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World Journal of Emergency Medicine 2025年第1期16卷 3-9页

作者： Chuanbao Li Shengchuan Cao Yue Zheng mengzhi zong Haitao Zhang Xuezhong Yu Feng Xu Yuguo Chen the Chinese Clinical Practice Consensus for Device-supported Treatment in Adults with Post-cardiac Arrest Syndrome Work group Department of Emergency Medicine Chest Pain CenterShandong Provincial Clinical Research Center for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinan 250012China Department of Critical Care Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China 不详

During cardiac arrest (CA),severe ischemia and hypoxia occur in tissues and organs of the entire body,inflammatory cytokines are released,and ischemiareperfusion injury occurs after the return of spontaneous circulation (ROSC),leading to multiple organ dysfunction in the body;this condition is called post-CA syndrome(PCAS).^([1])According to the BASeline Investigation of Out-of-Hospital Cardiac Arrest (BASIC-OHCA) study,the crude incidence of emergency medical service (EMS)-assessed OHCA was 95.7 per 100,000 individuals,and only1.2%of those individuals survived to hospital discharge or30 d after being resuscitated by the EMS in China.

关键词： cardiac organs return

Comparative effects of rosuvastatin and atorvastatin on the risk of new-onset diabetes mellitus in patients with acute coronary syndrome receiving percutaneous coronary intervention:a retrospective cohort study

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Emergency and Critical Care Medicine 2022年第4期2卷 209-213页

作者： Cunhui Jia Rui Tian mengzhi zong Fangyun Luan Wenjun Wang Chuanbao Li Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Qilu Hospital of Shandong UniversityJinanShandongChina.

Background:Statins are frequently prescribed to reduce cardiovascular morbidity and mortality by lowering low-density lipoprotein cholesterol ***,the use of statins leads to an increased incidence of new-onset type 2 diabetes mellitus(NODM).Our study aims to compare the effect of rosuvastatin versus atorvastatin on NODM in patients with acute coronary syndrome(ACS)who underwent percutaneous coronary intervention(PCI)within 18 months of ***:A retrospective cohort study was conducted on patients with ACS who underwent PCI and were treated with rosuvastatin or atorvastatin between June 2012 and June *** survival functions between the 2 groups were estimated using the Kaplan-Meier method and compared using the log-rank test with NODM as the *** proportional hazards models were used to calculate hazard ratios(HRs)and 95%confidence intervals(CIs)for the risk factors of ***:In total,220 patients received rosuvastatin and 168 *** cumulative incidence of NODM in the rosuvastatin group was lower but did not reach statistical significance,compared with that in the atorvastatin group(7.27%vs.12.50%,respectively;log-rank P=0.08).Using Cox proportional hazards models,baseline fasting blood glucose level was associated with a statistically significant increase in the risk of NODM(HR:4.56;95%CI:2.83–7.36;P<0.01).Conclusion:Long-term use of moderate rosuvastatin had a similar incidence of NODM compared with atorvastatin in patients with ACS receiving PCI.

关键词： Acute coronary syndrome Atorvastatin New-onset diabetes mellitus Percutaneous coronary intervention Rosuvastatin

基于Kraken2扩展标准数据库对反刍动物消化道微生物分类能力

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微生物学报 2025年第1期65卷 402-415页

作者：翁玉楠甄永康王梦芝王洪荣扬州大学动物科学与技术学院江苏扬州225009

宏基因组学技术的应用丰富了对动物消化道中微生物组成以及功能的认识。当前,基于宏基因组测序读长(reads)水平的物种组成的分类比对水平普遍在15%-45%。因此,提高宏基因组测序reads水平微生物的比对率,可进一步挖掘宏基因数据中的微生... 详细信息

宏基因组学技术的应用丰富了对动物消化道中微生物组成以及功能的认识。当前,基于宏基因组测序读长(reads)水平的物种组成的分类比对水平普遍在15%-45%。因此,提高宏基因组测序reads水平微生物的比对率,可进一步挖掘宏基因数据中的微生物信息。【目的】通过扩展Kraken2标准数据库来提高反刍动物消化道微生物的分类能力,从而进一步挖掘宏基因组数据中的微生物信息。【方法】本研究共收集了来自牛、绵羊和山羊瘤胃液、粪便以及消化道中14827个宏基因组组装基因组(metagenome-assembled genomes,MAGs),经质控过滤后,保留了3095个物种级基因组箱(species-levelgenomebins,SGBs),经物种分类以及功能预测后,SGBs被整合进Kraken2标准数据库,并对其分类效果予以评估。【结果】在SGBs在基因组分类数据库(genome taxonomy database,GTDB)物种分类中,3053个SGBs为细菌,可归类为28门782属;42个SGBs为古菌,可归类为2门8属。基于eggNOG软件功能预测,SGBs在蛋白相邻类的聚簇(clusterof orthologous groups of proteins,COG)功能分类中可注释到26种分类;在京都基因与基因组百科全书(Kyotoencyclopediaofgenesandgenomes,KEGG)功能预测中,前25个直系同源物(KEGG orthology,KO)通路号可归类为14种通路类型;碳水化合物酶(carbohydrate-active enzymes,CAZy)预测中,593个SGBs可注释到6类碳水化合物酶,分别是辅助氧化还原酶类(auxiliaryactivities,AA)、碳水化合物酯酶(carbohydrate esterases,CE)、糖苷转移酶(glycosyltransferases,GT)、碳水化合物结合模块(carbohydrate-binding modules,CBM)、糖苷水解酶(glycoside hydrolases,GH)、多糖裂解酶(polysaccharide lyases,PL);其中,GH是最为广泛的碳水化合物酶种类。3095个SGBs加入Kraken2标准数据库(2024年5月)后,使得数据库中物种数量增加了5.00%,数据库大小从87.2 Gb提升为98.2Gb。通过对一项基于宏基因组技术解析日粮精粗比对荷斯坦奶牛瘤胃微生物组成影响的研究再评估,加入SGBs的数据库使得该研究中瘤胃液宏基因组reads水平的物种比对率从(19.35±1.81)%提升到(51.04±2.05)%,种水平主成分(principal components analysis,PCA)分析结果表明,扩展的数据库增强了区分2种不同日粮精粗比水平下的瘤胃微生物结构的能力,线性判别丰度差异分析(linear discriminant analysis effect size,LEfSe)结果表明,在标准数据库中,Xylanibacter ruminicola和Aristaeella hokkaidonensis分别是低粗料和高粗料日粮条件下的微生物标志物;而在扩展后的数据库中,Prevotella sp.902800365和Prevotella sp.900316445分别是低粗料和高粗料日粮条件下的微生物标志物。【结论】通过引入SGBs扩展Kraken2标准数据库,可进一步增加数据库中物种覆盖度,提高宏基因组reads水平物种比对率,从而增进对宏基因数据中微生物的理解。

关键词： Kraken2 反刍动物消化道微生物分类数据库

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肽类添加剂在反刍动物生产中的应用研究进展

动物营养学报 2025年第1期37卷 115-125页

作者：钟新皇张振斌蔡青和王梦芝扬州大学动物科学与技术学院扬州225009 上海欧耐施生物技术有限公司上海201613 省部共建绵羊遗传改良与健康养殖国家重点实验室新疆农垦科学院畜牧兽医研究所石河子832000

肽是由氨基酸组合连接的活性物质,不仅具有营养性作用,而且具备特定的生物活性功能。肽对机体的活性作用表现在促进养分吸收和代谢、抗炎、抗氧化、免疫调节和维护肠道健康等方面。在动物生产中,肽能够促进动物生长、提高生产力、维持健... 详细信息

肽是由氨基酸组合连接的活性物质,不仅具有营养性作用,而且具备特定的生物活性功能。肽对机体的活性作用表现在促进养分吸收和代谢、抗炎、抗氧化、免疫调节和维护肠道健康等方面。在动物生产中,肽能够促进动物生长、提高生产力、维持健康,具有广阔的应用前景,因此成为21世纪的研究热点。本文聚焦于肽和反刍动物,旨在综述各种肽类物质尤其是活性小肽的作用及其在反刍动物生产中的应用研究进展,以期为反刍动物生产中肽的应用提供参考。

关键词：肽反刍动物应用研究进展

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基于数据驱动的智能变电站信息高效校验技术

中国电力 2025年第1期58卷 100-106页

作者：计荣荣张淦锋王梦芝金颖杰李海黄若钒国网浙江省电力有限公司超高压分公司浙江杭州311121 武汉凯默电气有限公司湖北武汉430223 三峡大学电气与新能源学院湖北宜昌443000

为提高变电站的远动遥信对点效率,提出一种基于数据驱动的智能站信息高效校验技术。面向智能变电站,基于远动信息对点系统架构,采用多点随机不重复抽取方法实现信息全覆盖,并通过不一致效验分析方法进行信息对点检验,利用抽取校核方法... 详细信息

为提高变电站的远动遥信对点效率,提出一种基于数据驱动的智能站信息高效校验技术。面向智能变电站,基于远动信息对点系统架构,采用多点随机不重复抽取方法实现信息全覆盖,并通过不一致效验分析方法进行信息对点检验,利用抽取校核方法实现远动遥信对点的闭环处理。通过仿真算例,验证了所提方法的高效性与准确性。

关键词：数据驱动遥信对点不一致分析

Bacteriophages in water pollution control:Advantages and limitations

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 29-43页

作者： mengzhi Ji Zichen Liu Kaili Sun Zhongfang Li Xiangyu Fan Qiang Li School of Biological Science and Technology University of JinanJinan250022China College of Food and Bioengineering Hezhou UniversityHezhou542899China

Wastewater is a breeding ground for many pathogens,which may pose a threat to human health through various water transmission ***,a simple and effective method is urgently required to monitor and treat *** bacterial viruses,bacteriophages(phages)are the most widely distributed and abundant organisms in the *** to their capacity to specifically infect bacterial hosts,they have recently been used as novel tools in water pollution *** purpose of this review is to summarize and evaluate the roles of phages in monitoring pathogens,tracking pollution sources,treating pathogenic bacteria,infecting bloom-forming cyanobacteria,and controlling bulking sludge and biofilm pollution in wastewater treatment *** also discuss the limitations of phage usage in water pollution control,including phage-mediated horizontal gene transfer,the evolution of bacterial resistance,and phage concentration *** review provides an integrated outlook on the use of phages in water pollution control.

关键词： Phage Water pollution monitoring Harmful bacteria biocontrol Horizontal gene transfer Bacterial resistance

Research on the Audio Publishing of Classical Books Based on the Theory of Business Model Canvas: Taking Romance of the Three Kingdoms in Digital Audio Platforms as an Example

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Contemporary Social Sciences 2024年第1期9卷 58-74页

作者： Ding Qin Liu mengzhi Shaanxi Normal University

Visual media have dominated sensory communications for decades,and the resulting“visual hegemony”leads to the call for the“auditory return”in order to achieve a holistic balance in cultural *** of the Three Kingdoms,a classic literary work in China,has received significant attention and promotion from leading audio ***,the commercialization of digital audio publishing faces unprecedented challenges due to the mismatch between the dissemination of long-form content on digital audio platforms and the current trend of short and fast information *** on the Business Model Canvas Theory and taking Romance of the Three Kingdoms as the main focus of analysis,this paper argues that the construction of a business model for the audio publishing of classical books should start from three aspects:the user evaluation of digital audio platforms,the establishment of value propositions based on the“creative transformation and innovative development”principle,and the improvement of the audio publishing infrastructure to ensure the healthy operation and development of the digital audio platforms and consequently improve their current state of development and expand the boundaries of cultural heritage.

关键词： Romance of the Three Kingdoms audio publishing Business Model Canvas digital audio platforms

Satellite integrity monitoring for satellite-based augmentation system:an improved covariance-based method

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Satellite Navigation 2022年第1期3卷 74-84,I0003页

作者： Shuaiyong Zheng mengzhi Gao Zhigang Huang Xiaoqin Jin Kun Li School of Integrated Circuit Science and Engineering Tianjin University of TechnologyNo.391 Bin Shui Xi Dao RoadXiqing DistrictTianjin 300384China School of Electronic and Information Engineering Beihang UniversityNo.37 Xueyuan RoadHaidian DistrictBeijing 100191China Tianjin Navigation Instrument Research Institute No.268 No.1 RoadDing Zi Gu StreetHongqiao DistrictTianjin 300131China

Satellite integrity monitoring is vital to satellite-based augmentation systems,and can provide the confdence of the diferential corrections for each monitored satellite satisfying the stringent safety-of-life *** integrity information includes the user diferential range error and the clock-ephemeris covariance which are used to deduce integrity ***,the existing direct statistic methods sufer from a low integrity bounding *** address this problem,we develop an improved covariance-based method to determine satellite integrity information and evaluate its performance in the range domain and position *** with the direct statistic method,the integrity bounding percentage is improved by 24.91%and the availability by 5.63%.Compared with the covariance-based method,the convergence rate for the user diferential range error is improved by 8.04%.The proposed method is useful for the satellite integrity monitoring of a satellite-based augmentation system.

关键词： Clock-ephemeris covariance matrix Groove model Satellite-based augmentation system Scale model User diferential range error

Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells

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Journal of Molecular Cell Biology 2020年第5期12卷 359-371页

作者： Qiuping He mengzhi Hong Jincan He Weixin Chen Meng Zhao Wei Zhao RNA Biomedical Institute Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Key Laboratory of Stem Cells and Tissue Engineering Sun Yat-sen UniversityMinistry of EducationGuangzhou 510080China

Bromodomain-containing proteins are known readers of histone acetylation that regulate chromatin structure and *** the functions of bromodomain-containing proteins in development,homeostasis,and disease states have been well studied,their role in self-renewal of hematopoietic stem and progenitor cells(HSPCs)remains poorly ***,we performed a chemical screen using nine bromodomain inhibitors and found that the bromodomain and PHD finger-containing protein 1(Brpf1)inhibitor OF-1 enhanced the expansion of Lin−Sca-1+c-Kit+HSPCs ex vivo without skewing their lineage differentiation ***,our results also revealed distinct functions of Brpf1 isoforms in ***1b promoted the expansion of *** contrast,Brpf1a is the most abundant isoform in adult HSPCs but enhanced HSPC quiescence and decreased the HSPC ***,inhibition of Brpf1a by OF-1 promoted histone acetylation and chromatin accessibility leading to increased expression of self-renewal-related genes(***1).The phenotypes produced by OF-1 treatment can be rescued by suppression of Mn1 in *** findings demonstrate that this novel bromodomain inhibitor OF-1 can promote the clinical application of HSPCs in transplantation.

关键词： Brpf1 inhibitor OF-1 Brpf1a Mn1 hematopoietic stem and progenitor cell expansion

Dietary N-carbamylglutamate or L-arginine supplementation improves hepatic energy status and mitochondrial function and inhibits the AMP-activated protein kinase-peroxisome proliferator- activated receptor γ coactivator-1α-transcription factor A pathway in intrauterine-growth-retarded suckling lambs

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Animal Nutrition 2021年第3期7卷 859-867页

作者： Hao Zhang Xiaoyun Liu Shengnan Ren Mabrouk Elsabagh mengzhi Wang Hongrong Wang Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou225009China Department of Animal Production and Technologies Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityCampusNigde51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafr El-SheikhEgypt

The objective of this study was to investigate the effects of dietary administration of L-arginine(Arg)or N-carbamylglutamate(NCG)on hepatic energy status and mitochondrial functions in suckling Hu lambs with intrauterine growth retardation(IUGR).Forty-eight newborn Hu lambs of 7 d old were allocated into 4 treatment groups of 12 lambs each,in triplicate with 4 lambs per replicate(2 males and 2 females)as follows:CON(lambs of normal birth weight,4.25±0.14 kg),IUGR(3.01±0.12 kg),IUGR+1%Arg(2.99±0.13 kg),or IUGR+0.1%NCG(3.03±0.11 kg).The experiment lasted for 21 d,until d 28 after birth,and all lambs were fed milk replacer as a basal *** with IUGR lambs,NCG or Arg administration increased(P<0.05)the adenosine triphosphate(ATP)level and the activities of com-plexes I/III/IV,isocitrate dehydrogenase and citrate synthase in the *** with CON lambs,the relative mRNA levels of adenosine monophosphate-activated protein kinaseα1(AMPKα1),peroxisome proliferator-activated receptorγcoactivator-1α(PGC1α)and transcription factor A(TFAM)were increased(P<0.05)in the liver of IUGR lambs,but were decreased(P<0.05)in the liver of NCG-or Arg-treated lambs compared with those in the IUGR *** with IUGR lambs,NCG or Arg administration decreased(P<0.05)the total AMPKα(tAMPKα)-to-phosphorylated AMPKα(pAMPKα)ratio and the protein expression of PGC1αand *** results suggested that dietary Arg or NCG supplements improved hepatic energy status and mitochondrial function and inhibited the AMPK-PGC1α-TFAM pathway in IUGR suckling lambs.

关键词： L-Arginine Liver Intrauterine growth restriction Energy status Mitochondrial function N-carbamylglutamate