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SDHA: a key player in T cell-mediated intestinal disease severity

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Cellular & Molecular Immunology 2022年第2期19卷 139-141页

作者： José M.izquierdo Centro de Biología Molecular Severo Ochoa.Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent article in Nature Immunology,Fujiwara et *** reduced mitochondrial respiration and increased succinate levels in intestinal epithelial cells(IECs)from several distinct models of T cell-mediated *** observations point to a specific link between alterations in the mitochondrial complex II component SDHA and the severity of T cell-mediated intestinal diseases and suggest that SDHA dysfunction could be a diagnostic and/or prognostic biomarker in T cell-mediated immunopathology.

关键词： severity alterations mediated

What good is the reserve? A translational perspective for the managing of cognitive decline

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Neural Regeneration Research 2019年第7期14卷 1219-1220页

作者： Laura serra Francesca Gelfo Neuroimaging Laboratory IRCCS Fondazione Santa Lucia Department of Clinical and Behavioural Neurology IRCCS Fondazione Santa Lucia Department of Human Sciences Guglielmo Marconi University

The concept of reserve appears in the neurological literature in the 1940s arising from the observation that there is no linear relationship between neurological damage and severity of the clinical ***,this concept sustains that the experiences pursued during life-span enrich the brain by making it more resilient to neuronal ***,in the last three decades the reserve concept has become very popular in the scientific field,mainly associated with the pathophysiological mechanisms underlying the Alzheimer’s Disease(AD)(serra et al.,2018;Stern et al.,2018).

关键词： reserve appears neurological literature reserve concept

Dynamical Criticality:Overview and Open Questions

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Journal of Systems Science & Complexity 2018年第3期31卷 647-663页

作者： ROLI Andrea VILLANI Marco FILISETTI Alessandro serra Roberto Department of Computer Science and Engineering (DISI) Campus of Cesena University of Bologna Italy Department of Physics Informatics and Mathematics University of Modena and Reggio Emilia Italy European Centre for Living Technology Venezia Italy Explora s.r.l. Roma Italy & European Centre for Living Technology Venezia Italy

Systems that exhibit complex behaviours are often found in a particular dynamical con- dition, poised between order and disorder. This observation is at the core of the so-called criticality hypothesis, which states that systems in a dynamical regime between order and disorder attain the highest level of computational capabilities and achieve an optimal trade-off between robustness and flexibility. Recent results in cellular and evolutionary biology, ueuroscience and computer science have revitalised the interest in the criticality hypothesis, emphasising its role as a viable candidate general law in adaptive complex systems. This paper provides an overview of the works on dynamical criticality that are -- To the best of our knowledge -- Particularly relevant for the criticality hypothesis. The authors review the main contributions concerning dynamics and information processing at the edge of chaos, and illustrate the main achievements in the study of critical dynamics in biological systems. Finally, the authors discuss open questions and propose an agenda for future work.

关键词： Attractors criticality dynamical regimes edge of chaos phase transitions.

Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases

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Neural Regeneration Research 2022年第4期17卷 741-747页

作者： serra Ozgen Judith Krigman Ruohan Zhang Nuo Sun Departments of Physiology and Cell Biology The Ohio State University Wexner Medical CenterColumbusOHUSA College of Medicine Graduate Research in the Department of NeuroscienceThe Ohio State UniversityColumbusOHUSA Dorothy M.Davis Heart and Lung Research Institute The Ohio State University Wexner Medical CenterColumbusOHUSA College of Pharmacy Department of Graduate ResearchThe Ohio State UniversityColumbusOHUSA

Mitochondria play a multidimensional role in the function and the vitality of the neurological *** the generation of neural stem cells to the maintenance of neurons and their ultimate demise,mitochondria play a critical role in regulating our neural pathways'homeostasis,a task that is critical to our cognitive health and neurological *** provide energy via oxidative phosphorylation for the neurotransmission and generation of an action potential along the neuron's *** paper will first review and examine the molecular subtleties of the mitochondria's role in neurogenesis and neuron vitality,as well as outlining the impact of defective mitochondria in neural *** authors will then summarize neurodegenerative diseases related to either neurogenesis or homeostatic *** of the significant detriment neurodegenerative diseases have on the quality of life,it is essential to understand their etiology and ongoing molecular *** mitochondrial role in neurogenesis and neuron vitality is *** and understanding this organelle's role in the genesis and homeostasis of neurons should assist in finding pharmaceutical targets for neurodegenerative diseases.

关键词： Alzheimer's disease autophagy mitochondria mitophagy neural stem cells neurodegenerative diseases neurogenesis Parkin Parkinson's disease PINK1

Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix

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World Journal of Gastroenterology 2009年第27期15卷 3431-3433页

作者： Khaled O Alsaad Stefano serra Runjan Chetty Depart-ment of Laboratory Medicine and Pathobiology University of Toronto and University Health Network20 Elizabeth Street 11th Floor Eaton Wing Toronto Ontario M5G 2C4 Canada Department of Pathology and Laboratory Medicine King Abdulaziz Medical City and College of Medicine King Saud bin Abdulaziz University for Health SciencesPO Box 22490 Riyadh 11426 MC 1122 Saudi Arabia

Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation. Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture. Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented. In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination.

关键词： Goblet cell carcinoid Mucinous cystadenoma Vermiform appendix

Anticoagulation in elderly patients at high risk of atrial fibrillation without documented arrhythmias

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Journal of Geriatric Cardiology 2017年第3期14卷 166-168页

作者： Manuel Martinez-Selles Eusebio Garcia-izquierdo Jaen Ignacio Fernandez Lozano Servicio de Cardiologia Hospital General Universitario Gregorio Maranon Universidad Complutense CIBERCV Madrid Spain Servieio de Cardiologia Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain

Recent studies have suggested that patients with high CHA2DS2VASc-score [Congestive Heart failure, hyperten- sion, Age ≥ 75 years （doubled）, Diabetes, Stroke （doubled）, Vascular disease, Age 65-74 years, Sex category （female sex）] thromboembolic complications occurred irrespective of the presence of atrial fibrillation （AF） and anticoagulant therapy may be initiated irrespective of documented AF.

关键词： Anticoagulation Atrial fibrillation Interatrial block Prognosis

Catalytic combustion of soot over Ru-doped mixed oxides catalysts

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Journal of Rare Earths 2014年第7期32卷 610-620页

作者： L.F.Nascimento R.F.Martins O.A.serra Department of Chemistry Faculdade de FilosofiaCiências e Letras de Ribeirao PretoUniversity of Sao PauloAv.Bandeirantes 3900CEP 14040-901 Ribeirao PretoSPBrazil

We employed modified substrates as outer heterogeneous catalysts to reduce the soot originating from the incomplete diesel combustion. Here, we proposed that ceria（CeO2）-based catalysts could lower the temperature at which soot combustion occurred from 610 oC to values included in the operation range of diesel exhausts（270–400 oC）. Here, we used the sol-gel method to synthesize catalysts based on mixed oxides（ZnO：CeO2） deposited on cordierite substrates, and modified by ruthenium nanoparticles. The presence of ZnO in these mixed oxides produced defects associated with oxygen vacancies, improving thermal stability, redox potential, sulfur resistance, and oxygen storage. We evaluated the morphological and structural properties of the material by X-ray diffraction（XRD）, Brumauer-emmett-teller method（BET）, temperature programmed reduction（H2-TPR）, scanning electron microscopy（SEM）, and transmission electron microscopy（TEM）. We investigated how the addition of Ru（0.5 wt.%） affected the catalytic activity of ZnO：CeO2 in terms of soot combustion. Thermogravimetric analysis（TG/DTA） revealed that presence of the catalyst decreased the soot combustion temperature by 250 oC, indicating that the oxygen species arose at low temperatures, which was the main reason for the high reactivity of the oxidation reactions. Comparative analysis of soot emission by diffuse reflectance spectroscopy（DRS） showed that the catalyst containing Ru on the mixed oxide-impregnated cordierite samples efficiently oxidized soot in a diesel stationary motor： soot emission decreased 80%.

关键词： soot combustion ceria mixed oxides ruthenium nanoparticles rare earths

Assessing architectural color preference after Le Corbusier’s 1931 Salubra keyboards:A cross cultural analysis

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Frontiers of Architectural Research 2021年第3期10卷 502-515页

作者： Juan serra Banu Manav Yacine Gouaich Department of Architectural Graphic Expression Escuela Tecnica Superior de ArquitecturaUniversitat Polite`cnica de Vale`nciaValencia46022Spain Department of Interior Architecture and Environmental Design Faculty of Art and DesignKadir Has UniversityIstanbul34083Turkey Laboratory LCTPE University Abdelhamid Ibn BadisMostaganem27000Algeria

Color preference for the interior of a bedroom of Le Corbusier’s Swiss Pavilion was studied using 1931 Salubra color keyboards in a cross-cultural *** indicate that students from architecture and interior design slightly dislike or are indifferent to Le Corbusier color combinations and prefer pale and low saturated colors for interior *** least preferred colors belong to green and brown *** significant gender differences are found that follow a stereotyped tendency,with females preferring pinks,light blues and light greens,while males vivid oranges and *** Easterners are significantly more likely to green colors,while Western Europeans to dark *** data indicate that not only hue,but also value and saturation are important color features to inform preference for interior architecture.

关键词： Color preference Salubra Le Corbusier Swiss Pavilion Architectural Policromie

Current trends in access to treatment for hepatitis B in immigrants vs non-immigrants

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Gastroenterology Report 2020年第5期8卷 362-366,I0002页

作者： Mireia Miquel Albert Pardo Montse Forné Gemma Martínez-Alpin AdriàRodríguez-Castellano Meritxell Casas mercèRosinach mercèRoget Blai Dalmau Rocío Temiño Joan Carlos Quer Jordi Sanchez-Delgado Jordi Ortiz mercedes Vergara Liver Unit Gastroenterology DepartmentParc TaulíUniversity HospitalInstitut d’Investigacio i InnovacióParc TaulíI3PTAutonomous University of BarcelonaSabadellSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadridSpain Gastroenterology Department University Hospital Joan XXIIITarragonaSpain Liver Unit Gastroenterology DepartmentUniversity Hospital Mútua TerrassaBarcelonaSpain Liver Unit Gastroenterology DepartmentConsorci Sanitari de TerrassaTerrassaSpainó

Background:Universal vaccination for hepatitis B virus(HBV)and migratory movements have changed the demographic characteristics of this disease in Spain and in ***,we evaluated the characteristics of the disease and the possible differences according to origin(immigrants vs non-immigrants)and access to ***:This is a multicenter cross-sectional study(June 2014 to May 2015)in which outpatients with a positive HBsAg were seen and followed in four Hepatology *** and clinical data and indication and access to treatment were collected in two different regions of Catalonia(Spain)where there are no barriers to treatment due to a comprehensive coverage under the National Health ***:A total of 951 patients were evaluated(48.1%men).Of these,46.6%were immigrants(58.7%of them were born in Africa)and were significantly younger compared to *** proportions of patients with alcohol consumption,being overweight,and other indicators of metabolic co-morbidities were significantly higher in *** the 937 patients receiving HBeAg examination,91.7%were *** HBeAg-positive infection was significantly higher in immigrants(3.9%vs 0.6%,P=0.001)and chronic HBeAg-negative hepatitis was higher non-immigrants(31.7%vs 21.4%,P<0.001).Not only was the proportion of patients who met treatment criteria significantly higher among nonimmigrants(38.4%vs 29.2%,P=0.003),but also the proportion of those with indication of effectively receiving therapy at the time of data collection(83.2%vs 57.8%,P<0.001).Conclusions:The immigrant population with HBV is younger and has a lower prevalence of metabolic co-morbidities and a higher frequency of chronic HBeAg *** having access to care and an indication for treatment,some do not get adequately treated due to several factors including local adaptation that precludes access to treatment.

关键词： hepatitis B prevalence immigration access to treatment