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优质抗病水稻新品种宏稻59选育与应用

种子 2020年第11期39卷 133-136,F0003页

作者：周静姬汉轩王君怡王思媛曹梦雨王亚男闻健李万昌桑世飞姬生栋河南师范大学生命科学学院河南新乡453007

水稻新品种宏稻59属粳型常规水稻品种,以玉稻518为母本,新稻21为父本进行杂交,经系谱法选育而成。该品种2017年、2018年参加国家北方黄淮粳稻组品种区域试验,2年平均产量9631.20 kg·hm^-2,比徐稻3号增产6.67%。宏稻59株高101.7 cm,全... 详细信息

水稻新品种宏稻59属粳型常规水稻品种,以玉稻518为母本,新稻21为父本进行杂交,经系谱法选育而成。该品种2017年、2018年参加国家北方黄淮粳稻组品种区域试验,2年平均产量9631.20 kg·hm^-2,比徐稻3号增产6.67%。宏稻59株高101.7 cm,全生育期156.7 d;稻瘟病综合指数2年分别为3.8和2.4,穗瘟损失率最高级为3级,中抗稻瘟病;米质达到农业行业《食用稻品种品质》标准2级。该品种具有优质、抗病、高产等优点,适宜在河南黄淮及信阳地区、山东南部及沿黄区、江苏淮北稻区、安徽淮北及沿淮区等地种植。

关键词：水稻育种宏稻59 品质抗病

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体外冲击波治疗慢性非特异性腰痛的疗效观察

解放军医学院学报 2020年第8期41卷 793-795页

作者：周明彭楠曹梦宇戈含笑张攻孜祁晓磊黄丽萍高谦王宁解放军总医院第一医学中心康复医学科北京100853 解放军总医院第二医学中心康复医学科北京100853

目的观察体外冲击波治疗慢性非特异性腰痛的临床疗效。方法将2018年12月-2019年7月在解放军总医院第一医学中心康复医学科门诊诊断为慢性非特异性腰痛的80例患者分为试验组40例及对照组40例。对照组给予常规康复理疗(如电刺激、热疗、... 详细信息

目的观察体外冲击波治疗慢性非特异性腰痛的临床疗效。方法将2018年12月-2019年7月在解放军总医院第一医学中心康复医学科门诊诊断为慢性非特异性腰痛的80例患者分为试验组40例及对照组40例。对照组给予常规康复理疗(如电刺激、热疗、超声波治疗等),每天1次,连续2周;试验组给予体外冲击波治疗(治疗压力为2~2.5 bar,频率8 Hz,冲击2000次),隔天1次,共5次。于治疗前、治疗2周后进行疼痛视觉模拟评分(VAS)和Oswestry功能障碍指数问卷表(Oswestry Disability Index,ODI)评价,并进行组间比较。结果试验组4例脱落。治疗前两组VAS评分差异无统计学意义(P>0.05),但ODI评分实验组显著劣于对照组(P<0.05)。治疗2周后两组患者VAS评分及ODI评分均较治疗前明显改善(P均<0.05),且试验组VAS评分及ODI评分显著优于对照组(P均<0.05)。结论低能量、短疗程的冲击波治疗可减轻慢性非特异性腰痛患者疼痛症状,改善腰部功能障碍。

关键词：体外冲击波慢性腰痛 VAS评分 ODI评分康复医学

3种诊断标准下北京社区老年男性的肌少症患病率比较

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老年医学与保健 2020年第4期26卷 524-527页

作者：刘陪沛王惠周明朱亚琼曹梦宇刘金炜刘加强彭楠解放军总医院第二医学中心康复医学科国家老年疾病临床医学研究中心北京100853 解放军医学院北京100853 中央军委机关事务管理总局服务局保健室北京100034 联合参谋部警卫局卫生保健处北京100017

目的比较不同诊断标准下北京社区老年男性的肌少症患病率及各诊断标准的一致性。方法以北京某社区527例60~94岁老年男性为研究对象,采用面对面问卷方法,记录一般情况及SARC-F问卷评分;通过生物电阻抗分析法检测骨骼肌的肌量,计算骨骼肌... 详细信息

目的比较不同诊断标准下北京社区老年男性的肌少症患病率及各诊断标准的一致性。方法以北京某社区527例60~94岁老年男性为研究对象,采用面对面问卷方法,记录一般情况及SARC-F问卷评分;通过生物电阻抗分析法检测骨骼肌的肌量,计算骨骼肌质量指数;测试握力、5次起坐时间及步速。分别用3种不同标准进行肌少症诊断。结果采用SARC-F问卷、AWGS标准、EWGSOP2标准,肌少症患病率分别为6.45%、17.08%、17.46%,其中80岁以上人群的肌少症患病率明显增高,达39.36%(P<0.01)。AWGS标准与EWGSOP2标准下肌少症患病率的差异无统计学意义(χ^2=485.92,P=0.69),2个标准具有几乎完全的一致性(Kappa值为0.96,P<0.05)。采用SARC-F问卷,肌少症患病率明显偏低,与AWGS标准、EWGSOP2标准相比,差异均有统计学意义(χ^2=90.53、χ^2=87.84,P=0.00);灵敏度为28.89%、28.26%,特异度为98.17%、98.16%;诊断一致性偏低(Kappa值为0.36、0.35,P<0.05)。结论尽管EWGSOP2标准和AWGS标准诊断流程不同,但2者对肌少症的诊断有很好的一致性。SARC-F问卷具有特异度高、灵敏度低的特点,可用于缺乏测试设备的基层医疗机构进行筛查,但可能会低估肌少症的患病率。

关键词：老年肌少症患病率诊断标准

LC-Q-TOF/MS法用于伤科天芍凝胶中化学成分的研究

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世界科学技术-中医药现代化 2024年第6期26卷 1515-1527页

作者：杨丽李孟璇钱梦雨刘文君闫明曹亮章晨峰付娟王振中江苏康缘药业股份有限公司连云港222001 中药制药过程控制与智能制造技术全国重点实验室连云港222001

目的采用LC-Q-TOF/MS技术对伤科天芍凝胶的化学成分进行鉴定。方法以Agilent Eclipse Plus C18柱(250 mm×4.6 mm,5μm)色谱柱,甲醇-0.1%甲酸水为流动相进行梯度洗脱,流速为1.0 mL·min^(-1),柱温30℃。在正、负离子全扫描模式下采集伤... 详细信息

目的采用LC-Q-TOF/MS技术对伤科天芍凝胶的化学成分进行鉴定。方法以Agilent Eclipse Plus C18柱(250 mm×4.6 mm,5μm)色谱柱,甲醇-0.1%甲酸水为流动相进行梯度洗脱,流速为1.0 mL·min^(-1),柱温30℃。在正、负离子全扫描模式下采集伤科天芍凝胶成分的质谱数据,结合对照品与文献数据信息进行主成分辨析。结果共鉴别出伤科天芍凝胶中103个化学成分,并对所有化合物的药材来源进行了归属,其中22个化合物来源于赤芍、33个化合物来源于大黄、20个化合物来源于白芷、23个化合物来源于黄柏、14个化合物来源于天花粉,共有成分9个。结论该方法快速鉴定了伤科天芍凝胶中的主要成分,为其质量控制指标和药效物质基础的深入研究提供依据。

关键词：伤科天芍 LC-Q-TOF/MS 化学成分归属

Use of the ulcerative colitis endoscopic index of severity and Mayo endoscopic score for predicting the therapeutic effect of mesalazine in patients with ulcerative colitis

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第2期4卷 33-39页

作者： Haotian Chen Lexi Wu mengyu Wang Bule Shao Lingna Ye Yu Zhang Qian cao Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Inflammatory Bowel Disease Center Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Objective:The ulcerative colitis endoscopic index of severity(UCEIS)and the Mayo endoscopic score(MES)are developed as objective methods of evaluating endoscopic severity in patients with ulcerative colitis(UC).The aim of this study is to investigate the diagnostic accuracy of the UCEIS and MES in predicting the patient's response to ***:Consecutive patients with UC who had undergone colonoscopy within 1 month before starting mesalazine between October 2011 and July 2016 were retrospectively collected at the Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of *** median follow-up was 81 months,and all the data were analyzed in January *** primary outcome was the need for step-up treatment,which included the use of corticosteroids,immunomodulatory,or surgery during admission and *** were analyzed using the c2 or Fisher exact test,Spearman test,t-test,and ManneWhitney U ***:Totally,65 patients were enrolled,of whom 12(18.5%)needed step-up treatment due to nonresponse to *** UCEIS score,MES,and the ulcerative colitis disease activity index(UCDAI)score were significantly higher in patients who had nonresponse to mesalazine(UCEIS score:6.92±0.69 vs.4.45±1.17,p<0.001;MES:2.67±0.49 vs.2.15±0.69,p=0.024;UCDAI score:9.33±1.87 vs.6.70±2.38,p=0.002).In the multivariate analysis,the UCEIS score(OR=25.65,95%CI:3.048 e45.985,p=0.003),UCDAI score(OR=1.605,95%CI:1.144e2.254,p=0.006),and C-reactive protein level(OR=1.056,95%CI:1.006e1.108,p=0.026)were independent risk factors of *** area under the ROC curve of UCEIS was 0.95,with a sensitivity of 100%and specificity of 84.6%,a cut-off value of 6,which outperformed the MES with an area under the ROC curve of *** the UCEIS score≥6,60%of patients eventually needed step-up ***:The UCEIS is a useful instrument for predicting the therapeutic effect in patients with UC treated with *** high probabili

关键词： Mesalazine Ulcerative colitis Ulcerative colitis endoscopic index of severity Mayo endoscopic score Ulcerative colitis disease activity index

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醋酸酸解磷尾矿制备醋酸钙镁融雪剂工艺研究

无机盐工业 2024年第1期56卷 73-80页

作者：李梦雨汤建伟刘咏化全县刘鹏飞王保明郑州大学生态与环境学院河南郑州450001 国家钙镁磷复合肥技术研究推广中心河南郑州450001 郑州大学化工学院河南郑州450001 河南省减污降碳协同工程技术研究中心河南郑州450001

以磷矿经过选矿后产生的固体废弃物磷尾矿为原料,回收其中的有价元素钙、镁制备环保型融雪剂醋酸钙镁并同时富集其中的P_(2)O_(5)。通过醋酸酸解磷尾矿实验研究,考察了醋酸用量、液固质量比、反应温度、搅拌转速、反应时间对磷尾矿中钙... 详细信息

以磷矿经过选矿后产生的固体废弃物磷尾矿为原料,回收其中的有价元素钙、镁制备环保型融雪剂醋酸钙镁并同时富集其中的P_(2)O_(5)。通过醋酸酸解磷尾矿实验研究,考察了醋酸用量、液固质量比、反应温度、搅拌转速、反应时间对磷尾矿中钙镁浸出率的影响,结果表明,在醋酸用量为理论用量的130%、液固质量比为14∶1、反应温度为90℃、搅拌速率为1000 r/min、反应时间为3 h的条件下,cao的浸出率可达到78.26%,MgO的浸出率可达到76.32%,磷尾矿中P_(2)O_(5)的质量分数从8.82%提高至25.91%。酸解液经调节pH后蒸发结晶得到醋酸钙镁盐,对其进行表征和性能测试,结果表明,其各项指标均符合GB/T 23851—2017《融雪剂》要求,是一种低腐蚀性、可降解、融冰雪性能优异的环保型融雪剂。

关键词：磷尾矿醋酸酸解环保型融雪剂醋酸钙镁

A 115 ps,100 Hz high-beam-quality laser based on transient stimulated Brillouin scattering pulse compression

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High Power Laser Science and Engineering 2023年第6期11卷 39-46页

作者： Jianfeng Yue Yulei Wang mengyu Jia Kai Li Chen cao Yu Yu Yunfei Li Zhiwei Lü Center for Advanced Laser Technology Hebei University of TechnologyTianjinChina Hebei Key Laboratory of Advanced Laser Technology and Equipment TianjinChina

This work demonstrates the generation of short pulse duration and high-beam-quality laser pulses using transient stimulated Brillouin scattering at a high repetition *** effects and optical breakdown are identified as the main factors that restrict energy reflectivity and beam quality under high repetition rates and transient *** experimental analysis,the interaction length and focal point size are determined to be the key parameters in reducing the thermal effect by reducing the absorption of the laser pulse by the *** obtained results show that pulses with a duration of 175 ps and beam quality M^(2)of around 1.2 can be achieved with a maximum energy reflectivity of over 40%under an interaction length of 50 ***,at an interaction length of 90 mm,a pulse output with a minimum duration of 115 ps(0.5τQ)is achieved.

关键词： high beam quality high energy nonlinear optics stimulated Brillouin scattering

A mechanistic consideration of oxygen enhancement ratio, oxygen transport and their relevancies for normal tissue sparing under FLASH irradiation

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Holistic Integrative Oncology 2022年第1期1卷 170-180页

作者： mengyu Jia Xu cao Brian W.Pogue Hao Peng School of Precision Instrument and Opto-Electronics Engineering Tianjin UniversityTianjin 300072China Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education&School of Life Science and Technology Xidian UniversityXi’an 710126ShanxiChina Thayer School of Engineering Dartmouth CollegeHanoverNHUSA Department of Medical Physics Wuhan UniversityWuhan 430072China NewRT Medical Systems Inc. Wuxi 214144China

Our study investigated the role of oxygen in mediating the FLASH *** efect,which was frst reported in vitro in the 1950s and in vivo in the 1970s,recently gained prominence with a number of publications showing diferential sparing between normal tissues and *** depletion(and subsequent induction of transient hypoxia)is the oldest and most prominent hypothesis to explain this *** better understand how the oxygen depletion hypothesis and oxygen enhancement ratio(OER)are relevant for interpreting FLASH benefts,an analytical model was proposed to estimate the sparing *** model incorporated factors such as OER,oxygen partial pressure(pO_(2)),loco-regional oxygen difusion/metabolism,total dose and dose *** sparing factor,was used to quantify the sparing of normal tissue(initially physoxic).The radiosensitivity parameters of two cell types(V79 Chinese hamster cells and T1 human kidney cells)were ***,the transient behavior of OER during fnite time intervals was modeled,for both without and with the presence of oxygen transport using a difusion *** tissues with an oxygen consumption rate of 20mmHg/s and a distance of 60μm away from blood vessels,the sparing factor demonstrates an increase from 1.03/1.06(V79/T1)at 2.5Gy/s up to 1.28/1.72(V79/T1)at 100Gy/s(total dose:10Gy).For normal tissues of initial pO_(2) between 1.5 and 8mmHg,the beneft from pushing the dose rate above 100Gy/s is found to be *** animal experiments have been conducted for ***,our study predicts that the dose rate associated with maximum normal tissue protection is between 50Gy/s and 100Gy/*** than the postulation of the hypoxic stem cell niches in normal tissues,we believe that a framework based upon the oxygen depletion hypothesis and OER is not able to efciently interpret diferential responses between normal and tumor tissue under FLASH irradiation.

关键词： FLASH radiotherapy OER Oxygen depletion

A large-scale proteogenomic atlas of pear

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Molecular Plant 2023年第3期16卷 599-615页

作者： Peng Wang Xiao Wu Zebin Shi Shutian Tao Zhe Liu Kaijie Qi Zhihua Xie Xin Qiao Chao Gu Hao Yin mengyu Cheng Xiaoyu Gu Xueying Liu Chao Tang Peng cao Shaohang Xu Baojin Zhou Tingting Gui Yangyang Bian Juyou Wu Shaoling Zhang Sanya Institute of Nanjing Agricultural University National Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095China institute of Horticulture Zhejiang Academy of Agricutural SciencesHangzhou 310021China Deepxomics Co. LtdShenzhen 518000China College of Life Sciences Northwest UniversityXi'an 710127China

Pear is an important fruit tree that is widely distributed around the *** first pear genome map was reported from our laboratory approximately 10 years *** further study global protein expression patterns in pear,we generated pear proteome data based on 24 major *** tissue-resolved profiles provided evidence of the expression of 17953 *** identified 4294 new coding events and improved the pear genome annotation via the proteogenomic strategy based on 18090 peptide spectra with peptide spectrum matches>*** the eight randomly selected new short coding open reading frames that were expressed in the style,four promoted and one inhibited the growth of pear pollen *** on gene coexpression module analysis,we explored the key genes associated with important agronomic traits,such as stone cell formation in *** network regulating the synthesis of lignin,a major component of stone cells,was reconstructed,and receptor-like kinases were implicated as core factors in this regulatory ***,we constructed the online database PearEXP(http://***)to enable access to the pear proteogenomic *** study provides a paradigm for in-depth proteogenomic studies of woody plants.

关键词： pear Pyrus proteome transcriptome proteogenomics genome annotation database