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Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3705-3715页

作者： Hui-Min Li Yin Liu meng-di hao Xiao-Qing Liang Da-Jin Yuan Wen-Bin Huang Wen-Jie Li Lei ding Department of Gastrointestinal Oncology Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related *** the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of *** causal relationship between the presence of specific TJ proteins and the development of CRC has also been *** the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been *** To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research *** We searched the Science Citation Index Expanded database for all literature on CRC and TJs from *** used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and ***-authorship,co-citation,and co-occurrence analyses were the main methods of *** and VOSviewer were used to visualize the *** A total of 205 studies were ultimately *** number of publications on this topic has steadily increased since *** and the United States have made the largest contributions to this *** Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this ***-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this *** This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between th

关键词： Colorectal cancer Tight junctions Bibliometric analysis Research trends Hot spots

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A Recursive DRL-Based Resource Allocation Method for Multibeam Satellite Communication Systems

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Chinese Journal of Electronics 2024年第5期33卷 1286-1295页

作者： haowei meng Ning XIN hao QIN di Zhao State Key Laboratory of Integrated Services Networks Xidian University China Academy of Space Technology Institute of Telecommunication Satellite

Optimization-based radio resource management(RRM) has shown significant performance gains on high-throughput satellites(HTSs). However, as the number of allocable on-board resources increases, traditional RRM is difficult to apply in real satellite systems due to its intense computational complexity. Deep reinforcement learning(DRL) is a promising solution for the resource allocation problem due to its model-free advantages. Nevertheless, the action space faced by DRL increases exponentially with the increase of communication scale, which leads to an excessive exploration cost of the algorithm. In this paper, we propose a recursive frequency resource allocation algorithm based on long-short term memory(LSTM) and proximal policy optimization(PPO), called PPO-RA-LOOP,where RA means resource allocation and LOOP means the algorithm outputs actions in a recursive manner. Specifically, the PPO algorithm uses LSTM network to recursively generate sub-actions about frequency resource allocation for each beam, which significantly cuts down the action space. In addition, the LSTM-based recursive architecture allows PPO to better allocate the next frequency resource by using the generated sub-actions information as a prior knowledge, which reduces the complexity of the neural network. The simulation results show that PPO-RA-LOOP achieved higher spectral efficiency and system satisfaction compared with other frequency allocation algorithms.

关键词： High-throughput satellites Proximal policy optimization Deep reinforcement learning Long-short term memory High-throughput satellites Proximal policy optimization Deep reinforcement learning Long-short term memory OPTIMIZATION POWER

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Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

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Zoological Research 2024年第4期45卷 791-804页

作者： Wen-hao Li Zhi-Qiang Li meng-di Bu Jia-Zhen Li Liang-Biao Chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress Ovarian failure Metabolome Zebrafish

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Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

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Nano Research 2024年第7期17卷 6342-6352页

作者： Xinyang Li Binbin ding Jing Li di Han hao Chen Jia Tan Qi meng Pan Zheng Ping’an Ma Jun Lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Chemodynamic therapy(CDT),an inventive approach to cancer treatment,exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species(ROS).While offering advantages over conventional treatments,the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione(GSH).In this study,we aim to address this dual challenge by delving into the role of copper valence states in *** the unique attributes of copper-based nanoparticles,especially zero-valent copper nanoparticles(CuPd NPs),we aim to enhance the therapeutic potential of *** experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles(Ox-CuPd NPs)by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like(POD-like)activity and Cu+***,zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts,thereby intensifying CDT and inducing ferroptosis,ultimately resulting in high-efficiency tumor growth *** findings reveal the impact of valences on CDT,providing novel insights for the optimization and design of CDT agents.

关键词： CuPd nanoparticle ferroptosis chemodynamic therapy valance tailoring tumor therapy

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Restricted Arc-Connectivity of Harary digraphs

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Journal of the Operations Research Society of China 2024年第2期12卷 540-547页

作者： Jun-hao Zhang Ji-Xiang meng College of Mathematics and System Science Xinjiang UniversityUrumqi 830046XinJiangChina

The h-restricted arc-connectivity of a digraph is an important parameter to measure fault-tolerance of interconnection *** paper determines that the h-restricted arc-connectivity of the Harary digraph D=G(n;1,2,.:,k)is equal to n/2 for 2≤h≤n/2,k=2 and n iseven,andλ_(h)(D)=g(k-1)for 2digraph D is obtained *** particular,for k=2 and n is even or 3≤kdivided by k,it can be determined that distinct positive(respectively,negative)Ah-superatoms of D are vertex disjoint for 2≤h≤g.

关键词： Restricted arc-connectivity λ_(h)(D) Super-λ_(h) λ_(h)-Atom λ_(h)-Superatom

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Key processes of carbon cycle and sink enhancement paths in natural wetland ecosystems in China

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Science China Earth Sciences 2024年第8期67卷 2444-2459页

作者： Jinshuai LI Tianxiang hao meng YANG Guirui YU Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Wetland ecosystems have become one of the long-term solutions for mitigating global climate change due to their strong carbon sequestration ***,the key carbon cycle processes in wetland ecosystems still lack a systematic *** the context of wetland protection and restoration,there is still a lack of consensus on the technical pathways to realize carbon sink multiplication in wetland *** this paper,the key processes of carbon cycle,such as photosynthetic carbon uptake,microbial carbon decomposition and carbon deposition and burial,are sorted out and summarized in four major wetland types,namely,swamp and peat wetlands,river and riparian wetlands,lake and lakeshore wetlands,and estuarine and coastal *** on the key processes of carbon cycle,three technological pathways for carbon sink multiplication are proposed,including,vegetation carbon sequestration and sink enhancement technology,soil carbon emission reduction technology and carbon deposition and burial *** key technologies under each pathway are further *** the carbon sink effects of the carbon sink technologies in different wetland types are qualitatively ***,wetland protection and restoration methods in corresponding regions are given in the light of the regional characteristics of wetlands in *** will provide a scientific basis for the strategy of doubling the carbon sinks of China′s wetland ecosystems.

关键词： Wetlands Carbon cycle Carbon sinks Technology pathways Conservation and restoration

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distributed Economic MPC for Synergetic Regulation of the Voltage of an Island DC Micro-Grid

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 734-745页

作者： Yi Zheng Yanye Wang Xun meng Shaoyuan Li hao Chen IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China Haixi Institutes Chinese Academy of SciencesJinjiang 362216China

In this paper,distributed model predictive control(DMPC) for island DC micro-grids(MG) with wind/photovoltaic(PV)/battery power is proposed,which coordinates all distributed generations(DG) to stabilize the bus voltage together with the insurance of having computational efficiency under a real-time *** on the feedback of the bus voltage,the deviation of the current is dispatched to each DG according to cost over the prediction ***,to avoid the excessive fluctuation of the battery power,both the discharge-charge switching times and costs are considered in the model predictive control(MPC) optimization problems.A Lyapunov constraint with a time-varying steady-state is designed in each local MPC to guarantee the stabilization of the entire *** voltage stabilization of the MG is achieved by this strategy with the cooperation of *** numeric results of applying the proposed method to a MG of the Shanghai Power Supply Company shows the effectiveness of the distributed economic MPC.

关键词： distributed model predictive control(DMPC) Lyapunovbased model predictive control micro-grid(MG) voltage control

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Energy-absorbing porous materials:Bioinspired architecture and fabrication

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Nano Research 2024年第2期17卷 679-690页

作者： Junheng Zhao meng Li Jiewei Chen Weiwei Gao hao Bai State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310058China

Energy-absorbing materials are widely used in transportations,sports,and the military ***,porous materials,including natural and artificial materials,have attracted tremendous attentions due to their light weight and excellent energy absorption *** review summarizes the recent progresses in the natural and artificial energy-absorbing porous ***,we review the typical natural porous materials including cuttlebone,bighorn sheep horn,pomelo peel,and sunflower stem *** architectures,energy absorption abilities,and mechanisms of these typical natural materials and their bioinspired materials are ***,we provide a review on the fabrication methods of artificial energy-absorbing porous materials,such as conventional foaming and three-dimensional(3D)***,we address the challenges and prospects for the future development of energy-absorbing porous *** importantly,our review provides a direct guidance for the design and fabrication of energy-absorbing porous materials required for various engineering applications.

关键词： energy-absorbing porous materials natural materials natural structures bioinspired materials

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A LiDAR Point Clouds Dataset of Ships in a Maritime Environment

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1681-1694页

作者： Qiuyu Zhang Lipeng Wang hao meng Wen Zhang Genghua Huang the College of Intelligent Systems Science and Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Space Active Opto-Electronics Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

For the first time, this article introduces a LiDAR Point Clouds Dataset of Ships composed of both collected and simulated data to address the scarcity of LiDAR data in maritime applications. The collected data are acquired using specialized maritime LiDAR sensors in both inland waterways and wide-open ocean environments. The simulated data is generated by placing a ship in the LiDAR coordinate system and scanning it with a redeveloped Blensor that emulates the operation of a LiDAR sensor equipped with various laser beams. Furthermore,we also render point clouds for foggy and rainy weather conditions. To describe a realistic shipping environment, a dynamic tail wave is modeled by iterating the wave elevation of each point in a time series. Finally, networks serving small objects are migrated to ship applications by feeding our dataset. The positive effect of simulated data is described in object detection experiments, and the negative impact of tail waves as noise is verified in single-object tracking experiments. The Dataset is available at https://***/zqy411470859/ship_dataset.

关键词： 3D point clouds dataset dynamic tail wave fog simulation rainy simulation simulated data

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Atomically dispersed Fe sites on hierarchically porous carbon nanoplates for oxygen reduction reaction

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Journal of Energy Chemistry 2024年第3期90卷 7-15,I0002页

作者： Ruixue Zheng Qinglei meng hao Zhang Teng Li di Yang Li Zhang Xiaolong Jia Changpeng Liu Jianbing Zhu Xiaozheng Duan Meiling Xiao Wei Xing State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina Laboratory of Advanced Power Sources Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesJiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123JiangsuChina State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina

Developing cost-effective,robust and stable non-precious metal catalysts for oxygen reduction reaction(ORR) is of paramount importance for electrochemical energy conversion devices such as fuel cells and metal-air *** Fe-N-C single atom catalysts(SACs) have been hailed as the most promising candidate due to the optimal binding strength of ORR intermediates on the Fe-N_(4) sites,they suffer from serious mass transport limitations as microporous templates/substrates,i.e.,zeolitic imidazolate frameworks(ZIFs),are usually employed to host the active *** by this challenge,we herein develop a hydrogen-bonded organic framework(HOF)-assisted pyrolysis strategy to construct hierarchical micro/mesoporous carbon nanoplates for the deposition of atomically dispersed Fe-N_(4) *** a design is accomplished by employing HOF nanoplates assembled from 2-aminoterephthalic acid(NH_(2)-BDC) and p-phenylenediamine(PDA) as both soft templates and C,N *** from the structural merits inherited from HOF templates,the optimized catalyst(denoted as Fe-N-C SAC-950) displays outstanding ORR activity with a high half-wave potential of 0.895 V(*** hydrogen electrode(RHE)) and a small overpotential of 356 mV at 10 mA cm^(-2) for the oxygen evolution reaction(OER).More excitingly,its application potential is further verified by delivering superb rechargeability and cycling stability with a nearly unfading charge-discharge gap of 0.72 V after 160 *** dynamics(MD) simulations reveal that micro/mesoporous structure is conducive to the rapid mass transfer of O_(2),thus enhancing the ORR *** situ Raman results further indicate that the conversion of O_(2) to~*O_(2)-the rate-determining step(RDS) for Fe-N-C *** work will provide a versatile strategy to construct single atom catalysts with desirable catalytic properties.

关键词： Fe single atom catalysts Oxygen reduction reaction Mesoporous structure Active sites Zinc-air battery

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