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Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel

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China Foundry 2024年第3期21卷 205-212页

作者： Guan-yu Jiang meng-wu wu Xiao-guang Yang Hui Wang Yu-yuan Zhu Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina Wescast Industries(China)Co. Ltd.Wuhan 430100China

Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents(2wt.%,6wt.%,and 12wt.%).Thermodynamic calculation,microstructure characterization and mechanical property tests were conducted to investigate the effect of Mn addition on the microstructure and mechanical properties of the austenitic heat resistant *** show that the matrix structure in all the three types of steels at room temperature is completely *** NbC and M_(23)C_(6)precipitate at grain boundaries of austenite *** the increase of Mn content,the number of carbides increases and their distribution becomes more *** the Mn content increases from 1.99%to 12.06%,the ultimate tensile strength,yield strength and elongation increase by 14.6%,8.0%and 46.3%,*** improvement of the mechanical properties of austenitic steels can be explained by utilizing classic theories of alloy strengthening,including solid solution strengthening,precipitation strengthening,and grain *** increase in alloy strength can be attributed to solid solution strengthening and precipitation strengthening caused by the addition of *** improvement of the plasticity of austenitic steels can be explained from two aspects:grain refinement and homogenization of precipitated phases.

关键词： austenitic heat resistant steel manganese microstructure mechanical properties

重型商用车平衡轴支架铁型覆砂铸造工艺设计与优化

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铸造 2024年第3期73卷 396-402页

作者：白红冀元贵罗铖吴孟武武汉理工大学现代汽车零部件技术湖北省重点实验室湖北武汉430070 湖北星源科技有限公司湖北十堰442000 湖北隆中实验室湖北襄阳441022

以某重型商用车平衡轴支架为研究对象,根据平衡轴支架的结构特点与质量要求,初步设计了平衡轴支架的铁型覆砂铸造工艺方案并进行样件试制。样件剖切结果发现在平衡轴根部厚大区域出现了较为严重的缩孔缩松缺陷。利用AnyCasting软件对平... 详细信息

以某重型商用车平衡轴支架为研究对象,根据平衡轴支架的结构特点与质量要求,初步设计了平衡轴支架的铁型覆砂铸造工艺方案并进行样件试制。样件剖切结果发现在平衡轴根部厚大区域出现了较为严重的缩孔缩松缺陷。利用AnyCasting软件对平衡轴支架铸件的充型与凝固过程进行模拟仿真,仿真结果预测的铸件缩孔缩松位置与实际情况相一致。基于平衡轴支架充型与凝固过程及铸件缺陷产生原因的分析,对初始铸造工艺方案进行优化。优化后的仿真结果显示平衡轴支架铸件的缩孔缩松缺陷已基本消除。根据优化后的铸造工艺方案再次进行样件试制,样件剖切结果表明原平衡轴根部厚大区域的缩孔缩松缺陷已完全消除,平衡轴支架铸件内部质量满足要求。

关键词：平衡轴支架铁型覆砂铸造数值模拟工艺优化

Defect band formation in high pressure die casting AE44 magnesium alloy

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China Foundry 2022年第3期19卷 201-210页

作者： Ying-ying Hou meng-wu wu Feng Huang Xiao-bo Li Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were *** attention was paid to the effects of process parameters during the HPDC process and casting structure on the distribution of defect *** show that the defect bands are solute segregation bands with the enrichment of Al,Ce and La elements,which are basically in the form of Al_(11)RE_(3) *** is no obvious aggregation of porosities in the defect *** width of the inner defect band is 4-8 times larger than that of the outer *** variation trends of the distribution of the inner and outer defect bands are not consistent under different process parameters and at different locations of *** is due to the discrepancy between the formation mechanisms of double defect *** filling and solidification behavior of the melt near the chilling layer is very complicated,which finally leads to a fluctuation of the width and location of the outer defect *** affecting the content and aggregation degree of externally solidified crystals(ESCs)in the cross section of die castings,the process parameters and casting structure have a great influence on the distribution of the inner defect band.

关键词： high pressure die casting magnesium alloy AE44 defect band microstructure

Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix

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Biomedical and Environmental Sciences 2024年第6期37卷 565-580页

作者： meng wu Jialu Zhou Zhe Zhang Yuanguang meng School of Medicine Nankai UniversityTianjin 300071China Department of Obstetrics and Gynecology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology Chinese PLA Medical SchoolBeijing 100853China Department of Obstetrics and Gynecology The Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC *** Sequencing was performed to analyze neoantigen *** Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in *** mutations were the most frequent types of somatic mutation in the coding sequence *** signature analysis detected signature 2,signature 6,and signature 7 in CSCC ***3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported *** variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related *** The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

关键词： Cervical squamous cell carcinoma Genome alteration Neoantigens Immunotherapy

Multi-Objective Optimization Based on Life Cycle Assessment for Hybrid Solar and Biomass Combined Cooling,Heating and Power System

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Journal of Thermal Science 2024年第3期33卷 931-950页

作者： LIU Jiejie LI Yao meng Xianyang wu Jiangtao Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’an710049China

The complementary of biomass and solar energy in combined cooling,heating and power(CCHP)system provides an efficient solution to address the energy crisis and environmental *** work aims to propose a multi-objective optimization model based on the life cycle assessment(LCA)method for the optimal design of hybrid solar and biomass *** life-cycle process of the poly-generation system is divided into six phases to analyze energy consumption and greenhouse gas *** comprehensive performances of the hybrid system are optimized by incorporating the evaluation criteria,including environmental impact in the whole life cycle,renewable energy contribution and economic *** non-dominated sorting genetic algorithmⅡ(NSGA-Ⅱ)with the technique for order preference by similarity to ideal solution(TOPSIS)method is employed to search the Pareto frontier result and thereby achieve optimal *** developed optimization methodology is used for a case study in an industrial *** results indicate that the best performance from the optimized hybrid system is reached with the environmental impact load reduction rate(EILRR)of 46.03%,renewable energy contribution proportion(RECP)of 92.73%and annual total cost saving rate(ATCSR)of35.75%,*** comparing pollutant-eq emissions of different stages,the operation phase emits the largest pollutant followed by the phase of raw material ***,this study reveals that the proposed multi-objective optimization model integrated with LCA method delivers an alternative path for the design and optimization of more sustainable CCHP system.

关键词： combined cooling heating and power system solar-biomass multi-objective optimization life cycle assessment optimal design

LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu Jing wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan wu Qinghua meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex *** hypoglycemia is common in patients with ACLF and often predicts a worse *** evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of *** protease-1(LONP1)is a novel mediator of energy and glucose ***,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains ***:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury ***1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis *** histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ***:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver ***,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF ***,mitochondrial morphology was improved upon overexpression of ***,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 ***,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis ***

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong wu Wei Sun Xiangsong meng Jianhua Kang Yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

Mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining *** this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater *** photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were *** showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment ***,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product *** on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance

Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： meng-xin Wang Zi-xiang wu Jing-yu He Xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion *** stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different *** microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room *** show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of *** austenite with a lower Ni content undergoes a martensitic transformation during plastic *** tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging *** enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase

A CSP-based retraining framework for motor imagery based brain-computer interfaces

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Science China(Information Sciences) 2024年第8期67卷 349-350页

作者： Xue JIANG Lubin meng Xinru CHEN Dongrui wu Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and AutomationHuazhong University of Science and Technology Shenzhen Huazhong University of Science and Technology Research Institute

Motor imagery(MI) is a classic paradigm of electroencephalogram(EEG)-based brain-computer interfaces(BCIs). It entails individuals mentally imagining the movement of a body part without physically performing it. EEG s... 详细信息

关键词： Classification (of information)

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