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Science China Chemistry 2024年第7期67卷 2206-2214页

作者： menglin Xie Ting Li Chao Wu Xiaoling Liu Jinling Ni Siqin yao Yu Zhou Shibo Xi Jun Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)Singapore 627833Republic of Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

The selective oxidation of cyclohexane is a promising green route for the production of KA oil(cyclohexanol and cyclohexanone),but remains a huge challenge to design high-performing heterogeneous catalysts under mild conditions.Herein,a pure silica ZSM-12(MTW topology)zeolite was applied as the support to immobilize highly dispersive tetrahedrally coordinated vanadium(V)species and the constructed catalyst 1%V/SZ-12 exhibited high efficiency in the fast and selective oxidation of cyclohexane into cyclohexanone with H2O2.The reaction completed within 30 s,affording the selectivity of 99%towards cyclohexanone and the extremely high turnover frequency(TOF)of 5,891 h^(-1).1%V/SZ-12 was facilely reused with stable activity and feasibly extended to the oxidation of various cyclohexane derivatives.The one-dimensional 12-membered ring microchannels contributed to the formation and accessibility of tetrahedrally coordinated high valent V5+species as the robust active centers,which activated H2O2to generate V–O–O·,the active oxygen species for the electrophilic attack on cyclohexane to produce cyclohexanone as the sole product.

关键词： zeolite metal doping cyclohexane oxidation heterogeneous catalysis

Artificial optical microfingerprints for advanced anticounterfeiting

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Nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang Zhang Jingyang Wang Xin Jiang menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for anti-counterfeiting.However,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are introduced.This study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML attacks.Our approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical layers.Notably,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition accuracy.Furthermore,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting

Estimating global prevalence,incidence,and outcomes of nonalcoholic fatty liver disease from 2000 to 2021:systematic review and meta-analysis

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Chinese Medical Journal 2022年第14期135卷 1682-1691页

作者： Jiaye Liu Ye Tian Xia Fu Chunyang Mu menglin yao Yinyun Ni Yong Liu Zhihui Li Department of Thyroid and Parathyroid Surgery West China HospitalSichuan UniversityChengduSichuan 610000China Laboratory of Thyroid and Parathyroid Diseases Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610000China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengduSichuan 610000China Respiratory Health Institute Frontiers Science Center for Disease Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Ultrasound West China Hospital of Sichuan UniversityChengduSichuan 610000China Department of Outpatients West China HospitalSichuan UniversityChengduSichuan 610000China Department of Liver Surgery and Liver Transplantation Center West China HospitalSichuan UniversityChengduSichuan 610000China Department of Gastroenterological Surgery West China HospitalSichuan UniversityChengduSichuan 610000China

Background:The increasing burden of non-alcoholic fatty liver disease(NAFLD)worldwide imposes an emerging public health issue.We perform the current study to estimate the global prevalence,incidence,disease progression,and clinical outcomes of NAFLD.Methods:A systematic search was conducted in Medline,Embase,Web of Science,Google Scholar,and Cochrane CENTRAL that screened articles in English language published from January 2000 to December 2021.NAFLD prevalence,incidence,rate of disease progression,and outcomes were calculated with the DerSimonian-Laird random effects model with arcsine transformation.Results:Our search identified 59,156 records,of which 578 studies fulfilled our inclusion criteria.The overall prevalence of NAFLD was 29.38%(95%confidence interval[CI]28.09-30.69)regardless of the diagnostic techniques.Looking at the group in which the diagnosis was made by ultrasound exclusively,the pooled prevalence was 30.49%(95%CI 29.55-31.43).NAFLD has become more prevalent during the year 2011-2021(31.63%,95%CI 30.23-33.04)compared with year 2000-2010(27.94%,95%CI 26.23-29.69).The pooled estimation of non-alcoholic steatohepatitis prevalence was 8.26%(95%CI 1.13-21.01),46.49%(95%CI 35.93-57.20),and 46.72%(95%CI 37.57-55.98)in general population,NAFLD patients,and severe/morbidly obese patients,respectively.Based on a total of 110,142 newly developed NAFLD patients,the pooled incident rate was estimated as 46.24 cases per 1000 person-years(95%CI 43.21-49.30).In patients with NAFLD,the incident rate of hepatocellular carcinoma was 1.46(95%CI 0.90-2.03)cases per 1000 person-years.The overall pooled estimate of NAFLD related mortality was 23.91(95%CI 13.55-37.18)death per 1000 person-years.Conclusions:The prevalence of NAFLD is increasing globally.It is contributing to poor clinical outcomes including hepatocellular carcinoma and death.Rising awareness and urgent actions are warranted to control the NAFLD pandemic across the globe.Registration:PROSPERO,No.CRD42020171104.

关键词： Incidence Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Outcome Prevalence

Integrative Identification by Hi‑C Revealed Distinct Advanced Structural Variations in Lung Adenocarcinoma Tissue

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Phenomics 2023年第4期3卷 390-407页

作者： Tingting Song menglin yao Ying Yang Zhiqiang Liu Li Zhang Weimin Li Department of Respiratory and Critical Care Medicine Center of Precision MedicinePrecision Medicine Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease‑Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Advanced three-dimensional structure variations of chromatin in large genome fragments,such as conversion of A/B compartment,topologically associated domains(TADs)and chromatin loops are related closely to occurrence of malignant tumors.However,the structural characteristics of lung cancer still remain uncovered.In this study,we used high-throughput chromosome(Hi-C)conformation capture technology to detect the advanced structural variations in chromatin of two nonsmoking lung adenocarcinoma(LUAD)tumor and paired normal tissues.The results indicate that significant chromatin variations are detected in tumor tissues compared with normal tissues.At compartment scale,the main conversion type of compartment is A→B in tumor tissues,which are concentrated mainly on chromosome 3(Chr3)(33.6%).A total of 216 tumor-specific TADs are identified in tumor tissues,which are distributed mainly in Chr1(19),Chr2(15)and Chr3(17).Forty-one distinct enhancer-promoter loops are observed in tumor tissue,which are associated closely to tumor-related pathways including mitogen-activated protein kinase(MAPK),Phosphatidylinositol-3-kinase-Protein kinase B(PI3K-AKT),Ras,Wnt and Ras1.The most important observation in this study is that we identify five important genes(SYT16,NCEH1,NXPE3,MB21D2,and DZIP1L),which are detected in both A→B compartment,TADs and chromatin loops in tumor samples,and four of these genes(NCEH1,NXPE3,MB21D2,and DZIP1L)locate on q arm of Chr3.Further gene expression and invasion experiment analysis show that NCEH1,MB21D2 and SYT16 are involved in the tumor development.Thus,we provide a comprehensive overview of advanced structures in LUAD for the first time and provide a basis for further research on the genetic variation of this tumor.

关键词： High-throughput chromosome Lung cancer Advanced structural variations Chromosome 3 Tumor-related genes

Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer

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Signal Transduction and Targeted Therapy 2022年第2期7卷 479-491页

作者： Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song menglin yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li Department of Respiratory and Critical Care Medicine National Clinical Research Center for GeriatricsCenter of Precision MedicinePrecision Medicine Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalWest China School of MedicineSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children West China Second University HospitalState Key Laboratory of BiotherapySichuan UniversityChengduChina Department of Neurology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduChina Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and Technology and University HospitalMacaoChina

Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer.

关键词： lung cancer diagnosis

Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice

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Food Science and Human Wellness 2023年第4期12卷 1109-1118页

作者： menglin Chen Hong yao Huizi Tan Wenqi Huang Quanyong Wu Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Nanchang UniversityNanchang 330047China

Most scientific investigations regarding inflammatory bowel disease(IBD)pathogenesis or therapeutic strategies use dextran sulfate sodium(DSS)-induced models performed on mice.However,differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical trials.In this study,the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised microbiota.Disorders in disease activity index(DAI),morphology and histology of colon tissue,intestinal permeability,and secretion of MPO,TNF-αand IL-6 were ameliorated by daily intake of live B.longum NSP001 cells in both conventional and humanised colitis mice.But the abnormal thymus index,and colonic production of ZO-1 and iNOS were improved only in colitis mice treated with B.longum NSP001 and humanised microbiome.The accumulation of acetic acid and propionic acid in colon microbiome,and the optimization of primary bile acid biosynthesis and glycerophospholipid metabolism pathways in cecum commensals were likely to explain the beneficial effects of B.longum NSP001.These data revealed that intestinal microbiome baseline would possibly affect the manifestation features of interventions by probiotics or dietary components and highlighted the necessity to include humanised microbiome while investigating potential therapeutic strategies based on rodent models.

关键词： Bifidobacterium longum Ulcerative colitis Humanised mice Inflammation Metabolism pathways

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新疆资源植物多样性的组成特点及分布特征

陆地生态系统与保护学报 2024年第1期4卷 11-22,34页

作者：佟瑶曹喆李梦琳徐舒逸黄继红丁易臧润国中国林业科学研究院森林生态环境与自然保护研究所生物多样性保护国家林业和草原局重点实验室北京100091 南京林业大学南方林业创新中心南京210037

【目的】确定新疆资源植物的物种组成和空间分布,对其开展有效保护至关重要。【方法】本研究基于大量文献资料的查阅、收集和整理,以自然分布于新疆的维管植物为研究对象,对新疆资源植物的种类、分布和生境等信息进行收集、整理和归纳,... 详细信息

【目的】确定新疆资源植物的物种组成和空间分布,对其开展有效保护至关重要。【方法】本研究基于大量文献资料的查阅、收集和整理,以自然分布于新疆的维管植物为研究对象,对新疆资源植物的种类、分布和生境等信息进行收集、整理和归纳,并分析了新疆资源植物的基本组成、地理和生境分布特征。【结果】1)自然分布于新疆的资源植物共计1003种,隶属于104科460属。在蕨类植物、裸子植物和被子植物3个类群中,被子植物相对丰富,占据了总物种的96.31%。按利用类型可分为食用植物、药用植物、工业植物和环保植物4类,数量占比最多的是药用植物,为77.77%。生活型包括草本、灌木和乔木3类,其中草本植物占据了主体,占比高达82.35%。2)在市域上的水平地理分布不均匀,主要集中分布在北疆的几个大地级市中,阿勒泰地区物种组成最丰富,包含了70.09%的物种。3)在海拔上的垂直地理分布范围很广,主要集中分布于1000~2100 m的中海拔范围内,呈随海拔升高而先增加后降低的单峰分布模式。4)在生境上的分布不均匀,草原、森林是包含物种数最多的2类(自然)植被,占比分别为32.70%和31.80%。【结论】新疆资源植物组成丰富,草本植物是主体,其中药用植物数量最多。新疆资源植物空间分布不均匀,主要集中分布于北疆山区中海拔地段,以草原和森林生境为主。本研究可为新疆资源植物多样性保护提供科学参考依据。

关键词：资源植物物种组成地理分布格局生物多样性保护新疆

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简道云在科研试剂耗材管理中的应用

实验科学与技术 2024年第1期22卷 155-160页

作者：晁宁宁姚梦琳刘志强张立四川大学华西医院呼吸健康研究所成都610041

科研试剂耗材采购、使用和报销是科学研究中不可或缺的一环,但是由于科研试剂耗材的特殊性,往往都是采用以课题组为单位自主选择、随买随用、实时报销的管理模式。课题组作为科研中的基本单元,可以通过做好试剂耗材管理和经费报销为科... 详细信息

科研试剂耗材采购、使用和报销是科学研究中不可或缺的一环,但是由于科研试剂耗材的特殊性,往往都是采用以课题组为单位自主选择、随买随用、实时报销的管理模式。课题组作为科研中的基本单元,可以通过做好试剂耗材管理和经费报销为科研工作和经费管理打下良好基础。本课题组在实际工作中,依靠在线表单系统——简道云搭建了一整套耗材试剂管理系统,覆盖了从采购、入库、领用、出库到报账的全流程,实现了耗材试剂管理的无纸化高效管理,并实现了经费管理中的使用追踪。

关键词：科研试剂耗材管理简道云

微信结合SBAR沟通方式在急诊护理管理中的应用效果评价

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中国卫生产业 2023年第21期20卷 75-78页

作者：姚孟琳烟台芝罘医院急诊科山东烟台264000

目的探究微信结合标准化医护沟通模式(SBAR)在急诊护理管理中的应用效果。方法选取2020年6月—2021年7月烟台芝罘医院11名护士作为对照组,行常规管理;另选取2021年8月—2022年9月11名护士作为观察组,行微信结合SBAR沟通方式,对比分析两... 详细信息

目的探究微信结合标准化医护沟通模式(SBAR)在急诊护理管理中的应用效果。方法选取2020年6月—2021年7月烟台芝罘医院11名护士作为对照组,行常规管理;另选取2021年8月—2022年9月11名护士作为观察组,行微信结合SBAR沟通方式,对比分析两组目标达成度、急诊护理服务质量评分、病情掌握评分。结果与对照组比较,观察组的目标达成度(团队角色、团队协作、沟通、自主决策、尊重患者、共情与共同参与、个性化护理措施)显著较高,差异有统计学意义(P<0.05);与对照组比较,观察组的急诊护理服务质量(移情性、保证性、有条性、可靠性、响应性)评分较高,差异有统计学意义(P<0.05);与对照组比较,观察组的病情掌握(异常化验结果、护理、风险)评分较高,差异有统计学意义(P<0.05)。结论急诊护理管理中行微信结合SBAR沟通方式可显著提升目标达成度,急诊护理服务质量,病情掌握。

关键词：微信标准化医护沟通模式急诊护理管理效果评价

基质金属蛋白酶/基质金属蛋白酶水解酶对肝纤维化的调控及相关治疗药物研究进展

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临床肝胆病杂志 2022年第6期38卷 1420-1425页

作者：黄倩杨燕曾锐姚孟林孙琴西南医科大学药学院四川泸州646000 西南医科大学中西医结合学院四川泸州646000 西南医科大学附属中医医院中西医结合药物研究中心四川泸州646000

肝纤维化是多种慢性肝损伤的共同后果,其主要特征是细胞外基质(ECM)产生与降解不平衡,导致间质胶原及其他基质成分积聚。而基质金属蛋白酶(MMP)及其特异性抑制剂[金属蛋白酶的组织抑制剂,基质金属蛋白酶水解酶(TIMP)]在胶原生成和溶解... 详细信息

肝纤维化是多种慢性肝损伤的共同后果,其主要特征是细胞外基质(ECM)产生与降解不平衡,导致间质胶原及其他基质成分积聚。而基质金属蛋白酶(MMP)及其特异性抑制剂[金属蛋白酶的组织抑制剂,基质金属蛋白酶水解酶(TIMP)]在胶原生成和溶解中起着关键作用。本文通过文献综述,整合基于MMP/TIMP的肝纤维化实验研究,并总结可能通过影响MMP/TIMP表达或活性发挥抗肝纤维化作用的组分,尝试阐明MMP/TIMP调控胶原平衡的机制,以期为抗肝纤维化药物的开发提供支持。

关键词：肝硬化基质金属蛋白酶类金属蛋白酶类组织抑制剂