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A Spatiotemporal Interactive Processing Bias Correction Method for Operational Ocean Wave Forecasts

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Journal of Ocean University of China 2022年第2期21卷 277-290页

作者： AI Bo yu mengchao GUO Jingtian ZHANG Wei JIANG Tao LIU Aichao WEN Lianjie LI Wenbo College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China North China Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266100China 391033 Troops People’s Liberation Army of ChinaQingdao 266000China

Numerical models and correct predictions are important for marine forecasting,but the forecasting results are often unable to satisfy the requirements of operational wave *** bias between the predictions of numerical models and the actual sea state has been observed,predictions can only be released after correction by *** paper proposes a spati-otemporal interactive processing bias correction method to correct numerical prediction fields applied to the production and release of operational ocean wave forecasting *** proposed method combines the advantages of numerical models and Forecast Discussion;specifically,it integrates subjective and objective information to achieve interactive spatiotemporal correc-tions for numerical *** method corrects the single-time numerical prediction field in space by spatial interpolation and sub-zone numerical analyses using numerical model grid data in combination with real-time observations and the artificial judg-ment of forecasters to achieve numerical prediction *** difference between the original numerical prediction field and the spatial correction field is interpolated to an adjacent time series by successive correction analysis,thereby achieving highly efficient correction for multi-time forecasting *** this paper,the significant wave height forecasts from the European Centre for Medium-Range Weather Forecasts are used as background field for forecasting correction and *** indicate that the proposed method has good application potential for the bias correction of numerical predictions under different sea *** method takes into account spatial correlations for the numerical prediction field and the time series development of the numerical model to correct numerical predictions efficiently.

关键词： numerical models ocean wave forecasts spatial interpolation time series interpolation successive correction

Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2017年第6期8卷 455-466页

作者： yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang mengchao yu Zhicong Liao Yong Zhou Chen-yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for Micro-RNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University Nanjing 210046 China The Second Department of Medical Oncology Linyi Tumor Hospital Linyi 276000 China Department of Cardio-Thoracic Surgery Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing Universityand Nanjing Multi-Center Biobank Nanjing 210008 China

MTUS1 （microtubule-associated tumor suppressor 1） has been identified that can function as a tumor sup- pressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b （miR-19a/b） promote prolifer- ation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell prolif- eration and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was experimentally affirmed by cell transfection assay and luciferase reporter assay. Finally, miR-19a/b were shown to cooperatively repress MTUS1 expression and synergistically regulate MTUS1 expression to pro- mote lung cancer cell proliferation and migration. In conclusion, our findings have provided the first cluesregarding the roles of miR-19a/b, which appear to func- tion as oncomirs in lung cancer by downregulating MTUSI.

关键词： microRNA MTUS1 miR-19a/b,lung cancer proliferation migration

miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ

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Protein & Cell 2016年第10期7卷 722-734页

作者： Yanqing Liu Uzair-ur-Rehman yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu mengchao yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-yu Zhang Feng Zhi Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry for Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University 163 Xianlin Road Nanjing 210046 China Modern Medical Research Center Third Affiliated Hospital of Soochow University 185 Juqian Road Changzhou 213003 China Department of Gastrointestinal Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan Road Nanjing 210008 China

Programmed cell death 4 （PDCD4） is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer （CRC）. During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and conse- quently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken toge- ther, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.

关键词： microRNA colorectal cancer miR-181b,PDCD4

Correction to:Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2024年第11期15卷 866-866页

作者： Gu, yuanyuan Liu, Shuoxin Zhang, Xiaodan Chen, Guimin Liang, Hongwei yu, mengchao Liao, Zhicong Zhou, Yong Zhang, Chen-yu Wang, Tao Wang, Chen Zhang, Junfeng Chen, Xi

This is a correction to:yuanyuan Gu,Shuoxin Liu,Xiaodan Zhang,Guimin Chen,Hongwei Liang,mengchao yu,Zhicong Liao,Yong Zhou,Chen-yu Zhang,Tao Wang,Chen Wang,Junfeng Zhang,Xi Chen,Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer,Protein&Cell,Volume 8,Issue 6,June 2017,Pages 455-466,https://***/10.1007/s13238-017-0393-7.

关键词： suppressor miR lung

NIPS法疏水PVDF膜的结构与性能调控研究进展

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膜科学与技术 2024年第1期44卷 147-156,178页

作者：徐小洁于孟超王钰王涛冯英楠赵之平北京理工大学化学与化工学院北京102488

非溶剂致相分离法(NIPS)是制备多孔有机膜一种高效工艺手段,其过程中涉及的热力学与动力学因素对于疏水多孔膜的成膜结构与性质起着至关重要的决定性作用.为此,本文以常用疏水膜制备原材料聚偏氟乙烯(PVDF)为研究对象,系统阐述采用传统... 详细信息

非溶剂致相分离法(NIPS)是制备多孔有机膜一种高效工艺手段,其过程中涉及的热力学与动力学因素对于疏水多孔膜的成膜结构与性质起着至关重要的决定性作用.为此,本文以常用疏水膜制备原材料聚偏氟乙烯(PVDF)为研究对象,系统阐述采用传统浸没沉淀相转化法和新兴喷雾辅助相转化法两种NIPS制膜工艺路线对PVDF疏水膜微纳结构的影响及其内在成膜机理,旨在通过明晰制膜过程中影响因素对成膜疏水性、孔结构参数的作用规律,为疏水膜的可控制备提供理论指导与技术支持.

关键词：疏水有机膜非溶剂致相转化法喷雾辅助相转化法膜蒸馏

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基于角动量模型的流场涡旋提取方法

海洋通报 2020年第2期39卷 206-214页

作者：孙德成艾波于梦超尚恒帅刘艳梅山东科技大学测绘科学与工程学院山东青岛266590 青岛阅海信息服务有限公司山东青岛266590 西海岸新区城市规划设计研究院山东青岛266590

分析海洋流场数据进行流场涡旋提取是流场可视化的重要方法。通常实际存在的涡旋具有不规则性,导致涡旋的提取通常需要复杂的计算。本文分析流场数据中涡旋的特点,提出一种基于角动量最大值模型提取涡旋的方法。建立角动量模型计算获得... 详细信息

分析海洋流场数据进行流场涡旋提取是流场可视化的重要方法。通常实际存在的涡旋具有不规则性,导致涡旋的提取通常需要复杂的计算。本文分析流场数据中涡旋的特点,提出一种基于角动量最大值模型提取涡旋的方法。建立角动量模型计算获得近似涡旋中心点,然后通过空间聚集分析和流场信息熵的计算来提取区域内涡旋。实验结果表明,与传统的提取方法相比,该方法不需要通过复杂计算即可提取涡旋区域并保证准确度,可以应用于不同空间分辨率的数据,同时解决了流场信息熵计算时鞍点对涡旋影响的问题,对于弱涡旋也有较好的提取效果。

关键词：角动量空间分析信息熵涡旋

基于多模型平差接力的长时序风暴增水预测方法

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海洋预报 2023年第2期40卷 32-44页

作者：杨彬艾波商杰刘清容于梦超山东科技大学测绘与空间信息学院山东青岛266590 自然资源部北海预报减灾中心山东青岛266061

利用神经网络模型预测未来风暴增水时,预测精度会随预测时序的延伸不断降低。基于长短期记忆(Long Short-Term Memory)神经网络模型,以风速、风向、气压和前时序的风暴增水数据作为模型输入,利用多个模型接力预测风暴增水时间序列,减小... 详细信息

利用神经网络模型预测未来风暴增水时,预测精度会随预测时序的延伸不断降低。基于长短期记忆(Long Short-Term Memory)神经网络模型,以风速、风向、气压和前时序的风暴增水数据作为模型输入,利用多个模型接力预测风暴增水时间序列,减小误差随模型的迭代累积,建立基于多模型平差接力的长时序风暴增水预测方法。对比不同地点和不同台风下的风暴增水预测分析结果,模型在渤黄海北部区域每月的均方根误差为4~7 cm,在黄海中部区域可控制在10 cm以内,能够较准确预测未来24 h的风暴增水。

关键词：风暴增水长短期记忆神经网络时间序列预测多模型平差接力

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连续流动分析法在某河挥发酚监测中的应用

当代化工研究 2023年第8期 77-79页

作者：吴晴马添翼俞梦超江苏常睿环境科技有限公司江苏215500

本文采用流动注射法对河流流域不同剖面中的挥发性酚类物质进行测定,采用加标法、重复法、并行测定等质量控制手段,确保测定结果的可靠、准确。在对河道近几年来不同剖面挥发性物质进行研究的基础上,对该河水体中挥发性物质的变化特征... 详细信息

本文采用流动注射法对河流流域不同剖面中的挥发性酚类物质进行测定,采用加标法、重复法、并行测定等质量控制手段,确保测定结果的可靠、准确。在对河道近几年来不同剖面挥发性物质进行研究的基础上,对该河水体中挥发性物质的变化特征及其成因进行研究。

关键词：连续流动分析法某河挥发酚监测应用分析

主要城市群环境空气中臭氧浓度的变化规律解析

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当代化工研究 2023年第14期 67-69页

作者：吴晴马添翼俞梦超江苏常睿环境科技有限公司江苏215500

近年来,我国城市大气污染问题日益突出。本文主要分析了我国苏州市环境空气中臭氧浓度的变化规律,臭氧浓度的时空分布及其季节性变化特点。研究发现该城市臭氧浓度具有明显的季节性特征,春季和夏季最强,秋季其次。臭氧含量日变化呈现出... 详细信息

近年来,我国城市大气污染问题日益突出。本文主要分析了我国苏州市环境空气中臭氧浓度的变化规律,臭氧浓度的时空分布及其季节性变化特点。研究发现该城市臭氧浓度具有明显的季节性特征,春季和夏季最强,秋季其次。臭氧含量日变化呈现出一种“单峰”式的趋势,即白天为高,晚上为低。在周末的臭氧浓度比平时要高。以此为基础针对降低臭氧浓度提出有效的措施,提高整体环境质量。

关键词：主要城市群环境空气臭氧浓度变化规律