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Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation

Signal Transduction and Targeted Therapy 2020年第1期5卷 1407-1418页

作者： Bing Zhao mengfang wu Zhihuang Hu Yixin Ma Wang Qi Yanling Zhang Yaran Li Min Yu Huijie Wang Wei Mo Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationFudan UniversityShanghaiChina The Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFudan UniversityShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Medical Oncology Shanghai Cancer CenterFudan UniversityShanghaiChina Collaborative Innovation Center for Biotherapy Sichuan UniversityChengduChina

Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition,which is characterized by vasculogenic mimicry(VM).VM not only accelerates tumor progression but also increases drug-induced ***,very little is currently known about the molecular determinants that enable *** VM might bring a new breakthrough in cancer *** is the key enzyme of the blood coagulation system and could contribute to tumor ***,the association between thrombin and VM formation remains largely *** found that VM was associated with the overall survival of non-small-cell lung cancer(NSCLC)patients,and that thrombin expression was closely related to VM *** research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling *** novel thrombin inhibitors r-hirudin and DTIP inhibited VM formation and spontaneous metastases in subcutaneous *** pathological analysis confirmed that NSCLC patients with thrombin-positive/PAR-1-high expression had the poorest prognosis and were the most likely to form *** promotional activity of thrombin in VM formation and tumor metastasis was abolished in PAR-1-deficient NSCLC *** EGFR inhibitor gefitinib had no effect on VM and increased VEGF expression in *** combination therapy of DTIP and gefitinib achieved a better therapeutic effect than either agent *** study is the first to illustrate that thrombin substantially contributes,together with PAR-1,to VM formation and to illustrate that VM might be a target of r-hirudin and DTIP to suppress tumor *** anticoagulants r-hirudin and DTIP could be employed for antitumor *** therapy with DTIP with an EGFR inhibitor might achieve superior therapeutic effects.

关键词： therapeutic cancer inhibited

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Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 284-297页

作者： mengfang wu Tian Xia Yaran Li Tianfa Wang Shijia Yang Jinchao Yu Qiaoyan Liang Teng Shen Min Yu Bing Zhao Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationFudan UniversityShanghai 200032China The Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFudan UniversityShanghai 200032China Key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Cardiovascular disease is the leading cause of global mortality,with anticoagulant therapy being the main prevention and treatment *** hirudin(r-hirudin)is a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous(SC)and intravenous(IV)administration,but there is a risk of haemorrhage via SC and ***,microneedle(MN)provides painless and sanitary alternatives to syringes and oral ***,the current technological process for the micro mould is complicated and *** micro mould obtained via three-dimensional(3D)printing is expected to save time and cost,as well as provide a diverse range of ***,we explored a method for MNs array model production based on 3D printing and translate it to micro mould that can be used for fabrication of dissolving MNs *** results show that r-hirudin-loaded and hyaluronic acid(HA)-based MNs can achieve transdermal drug delivery and exhibit significant potential in the prevention of thromboembolic disease without bleeding in animal *** results indicate that based on 3D printing technology,MNs combined with r-hirudin are expected to achieve diverse customizableMNs and thus realize personalized transdermal anticoagulant delivery for minimally invasive and long-term treatment of thrombotic disease.

关键词： Anticoagulant r-hirudin Microneedle patch 3D printing technology

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贻贝肽——食用新功效研究

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食品工业 2018年第11期39卷 242-247页

作者：吴梦芳靳祯亮莫炜复旦大学基础医学院生物化学与分子生物学系上海200032 复旦大学代谢与分子医学教育部重点实验室上海200032 湖北瑞邦生物科技有限公司荆州434200

研究贻贝肽预防和辅助治疗类风湿性关节炎药效作用。采用完全弗氏佐剂和1 mg/mLⅡ型胶原分别构建急性和慢性类风湿性关节炎SD大鼠模型,后期分别用2.5μg/m L TNFα和1 mg/mLⅡ型胶原于同一位置加强免疫,通过定期对SD大鼠骨关节进行核磁... 详细信息

研究贻贝肽预防和辅助治疗类风湿性关节炎药效作用。采用完全弗氏佐剂和1 mg/mLⅡ型胶原分别构建急性和慢性类风湿性关节炎SD大鼠模型,后期分别用2.5μg/m L TNFα和1 mg/mLⅡ型胶原于同一位置加强免疫,通过定期对SD大鼠骨关节进行核磁共振扫描、血清类风湿因子水平ELISA检测、骨关节病理切片分析等,评价大鼠类风湿性关节炎等级,探讨贻贝肽对类风湿性关节炎的预防和辅助治疗作用。结果表明:贻贝肽能够缓解模型大鼠骨关节肿胀畸变及炎症发生,但个体差异较大且大鼠血清类风湿因子水平变化无参考意义。贻贝肽能在一定程度上预防和辅助治疗类风湿性关节炎。

关键词：类风湿性关节炎预防辅助治疗贻贝肽

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新型节能聚酯纤维DTY生产工艺研究

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丝绸 2015年第9期52卷 11-15页

作者：郭桥生吴梦芳裴付宇浙江永能化纤有限公司浙江湖州313100 国家纺织服装产品质量监督检验中心(浙江桐乡) 浙江嘉兴314500

介绍了一种新型节能聚酯纤维DTY的生产工艺。通过对村田33H型花式假捻变形机进行PIC＋变频控制、TCS张力控制系统、热箱结构等一系列技术改造,研究生产工艺条件变化对纤维织物风格的影响,并对比测算实际节能效果。研究结果表明：研究开... 详细信息

介绍了一种新型节能聚酯纤维DTY的生产工艺。通过对村田33H型花式假捻变形机进行PIC＋变频控制、TCS张力控制系统、热箱结构等一系列技术改造,研究生产工艺条件变化对纤维织物风格的影响,并对比测算实际节能效果。研究结果表明：研究开发的DTY与常规网络丝相比,折算每吨产品可节约能耗1.19×106k J,具有巨大的成本优势;采用该种DTY纺制麻纤维风格,应控制较低的牵伸比;变形热箱温度应控制在210~220℃,定型热箱温度应不低于180℃;在保证产品质量和生产稳定性的前提下,丝速不超过680 m/min。

关键词：涤纶聚酯纤维 DTY 节能生产工艺

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

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Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung Chengbiao wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

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老年急性中毒患者临床特点和死亡危险因素分析

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中华劳动卫生职业病杂志 2017年第5期35卷 353-355页

作者：吴一旭王蕾吴章洪广亮赵光举李萌芳李冬吴斌邱俏檬卢中秋温州医科大学附属第一医院急诊医学中心 325000

目的探讨老年急性中毒患者的临床特点及死亡危险因素，为提高老年中毒患者诊治水平提供依据。方法回顾性分析自2009年7月至2015年5月温州医科大学附属第一医院急诊科收治的177例老年急性中毒患者。根据患者治疗结果分为死亡组（31例）... 详细信息

目的探讨老年急性中毒患者的临床特点及死亡危险因素，为提高老年中毒患者诊治水平提供依据。方法回顾性分析自2009年7月至2015年5月温州医科大学附属第一医院急诊科收治的177例老年急性中毒患者。根据患者治疗结果分为死亡组（31例）和存活组（146例），对两组患者临床资料，用logistic回归分析影响预后的相关因素。结果177例患者死亡31例（17.5%），存活146（82.5%）例，其中102例（57.6%）有慢性基础疾病。死亡组农药中毒28例，农药中毒病死率为23.5%。60~69岁组死亡率12.8%（11/86），70~79岁组20.0%（13/65），80~89岁组26.9%（7/26）。主要中毒原因为有意口服中毒（100例，56.5%）。中毒途径以消化道为主（148例，83.6%）。死亡组和存活组的PSS评分和APACHE-II评分分别为2.97±0.18、2.27±0.81和19.8±2.8、12.8±5.3。与存活组比较，死亡组农药中毒、消化道中毒、有意口服中毒所占比例、PSS评分、APACHE-II评分均明显升高，差异有统计学意义（P〈0.05）。毒物种类（农药与非农药）、PSS评分、APACHE-II评分是老年患者死亡的独立危险因素。结论老年急性中毒患者多数存在一种或多种慢性基础病，有意经消化道摄入、农药中毒较常见，总体病死率较非老年中毒病死率明显升高。毒物种类、PSS评分、APACHE-II评分是老年患者预后的影响因素。

关键词：老年人中毒死亡危险因素

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Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi Yin Jiannan wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

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