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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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A novel conformationally adaptive macrocyclic tetramaleimide with flipping pyrene sidewalls

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Chinese Chemical Letters 2022年第1期33卷 229-233页

作者： lingyun Zhu Wei Zeng menghua li Meijin lin Key Laboratory of Molecule Synthesis and Function Discovery and Fujian Provincial Key Laboratory of Electrochemical Energy Storage MaterialsCollege of ChemistryFuzhou UniversityFuzhou 350116 China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350116China

The synthesis,structure,and properties of pyrene-based conformationally adaptive macrocycles are *** new type of conformationally adaptive macrocycle was constructed through Perkin reaction,followed by *** changing the condensation partner as the linking unit,a family of conjugated macrocycles with different sizes of the cavity was synthesized,which provide a simple and modular synthetic strategy towards the conformationally adaptive ***,the macrocycles provide two well-defined conformations through flipping pyrene subunit,which were unambiguously determined by single-crystal X-ray diffraction *** conformational interconversion barrier was determined by density functional theory(DFT)*** new macrocycle also demonstrated unique properties,such as vapochromic behavior and aggregation emission enhancement ***,we have also investigated the effect of the linker on the shape and photophysical properties of the resulting macrocyclic products.

关键词： AEE Conjugated macrocycles DFT Flipping sidewalls Vapochromic

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Time-series variation and attribution analysis of downward shortwave radiation over the Yunnan-Kweichow plateau from 1984 to 2018

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International Journal of Digital Earth 2023年第1期16卷 337-354页

作者： lijia Cheng Bo-Hui Tang Zhiwei He Zhitao Fu menghua li Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunmingPeople’s Republic of China State Key Laboratory of Resources and Environment Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingPeople’s Republic of China

The downward shortwave radiation(DSR)is a key input parameter for land surface models and climate *** on the daily averaged Global Land Surface Satellite downward shortwave radiation(GLASS-DSR)dataset over the Yunnan-Kweichow Plateau(YKP)from 1984 to 2018,this paper analyzes variation trend and breakpoints of *** results show that:annual averaged DSR decreases at a decreasing rate of-1.84 W·m^(-2)·decade^(-1) over the YKP from 1984 to 2018;the overall distribution of interannual averaged DSR shows higher in the mid-west,and gradually decreasing from west to northeast over the YKP;the estimated averaged DSR is larger in spring than in summer due to the influence of the monsoon;monthly averaged DSR reaches its maximum in May and its minimum in December;breakpoints are found in the seasonal and trend components of daily averaged *** driving factors are examined for their effects on DSR variation,including annual average temperature,precipitation,10 m wind speed,aerosol optical thickness(AOT),total cloud cover,elevation,slope,aspect,longitude,latitude,and climate *** to thefindings,AOT predominates in the spatio-temporal distribution of DSR over the *** study will contribute to studies related to climate change and highland radiation.

关键词： Yunnan-Kweichow plateau downward shortwave radiation time-series analysis breakpoints detection attribution analysis

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Who Will Care for Middle Aged and Elderly Parents in Rural China?

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China & World Economy 2021年第2期29卷 123-150页

作者： menghua li Yun Zhou Xinjie Shi China Academy for Rural Development School of Public AffairsZhejiang UniversityChina

Using data from the 2015 China Health and Retirement Longitudinal Study,this paper analyzes how the health of parents is causally linked to the gender of their *** find that,compared with parents with no daughters,those with one daughter are healthier by 0.155 more activities of daily *** effect is mainly channeled through the provision of emotional comfort and financial support,and not through living with *** also confirm that daughters are an important source of financial and emotional support for elderly parents,regardless of whether the parents have pension *** study has important policy implications fo r China as it focuses on the support from daughters,who historically have not been considered to be as reliable as sons in supporting their parents.

关键词： family pension gender of children health of parents

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Recent advances in metal-organic frameworks for X-ray detection

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Science China Chemistry 2022年第12期65卷 2338-2350页

作者： Hongming Chen Jingru Chen menghua li Minghua You Qiushui Chen Meijin lin Huanghao Yang College of Materials Science and Engineering Fuzhou UniversityFuzhou 350116China College of Chemistry Fuzhou UniversityFuzhou 350116China College of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China

Metal-organic frameworks(MOFs)are a class of fascinating supramolecular crystalline materials that have been widely developed for catalysis,gas storage,illumination,drug delivery/cytoprotection,and so ***,MOFs have been found to have potential applications in X-ray detection due to their high sensitivity,fast response time,high absorption coefficient,and radiation *** this review,we present an overview on the fundamental mechanism of using MOFs for X-ray *** further discuss the recent developments in X-ray detection based on indirect X-ray scintillation and direct X-ray ***,we provide a summary and a perspective on the future of this promising research field.

关键词： metal-organic frameworks scintillation X-ray detection semiconducting

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Exploring the efficacy of(R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation

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Journal of Otology 2024年第4期19卷 200-206页

作者： Dawei Ren Xuemin Chen Hongdong liu menghua li liting Zheng Pan Yong Mohe Huang Xi Shi Yice Xu Shujin Chen Yan Zhang Wei Zhu Department of Otorhinolaryngology the First Hospital of Jilin UniversityChangchun130021JilinChina Department of Otorhinolaryngology No.971 Hospital of People’s Liberation Army NavyQingdao266000Shandong ProvinceChina Senior Department of Otolaryngology-Head&Neck Surgery Chinese PLA General HospitalNational Clinical Research Center for Otolaryngologic DiseasesState Key Lab of Hearing ScienceMinistry of EducationBeijing Key Lab of Hearing Impairment Prevention and TreatmentBeijing100083China Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhou221000JiangsuChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou570228Hainan ProvineChina Song li’s Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanya572000Hainan ProvineChina Department of Otolaryngology-Head and Neck Surgery The Central Hospital of XiaoganXiaogan432000HubeiChina ENT Department The People’s Hospital of Rongchang DistrictChongqing402460China

Noise-induced hearing loss(NIHL)is primarily driven by inflammatory processes within the cochlea,where noise exposure triggers the activation of the NOD-like receptor protein 3(NLRP3)inflammasome,leading to an inflammatory *** interaction between increased NLRP3 expression and NF-κB activity can further amplify cochlear *** findings reveal that(R)-PFI-2 hydrochloride,a selective inhibitor of the SETD7 enzyme,effectively inhibits the activation of the cochlear NF-κB pathway,suppresses the release of proinflammatory factors,and prevents inflammasome *** intervention disrupts the perpetuating cycle of inflammation,thereby alleviating damage to cochlear hair cells attributed to acoustic ***,(R)-PFI-2 hydrochloride emerges as a promising pharmacological candidate for NIHL,targeting and moderating the excessive immune and inflammatory responses implicated in the pathology of hearing loss.

关键词： NIHL (R)-PFI-2 hydrochloride NLRP3 NF-κB SETD7

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Analysis on Influencing Factors of Enterprise Information System Innovation Capacity based on Bayesian Network Model

Analysis on Influencing Factors of Enterprise Information Sy...

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第30届中国控制与决策会议

作者： Haiwang Cao Chaogai Xue menghua li School of Electronic and Communication Engineering Zhengzhou University of Aeronautics School of Management Engineering Zhengzhou University

This paper deals with the factor analysis on enterprise information system innovation capacity based on the Bayesian network model. Firstly, "Internet Plus" environment and its impact on enterprise information system are analyzed. Secondly, the influencing factors of enterprise information system innovation capacity are analyzed. Thirdly, the relation model of factors influencing innovation capacity under "Internet plus" environment is established by Bayesian network model. Finally, an example is given to illustrate the analysis and verification of the Bayesian network model, and the key influencing factors are obtained and the strategies to enhance the innovation capacity of enterprise information system under the "internet plus" environment are put forward. This study breaks the situation of qualitative studies on factors analysis on enterprise information system, and proposes to use firstly Bayesian network model to quantify the causal relationship between factors, which verifies its effectiveness.

关键词： Influencing Factor Innovation Capacity Enterprise Information System Evaluation Bayesian Network

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Neural-Network-Based Self-Learning Disturbance Rejection Design for Continuous-Time Nonlinear Constrained Systems

Neural-Network-Based Self-Learning Disturbance Rejection Des...

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第40届中国控制会议

作者： menghua li Ding Wang Junfei Qiao Xin Xu Faculty of Information Technology Beijing University of Technology Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing University of Technology Beijing Institute of Artificial Intelligence Beijing University of Technology

In this paper, we adopt a neural-network-based adaptive dynamic programming（ADP） method to solve the disturbance rejection problem for continuous-time nonlinear systems with control constraints. First, we define a suitable function and then derive the optimal control law with control constraints and the worst disturbance law. Besides, the constrained Hamilton-JacobiIsaacs equation for continuous-time nonlinear constrained systems is derived. Then, only one critic neural network is used to approximate the optimal cost function. Consequently, the approximate optimal control law and the approximate worst disturbance law are obtained. Additionally, a new updating rule is developed in the process of neural critic learning. Finally, the simulation results show that the self-learning optimal control is realized and the effectiveness of the disturbance rejection is verified by using the neural-network-based ADP method.

关键词： Optimal control Nonlinear constrained systems Adaptive dynamic programming Neural networks Self-learning disturbance rejection H∞ control

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基于自聚焦效应的新型模斑变换器

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光学学报 2019年第4期39卷 226-232页

作者：李梦华孙崇磊赵佳山东大学信息科学与工程学院山东青岛266237

提出了一种新型的基于渐变折射率波导自聚焦效应的模斑变换器,分析了均匀折射率波导和渐变折射率波导的模式场分布及传输特性,研究了自聚焦效应的原理。利用时域有限差分法,计算得到了该变换器的插入损耗和回波损耗,所提模斑变换器与现... 详细信息

提出了一种新型的基于渐变折射率波导自聚焦效应的模斑变换器,分析了均匀折射率波导和渐变折射率波导的模式场分布及传输特性,研究了自聚焦效应的原理。利用时域有限差分法,计算得到了该变换器的插入损耗和回波损耗,所提模斑变换器与现有的最好模斑变换器的性能相当,但长度缩短至其1/6。该新型模斑变换器可用于集成光学系统中。

关键词：集成光学硅基光电集成模斑变换器渐变折射率波导自聚焦效应

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学校治理视角下英国教育惩戒政策实施及取向分析

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比较教育研究 2020年第11期42卷 105-112页

作者：李梦花马早明华南师范大学教育科学学院国际与比较教育研究所广东广州510631 国家民委华南师范大学东南亚文化教育研究中心广东广州510631

英国自20世纪80年代以来出台了多部有关教育惩戒的法例,成为教育惩戒政策实践经验较为丰富的国家之一。聚焦于学校这一单位,在宏观层面,英国教育惩戒政策阐明了惩戒的条件和限度,即实施惩戒的合法条件与合法情境。此外,英国学校通过"内... 详细信息

英国自20世纪80年代以来出台了多部有关教育惩戒的法例,成为教育惩戒政策实践经验较为丰富的国家之一。聚焦于学校这一单位,在宏观层面,英国教育惩戒政策阐明了惩戒的条件和限度,即实施惩戒的合法条件与合法情境。此外,英国学校通过"内外联动"的方式为教育惩戒提供三类行政支持:实施恢复性惩戒、成立情绪和行为障碍支持队,开展与教育福利服务机构的合作;微观层面,学校教育惩戒政策依据行为失范程度界定教师制裁方式,如口头警告、拘留、搜查、没收等,同时划分出正式奖励和非正式奖励两大奖励类别。英国教育惩戒政策的实施折射出以人为本、注重公平、强调理性的价值取向。

关键词：英国教育惩戒学校治理

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