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Isolated hepatic perfusion for unresectable hepatic malignancies:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2016年第5期4卷 105-117页

作者： Tian meng Guan-Qiao Li meng-hua dai Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College Medical School Tsinghua University

AIMTo investigate the effcacy and safety of isolated hepatic perfusion （IHP） in the management of unresectable liver *** were identified manually and on-line by using PubMed and EMBASE database. We formulate the eligibility criteria according to the PICOS elements, and accessed the quality of studies using the MINORS instrument. Data from all included studies were carefully investigated. We calculated the pooled response rate and incidences of mortality reported from all eligible studiesby using the Meta-Analyst software, and we computed a pooled relative risk （RR） and 95%CI by using the Comprehensive Meta-Analysis software. Heterogeneity was quantifed evaluated using I2 *** Eight studies, including 502 patients, were selected. Of these, six studies performed IHP, while the other two studies performed percutaneous IHP. The results showed that the pooled response rate was 60.8% （95%CI： 53.1%-68%）, I2 = 37.1%. The median overall survival was 20 mo （range： 12.1 to 25 mo） following IHP or PIHP. The pooled mortality rate was 5.4% （95%CI： 2.5%-11.2%）, I2 = 37.5%. Prognostic factors predict the response to IHP or survival, and were reported in six studies. Meta-analysis demonstrated that Gender was not associated with overall survival （RR = 0.877, 95%CI： 0.564-1.365）; however, carcino-embryonic antigen ≤ 30 ng/mL was associated with a signifcant improvement in survival outcomes with colorectal cancer patients （RR = 2.082, 95%CI： 1.371-3.163）, and there was no signifcant *** present systemic review and meta-analysis suggest that IHP and PIHP are potentially efficient and safe techniques for unresectable liver primary and secondarymalignancies.

关键词： Isolated hepatic perfusion Unresectable Hepatic malignancy Systematic review Meta-analysis

Effect of Blumgart anastomosis in reducing the incidence rate of pancreatic fistula after pancreatoduodenectomy

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World Journal of Gastroenterology 2019年第20期25卷 2514-2523页

作者： Ya-Tong Li Han-Yu Zhang Cheng Xing Cheng Ding Wen-Ming Wu Quan Liao Tai-Ping Zhang Yu-Pei Zhao meng-hua dai Department of General Surgery Peking Union Medical College Hospital

BACKGROUND Pancreatic fistula is one of the most serious complications after pancreatoduodenectomy for treating any lesions at the pancreatic head. For years, surgeons have tried various methods to reduce its incidence. AIM To investigate and emphasize the clinical outcomes of Blumgart anastomosis compared with traditional anastomosis in reducing postoperative pancreatic fistula. METHODS In this observational study, a retrospective analysis of 291 patients who underwent pancreatoduodenectomy, including Blumgart anastomosis (201 patients) and traditional embedded pancreaticojejunostomy (90 patients), was performed in our hospital. The preoperative and perioperative courses and longterm follow-up status were analyzed to compare the advantages and disadvantages of the two methods. Moreover, 291 patients were then separated by the severity of postoperative pancreatic fistula, and two methods of pancreaticojejunostomy were compared to detect the features of different anastomosis. Six experienced surgeons were involved and all of them were proficient in both surgical *** The characteristics of the patients in the two groups showed no significant differences, nor the preoperative information and pathological diagnoses. The operative time was significantly shorter in the Blumgart group (343.5 ± 23.0 vs 450.0 ± 40.1 min, P = 0.028), as well as the duration of pancreaticojejunostomy drainage tube placement and postoperative hospital stay (12.7 ± 0.9 d vs 17.4 ± 1.8 d, P = 0.031;and 21.9 ± 1.3 d vs 28.9 ± 1.3 d, P = 0.020, respectively). The overall complications after surgery were much less in the Blumgart group than in the embedded group (11.9% vs 26.7%, P = 0.002). Patients who underwent Blumgart anastomosis would suffer less from severe pancreatic fistula (71.9% vs 50.0%, P = 0.006), and this pancreaticojejunostomy procedure did not have worse influences on long-term complications and life quality. Thus, Blumgart anastomosis is a feasible pancreaticojejunost

关键词： Blumgart anastomosis Pancreaticojejunostomy Postoperative pancreatic fistula Pancreatoduodenectomy Incidence

Laparoscopic Partial Splenectomy for Splenic Hemangioma： Experience of a Single Center in Six Cases

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Chinese Medical Journal 2015年第5期128卷 694-697页

作者： Xian-Lin Han Yu-Pei Zhao Ge Chen Wen-Ming Wu meng-hua dai Department of General Surgery Peking Union Medical College Hospital Beijing 100730 China

INTRODUCTION Despite a higher incidence of postoperative complications, splenectomy is a commonly performed procedure for splenic space-occupying lesions. A retrospective analysis of 2796 splenectomy patients showed t... 详细信息

关键词： Laparoscopic Partial Splenectomy Splenic Function Splenic Hemangioma

Current perspectives on pancreatic serous cystic neoplasms:Diagnosis, management and beyond

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World Journal of Gastrointestinal Surgery 2016年第3期8卷 202-211页

作者： Xiao-Peng Zhang Zhong-Xun Yu Yu-Pei Zhao meng-hua dai Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Peking Union Medical College Beijing 100730 China School of Medicine Tsinghua UniversityBeijing 100084 China

Pancreatic cystic neoplasms have been increasingly recognized recently. Comprising about 16% of all resected pancreatic cystic neoplasms, serous cystic neoplasms are uncommon benign lesions that are usually asymptomatic and found incidentally. Despite overall low risk of malignancy, these pancreatic cysts still generate anxiety, leading to intensive medical investigations with considerable financial cost to health care systems. This review discusses the general background of serous cystic neoplasms, including epidemiology and clinical characteristics, and provides an updated overview of diagnostic approaches based on clinical features, relevant imaging studies and new findings that are being discovered pertaining to diagnostic evaluation. We also concisely discuss and propose management strategies for better quality of life.

关键词： Pancreatic cystic neoplasm Serous cystic neoplasm Diagnosis Management strategy Surgery

Laparoscopic distal pancreatectomy with or without splenectomy: spleen-preservation does not increase morbidity

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 536-541页

作者： Yu-Pei Zhao, Xiao Du, meng-hua dai, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Lin Cong ,Ge Chen Department of General Surgery, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730, China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 Beijing China

BACKGROUND: The indications for laparoscopic spleen- preserving distal pancreatectomy (LSPDP) and its morbidity compared with laparoscopic distal pancreatectomy with splenectomy (LDPS) are ill-defined. This study aimed to share the indications for spleen-preservation and investigate the safety and outcome of LSPDP at our institution. METHODS: A retrospective review of patients who were scheduled to receive laparoscopic surgery for distal pancreatic lesions was conducted. The indications, surgical procedures, intra-operative data, and outcomes of the two procedures were collected and compared by statistical analysis. RESULTS: LDPS and LSPDP were successfully performed in 16 and 21 patients respectively, whereas they were converted to open surgery in 9 patients. There were no significant differences in age, gender, operation time, blood loss, and conversion rate between the LDPS and LSPDP groups. The mean tumor size showed an inter-group difference (5.05 vs 2.53 cm, P<0.001). There were no significant differences in complication and morbidity rates between the two groups. All patients remained alive without recurrence during a follow-up of 9 to 67 months (median 35).CONCLUSION: LSPDP has a morbidity and outcome comparable to LDPS.

关键词： splenectomy pancreatectomy laparoscopy spleen-preservation pancreatic diseases

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-hua Wan Hong-Wei Zhang Xiao Guo hua Guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu meng-meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

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Practical Green’s function for the thermal stress field induced by a heat source in plane thermoelasticity

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Applied Mathematics and Mechanics(English Edition) 2020年第4期41卷 543-550页

作者： Jian hua Ming dai State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The classical Green’s functions used in the literature for a heat source in a homogeneous elastic medium cannot lead to ?nite remote thermal stresses in the medium,so that they may not work well in practical thermal stress analyses. In this paper, we develop a practical Green’s function for a heat source disposed eccentrically into an elastic disk/cylinder subject to plane deformation. The edge of the disk/cylinder is assumed to be thermally permeable and traction-free. The full thermal stress ?eld induced by the heat source in the disk/cylinder is determined exactly and explicitly via the Cauchy integral techniques. In particular, a very simple formula is obtained to describe the hoop thermal stress on the edge of the disk/cylinder, which may be conveniently useful for analyzing the thermal stresses in microelectronic components.

关键词： heat source Green’s function thermal stress finite matrix

Numerical modeling and simulation of PEM fuel cells: Progress and perspective

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Acta Mechanica Sinica 2013年第3期29卷 318-334页

作者： Guang-hua Song hua meng School of Aeronautics and Astronautics Zhejiang University

This paper provides a comprehensive review on the research and development in multi-scale numerical modeling and simulation of PEM fuel cells. An overview of recent progress in PEM fuel cell modeling has been provided. Fundamental transport phenomena in PEM fuel cells and the corresponding mathematical formulation of macroscale models are analyzed. Various important issues in PEM fuel cell modeling and simulation are examined in detail, including fluid flow and species transport, electron and proton transport, heat transfer and thermal management, liquid water transport and water management, transient response behaviors, and cold-start processes. Key areas for further improvements have also been discussed.

关键词： PEM fuel cell · Numerical modeling · Multiscale simulation · Two-phase transport · Water management · Thermal management