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Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large(≥3 cm)gastric submucosal tumors

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World Journal of Gastroenterology 2024年第9期30卷 1143-1153页

作者： shan-shan Wang meng-Yao Ji Xu Huang Yan-Xia Li Shi-jie Yu Yu Zhao Lei Shen Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430000Hubei provinceChina

BACKGROUND Endoscopic full-thickness resection(EFTR)of gastric submucosal tumors(SMTs)is safe and effective;however,postoperative wound management is equally important.Literature on suturing following EFTR for large(≥3 cm)SMTs is scarce and limited.AIM To evaluate the efficacy and clinical value of double-nylon purse-string suture in closing postoperative wounds following EFTR of large(≥3 cm)SMTs.METHODS We retrospectively analyzed the data of 85 patients with gastric SMTs in the fundus of the stomach or in the lesser curvature of the gastric body whose wounds were treated with double-nylon purse-string sutures after successful tumor resection at the Endoscopy Center of Renmin Hospital of Wuhan University.The operative,postoperative,and follow-up conditions of the patients were evaluated.RESULTS All tumors were completely resected using EFTR.36(42.35%)patients had tumors located in the fundus of the stomach,and 49(57.65%)had tumors located in the body of the stomach.All patients underwent suturing with double-nylon sutures after EFTR without laparoscopic assistance or further surgical treatment.Postoperative fever and stomach pain were reported in 13(15.29%)and 14(16.47%)patients,respectively.No serious adverse events occurred during the intraoperative or postoperative periods.A postoperative review of all patients revealed no residual or recurrent lesions.CONCLUSION Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture,especially for large(≥3 cm)EFTR wounds in SMTs.

关键词： Endoscopic full-thickness resection Purse-string suture Postoperative wounds Submucosal tumors

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Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： shan-shan Xu Li-Hai Hao Yan-meng Guan Hemodialysis Center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： Secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

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DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： meng-jie WANG Yu XIA Qing-lei GAO Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor development.Tumor intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor progression.Accumulating evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse cytokines.These cytokines possess multifaced functions in the anti-tumor immune response.Thus,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor therapies.This manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these cytokines.We also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway

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Current Medical Science 2024年第1期44卷 232-240页

作者： Zhi-bin ZHU meng-jie LIU Jing WANG Zhou SHU jie CAO Department of Stomatology Chengdu Seventh People's HospitalChengdu 610044China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.However,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear.This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.Methods In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western blotting.An in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.Results SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells.In addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model.SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.Conclusion The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

关键词： secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation

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Extensive Resetting of Feldspar Pb Isotopic Composition in Archean–Paleoproterozoic Granitic Rocks from the Kongling Terrane,South China:Implications for Tracing Thermal Evolutionary History

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 386-398页

作者： meng Fanxue LU jie ZOU Zongqi GUO Jingliang meng Yuanku College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China

Feldspar Pb isotopes have been widely used to trace magmatic formation and evolution processes.However,it remains unclear whether post-magmatic thermal events can affect feldspar Pb isotopic ratios.Here,the in situ Pb isotopic composition of feldspar hosted in granitic rocks(thirteen Archean and one Paleoproterozoic)from the northern Kongling terrane,Yangtze Craton,South China,is analyzed.The samples reveal a substantial variation in their Pb isotopic composition,spanning the gap between the 1.9 Ga and present-day geochrons,which indicates extensive resetting by later tectonothermal events.This resetting was interpreted to have likely resulted from Paleoproterozoic and Neoproterozoic tectonothermal events related to the assembly and breakup of the Columbia and Rodinia supercontinents.These results suggest that Pb isotopes should be used cautiously when tracing magma sources and petrogenesis in magmatic rocks that have experienced post-magmatic reworking.However,the in situ Pb isotopic composition of feldspar in ancient granitoids may also potentially be used to reveal later tectonothermal events.The extensive resetting of the Pb isotopic composition in feldspar by regional thermal events may also provide new insights into our understanding of the Pb isotope paradox.

关键词： in situ Pb isotope Pb isotope resetting thermal event Archean-Paleoproterozoic Kongling terrane

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A survey of decision making in adversarial games

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Science China(Information Sciences) 2024年第4期67卷 85-112页

作者： Xiuxian LI Min meng Yiguang HONG jie CHEN College of Electronics and Information Engineering Tongji University shanghai Research Institute for Intelligent Autonomous Systems

In many practical applications, such as poker, chess, drug interdiction, cybersecurity, and national defense, players often have adversarial stances, i.e., the selfish actions of each player inevitably or intentionally inflict loss or wreak havoc on other players. Therefore, adversarial games are important in realworld applications. However, only special adversarial games, such as Bayesian games, are reviewed in the literature. In this respect, this study aims to provide a systematic survey of three main game models widely employed in adversarial games, i.e., zero-sum normal-form and extensive-form games, Stackelberg(security) games, and zero-sum differential games, from an array of perspectives, including basic knowledge of game models,(approximate) equilibrium concepts, problem classifications, research frontiers,(approximate) optimal strategy-seeking techniques, prevailing algorithms, and practical applications. Finally, promising future research directions are also discussed for relevant adversarial games.

关键词： adversarial games zero-sum games Stackelberg games differential games Nash equilibrium correlated equilibrium regret

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Assembling S-scheme heterojunction between basic bismuth nitrate and bismuth tungstate with promoting charges’separation for accelerated photocatalytic sulfamethazine degradation

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Journal of Materials Science & Technology 2024年第4期171卷 185-197页

作者： Wenhan Chen meng Dai Li Xiang shan Zhao Shuguang Wang Zuoli He shandong Key Laboratory of Water Pollution Control and Resource Reuse Shandong Key Laboratory of Environmental Processes and HealthSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China CEDAR Knight Cancer InstituteSchool of MedicineOregon Health and Science UniversityPortlandOR 97201United States Weihai Research Institute of Industrial Technology of shandong University Shandong UniversityWeihai 264209China

The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated carriers.In this study,a one-pot glycerol-assisted hydrothermal process was utilized to successfully synthesize S-scheme heterojunction photocatalysts comprising basic bismuth nitrate(BBN)and bismuth tungstate(BWO).Interestingly,the BBN/BWO heterogeneous photo-catalysts exhibited the highest photocatalytic properties.The optimized product achieved the degradation of sulfamethazine(SMZ)within 1 h,with a kinetic constant(k)value of 0.05818 min^(−1).The degradation process was influenced significantly by·O^(2)−and h^(+)species.To determine the degradation pathway of SMZ in the presence of BBN/BWO-0.6,liquid chromatography-mass spectrometry(LC-MS)analysis was performed,which revealed a decrease in the toxicity of intermediates and products.The enhanced pho-tocatalytic activity can be attributed to the internal electric field(IEF)of the S-scheme heterojunction between BBN and BWO,effectively promoting the separation of photogenerated carriers.This research presents a viable approach for developing S-scheme heterojunctions in SMZ photodegradation and other environmental applications.

关键词： Photocatalysis S-scheme Heterojunction Bi_(2)WO_(6) Sulfamethazine

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Numerical study on the effective thermal conductivity and thermal tortuosity of porous media with different morphologies

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Science China Technological Sciences 2024年第6期67卷 1685-1694页

作者： DU Shen LI Dong LI meng-jie HE Ya-Ling Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power Engineering Xi’an Jiaotong University

Effective thermal conductivity and thermal tortuosity are crucial parameters for evaluating the effectiveness of heat conduction within porous media. The direct pore-scale numerical simulation method is applied to investigate the heat conduction processes inside porous structures with different morphologies. The thermal conduction performances of idealized porous structures are directly compared with real foams across a wide range of porosity. Real foam structures are reconstructed using X-ray computed tomography and image processing techniques, while Kelvin and Weaire-Phelan structures are generated through periodic unit cell reconstruction. The detailed temperature fields inside the porous structures are determined by solving the heat conduction equation at the pore scale. The results present that the equivalent thermal conductivity of Kelvin and Weaire-Phelan structures is similar to and greater than that of the real foam structure with the same strut porosity. The thermal tortuosity of real foam structure is relatively larger and the heat conduction path becomes straighter by adopting the anisotropic design. The thermal tortuosity of the fluid channels for Kelvin, Weaire-Phelan, and real foam structures is close to one. The thermal conductivity of porous structures with heat transfer fluid increases as the thermal conductivity ratio of fluid to solid becomes larger. A small porosity of porous media leads to a larger equivalent thermal conductivity due to the dominant contribution of porous skeleton in the heat conduction process. Correlations derived from parallel and series models, as well as the Maxwell-Eucken models,provide decent predictions of effective thermal conductivity, with an average error of less than 8% in the entire range of thermal conductivity ratio.

关键词： volumetric solar receiver porous morphology direct pore-scale simulation equivalent thermal conductivity thermal tortuosity empirical correlation

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New Vacuum Solar Telescope Achieves Narrowband Infrared Solar Imaging Observation at He I 10830 A

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Research in Astronomy and Astrophysics 2024年第5期24卷 76-84页

作者： Wei-jie meng Fang-Yu Xu Zhen-Yu Jin Yunnan ObservatoriesChinese Academy of SciencesKunming 650011China Yunnan Key Laboratory of Solar Physics and Space Sciene Kunming 650216China University of Chinese Academy of Sciences Beijing 100049China

The near-infrared imaging channel constitutes a crucial component of the multichannel high-resolution imaging system of the New Vacuum Solar Telescope(NVST). We have successfully achieved high-resolution, narrowband imaging of the chromosphere using He I 10830 A triplet within this channel, which significantly enhances the imaging observation capabilities of NVST. This paper provides a concise overview of the optical system associated with the near-infrared imaging channel, detailing data processing procedures and presenting several observed images. Leveraging a high-resolution image reconstruction algorithm, we were able to generate a narrowband image near the diffraction limit at 10830 A with a temporal resolution of less than 10 s.

关键词： instrumentation detectors-instrumentation high angular resolution-Sun chromosphere-Sun infrared

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Human influence on the duration of extreme temperature events in Asia's hotspot regions

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Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： Zi-meng WANG Hong-Yun MA Wei LI Hai-shan CHEN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global warming.However,changes in the duration of extreme temperature events and their association with human influence have not been considered in most studies.Thus,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)data.Constraint projection based on these attribution results was also performed.The optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 models.Results show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas forcing.However,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast Asia.The influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme temperatures.The attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast Asia.However,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions

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