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Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National Science Review 2024年第7期11卷 106-125页

作者： Yan-Nong Dou Yuan Liu Wen-Qun Ding Qing Li Hua Zhou Ling Li meng-ting zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan Zou Anan Li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

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Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of Environmental Sciences 2024年第5期139卷 123-137页

作者： Feng-Yang Bai Xiang-Huan Liu ting-ting meng Zhou Yu Yi-Chen Wang Shuang Ni Zhen zhao Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high *** study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) *** further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct CO,NO_(2),and HCO elimination routes in the presence of O_(2) and ***,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate *** H-extraction from the-CHO group was the dominant pathway with a negative activation energy of-1.22 kcal/*** calculated rate coefficients at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational ***,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…C,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) *** indicted that the chemisorptions of aldehyde oxygen have largest *** results suggested adsorption conformations have a respectable impact on the catalysis *** study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coefficient Photolysis mechanism Adsorption catalysis

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Tough Polymeric Hydrogels Based on Amino Acid Derivative Mediated Dynamic Metal Coordination Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1578-1588,I0014页

作者： meng Li meng-Yuan Zhang Wu-Xuan Lei Zhu-ting Lv Qing-Hua Shang Zheng zhao Jiang-Tao Li Yi-Long Cheng Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi’an Jiaotong UniversityXi’an710049China Polymer Materials&Engineering Department School of Materials Science&Engineering Chang’an UniversityXi’an710064China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China Department of Nuclear Medicine the First Affiliated Hospital of ChinaXi’an Jiaotong UniversityXi’an710049China

Abstract The development of physically crosslinked hydrogels with excellent mechanical and sensing properties is of importance for expanding the practical applications of intelligent soft hydrogel ***,after copolymerization of hydroxyl-containing amino acid derivative N-acryloyl serine(ASer)with acrylamide(AM),we introduce Zr4+through an immersion strategy to construct metal ion-toughened non-covalent crosslinked hydrogels(with tensile strength of up to 5.73 MPa).It is found that the synergistic coordination of hydroxyl and carboxyl groups with Zr^(4+)substantially increases the crosslinking density of the hydrogels,thereby imparting markedly superior mechanical properties compared to hydroxyl-free Zr^(4+)-crosslinked hydrogels,such as N-acryloyl alanine(AAla)copolymerized with AM hydrogels(with tensile strength of 2.98 MPa)Through the adjustment of the composition of the copolymer and the density of coordination bonds,the mechanical properties of the hydrogels can be modulated over a wide ***,due to the introduction of metal ions and the dynamic nature of coordination bonds,the hydrogels also exhibit excellent sensing performance and good self-recovery properties,paving the way for the development of flexible electronic substrates with outstanding comprehensive performances.

关键词： Hydrogel Amino acid Metal coordination Mechanical performance Flexible sensor

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Enhancing Defect-Induced Dipole Polarization Strategy of SiC@MoO_(3)Nanocomposite Towards Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第12期16卷 406-426页

作者： ting Wang Wenxin zhao Yukun Miao Anguo Cui Chuanhui Gao Chang Wang Liying Yuan Zhongning Tian Alan meng Zhenjiang Li meng Zhang College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042People’s Republic of China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042People’s Republic of China Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-Materials College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdao 266061People’s Republic of China Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042People’s Republic of China

Defect engineering in transition metal oxides semiconductors(TMOs)is attracting considerable interest due to its potential to enhance conductivity by intentionally introducing defects that modulate the electronic structures of the ***,achieving a comprehensive understanding of the relationship between micro-structures and electromagnetic wave absorption capabilities remains elusive,posing a substantial challenge to the advancement of TMOs *** current research describes a process for the deposition of a MoO_(3)layer onto SiC nanowires,achieved via electro-deposition followed by high-temperature ***,intentional creation of oxygen vacancies within the MoO_(3)layer was carried out,facilitating the precise adjustment of electromagnetic properties to enhance the microwave absorption performance of the ***,the SiC@MO-t4 sample exhibited an excellent minimum reflection loss of-50.49 dB at a matching thickness of 1.27 ***,the SiC@MO-t6 sample exhibited an effective absorption bandwidth of 8.72 GHz with a thickness of 2.81 mm,comprehensively covering the entire Ku *** results not only highlight the pivotal role of defect engineering in the nuanced adjustment of electromagnetic properties but also provide valuable insight for the application of defect engineering methods in broadening the spectrum of electromagnetic wave absor ption ***@MO-t samples with varying concentrations of oxygen vacancies were prepared through in-situ etching of the SiC@MoO_(3)*** presence of oxygen vacancies plays a crucial role in adjusting the band gap and local electron distribution,which in turn enhances conductivity loss and induced polarization loss *** finding reveals a novel strategy for improving the absorption properties of electromagnetic waves through defect engineering.

关键词： Defect engineering Oxygen vacancies SiC@MoO_(3)nanocomposite Electromagnetic wave absorption Induced dipole polarization

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Programming Supramolecular Hydrogels by Constructing a Multibranch Selection Structure

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CCS Chemistry 2024年第8期6卷 1951-1964页

作者： Zhongrui Wang ting zhao Shenghao Yang Yuwen meng Xu Wang National Engineering Research Center for Colloidal Materials School of Chemistry and Chemical EngineeringShandong UniversityJinanShandong 250100 Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical EngineeringShandong UniversityJinanShandong 250100

Developing chemical systems capable of executing multipath nonequilibrium processes provides valuable insights into the study of multistage dissipative structures in living ***,we report a nonequilibrium multipath evolution in a three-state supramolecular system,which is clarified by associating it with a multibranch selection *** system is constructed by synergistically combining an assembly-induced sol-gel transition with the color change of an acid-base *** on the initial condition and chemical fuel composition,this system can execute five distinct nonequilibrium *** addition,the set of structured programming can be replayed by repeatedly introducing the chemical *** is further utilized to explore the applications of information encryption and establish its *** findings offer novel avenues for future transient material design and may make significant contributions to systems chemistry.

关键词： supramolecular hydrogels nonequilibrium processes programmable self-assembly chemical fuels multibranch selection structure

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Optimizing FeCoNiCrTi high-entropy alloy with hydrogen pumping effect to boost de/hydrogenation performance of magnesium hydride

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Rare Metals 2024年第7期43卷 3273-3285页

作者： meng-Chen Song Fu-Ying Wu Yi-Qun Jiang Xiu-Zhen Wang Hu zhao Li-Xin Chen Liu-ting Zhang School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and TechnologyZhenjiang 212003China Max Planck Institute for Iron Research 40237DuisseldorfGermany School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The exploration of efficient,long-lived and cost-effective transition metal catalysts is highly desirable for the practical hydrogen storage of magnesium hydride(MgH_(2)) in sustainable energy ***,FeCoNiCrTi high-entropy alloy(HEA) nanosheets were prepared via a facile wet chemical ball milling strategy and they were introduced into MgH_(2) to boost the hydrogen storage *** refined HEA exhibited superior catalytic activity on MgH_(2).In contrast to additive-free MgH_(2),the initial desorption temperature of the constructed MgH_(2)-HEA composite was reduced from 330.0 to 198.5℃ and a remarkable 51% reduction in the dehydrogenation activation energy was ***,the MgH_(2)-HEA composite only required one-twentieth time of that consumed by pure MgH_(2) to absorb 5.0 wt% of H_(2) at 225℃.The synergy between the "hydrogen pumping" effect of Mg_2Ni/Mg_2NiH_4 and Mg_2Co/Mg_2CoH_5 couples,as well as the good dispersion of Fe,Cr and Ti on the surface of MgH_(2) contributed to the enhanced de/hydrogenation performance of the MgH_(2)-HEA *** study furnishes important steering for the design and fabrication of multiple transition metal catalysts and may push the commercial application of magnesium-based hydrides one step forward.

关键词： Hydrogen storage Magnesium hydride High-entropy alloys Catalysis

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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

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Zoological Research 2024年第4期45卷 857-874页

作者： Na zhao Xiu Chen Qiu-Gu Chen Xue-ting Liu Fan Geng meng-meng Zhu Fu-Ling Yan Zhi-Jun Zhang Qing-Guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

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UNCONDITIONAL ERROR ANALYSIS OF VEMS FOR A GENERALIZED NONLINEAR SCHRODINGER EQUATION

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Journal of Computational Mathematics 2024年第2期42卷 500-543页

作者： meng Li Jikun zhao Shaochun Chen School of Mathematics and Statistics Zhengzhou UniversityZhengzhouHenan 450001China

In this work,we focus on the conforming and nonconforming leap-frog virtual element methods for the generalized nonlinear Schrodinger equation,and establish their unconditional stability and optimal error *** constructing a time-discrete system,the error between the solutions of the continuous model and the numerical scheme is separated into the temporal error and the spatial error,which makes the spatial error τ-*** inverse inequalities in the existing conforming and new constructed nonconforming virtual element spaces are utilized to derive the L^(∞)-norm uniform boundedness of numerical solutions without any restrictions on time-space step ratio,and then unconditionally optimal error estimates of the numerical schemes are obtained *** needs to be emphasized is that if we use the pre-existing nonconforming virtual elements,there is no way to derive the L^(∞)-norm uniform boundedness of the functions in the nonconforming virtual element spaces so as to be hard to get the corresponding inverse ***,several numerical examples are reported to confirm our theoretical results.

关键词： Conforming and nonconforming Virtual element methods Leap-frog scheme Generalized nonlinear Schrodinger system Unconditionally optimal error estimates

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Attractor for the Extensible Beam Equation with Nonlocal Weak Damping on Time–Dependent Space

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang zhao Feng Juan meng Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of Mathematics and Physics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-time behavior of extensible beams with nonlocal weak damping:ε(t)u_(tt)+Δ^(2)u-m(‖▽u‖^(2))Δu+‖u_(t)‖^(p_(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of process on time-dependent spaces,we investigate the existence of the time-dependent attractor by using the Condition(C_(t))method and more detailed *** results obtained essentially improve and complete some previous works.

关键词： Time-dependent attractor extensible beams equation nonlocal weak damping

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Relativistic configuration-interaction density functional theory:Nonaxial effects on nuclear ββ decay

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Science Bulletin 2024年第13期69卷 2017-2020页

作者： Yakun Wang Pengwei zhao Jie meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Nuclear ββ decay is a second-order weak process in which an even-even nucleus decays to its neighboring even-even nucleus by turning two neutrons to two protons while emitting two electrons.A nucleus undergoes such ... 详细信息

关键词： decay neighboring interaction

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