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A modified back analysis method for deep excavation with multi-objective optimization procedure

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1373-1387页

作者： Chenyang Zhao Le Chen Pengpeng ni Wenjun Xia Bin Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Guangdong Research Center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai519000China Jiangsu Provincial Transportation Engineering Construction Bureau Nanjing210004China

Real-time prediction of excavation-induced displacement of retaining pile during the deep excavation process is crucial for construction *** paper proposes a modified back analysis method with multi-objective optimization procedure,which enables a real-time prediction of horizontal displacement of retaining pile during *** opposed to the traditional stage-by-stage back analysis,time series monitoring data till the current excavation stage are utilized to form a multi-objective ***,the multi-objective particle swarm optimization (MOPSO) algorithm is applied for parameter *** optimized model parameters are immediately adopted to predict the excavation-induced pile deformation in the continuous construction *** achieve efficient parameter optimization and real-time prediction of system behavior,the back propagation neural network (BPNN) is established to substitute the finite element model,which is further implemented together with MOPSO for automatic *** proposed approach is applied in the Taihu tunnel excavation project,where the effectiveness of the method is demonstrated via the comparisons with the site monitoring *** method is reliable with a prediction accuracy of more than 90%.Moreover,different optimization algorithms,including non-dominated sorting genetic algorithm (NSGA-II),Pareto Envelope-based Selection Algorithm II (PESA-II) and MOPSO,are compared,and their influences on the prediction accuracy at different excavation stages are *** results show that MOPSO has the best performance for high dimensional optimization task.

关键词： Multi-objective optimization Back analysis Surrogate model Multi-objective particle swarm optimization(MOPSO) Deep excavation

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The CBL-interacting protein kinase OsCIPK1 phosphorylated by SAPK10 positively regulates responses to ABA and osmotic stress in rice

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The Crop Journal 2024年第2期12卷 364-374页

作者： Caihua Qin Xing Fan Qianqian Fang Lan ni Mingyi Jiang College of Life Sciences State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationKey Laboratory of Crop Physiology Ecology and Production ManagementMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

SubclassⅢsucrose nonfermenting1-related protein kinase 2s(SnRK2s)function in ABA and abiotic stress responses by unknown *** found that osmotic stress/ABA-activated protein kinase 10(SAPK10),a member of rice SnRK2s,physically interacted with CBL-interacting protein kinase 1(OsCIPK1).OsCIPK1 expression was up-regulated by ABA and PEG treatment,and overexpression increased the ABA sensitivity of seed germination and root growth and plant osmotic stress *** stress or ABA-induced activation of OsCIPK1 is dependent on ***10 phosphorylates Thr-24 of OsCIPK1 in vitro,and this phosphorylation increases the activity of OsCIPK1 and positively regulates the function of OsCIPK1 in ABA responses and plant osmotic stress *** study suggests that OsCIPK1 is a direct phosphorylated substrate of SAPK10,and SAPK10-mediated phosphorylation of OsCIPK1 functions in ABA signaling and increases rice osmotic stress tolerance.

关键词： Rice ABA Osmotic stress OsCIPK1 SAPK10

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Decadal prediction skill for Eurasian surface air temperature in CMIP6 models

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 9-13页

作者： Yanyan Huang ni Huang Qianfei Zhao Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina Nansen–Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Dalian Meteorological Bureau of Liaoning Province DalianChina

评估CMIP6年代际预测试验对季节平均SAT的预测技巧的结果表明:模式不能有效预测冬季和秋季SAT的年代际变率.IPSL-CM6A-LR和多模式集合平均对于春季SAT展现了预测技巧,其中对于变率的预测技巧好于振幅的结果.基于蒙古和我国华北地区的显... 详细信息

评估CMIP6年代际预测试验对季节平均SAT的预测技巧的结果表明:模式不能有效预测冬季和秋季SAT的年代际变率.IPSL-CM6A-LR和多模式集合平均对于春季SAT展现了预测技巧,其中对于变率的预测技巧好于振幅的结果.基于蒙古和我国华北地区的显著预测技巧,模式对于夏季SAT表现出最佳的预测水平.与外部强迫相比,模式对于SAT的预测技巧可能来自初始化.模式中的一个明显系统性误差值得注意,即模式中冬季SAT的变率可以持续到其他季节,而在观测中其他季节的SAT变化与冬季SAT相对独立.

关键词：欧亚地表温度年代际预测 CMIP6 DCPP

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Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

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World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： Yan Ren Yan-ni Cui Hong-Wei Wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital ***(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet *** a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and ***,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or *** propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of *** To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and *** CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental *** cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured ***-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant ***-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead *** Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all Pnificantly

关键词： Hematopoietic stem cells nicotinamide Concentration Proliferation Differentiation Sirtuin 1

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Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets

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Science China(Life Sciences) 2024年第2期67卷 379-390页

作者： Jing Li Fenfen Liu Kaibin Mo Hengjia ni Yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessHunan Research Center of Livestock and Poultry SciencesSouth Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100008China Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China

Weaning piglets usually suffer from severe diarrhea(commonly known as postweaning diarrhea,PWD)along with intestinal motility *** peristalsis is mainly regulated by the longitudinal muscle-myenteric plexus(LM-MP).To understand the relationship between intestinal LM-MP function and the development of PWD,we compared the intestinal electrical activity,and the transcriptional profile of the LM-MP between 21-day-old piglets(just weaned,n=7)and 24-day-old piglets(suffered the most severe weaning stress,n=7).The results showed that 24-day-old piglets exhibited different degrees of diarrhea.A significant increase in the slow-wave frequency in the ileum and colon was observed in 24-day-old piglets,while c-kit expression in the intestinal LM-MPs was significantly decreased,indicating that PWD caused by elevated slow-wave frequency may be associated with loss of *** real-time quantitative PCR(RT-q PCR)and enzyme-linked immunosorbent assay(ELISA)showed that intestinal LM-MPs in 24-day-old piglets may undergo inflammation and oxidative *** increases in 8-hydroxy-2′-deoxyguanosine and decreases in thioredoxin suggest that weaning may lead to DNA damage in the LM-MP of 24-day-old *** addition,activating transcription factor 3 was significantly upregulated,indicating nerve damage in the LM-MP of 24-day-old *** transcriptomic results showed that most of the differentially expressed genes in the ileal LM-MP after weaning were downregulated and closely related to the cell cycle *** RT-q PCR analysis showed that the relative expression of p21 was upregulated,while the expression of cyclin A2,cyclin B1,and proliferating cell nuclear antigen was downregulated in the ileal and colonic LM-MP of 24-day-old piglets,suggesting that weaning may inhibit cell proliferation and cause G1/S cell cycle arrest in ileal and colonic *** conclusion,weaning may lead to cell cycle arrest by causing DNA damage in the LM-MP,impairing i

关键词： weaning piglets diarrhea longitudinal muscle-myenteric plexus

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Progress of vegetation modelling and future research prospects

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Science China Earth Sciences 2024年第9期67卷 2718-2738页

作者： Siqi LI Xu ZHANG Zhengyao LU Jian ni Jianhua LU State Key Laboratory of Tibetan Plateau Earth System Resources and Environment (TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences British Antarctic Survey Department of Physical Geography and Ecosystem Science Lund University College of Life Sciences Zhejiang Normal University School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)

Terrestrial vegetation is a crucial component of the Earth system, and its changes not only represent one of the most distinct aspects of climate change but also exert significant feedback within the climate system by exchanging energy, moisture,and carbon dioxide. To quantitatively and mechanistically study climate-vegetation feedback, numerical vegetation models have been developed on the theory of ecophysiological constraints on plant functional types. The models eventually can simulate vegetation distribution and succession across different spatial and temporal scales, and associated terrestrial carbon cycle processes by categorizing vegetation into biomes according different plant functional types and their associated environmental factors. Here we review the developing history of vegetation models and provide recent advances and future directions. Before 21st century, static vegetation models, as developed statistical models, can only simulate equilibrated characteristics of vegetation distribution. In last several decades, Dynamic Global Vegetation Models(DGVMs) have been developed to simulate instantaneous responses of vegetation to climate change and associated dynamics, and can be coupled with Earth system models to investigate interactions among atmosphere, ocean, and land. DGVMs are also widely applied to investigate the dynamics accounting for changes in the geographic distribution patterns of land surface vegetation at different spatial and temporal scales and to assess the impacts of terrestrial carbon and water fluxes and land use changes. We suggest that future vegetation modeling could integrate with machine learning, and explore vegetation transient response and feedback as well as impacts of process hierarchies and human activities on climate and ecosystem.

关键词： Vegetation models DGVMs Ecosystems Plant functional types Plant functional traits

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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying Liu Shuai Ye Xin-ni Li Wei-Guang Li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

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Improved Particle Swarm Optimization for Parameter Identification of Permanent Magnet Synchronous Motor

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Computers, Materials & Continua 2024年第5期79卷 2187-2207页

作者： Shuai Zhou Dazhi Wang Yongliang ni Keling Song Yanming Li School of Information Science and Engineering Northeastern UniversityShenyang110819China China Northern Vehicle Research Institute Beijing100072China

In the process of identifying parameters for a permanent magnet synchronous motor,the particle swarm optimization method is prone to being stuck in local optima in the later stages of iteration,resulting in low parameter *** work proposes a fuzzy particle swarm optimization approach based on the transformation function and the filled *** approach addresses the topic of particle swarmoptimization in parameter identification from two ***,the algorithm uses a transformation function to change the form of the fitness function without changing the position of the extreme point of the fitness function,making the extreme point of the fitness function more prominent and improving the algorithm’s search ability while reducing the algorithm’s computational ***,on the basis of themulti-loop fuzzy control systembased onmultiplemembership functions,it is merged with the filled function to improve the algorithm’s capacity to skip out of the local optimal *** approach can be used to identify the parameters of permanent magnet synchronous motors by sampling only the stator current,voltage,and speed *** simulation results show that the method can effectively identify the electrical parameters of a permanent magnet synchronous motor,and it has superior global convergence performance and robustness.

关键词： Transformation function filled function fuzzy particle swarm optimization algorithm permanent magnet synchronous motor parameter identification

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Evolution and Effects of the Social-ecological System in Karst Mountainous Regions:A Case Study of Guangxi,China

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Journal of Resources and Ecology 2024年第4期15卷 991-1003页

作者： GONG ni ZHAO Yuluan School of Geographic and Environmental Sciences Guizhou Normal UniversityGuiyang 550001China The State Key Laboratory Incubation Base for Karst Mountain Ecology Environment of Guizhou Province Guiyang 550001China

Karst regions are the typical areas of interaction between human society and natural *** the historical mechanisms of the evolution of social-ecological systems(SES)is crucial for the future sustainable management of karst *** study selected Guangxi,a typical karst mountainous region in Southwest China,as the study area,and used population,cropland area,and forest coverage as the SES *** on the framework of SES research in the karst region,it adopted segmented linear regression to identify the stages of the interactions among these elements,to reveal the evolutionary stages of social development from the long-term *** addition,the driving factor indicators were constructed from the aspects of natural environment,social development,government policy,and climate change,and then the feedback changes brought about by the evolution were *** results show that the evolution of SES in Guangxi from 1363-2020 can be divided into seven *** the first,second,and early period of the third stages,the government of Guangxi mainly focused on agricultural activities,although the only way to meet the growing demand for food was by expanding the area of cropland,and the timber trade’s pursuit of economic development,resulting in an increase in rocky *** the fourth stage,the ecological environment improved under the implementation of measures such as the control of rocky desertification and the compensation of forest ecological *** the fifth stage,the effect of rocky desertification control has been *** the implementation of relevant policies has alleviated the environmental problems to some extent,the continual changes in the structure and function of SES can challenge further progress towards sustainability in karst *** study aims to provide a reference for the long-term national spatial planning and the development of environmental policies in karst regions.

关键词： evolution effect Karst region piecewise linear regression social-ecological systems

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O-linkedβ-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

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World Journal of Stem Cells 2024年第3期16卷 228-231页

作者： Xu-Chang Zhou Guo-Xin ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Department of Rehabilitation Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

Cumulative evidence suggests that O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)plays an important regulatory role in pathophysiological *** the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated,the potential mechanisms of O-GlcNAcylation in bone metabolism,particularly,in the osteogenic differentiation of bone marrow mesenchymal stromal cells(BMSCs)remains *** this study,the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed,assuming that it could trigger more scholars to focus on research related to OGlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.

关键词： O-GlcNAcylation Osteogenic differentiation Bone marrow mesenchymal stromal cells Osteoporosis

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