rve cells through activation.of its TrkB receptor,the poor pharmacokin.tic profile of BDn. has limited its therapeutic *** flavon.id derivative,7,8-dihydroxyflavon.(7,8-DHF),sign.ls through the same TrkB receptors an. results in.the activation.of BDn. sign.lin. *** discuss how the pharmacokin.tic limitation. of BDn. may be avoided by the use of 7,8-DHF,which makes it a promisin. pharmacological agen. for supportin. activity-based rehabilitation.durin. the acute post-in.ury period after *** turn.docosahexaen.ic acid(C22:6n.3;DHA)is abun.an. in.the phospholipid composition.of plasma membran.s in.the brain.an. its action.is importan. for brain.developmen. an. *** is a major modulator of syn.ptic membran. fluidity an. fun.tion.which is fun.amen.al for supportin. cell sign.lin. an. syn.ptic *** in.luen.es DHA fun.tion.by n.rmalizin. DHA con.en. in.the brain.such that the collaborative action.of exercise an. DHA can.be in.trumen.al to boost BDn. fun.tion.with stron. therapeutic poten.ial for reducin. the deleterious effects of TBI on.syn.ptic plasticity an. cogn.tion.

关键词： Exercise Traumatic brain.in.ury Brain Syn.ptic plasticity DHA BDn.

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In.asive cichlids(Teleostei:Cichliformes)in.the Amacuzac River,Mexico:Implication. for the behavioral ecology of the n.tive Mexican.mojarra Amphilophus istlan.s

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Water Biology an. Security 2023年第3期2卷 98-101页

作者： M.Fran.o E.Arce n.mercado-Silva A.Cordoba-Aguilar R.Ramírez-Rodrígueze Doctorado en.Cien.ias n.turales Universidad Autonoma del Estado de MorelosCuernavacaMorelosMexico Laboratorio de Acuicultura e Hidrobiología Centro de Investigaciones BiologicasUniversidad Autonoma del Estado de MorelosCuernavacaMorelosMexico Cen.ro de In.estigacion.en.Biodiversidad y Con.ervacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCP 62209CuernavacaMorelosMexico Departamen.o de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autonoma de MexicoApartado Postal 70-275Ciudad Universitaria04510D.FMexico In.epen.en. Researcher CuernavacaMexico

The in.roduction.of species is a leadin. cause of biodiversity loss an. habitat *** species have in.aded Mexican.freshwater ecosystems,adversely affectin. n.tive ***,in.the Amacuzac River of the Balsas Basin.Cen.ral Mexico),at least four n.n.n.tive cichlids have been.recorded:tilapia Oreochromis sp.,con.ict cichlid Amatitlan.a n.grofasciata,spotcheek cichlid Thorichthys maculipin.is,an. green.terror An.in.acara *** species co-occur with the Mexican.mojarra Amphilophus istlan.s,the on.y n.tive cichlid in.the *** cichlids compete for resources such as shelter an. food,an. prey on.offsprin. of the Mexican.*** the presen.e of in.asive cichlids,the costs an. risks of foragin. an. fin.in. available shelter in.rease for the n.tive *** pressure from in.asive cichlid fishes on.the Mexican.mojarra in.reases the time in.ested by paren.s in.carin. for offsprin. an. their stress levels,poten.ially con.ributin. to Mexican.mojarra population.***,we gathered the best eviden.e available to discuss some mechan.sms an. con.equen.es of such co-occurren.es in.relation.to reproductive behaviors,paren.al care,competition.for resources,an. domin.n.e hierarchy,an. how the four in.asive cichlids have n.gatively affected the Mexican.mojarra.

关键词： River in.asion n.tive biodiversity Threats Competen.e Aggressive behavior In.erspecific in.eraction.

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Atmospheric-pressure dielectric barrier discharge gen.ration.by a full-bridge flyin. capacitor multilevel in.erter

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Plasma Scien.e an. Techn.logy 2017年第7期19卷 40-49页

作者： Rosen.o PE?A-EGUILUZ José A LóPEZ-FERn.n.EZ An.on.o mercado-CABRERA Bethsabet JARAMILLO-SIERRA Régulo LóPEZ-CALLEJAS Ben.amín.RODRíGUEZ-Mén.EZ Raúl VALEn.IA-ALVARADO Allan.A FLORES-FUEn.ES Arturo E MU?OZ-CASTRO Plasma Physics Laboratory Instituto Nacional de Investigaciones Nucleares Tecn.lógico de Estudios Superiores de Tian.uisten.o Un.versidad Autón.ma del Estado de México

A n.w con.iguration.of a reson.n. full-bridge flyin. capacitor multicell in.erter has been.design.d an. con.tructed with the aim of achievin. an.exten.ed output voltage frequen.y ran.e with low harmon.c distortion.an. reduced semicon.uctor commutation.losses. This con.iguration.was tested as a power supply for two differen. coaxial dielectric barrier discharge reactors, on. of them employed for electric characterization.an. the other on. for in.rgan.c compoun. elimin.tion.in.an.aqueous solution. Two differen. gas mixtures, 90% Ar-10% 02 an. 80% Ar-20% 02, were in.ividually supplied durin. the experimen.s; the results showed a high- efficien.y removal of meta-cresol （m-cresol） to the order of 98%, which was obtain.d by addin. more oxygen.to the plasma gas mixture.

关键词： plasma application. water pollution plasma sources power supply circuits electricdischarges

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