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Synthesis and Anti-tumor Activity of Novel Glycyrrhetinic Acid Derivatives

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Chemical Research in Chinese Universities 2012年第2期28卷 214-219页

作者： meng Yan-qiu DING Jia-qi LIU yuan NIE hui-hui GUAN Sai ZOU Chao ZHAO Na CHEN Hong CAO Bo Department of Pharmaceutical Engineering Shenyang University of Chemical TechnologyShenyang 110142P.R.China Department of Pharmacognosy Medical College of Chinese People's Armed Police ForcesTianjin 300162P R.China

Twenty-five derivatives of glycyrrhetinic acid（GA） modified on the A-ring,at C30 and C11 positions were *** in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells（HeLa）,human hepatocellular liver carcinoma cells（HepG2） and human gastric carcinoma cells（BGC-823）] was evaluated by standard MTT[3-（4,5-dimethyl-2-thiazol-yl）-2,5-diphenyl-2H-tetrazolium bromide] *** the tested derivatives were found to have stronger cell growth inhibitory than their parent compound *** them,compounds 3a,5a,and 8d have similar activity on HeLa cell line,and compound 8a has similar activity on HeLa,HepG2 and BGC-823 cell lines as Gefitinib.

关键词： Glycyrrhetinic acid derivative Anti-tumor activity Structure modification

中性粒细胞与淋巴细胞比值和预后营养指数在老年急性肺栓塞患者预后评估中的价值

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临床心血管病杂志 2024年第4期40卷 312-316页

作者：孙亚召高旭苗袁蓉曼孙东旭孟杰杰李彬沧州市人民医院河北沧州061000 吕梁市人民医院承德医学院河北省沧州中西医结合医院

目的:探讨入院早期中性粒细胞与淋巴细胞比值(NLR)和预后营养指数(PNI)与老年急性肺栓塞患者预后的关系。方法:回顾性分析2019年6月—2022年9月首次确诊的270例老年急性肺栓塞患者的资料,并进行定期随访,根据患者的临床结局分为预后良好... 详细信息

目的:探讨入院早期中性粒细胞与淋巴细胞比值(NLR)和预后营养指数(PNI)与老年急性肺栓塞患者预后的关系。方法:回顾性分析2019年6月—2022年9月首次确诊的270例老年急性肺栓塞患者的资料,并进行定期随访,根据患者的临床结局分为预后良好组(218例)和预后不良组(52例)。采用LASSO回归来筛选与预后不良相关的预测变量,并构建多因素logistic回归模型来评估预后不良的影响因素。结果:在平均随访23.00(15.00,36.00)个月内,19.26%的患者经历了不良临床结局。通过LASSO回归筛选,确定了N末端脑钠肽前体、D-二聚体、白蛋白、NLR和PNI这5个预测变量,依据这些预测变量构建的多因素logistic回归模型显示,NLR(OR=1.732,95%CI 1.217~2.466,P=0.002)、PNI(OR=0.616,95%CI 0.428~0.886,P=0.009)是老年急性肺栓塞患者预后不良的独立影响因素。结论:入院早期高NLR和低PNI是老年急性肺栓塞患者预后不良的独立危险因素。

关键词：老年急性肺栓塞中性粒细胞与淋巴细胞比值预后营养指数临床结局

A review of the methods used for subjective evaluation of De Qi

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Journal of Traditional Chinese Medicine 2018年第2期38卷 309-314页

作者： yuan Hongwen Wang Pei hu Nijuan Zhang Peng Li Chunhua Liu Yuqi Ma Liangxiao Zhu Jiang School of Acupuncture Moxibustion and Tuina Beijing University of Chinese Medicine Beijing 100029 China School of Traditional Chinese Medicine Capital Medical University Beijing 100069 China Luhe Hospital of Beijing affiliated to Capital Medical University Beijing 101149 China Department of Chinese Medicine Beijing Tongren Hospital affiliated to Capital Medical University Beijing100730 China Department of Acupuncture and Physical Therapy Beijing Electric Power Hospital Capital Medical University Beijing 100073 China Institute of Basic Clinical Medicine China Academy of Traditional Chinese Medicine Beijing 100700 China

De Qi refers to a series of sensations experienced when acupuncture is performed at acupoints. De Qi comprises needling sensations felt by the patient, and the sensations perceived by the acupuncturist. Classical Traditional Chinese Medicine theory states that De Qi is closely related to curative *** modern studies, the main index that researchers have used to evaluate De Qi was the needling sensation reported by the patient. Between 1 st Aug and 31 st Oct 2014, we conducted an electronic database search of all fields in Chinese and English to select literature assessing acupuncture needle sensations. We then reviewed the methods used within these studies to evaluate De Qi. The methods included simple evaluation, and the use of a De Qi scale/questionnaire. The simple evaluation, a qualitative evaluation, was judged by typical sensations felt by the patient after needling at acupoints, such as soreness, numbness, fullness, and *** method was easy and practicable, and had been adopted widely by Chinese researchers. In contrast, the De Qi scale/questionnaire, a quantitative evaluation, had multiple compiling methods available for evaluating the intensity of De Qi. The standardization and objectification of the De Qi scale/questionnaire effectively improved the quality of studies on De Qi, thereby these scales/questionnaires have been acknowledged and applied by most researchers. The present review analyzed and compared the scales/questionnaires used to evaluate De Qi; furthermore, we provided suggestions for the development and improvement of these questionnaires through integration with classical De Qi theory.

关键词： arrival of Qi surveys and questionnaires needling sensation scale subjective evaluation review

Controllable printing of large-scale compact perovskite films for flexible photodetectors

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Nano Research 2022年第2期15卷 1547-1553页

作者： Zhenkun Gu Ying Wang Shiheng Wang Ting Zhang Rudai Zhao Xiaotian hu Zhandong huang meng Su Qun Xu Lihong Li Yiqiang Zhang Yanlin Song Henan Institute of Advanced Technology Green Catalysis Centerand College of ChemistrySchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450051China Institute of Chemistry Chinese Academy of Sciences(ICCAS)Beijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Perovskite materials are promising candidates for the next generation of wearable ***,due to uncontrolled crystallization and the natural brittle property of crystals,it remains a great challenge to fabricate large-scale compact and tough perovskite *** we report a facile method to print large-scale perovskite films with high quality for flexible *** introducing a soluble polyethylene oxide(PEO)layer during the inkjet printing process,the nucleation and crystal growth of perovskite is well *** films can be easily printed in large scale and patterned in high ***,this method can be extended to various kinds of perovskite materials,such as MAPbb(MA=methylammonium),MA_(3)Sb_(2)l_(9),and(BA)_(2)PbBr_(4)(BA=benzylammonium).The printed perovskite films show high quality and excellent mechanical *** photodetectors based on the MAPbBr3 perovskite films show a responsivity up to -1,036 mAA/V and maintain over 96.8%of the initial photocurrent after 15,000 consecutive bending *** strategy provides a facile approach to prepare large-scale flexible perovskite *** opens up new opportunities for the fabrication of diverse wearable optoelectronic devices.

关键词： inkjet printing perovskite polymer-assisted crystallization flexible photodetectors

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China

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Science China(Life Sciences) 2020年第5期63卷 706-711页

作者： Zhiliang hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen yuan Lin Yishan Zheng Jianming Wang Zhibin hu Yongxiang Yi Hongbing Shen Nanjing Infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Department of Radiology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Maternal Child and Adolescent HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Critical Medicine the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China

Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person *** data are available for asymptomatic *** study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus *** investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in *** carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab *** clinical records,laboratory assessments,and chest CT scans were *** a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid *** cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during ***(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the *** remaining 7(29.2%)cases showed normal CT image and had no symptoms during *** 7 cases were younger(median age:14.0 years;P=0.012)than the *** of the 24 cases developed severe COVID-19 pneumonia or *** median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 ***,the asymptomatic carriers identified from close contacts were prone to be mildly ill during ***,the communicable period could be up to three weeks and the communicated patients could develop severe ***

关键词： COVID-19 asymptomatic infections close contact China

Three-dimensional holographic vector of atomic interaction field for quantitative structure-retention relationship of purine bases

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Chinese Science Bulletin 2006年第13期51卷 1557-1562页

作者： TONG Jianbo ZHOU Peng ZHANG Shengwan ZHOU yuan MEI hu ZENG hui LI Meiping LI Zhiliang College of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China Key Laboratory of Biomedical Engineering of Ministry of Education and Chongqing Municipality Chongqing 400044 China

A newly developed descriptor, three- dimensional holographic vector of atomic interaction field (3D-HoVAIF), was used to describe the chemical structures of purine bases. After variable screening by stepwise multiple regression (SMR) technique, a partial least square (PLS) regression model was built with 3D-HoVAIF. The model was satisfactory com- paring to reference since correlation coefficients of molecular modeling ( Rc 2um), cross- validation ( Qc 2um) and standard deviation of estimation (SD) were 0.966, 0.860 and 0.112, respectively, showing that the model had favorable estimation and prediction capa- bilities. It was illustrated that information related to retention data of purine bases could preferably be expressed by 3D-HoVAIF with definite physico- chemical meanings and easy structural interpretation for purine bases. It was illustrated that 3D-HoVAIF was to preferably express retention data of purine bases and had definite physicochemical significance. So 3D-HoVAIF was a useful structural expression technique for quantitative structure activity (or prop- erty or retention) relationships (QSAR/QSPR/QSRR) study, such as structural characterization and chro- matographic retention prediction.

关键词： 3D-HoVAIF 嘌呤 SMR PLS QSAR/QSPR/QSRR

Palaeogeothermal response and record of the effusing of Emeishan basalts in the Sichuan basin

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Chinese Science Bulletin 2010年第10期55卷 949-956页

作者： Zhu ChuanQing XU Ming yuan YuSon ZHAO YongQing SHAN JingNan HE ZhiGuo TIAN YunTao hu ShengBiao Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China The Graduate University of Chinese Academy of Sciences Beijing 100049 China Exploration and Production Research Institute SINOPEC Beijing 100083 China Exploration Department of South Company of Prospecting SINOPEC Chengdu 610041 China Exploration and Development Research Institute of SINOPEC Southwest Branch Chengdu 610081 China

Thermal history of the Sichuan basin is reconstructed based on vitrinite reflectance from boreholes in the basin using a paleo-heat flow *** results show that the Sichuan basin experienced a relatively low heat flow period in the Early Paleozoic,and an elevated paleo-heat flow,ranging 60-80 mW/m2 with a maximum as high as 100 mW/m2 around 259 Ma,from the beginning of the Late Paleozoic to the end of the early Permian,and a decreased paleo-heat flow from the late Permian to the late Triassic,and then maintained nearly stable to the *** Late Paleozoic paleo-heat flow was quite high where there were extensive Emeishan flood basalts or concealed basalts which erupted between the early and the late Permian,such as the southwestern and northeastern areas of the Sichuan *** to the distribution of paleo-heat flow,it can be inferred that,the northeastern Sichuan basin was also influenced by the Emeishan magmatic activity during the Dongwu movement though there was lack of Emeishan flood *** addition,the results of thermal history reconstruction of the Sichuan basin provide paleogeothermal evidence for the existence and onset of the Emaishan mantle plume.

关键词：四川盆地东北部峨眉山玄武岩盆地热史古地温涌出反应镜质组反射率晚古生代

Solidification characteristics of Fe-Ni peritectic al oy thin strips under a near-rapid solidification condition

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China Foundry 2015年第3期12卷 189-195页

作者： Chang-jiang Song Yang Yang yuan-yi Guo Yun-hu Zhang Wei Lu Qi-jie Zhai State Key Laboratory of Advanced Special Steels Shanghai University Helmholtz-Zentrum Dresden-Rossendorf

This paper is an experimental investigation of the structure evolution and the solute distribution of 2 mm thick strips of Fe-(2.6, 4.2, 4.7, 7.9wt.%)Ni peritectic alloy under a near-rapid solidification condition, which were in the regions of δ-ferrite single-phase, hypo-peritectic, hyper-peritectic and γ-austenite single-phase, respectively. The highest area ratio of equiaxed grain zone in the hyper-peritectic of Fe-4.7wt.%Ni alloy strip was observed, while other strips were mainly columnar grains. The lowest micro-segregation was obtained in the Fe-7.9wt.%Ni alloy strip, while micro-segregation in the Fe-4.7wt.%Ni alloy was the highest. As opposed to the microsegregation, the macro-segregation of all the Fe-Ni strips was suppressed due to the rapid solidification rate. Finally, the structure formation mechanism of Fe-Ni alloy strips was analyzed.

关键词： solidification characteristics Fe-Ni peritectic alloy near-rapid solidification

Multilinear Calderón-Zygmund Operators and Their Commutators with BMO Functions in Herz-Morrey Spaces with Variable Smoothness and Integrability

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Communications in Mathematical Research 2017年第3期33卷 238-258页

作者： hu yuan-zhu xu jing-shi ji you-qing School of Mathematics and Statistics Hainan Normal University Haikou 571158 不详

In this paper, we obtain that multilinear Calderón-Zygmund operators and their commutators with BMO functions are bounded on products of Herz-Morrey spaces with variable smoothness and integrability. The vector-value... 详细信息

关键词： multilinear Calderón-Zygmund operator variable exponent Herz-Morrey space vector valued estimate