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Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

Zoological Research 2024年第5期45卷 1013-1026页

作者： Ling Wang Wei-Qiang Liu Juan Du meng Li rui-Feng Wu Ming Li Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

DNA methylation plays a crucial role in environmental ***,using whole-genome bisulfite sequencing,we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey(Rhinopithecus bieti)and the closely related golden snub-nosed monkey(***).Our findings indicated a slight increase in overall DNA methylation levels in golden snub-nosed monkeys compared to Yunnan snub-nosed monkeys,suggesting a higher prevalence of hypermethylated genomic regions in the *** genomic methylation analysis demonstrated that genes associated with differentially methylated regions were involved in membrane fusion,vesicular formation and trafficking,hemoglobin function,cell cycle regulation,and neuronal *** results suggest that the high-altitude-related epigenetic modifications are extensive,involving a complete adaptation process from the inhibition of single Ca^(2+)channel proteins to multiple proteins collaboratively enhancing vesicular function or inhibiting cell differentiation and *** assays demonstrated that overexpression or down-regulation of candidate genes,such as SNX10,TIMELESS,and CACYBP,influenced cell viability under stress ***,this research suggests that comparing DNA methylation across closely related species can identify novel candidate genomic regions and genes associated with local adaptations,thereby deepening our understanding of the mechanisms underlying environmental adaptations.

关键词： Snub-nosed monkeys Whole-genome bisulfite sequencing DNA methylation High-altitude adaptation

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Development and Application of High Power Directional Drilling Rig

Development and Application of High Power Directional Drilli...

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作者： rui ZHANG Ke YAO Peng FANG Xiang CHEN rui meng Xi’an Research Institute China Coal Technology ＆ Engineering Group Corp

The working face length of existing super large coal mines has been increased to more than 2000 *** rapid mechanized mining of super long working face of large coal mines has increasingly urgent demand for efficient prevention technology of gas and water disasters,etc.,and higher requirements have been put forward for the depth,drilling efficiency and quality of directional holes for disaster *** long-distance accurate detection and disaster prevention is a large modern coal mine safe and efficient mining of major requirements,in order to maintain dug balance,guarantee the safety in production,large diameter long directional hole is the key to meet the above requirements,to meet the above requirements,developed the capacity of 1,500 m drilling ZDY15000 LD power directional drilling *** general layout design,gyroscope,feed device,brake device,hydraulic system with protective function and other key technologies of high-power directional drilling rig were studied,and the load performance of drilling rig was *** industrial test was carried out in Pansan mine of Huainan mining industry to verify the technical performance of the drilling *** test results show that the high-power directional drilling rig has strong drilling capacity and strong accident handling capacity,which ensures safe and efficient underground mining.

关键词： gas drainage borehole directional drilling rig high-power full hydraulic power the key technology

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Mechanism and control of nonuniform phase transformation of microalloyed dual-phase steel during cooling process after hot rolling

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Journal of Iron and Steel Research International 2024年第2期31卷 428-441页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan Chao Liu San-bao Zhou rui-chun Guo meng-xia Tang National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Strip Production Plant Xichang Steel and Vanadium Corporation of Pangang GroupXichang615000SichuanChina

After cooling in the hot rolling process,the metallographic structure of microalloyed dual-phase steel is nonuniform along the rolling direction,while the thickness fluctuation of microalloyed dual-phase steel with a nonuniform metallographic structure will occur during cold *** mechanism of nonuniform phase transformation of microalloyed dual-phase steels was studied during the cooling process after hot rolling,and the nonuniform phase transformation of microalloyed dual-phase steel was regulated during the cooling process after hot rolling through process ***,the empirical equation of phase transformation temperature was measured by a dilatometer considering thermal ***,the phase field and temperature field of laminar cooling process were calculated to provide initial boundary conditions for the finite element *** that,the coupling finite element model of the temperature phase transformation of the strip steel in coiling transportation process was *** simulation results show that the different thermal contact conditions of the microalloyed dual-phase steel during coil transportation lead to uneven cooling of the coil,which leads to nonuniform transformation of the coil along the rolling *** addition,by prolonging the time interval from coiling to unloading,the phenomenon of nonuniform phase transformation of microalloyed dual-phase steel can be effectively *** simulation results are applied to industrial *** application results show that prolonging the time interval from coiling to unloading can effectively improve the nonuniform phase transformation of microalloyed dual-phase steel in the cooling process after hot rolling.

关键词： Microalloyed dual-phase steel Thickness fluctuation Cooling Heat conduction Nonuniform phase transition Finite element method

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Guided chemotherapy based on patient-derived mini-xenograft models improves survival of gallbladder carcinoma patients

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Cancer Communications 2018年第1期38卷 511-519页

作者： Ming Zhan rui-meng Yang Hui Wang Min He Wei Chen Sun-wang Xu Lin-hua Yang Qiang Liu Man-mei Long Jian Wang Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong University160 Pujian RoadShanghai 200127P.R.China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pathology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011P.R.China

Background:Gallbladder carcinoma is highly aggressive and resistant to chemotherapy,with no consistent strategy to guide first line ***,patient-derived xenograft(PDX)model has been increasingly used as an effective model for in preclinical study of ***:Mini-PDX model was established using freshly resected primary lesions from 12 patients with gallblad-der to examine the sensitivity with five of the most commonly used chemotherapeutic agents,namely gemcitabine,oxaliplatin,5-fluorouracil,nanoparticle albumin-bound(nab)-paclitaxel,and *** results were used to guide the selection of chemotherapeutic agents for adjunctive treatment after the ***-Meier method was used to compare overall survival(OS)and disease free survival(DFS)with 45 patients who received conventional chemo-therapy with gemcitabine and ***:Cell viability assays based on mini-PDX model revealed significant heterogeneities in drug ***-Meier analysis showed that patients in the PDX-guided chemotherapy group had significantly longer median OS(18.6 months;95%CI 15.9-21.3 months)than patients in the conventional chemotherapy group(13.9 months;95%CI 11.7-16.2 months)(P=0.030;HR 3.18;95%CI 1.47-6.91).Patients in the PDX-guided chemotherapy group also had significantly longer median DFS(17.6 months;95%CI 14.5-20.6 months)than patients in the conventional chemotherapy group(12.0 months;95%CI 9.7-14.4 months)(P=0.014;HR 3.37;95%CI 1.67-6.79).Conclusion:The use of mini-PDX model to guide selection of chemotherapeutic regimens could improve the out-come in patients with gallbladder carcinoma.

关键词： Gallbladder cancer Mini-PDX Chemosensitivity Overall survival Personalized therapy

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HYSYS流程模拟在溶剂再生脱硫装置的应用

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炼油技术与工程 2017年第12期47卷 18-23页

作者：孟锐中国石油化工股份有限公司镇海炼化分公司浙江省宁波市315207

利用HYSYS软件对中国石油化工股份有限公司镇海炼化分公司Ⅰ号催化裂化干气、液化石油气脱硫及配套溶剂再生装置进行流程模拟,运用软件自带Amine Pkg流体物性包中Li-Mather方法进行稳态模拟,对影响脱硫装置净化干气硫化氢超标的原因进... 详细信息

利用HYSYS软件对中国石油化工股份有限公司镇海炼化分公司Ⅰ号催化裂化干气、液化石油气脱硫及配套溶剂再生装置进行流程模拟,运用软件自带Amine Pkg流体物性包中Li-Mather方法进行稳态模拟,对影响脱硫装置净化干气硫化氢超标的原因进行技术分析,得出了因胺液净化器投用,胺液系统热稳态盐含量大幅下降,贫胺液浓度过低,最终导致再生效果不佳是净化干气硫化氢超标的主要原因。同时对装置进行节能优化,找出影响再生塔底重沸器热负荷的因素。对低盐胺液系统,当贫胺液浓度维持30%~35%、进料温度维持90~100℃、贫胺液中H_2S质量浓度为1.0~1.5 g/L时,既能满足产品质量需求,又能达到节能降耗目的。

关键词：溶剂再生流程模拟 MDEA 贫胺液富液硫化氢脱硫

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庚二酸处理硅灰石填充改性聚丙烯

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高分子材料科学与工程 2008年第11期24卷 153-156页

作者：孟明锐窦强南京工业大学材料科学与工程学院高分子系江苏南京210009

采用庚二酸对硅灰石进行表面处理,研究了复合材料的力学和结晶性能。DSC和WAXD结果表明,庚二酸处理的比未处理硅灰石有更强的诱发聚丙烯β晶的能力。偏光显微镜观察表明,庚二酸处理硅灰石大大减小了β晶的粒径,改善了硅灰石与聚丙烯的... 详细信息

采用庚二酸对硅灰石进行表面处理,研究了复合材料的力学和结晶性能。DSC和WAXD结果表明,庚二酸处理的比未处理硅灰石有更强的诱发聚丙烯β晶的能力。偏光显微镜观察表明,庚二酸处理硅灰石大大减小了β晶的粒径,改善了硅灰石与聚丙烯的相容性。

关键词：聚丙烯硅灰石庚二酸 β晶

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面向未来低碳道路养护的超薄罩面功能性研究综述

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Engineering 2024年第1期32卷 82-98页

作者： meng Guo rui Zhang Xiuli Du Pengfei Liu State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China The Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China Institute of Highway Engineering RWTH Aachen UniversityAachen 52074Germany

Highway maintenance mileage reached 5.25 million kilometers in China by ***-thin overlay is one of the most commonly used maintenance technologies,which can significantly enhance the economic and environmental benefits of *** promote the low-carbon development of ultrathin overlays,this paper mainly studied the mechanism and influencing factors of several ultra-thin overlay ***,the skid resistance,noise reduction,rutting resistance,and crack resistance of ultrathin overlays were *** results indicated that the high-quality aggregates improved the skid and rutting resistance of ultra-thin overlay by 5%-20%.The optimized gradations and modified binders reduced noise of ultra-thin overlay by 0.4-6.0 *** high viscosity modified binders improved the rutting resistance of ultra-thin overlay by about 10%-130%.Basalt fiber improved the cracking resistance of ultra-thin overlay by more than 20%.Due to the thinner thickness and better road performance,the performance-based engineering cost of ultra-thin overlay was reduced by about 30%-40%compared with conventional ***,several environmentally friendly functions of ultra-thin overlay were investigated,including snow melting and deicing,exhaust gas purification and pavement *** lower thickness of ultra-thin overlay was conducive to the diffusion of chloride-based materials to the pavement ***,the snow melting effect of self-ice-melting was *** addition,the ultra-thin overlay mixture containing photocatalytic materials could decompose 20%-50%of the exhaust *** colored ultra-thin overlay was able to reduce the temperature of the pavement by up to 8.1℃.The temperature difference between the upper and lower surfaces of the ultra-thin overlay containing thermal resistance materials could reach up to 12.8℃.In addition,numerous typical global engineering applications of functional ultra-thin overlay were *** review can help better under

关键词： Road maintenance Ultra-thin overlay Snow melting and deicing Exhaust gas purification Pavement cooling Low-carbon

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Engineering singlet and triplet excitons of TADF emitters by different host-guest interactions

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Aggregate 2024年第1期5卷 337-344页

作者： Wei Zhang Jie Kong rui Zhi An Jiachen Zhang Yujie Zhou Lin-Song Cui meng Zhou Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefeiChina Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China(USTC)HefeiChina CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiChina

Understanding the host-guest interactions for thermally activated delayed fluorescence(TADF)emitters is critical because the interactions between the host matrices and TADF emitters enable precise control on the optoelectronic performance,whereas technologically manipulating the singlet and triplet excitons by using different kinds of host-guest interactions remains ***,we report a comprehensive picture that rationalizes host-guest interaction-modulated exciton recombination by using time-resolved *** found that the early-time relaxation is accelerated in polar polymer because dipole-dipole interaction facilitates the stabilization of the 1CT ***,an opposite trend is observed in longer delay time,and faster decay in the less polar polymer is ascribed to theπ-πinteraction that plays the dominant role in the later stage of the excited *** findings highlight the technological engineering singlet and triplet excitons using different kinds of host-guest interactions based on their electronic characteristics.

关键词： host-guest interaction singlet TADF triplet

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Investigation on the low temperature rheological properties of polymer modified asphalt

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Journal of Traffic and Transportation Engineering(English Edition) 2023年

作者： Zhen Fu rui-meng Song Wen Qin Ke Shi Feng Ma Jia-rong Li Chao Li School of Materials Science and Technology， Chang'an University School of Highway， Chang'an University

Traditional pavement is prone to cracks， and other distresses in cold regions. In this case， asphalt modification is a common technique used to improve the performance of asphalt. This study attempts to compare the low temperature properties of three modified asphalts. For this purpose， the addition of crumb rubber (CR)， modified crumb rubber (MCR)， and styrene–butadiene–styrene (SBS) to the base asphalt， respectively， and CR modified asphalt， MCR modified asphalt， and SBS modified asphalt is firstly prepared. Then， the asphalt specimens are subjected to a thin film oven test (TFOT) and pressurized aging vessel (PAV) test. The bending beam rheometer (BBR) test is conducted to compare the rheology characteristics and anti-aging performance of three modified asphalts. Furthermore， the low temperature performance of three modified asphalts is compared by three approaches based on the performance grade (PG)， critical low temperature， and Burgers model. The BBR results show that the CR modified asphalt has the best low temperature performance. However， the CR modified asphalt show poor aging resistance， SBS modified asphalt， and MCR modified asphalt have better aging resistance. In terms of the Burgers model， it is established to analyze the resistance to low temperature cracking of four asphalts from the perspective of viscoelastic properties. Different viscoelastic parameters indicate that the low temperature performance of CR modified asphalt is superior to the other asphalts， which is consistent with the result of the critical low temperatures.

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Cathodic corrosion as a facile and universal method for scalable preparation of powdery single atom electrocatalysts

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Nano Research 2024年第6期17卷 4943-4950页

作者： rui Li Xiayan Yan meng Liu Qingkai Zhao Jie Du Xinxin Tan Jingwen Ba Rongguang Zeng Wenhua Luo Jingsong Xu Institute of Materials China Academy of Engineering PhysicsJiangyou 621907China Science and Technology on Surface Physics and Chemistry Laboratory Jiangyou 621908China

Top-down strategy has been widely applied for synthesis of metal single atom catalysts(SACs)via converting metal nanoparticles or bulk metals into atomically dispersed ***,we report a simple electrochemical atomic migration strategy for top-down synthesis of SACs via a facile cathodic corrosion process without involving high temperature or harsh *** of metal nanoparticles on cathode are firstly disbanded under high negative voltage,and emitted into the electrolyte in the form of atomic metal anions in Zintl *** escaped atomically dispersed metal species are then oxidized by water molecules and captured by the defects on the pre-added nitrogen doped carbon carriers in the *** cathodic corrosion strategy is confirmed to be suitable for scalable synthesis of kinds of metal SACs(e.g.,Pt,Pd,and Ir)on doped carbon ***,the as-prepared nitrogen doped carbon powder supported Pt SACs exhibit superior catalytic activity toward hydrogen evolution reaction(HER)with a low overpotential of 0.024 V at 10 mA·cm^(−2)and a low Tafel slope of 29.7 mV·dec^(−1)as well as a long-term durability.

关键词： cathodic corrosion top-down strategy powdery single atom catalysts hydrogen evolution reaction scalable synthesis

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