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P2X7 Receptor Mediated Growth-Inhibitory Effect in KG1a Cell Line

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Chinese Journal of Clinical Oncology 2008年第6期5卷 400-406页

作者： Xiujun Zhang lijun meng Department of Biological Sciences North China Coal Medical College Tangshan 063000 Heibei Province China Department of Environment ＆ Chemical Engineering Tangshan College Tangshan 063000. Heibei Province China

OBJECTIVE This study was conducted to investigate ATP- induced growth inhibition in human leukemic cells KG1a. METHODS ATP inhibited cell growth was analyzed by MTS assay. Externalization of phosphatidylserine could be detected by Annexin-V-FITC apoptosis staining after activation of the P2X7 receptor. P2X7 mediated pore formation was detected in KGla cells by Yo-Pro-1 uptake assay. RESULTS ATP inhibited cell growth in a dose-dependent manner. The cytotoxic effect could be blocked by P2X7 antagonists, oxidized ATP （oATP） and KN62. Externalization of phosphatidylserine could be detected in a time-dependent manner. P2X7 mediated pore formation could be detected in KG1a cells. These effects could not be observed in P2X7 null Ramos cells. CONCLUSION The results and our previously reports that mRNA, protein expression and calcium response of the P2X7 receptor in KGla cells, suggested that extracellular ATP effectively induces growth inhibition through apoptosis in KGla cells by activation of P2X7 receptor, and that may be mediated by extracellular Ca^2＋ in ux and pore formation.

关键词： P2X7 receptor growth inhibition apoptosis extracellular ATP leukemia cells.

How Media Opinion Influences Imports in the US

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China Economist 2020年第6期15卷 52-67页

作者： Li Gang meng lijun Institute of Industrial Economics(IIE) Chinese Academy of Social Sciences(CASS)BeijingChina School of Public Administration Tsinghua UniversityBeijing

Does public opinion influence US imports?Do countries with a good reputation export more to the US?And vice versa?Based on an extended trade gravity model,this paper employs news data from the GDELT database and US monthly import data to create an indicator of the influence of public opinion to examine the effects of US domestic public opinion on *** research findings suggest that:(i)US public opinion influences US ***,(ii)when public opinion turned negative during 2013-2017,it exerted a significantly negative effect on US imports;when public opinion was favorable during 2008-2012,it exerted an insignificantly positive effect on US imports.(iii)According to the pulse response function and variance decomposition,negative public opinion exerted a more significant and more lasting effect on US imports compared with positive public opinion.(iv)It can be discovered after further decomposing such effects on product categories that significant product heterogeneity exists in the public opinion effects on US imports:Complex and differentiated products are more influenced by negative public opinion while homogeneous and intermediate products are more influenced by positive public opinion.

关键词： public opinion trade barriers US imports product heterogeneity JEL Classification Codes:E7 F14

The Temporal Features of China's Opening to the Outside World and Its Theoretical Construction

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Social Sciences in China 2022年第1期43卷 173-193页

作者： Jiang Xiaojuan meng lijun 黄德远 School of Public Policy&Management Tsinghua University Institute for Service Economy and Digital Governance Tsinghua University 不详

Over the past 40-plus years of reform and opening up,China has taken a unique path of development that complies with both its national conditions and the laws of *** paper analyzes the uniqueness and the universality of Chinese experience and the theoretical logic that has permeated the process of China’s opening up and kept pace with the *** this framework we analyze the key issues and suitable options for China’s future opening up.

关键词： opening up incremental opening up opening up strategy institutional opening up

Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression

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Food Science and Human Wellness 2023年第6期12卷 2014-2021页

作者： Zhenhua Liu mengke Wang lijun meng Yixiao Chen Qiuyi Wang Yan Zhang Xuefeng Xi Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China Hebei Food Inspection and Research Institute Hebei Food Safety Key LaboratoryKey Laboratory of Special Food Supervision Technology for State Market RegulationHebei Engineering Research Center for Special Food Safety and HealthShijiazhuang 050017China College of Physical Education Henan UniversityKaifeng 475004China

Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and *** on our ongoing research on chemical constituents and hypoglycemic activity of ***,4 lignan compounds,(+)-isolariciresinol(1),7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside(2),4-O-methylcedrusin(3)and patrinian A(4),were isolated and identifi *** hypoglycemic activity showed that compounds 2 and 3 could extremely signifi cantly improve insulin resistance at 100(P<0.001),50(P<0.001)and 25μmol/L(P<0.01)in IR 3T3-L1 *** compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100μmol/L(P<0.01).Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS,PI-3K,p-AKT and glucose transporter 4(GLUT4),and promoted the transcription of GLUT4 ***,the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway.

关键词： Patrinia scabiosaefolia Insulin resistance Patrinian A 7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside

Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method

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Food Science and Human Wellness 2021年第3期10卷 278-288页

作者： Changqin Li Yiping Cui Jie Lu lijun meng Changyang Ma Zhenhua Liu Yan Zhang Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Henan ProvinceKaifeng475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceHenan UniversityKaifeng 475004China Hebei Food Inspection and Research Institute Shijiazhuang 050091China

This study was designed to elucidate the immunoregulation of Ganoderma *** fingerprint and spectrum-effect relationship of *** were established to predict the active compounds and BP neural network model was established to predict the *** the target compounds were identified by high resolution mass *** results indicated that there are both enhanced immunity and immunosuppressive components in *** neural network was trained with the common peak area and immune effi cacy index of *** fi ngerprint as samples,and a combined evaluation system of *** fi ngerprint effi cacy was *** correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal *** compounds were identifi ed by high resolution mass *** compounds related to immune activity in *** were determined in this study.

关键词： Ganoderma lucidum RAW 264.7 cell Spectrum-effect relationships Component knock-out BP neural network

Flowers: precious food and medicine resources

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Food Science and Human Wellness 2023年第4期12卷 1020-1052页

作者： Xuqiang Liu Senye Wang Lili Cui Huihui Zhou Yuhang Liu lijun meng Sitan Chen Xuefeng Xi Yan Zhang Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China College of Physical Education Henan UniversityKaifeng 475004China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Shenzhen Research Institute of Henan University Shenzhen 518000China

Flower plants are popular all over the world and important sources of ornamental plants,bioactive molecules and *** have a wide range of biological activities and beneficial pharmacological *** and their active ingredients are becoming more and more popular in the preparation of food,drugs and industrial *** paper summarizes the active ingredients,pharmacological activities and applications in the pharmaceutical and food industries of flower plants in recent *** addition,the possible molecular mechanism of pharmacological effects of flower plants were also discussed.302 active constituents from 55 species of flower plants were summarized,including flavonoids(115),terpenoids(90),phenylpropanoids(20),alkaloids(13),organic acids(27)and others(37).The pharmacological effects of flower plants are very extensive,mainly including antioxidant,anti-inflammatory,anti-tumor,anti-virus,and *** mechanisms of anti-inflammatory,anti-tumor and hypoglycemic activities present the characteristics of multi-way and *** of its rich nutrients,bioactive ingredients and plant essential oils,and its wide sources,flower plants are widely used in food,beverage,cosmetics and drug *** plants also play an important role in pharmaceutical industry,food industry and other fields.

关键词： Flowers Active ingredients Biological activity Mechanism

Natural products:Regulating glucose metabolism and improving insulin resistance

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Food Science and Human Wellness 2020年第3期9卷 214-228页

作者： Fatma S.A.Saadeldeen Yun Niu Honglin Wang Li Zhou lijun meng Sitan Chena Dongxiao Sun-Waterhouse Geoffrey Ivan Neil Waterhouse Zhenhua Liu Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceHenan UniversityKaifeng 475004China Kaifeng Key Laboratory of Functional Components in Health Food Kaifeng 475004HenanChina School of Chemical Sciences University of AucklandAuckland 1142New Zealand

Compounds with regulating glucose metabolism and improving insulin resistance(IR)activity are abundant in nature and can be obtained from several *** have high potential to be used to treat diabetes *** compounds isolated from natural plants can be classified seven categories:terpenoids,alkaloids,quinones,flavonoids,phenols,phenyl propanoids,steroids,and other types of *** exert biological effects by different ways and *** review illustrated the potential natural products as a rich resource in regulation of glucose metabolism and IR,as well as their mechanisms.

关键词： Natural products Glucose metabolism Insulin resistance(IR)

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超声激励-光纤光栅传感的板结构损伤识别

仪器仪表学报 2012年第10期33卷 2330-2336页

作者：孟丽君谭跃刚武汉理工大学机电工程学院武汉430070

为实现利用光纤光栅代替压电陶瓷进行固体中超声波信号的检测和结构损伤的识别,搭建了超声激励-光纤光栅检测系统。系统采用超声波探伤仪激励超声探头从而在薄板中产生超声波,利用粘贴型光纤光栅对超声波进行测量,用基于可调激光光源的... 详细信息

为实现利用光纤光栅代替压电陶瓷进行固体中超声波信号的检测和结构损伤的识别,搭建了超声激励-光纤光栅检测系统。系统采用超声波探伤仪激励超声探头从而在薄板中产生超声波,利用粘贴型光纤光栅对超声波进行测量,用基于可调激光光源的解调系统实现光纤光栅中心波长的解调。分析了该检测系统的工作原理,理论推导了其输出电压与所测超声应变的关系式。在此基础上,首先,将该装置用于5052铝合金板中超声波声轴线声强分布特征的研究,验证了该装置用于板中超声波信号测量的可行性;然后,利用该装置分别进行5052铝合金板中2处直径为6 mm的孔缺陷的检测,实验证明,当板中出现孔缺陷时,光纤光栅所测波形中将出现新的波包,可通过损伤前后新增波包到来的时刻确定孔的位置,两孔的缺陷定位偏差分别为3.3 mm和0.8 mm。

关键词：光纤光学光纤光栅超声激励损伤识别

Ti—Mo合金β结构稳定性和弹性性质的第一性原理研究

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金属学报 2008年第1期44卷 19-22页

作者：姚强邢辉孟丽君孙坚上海交通大学材料科学与工程学院上海200240

采用基于密度函数理论的缀加平面波加局域轨道方法和超晶胞方法对Mo含量(原子分数)为4.17%—37.5%的Ti-Mo二元合金的能量、电子结构以及弹性性质进行了理论计算,研究了Mo含量对Ti-Mo合金的β结构稳定性和弹性性质的影响.结果表明,随着M... 详细信息

采用基于密度函数理论的缀加平面波加局域轨道方法和超晶胞方法对Mo含量(原子分数)为4.17%—37.5%的Ti-Mo二元合金的能量、电子结构以及弹性性质进行了理论计算,研究了Mo含量对Ti-Mo合金的β结构稳定性和弹性性质的影响.结果表明,随着Mo含量的升高,Ti-Mo合金的β结构稳定性提高,正方剪切常数(tetragonal shear constant)C′以及弹性模量B,E和G均呈单调增加;当Mo含量为4.77%时,正方剪切常数C′略大于零,此时Ti-Mo合金的β结构稳定性和弹性模量均最低.

关键词： Ti—Mo合金结构稳定性弹性性质第一性原理