检索结果-南通市图书馆

黔南民族医专学报 1995年第Z1期8卷 95-96页

作者： R.Zandomeneghi L.serra U.baumgarti M.C.POPPi 李正安黔南州医院

表皮生长因子是一种6000道尔顿多肽,含53种氨基酸残基。已证明肽可抑制胃酸分泌。在人类肽的种类很多,可防止胃粘膜损害。经鼠实验证实,有促进溃疡愈合的作用。在十二指肠Brunners腺的表皮生长因子其局部作用提示。

关键词：表皮生长因子生长抑素消化性溃疡十二指肠溃疡病发病机理内分泌细胞十二指肠球部因子水平放射免疫测定抗体

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神经痛患者C伤害性感受器的温度依赖性双峰

世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 26-27页

作者： Bostock H. Campero M. serra J. Ochoa J.L. 袁海峰 Prof. Sobell Department Institute of Neurology University College London Queen Square London WC1N 3BG United Kingdom

Five patients with small-fibre neuropathy characterized by temperature-dependent spontaneous pain, hyperalgesia/allodynia and signs of neurogenic inflammation were studied clinically and thermographically, and by microneurography. Thermography revealed hyperthermia confined to painful and hyperalgesic skin of distal extremities, in absence of sympathetic vasomotor denervation. Quantitative sensory testing documented either reduced thresholds or increased suprathreshold magnitude for heat pain. Microneurography identified 13 primary cutaneous C-nocicep- tors generating abnormal impulses in response to electrical stimuli and, in one patient, nociceptors firing spontaneously. All five patients showed examples of double spikes, in which a single brief electrical stimulus occasionally or regularly evoked two impulses. In one case, a second impulse occurred at one of three different delays. In all five patients, warming of the skin increased the probability of a second impulse occurring. Impulse doubling has previously been reported as occurring rarely in normal subjects and is attributable to unfiltering of multiple orthodromic impulses due to unidirectional conduction failure at branch points. A higher incidence of double firing in neuropathic pain patients is probably due to a reduced safety factor for conduction in the terminal arborizations of their C-nociceptors. These observations show that unidirectional conduction block provides a peripheral mechanism of temperature-dependent nociceptor hyperactivity in small-fibre neuropathy that may contribute to hyperalgesia.

关键词：伤害性感受器温度依赖性交感缩血管神经痛觉过敏伤害感受器电刺激神经成像定量感觉测试热痛阈自发放电

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A Greener Future

FAIR Principles:Interpretations and Implementation Considerations

Beijing Review 2010年第50期 12-12页

作者： Abdullah Al-Saidi Sergio serra Alf Wills Jake Schmidt

In the past year, extreme weather events have erupted across the globe, and 2010 looks to be one of the hottest years in recorded history. That has placed an onus on the Cancun conference to prompt（共2页)

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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天疱疮患者细胞因子的多态性

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 8-9页

作者： Eberhard Y. Burgos E. Gaglia rdi J. H.M. serra 田中伟 School of Chemical Science National University of Cordoba Medina Allende Ciudad Universitaria Haya de la Torre esquina Cordoba 5000 Argentina

The aim of this study was to assess whether tumor necrosis factor α(TNF-α), transforming growth factor β1(TGF-β1) and interleukin-10 (IL-10) polymorph isms are among the factors influencing the development of pemphigus. Whole blood from 20 patients with pemphigus and 24 control subjects was taken. Genomic DNA was obtained and cytokine genotyping for IL-10 (-1082G/A;-819C/T),TGFB1(codon 10C/T,codon25G/C)and TNFA (-308 G/A) was performed using the ARMS-PCR method. The distribution of IL-10 (-819) alleles was significantly different between t he pemphigus and control groups (P= 0.009). In particular, allele T was associat ed with the disease (OR 3.291, 95%CI 1.350-8.020). Similar results were observ ed when only pemphigus vulgaris (PV) patients were analyzed (P= 0.012, OR 3.410, 95%CI 1.346-8.639). An increased frequency of the low producer IL-10 haploty pe (-1082/-819 A/T) in patients with pemphigus compared with controls was obse rved (OR 2.714, 95%CI 1.102-6.685) and this association was also significant w hen only PV patients were considered (OR 2.667, 95%CI 1.043-6.816). There were no differences between patients and controls in the frequency of any other gene polymorphism analyzed. The increased frequency of the low producer IL-10 haplo type (-1082 /-819 A/T) suggest that the carriage of this haplotype might predi spose to pemphigus or the high and intermediate producer haplotypes may be prote ctive factors. The prevalence of the allele IL-10 (-819 T) in pemphigus patien ts cannot be explained by the current hypothesis, according to which a particula r allele of the gene is associated with a different level of cytokine production and therefore affects the predisposition to a particular disease. However, this cytokine polymorphism might be linked to an unknown susceptibility factor.

关键词：天疱疮患者细胞因子寻常性天疱疮多态性转化生长因子肿瘤坏死因子α 密码子基因分型单倍型保护因子

Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2022年第8期19卷 965-966页

作者： Daniel Perez-Zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria izquierdo-Useros IrsiCaixa AIDS Research Institute 08916 Badalona Spain Germans Trias i Pujol Research Institute (IGTP) Can Ruti Campus 08916 Badalona Spain University of Vic—Central University of Catalonia (UVic-UCC) Vic 08500 Spain Catalan Institution for Research and Advanced Studies (ICREA) 08010 Barcelona Spain IRTA Centre de Recerca en Sanitat Animal (CReSA IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain CNAG-CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) 08028 Barcelona Spain Universitat Pompeu Fabra (UPF) Barcelona Spain Centro Nacional de Biotecnología CSIC 28049 Madrid Spain Division of Microbiology and Immunology Yerkes National Primate Research Center Emory University Atlanta GA USA Department of Pathology and Laboratory Medicine School of Medicine Emory University Atlanta GA USA Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA Barcelona Supercomputing Center (BSC) 08034 Barcelona Spain Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA 92037 USA UAB CReSA (IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain Departament de Sanitat i Anatomia Animals Facultat de Veterinària UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-021-00794-6,published online 15 November 2021 In the version of this correspondence initially published,one of the SARS-CoV-2 variants used in Fig.1B,which was originally described in the article as the SARS-CoV-2 variant‘B.1.***.248.2 Gamma’,is actually the‘P.2 Zeta’SARS-CoV-2 variant of *** GISAID accession ID EPI_ISL_1831696 provided is correct。

关键词： interaction media initially

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马南蒂亚莱斯大楼

建筑技艺 2010年第5期16卷 80-85页

作者： Luis izquierdo W.,Antonia Lehmann S.B.,Raimundo Lira V.,José Domingo Peafiel E. Miguel Villegas G.

马南蒂亚莱斯大楼位于圣地亚哥的一个始于20世纪50年代的花园社区规划的区域内，这个区域在过去的20年间经历了快速的城市化进程，社区内遍布着7～20层高的建筑，而且这里的土地价值也是目前圣地亚哥最高的，达到了2800USD／m2。该项目... 详细信息

马南蒂亚莱斯大楼位于圣地亚哥的一个始于20世纪50年代的花园社区规划的区域内，这个区域在过去的20年间经历了快速的城市化进程，社区内遍布着7～20层高的建筑，而且这里的土地价值也是目前圣地亚哥最高的，达到了2800USD／m2。该项目的客户是地产商，他们提出了以下几点要求：

关键词：大楼莱斯社区规划圣地亚哥城市化进程土地价值地产商花园

SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2021年第12期18卷 2676-2678页

作者： Daniel Perez-Zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria izquierdo-Useros IrsiCaixa AIDS Research Institute 089BadalonaSpain IRTA Centre de Recerca en Sanitat Animal(CReSAIRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain CNAG-CRG Centre for Genomic Regulation(CRGBarcelona Institute of Science and Technology(BIST)08028BarcelonaSpain Centro Nacional de Biotecnología CSIC28049MadridSpain Division of Microbiology and Immunology Yerkes National Primate Research CenterEmory UniversityAtlantaGAUSA Department of Pathology and Laboratory Medicine School of MedicineEmory UniversityAtlantaGeorgiaUSA Division of Pathology Yerkes National Primate Research CenterEmory UniversityAtlantaGeorgiaUSA Germans Trias i Pujol Research Institute(IGTP) Can Ruti Campus089BadalonaSpain Barcelona Supercomputing Center(BSC) 08034BarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) 08010BarcelonaSpain University of Vic-Central University of Catalonia(UVic-UCC) Vic08500Spain Department of Integrative Structural and Computational Biology Scripps ResearchLa JollaCA92037USA Universitat Pompeu Fabra(UPF) BarcelonaSpain UAB CReSA(IRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain Departament de Sanitat i Anatomia Animals Facultat de VeterinàriaUAB08193Bellaterra(Cerdanyola del Vallès)Spain

Antigen-presenting cells(APCs)may be resistant to SARS-CoV-2 infection but still contribute to viral *** such as sialic acid-binding Ig-like lectin 1(Siglec-1/CD169)mediate the attachment of viruses to ***,we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of *** receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants.

关键词： infection Antigen media

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大小冯

网球 2010年第4期 152-152页

作者： serra

大冯在看儿子打网球。早春的南方其实很凉．大冯屁股下的椅子就像冰棍一样．可是大冯坚决不肯动一下，必须要镇定．镇定，不能让儿子看见自己的任何不安和软弱，这是大冯的原则。大冯想．即使下面是根烙铁，他也必须有总教练的威严在那... 详细信息

大冯在看儿子打网球。早春的南方其实很凉．大冯屁股下的椅子就像冰棍一样．可是大冯坚决不肯动一下，必须要镇定．镇定，不能让儿子看见自己的任何不安和软弱，这是大冯的原则。大冯想．即使下面是根烙铁，他也必须有总教练的威严在那里．他本来就是个体委干部．心里明白训练的气场，这个说不清的东西对于运动员是多么重要．自己不威严．那就等于笑场了．然后训练课崩盘。

关键词：训练课总教练运动员网球

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来信选登

网球 2013年第9期 10-10页

作者： serra

serra先生：刚刚过去的夏季联赛我们队输掉了决赛,这可是三年的头一回,对手就像抢劫成功的土匪那样在庆祝,他们大声对着我们唱歌,互相泼洒饮料,饮料溅到我们身上,于是我们和他们发生了冲突,后来颁奖仪式都无法正常进行了,大家拿了奖品... 详细信息

serra先生：刚刚过去的夏季联赛我们队输掉了决赛,这可是三年的头一回,对手就像抢劫成功的土匪那样在庆祝,他们大声对着我们唱歌,互相泼洒饮料,饮料溅到我们身上,于是我们和他们发生了冲突,后来颁奖仪式都无法正常进行了,大家拿了奖品就赶紧散伙,请问对于这种过头的庆祝行为,有什么规则可以约束？

关键词：选登颁奖仪式饮料联赛