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Triplet bismuthinidenes featuring unprecedented giant and positive zero field splittings

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National Science Review 2023年第10期10卷 79-85页

作者： mengyuan wu Wang Chen Dongmin Wang Yizhen Chen Shengfa Ye Gengwen Tan Innovation Center for Chemical Sciences Key Laboratory of Organic Synthesis of Jiangsu ProvinceCollege of ChemistryChemical Engineering and Materials Science Soochow University State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryIGCME Sun Yat-sen University State Key Laboratory of Elemento-Organic Chemistry Nankai University

Isolation of triplet pnictinidenes,which bear two unpaired electrons at the pnictogen centers,has long been a great challenge due to their intrinsic high ***,we report the syntheses and characterizations of two bismuthinidenes MsFluindtBu-Bi（3） and MsFluind*-Bi（4） stabilized by sterically encumbered hydrindacene *** were facilely prepared through reductions of the corresponding dichloride precursors with 2 molar equivalents of potassium *** structural analyses revealed that 3 and 4contain a one-coordinate bismuth atom supported by a Bi-C single σ *** a consequence,the remaining two Bi 6p orbitals are nearly degenerate,and 3 and 4 possess triplet ground *** characterizations with multinuclear magnetic resonance,magne tome try and near infrared spectroscopy coupled to wavefunction based ab initio calculations concurred to evidence that there exist giant and positive zero field splittings(>4300 cm-1) in their S=1 ground *** even at room temperature the systems almost exclusively populate the lowest-energy nonmagnetic Ms=0 level,which renders them seemingly diamagnetic.

关键词： bismuth bismuthinidene triplet state zero field splitting theoretical calculation

Kidney organoids as a promising tool in nephrology

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Genes & Diseases 2022年第3期9卷 585-597页

作者： mengyuan wu Tingting Hu Ping Zhu Moussa Ide Nasser Jie Shen Fang Sun Qingnan He Mingyi Zhao Department of Pediatrics The Third Xiangya HospitalCentral South UniversityChangshaHunan 410013PR China Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100PR China XiangYa School of Medicine Central South UniversityChangshaHunan 410013PR China

Kidney disease has become a global public health problem affecting over 750 million people worldwide and imposing a heavy economic burden on *** complex architecture of the human kidney makes it very difficult to study the pathophysiology of renal diseases in vitro and to develop effective therapeutic options for *** though cell lines and animal models have enriched our understanding,they fail to recapitulate key aspects of human kidney development and renal disease at cellular and functional *** can be derived from either pluripotent stem cells or adult stem cells by strictly regulating key signalling ***,these self-differentiated organoids represent a promising technology to further understand the human kidney,one of the most complex organs,in an unprecedented *** newly established protocols improved by organ-on-chip and coculture with immune cells will push kidney organoids towards the next ***,we focus on recent achievements in the application of kidney organoids in disease modelling,nephrotoxic testing,precision medicine,biobanking,and regenerative therapy,followed by discussions of novel strategies to improve their utility for biomedical *** applications we discuss may help to provide new ideas in clinical fields.

关键词： Biomedical research Disease modelling Kidney organoids Precision medicine Stem cells

Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform

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Bioactive Materials 2024年第11期41卷 221-238页

作者： Dong Guo Hui Liu Sheng Zhao Xinya Lu Haoyu Wan Yitao Zhao Xinzhi Liang Anbiao Zhang mengyuan wu Zhisheng Xiao Ning Hu Zhong Li Denghui Xie Department of Orthopedic Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou510630PR China Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou510630PR China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and EnergySouthwest UniversityChongqing400715PR China Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Department of Biomedical Engineering The Chinese University of Hong KongNTHong KongPR China

Rapid and efficient tendon fixation to a bone following trauma or in response to degenerative processes can be facilitated using a tendon anchoring *** biomaterials,and in particular,bio-resorbable polymer composites designed to match the mineral phase content of native bone,have been shown to exhibit osteoinductive and osteoconductive properties in vivo and have been used in bone fixation for the past 2 *** this study,a resorbable,bioactive,and mechanically robust citrate-based composite formulated from poly(octamethylene citrate)(POC)and hydroxyapatite(HA)(POC-HA)was investigated as a potential tendon-fixation *** vitro analysis with human Mesenchymal Stem Cells(hMSCs)indicated that POC-HA composite materials supported cell adhesion,growth,and proliferation and increased calcium deposition,alkaline phosphatase production,the expression of osteogenic specific genes,and activation of canonical pathways leading to osteoinduction and ***,in vivo evaluation of a POC-HA tendon fixation device in a sheep metaphyseal model indicates the regenerative and remodeling potential of this citrate-based composite ***,this study presents a comprehensive in vitro and in vivo analysis of the functional response to a citrate-derived composite tendon anchor and indicates that citrate-based HA composites offer improved mechanical and osteogenic properties relative to commonly used resorbable tendon anchor devices formulated from poly(L-co-D,l-lactic acid)and tricalcium phosphate PLDLA-TCP.

关键词： Citrate Osteoinductive Tendon anchor Composite

国家与性别:民国时期反对女子“剧烈运动”的话语传播及再造

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成都体育学院学报 2022年第3期48卷 35-40页

作者：吴梦园长沙理工大学文学与新闻传播学院湖南长沙410114

20世纪20年代初到30年代中这段时期,在美国自然主义体育思潮影响下,国内女校教育逐渐突破单一的体操教学,出现篮球、田径等竞技类运动项目,这引发了社会空间中关于女子“剧烈运动”的一系列抵制话语。文章通过文献资料法、历史分析法、... 详细信息

20世纪20年代初到30年代中这段时期,在美国自然主义体育思潮影响下,国内女校教育逐渐突破单一的体操教学,出现篮球、田径等竞技类运动项目,这引发了社会空间中关于女子“剧烈运动”的一系列抵制话语。文章通过文献资料法、历史分析法、逻辑推理法等,对此女子“剧烈运动”的反对话语进行梳理,发现其中存在对西方体育生理知识展开选择性译介,并加以本土演绎的创造过程。其中,一方面在国家救亡的社会视域中,反对女子剧烈运动被赋予了女性身体必须适度锻炼以为国家“善种”的优生学意义;但在传统文化的礼俗视域中,反对其剧烈运动,又包含了妇女身体须恪守礼教、男女有别的性别政治意味。由此,以反对女子“剧烈运动”为线索,国家主义与男权政治在本土语境下形成一种微妙平衡,构成了霍尔所谓的“接合”关系。

关键词：女子“剧烈运动” 国家主义性别政治语际书写女性体育

cGAS-STING: mechanisms and therapeutic opportunities

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Science China Life Sciences 2025年

作者： mengyuan Zhang Changxin wu Defen Lu Xing Wang Guijun Shang Shanxi Medical University School and Hospital of Stomatology Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University College of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA(dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

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离轴非球面反射镜的装调方法

光学学报 2014年第13期34卷 381-386页

作者：韩娟段嘉友陈建军吴萌源中国科学院西安光学精密机械研究所陕西西安710119 西安电子科技大学物理与光电工程学院陕西西安710071 中国科学院大学北京100049

为了在光学装调中保证单件离轴非球面的精确定位，需要对其6个自由度进行严格控制，尤其要对影响离轴非球面装调最重要的离轴量和离轴角这两个自由度加以严格控制。现有离轴非球面加工和检测中，对这两个特殊参数难以给出精确数值，从... 详细信息

为了在光学装调中保证单件离轴非球面的精确定位，需要对其6个自由度进行严格控制，尤其要对影响离轴非球面装调最重要的离轴量和离轴角这两个自由度加以严格控制。现有离轴非球面加工和检测中，对这两个特殊参数难以给出精确数值，从而难以实现离轴非球面的精密光学装调。通过运用离轴反射镜的曲率半径中心像与工装基准光轴之间的变化规律，采用精密测量法实现对离轴量和离轴角的精确测量。装调实验证明，利用这一测量法，光学装调出的离轴非球面可达到离轴量0．05mm和离轴角10″级的精度，检测出的镜面波像差均方根（RMS）为0．022（λ=632．8nm），使该离轴非球面获得了理想的像质，实现了精确装调。

关键词：测量离轴非球面反射镜光学装调曲率半径中心像离轴量倾斜角

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初中生英语词汇学习存在的问题及策略探究

英语教师 2022年第1期22卷 184-185,192页

作者：吴梦圆扬州大学扬子津校区西校区江苏扬州225009

阐述英语词汇学习的重要性。分析初中生英语词汇学习存在的问题,如不认识音标,"哑巴英语"普遍;孤立地学习词汇,不懂得结合具体语境;被动学习词汇,死记硬背。结合词汇教学实例,探索初中生英语词汇学习策略,即重视音标学习、在语境中学习... 详细信息

阐述英语词汇学习的重要性。分析初中生英语词汇学习存在的问题,如不认识音标,"哑巴英语"普遍;孤立地学习词汇,不懂得结合具体语境;被动学习词汇,死记硬背。结合词汇教学实例,探索初中生英语词汇学习策略,即重视音标学习、在语境中学习词汇、开展趣味性词汇学习活动。

关键词：初中英语词汇学习音标语境

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南水北调邯邢段高填方渠段锥探灌浆试验施工

水利建设与管理 2015年第6期35卷 10-14页

作者：武孟元河北省水利工程局河北石家庄050021

锥探灌浆施工首先用造孔机具钻孔,然后在钻孔内进行微压灌浆,对土质坝体、堤防防渗加固具有良好的效果。本文从灌浆材料、机具的选择、施工方法和质量检查等多个方面详细阐述了锥探灌浆试验的整个过程,为类似工程施工提供了一定的借鉴... 详细信息

锥探灌浆施工首先用造孔机具钻孔,然后在钻孔内进行微压灌浆,对土质坝体、堤防防渗加固具有良好的效果。本文从灌浆材料、机具的选择、施工方法和质量检查等多个方面详细阐述了锥探灌浆试验的整个过程,为类似工程施工提供了一定的借鉴经验。

关键词：高填方渠道锥探灌浆试验施工南水北调

知信行模式对甲状腺功能亢进患者用药依从性及睡眠质量的影响

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现代医用影像学 2018年第8期27卷 2973-2975页

作者：吴梦媛商丘市第一人民医院内分泌科河南商丘476100

目的:探讨知信行模式对甲状腺功能亢进患者用药依从性及睡眠质量的影响。方法:选取2017年6月到2018年6月我院收治的甲状腺功能亢进患者80例,按照随机对照原则分成对照组和观察组,每组各40例。对照组实施常规护理,观察组接受知信行模式... 详细信息

目的:探讨知信行模式对甲状腺功能亢进患者用药依从性及睡眠质量的影响。方法:选取2017年6月到2018年6月我院收治的甲状腺功能亢进患者80例,按照随机对照原则分成对照组和观察组,每组各40例。对照组实施常规护理,观察组接受知信行模式护理干预。比较两组患者用药依从性、睡眠质量。结果:观察组患者干预1个月、3个月、6个月的用药依从性、PSQI评分均优于对照组,差异具有统计学意义(P<0.05)。结论:知信行模式护理可有效提高甲状腺功能亢进患者的用药依从性,改善睡眠质量,利于预后。

关键词：甲状腺功能亢进知信行模式用药依从性睡眠质量