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关节腔注射治疗骨关节炎药物载体系统中的软骨靶向功能

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中国组织工程研究 2024年第3期28卷 458-463页

作者：陈俊炎孟庆奇李斯明贵州医科大学贵州省贵阳市550025 暨南大学附属广州市红十字会医院广东省广州市510220

背景:关节腔注射给药已经在骨关节炎治疗中占有重要地位,新型的药物递送系统的开发给予了更多选择。软骨靶向功能是针对治疗骨关节炎时药物附着或留置在软骨层中形成药库,达到缓释和精准药物递送。目的:综述关节腔注射治疗骨关节炎中各... 详细信息

背景:关节腔注射给药已经在骨关节炎治疗中占有重要地位,新型的药物递送系统的开发给予了更多选择。软骨靶向功能是针对治疗骨关节炎时药物附着或留置在软骨层中形成药库,达到缓释和精准药物递送。目的:综述关节腔注射治疗骨关节炎中各种软骨靶向生物材料和其特点。

关键词：软骨靶向关节腔注射骨关节炎软骨穿透药物载体生物材料

Chemical constituents from leaves of Jatropha curcas

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Chinese Herbal Medicines 2023年第3期15卷 463-469页

作者： Yingjie Wang Di Zhou Xiaolin Bai qingqi meng Haihui Xie Guojiang Wu Gang Chen Yue Hou Ning Li School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Tasly Northeast Modern TCM Resources Co. Ltd.Benxi 117204China College of Life and Health Sciences Northeastern UniversityShenyang 110004China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

Objective:To investigate the chemical constituents from the leaves of Jatropha curcas and evaluate their inhibition on lipopolysaccharide(LPS)-activated BV-2 microglia ***:The n-BuOH extract of the leaves of *** was isolated by macroporous adsorption resin,silica gel,ODS,column chromatography and semi-preparative *** structures of the compounds were identified by MS,NMR,ECD,and other spectroscopic *** addition,anti-neuroinflammatory effects of isolated compounds were evaluated by measuring the production of nitric oxide(NO)in overactivated BV-2 ***:Seventeen compounds,including(7R,8S)-crataegifin A-4-O-β-D-glucopyranoside(1),(8R,8’R)-arctigenin(2),arctigenin-4’-O-β-D-glucopyranoside(3),(-)-syringaresinol(4),syringaresinol-4’-O-β-Dglucopyranoside(5),(-)-pinoresinol(6),pinoresinol-4’-O-β-D-glucopyranoside(7),buddlenol D(8),(2R,3R)-dihydroquercetin(9),(2S,3S)-epicatechin(10),(2R,3S)-catechin(11),isovitexin(12),naringenin-7-O-β-D-glucopyranoside(13),chamaejasmin(14),neochamaejasmin B(15),isoneochamaejasmin A(16),and tomentin-5-O-β-D-glucopyranoside(17)were isolated and *** 2,4and 8 significantly inhibited the release of NO in BV-2 microglia activated by LPS,with IC50values of18.34,29.33 and 26.30μmol/L,***:Compound 1 is a novel compound,and compounds 2,3,8,14–17 are isolated from Jatropha genus for the first *** addition,the lignans significantly inhibited NO release and the inhibitory activity was decreased after glycosylation.

关键词： anti-neuroinflammation flavonoid Jatropha curcas L. lignans

Evolutionary game analysis of shared parking market diffusion under government management

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Transportation Safety and Environment 2024年第3期6卷 17-27页

作者： qingqi Wei Guomei Xiao School of Economics and Management Chongqing Jiaotong UniversityChongqing 400074China

The imbalance between supply and demand in urban settings poses a significant barrier to the sustainable advancement of urban *** parking serves as a viable solution to mitigate these ***,for its sustained growth,a regulatory mechanism enforced by the government is *** promote shared parking market diffusion,we construct an evolutionary game model that incorporates the government,enterprises and parking *** explores stabilization strategies for these stakeholders and identifies multiple equilibrium states under different parameter *** results show that the rate and stability of these evolutionary strategies are constrained by the mutual benefits derived by the three ***,such stakeholders are reciprocally influenced by their willingness to engage in shared parking to varying *** subsidies serve as a determining factor for the strategic choices made by both enterprises and demanders,albeit at different evolutionary *** who have a higher value of time tend to park on-street,thereby influencing enterprise *** foster the long-term growth of the shared parking market,the government must enact appropriate subsidy policies,maintain consistent regulations and advocate for increased subsidies for parking demanders to reduce the effect of temporal heterogeneity on parking behavioural choices.

关键词： traffic management shared parking government management parking behaviour choice evolutionary game

Privacy Preserving Algorithm for Spectrum Sensing in Cognitive Vehicle Networks

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Chinese Journal of Electronics 2024年第1期33卷 30-42页

作者： Hongning LI Tonghui HU Jiexiong CHEN Xiuqiang WU qingqi PEI Guangzhou Institute of Technology Xidian University Guangzhou CEPREI Shaanxi Key Laboratory of Blockchain and Secure Computing

The scarcity of spectrum resources fails to meet the increasing throughput demands of vehicular networks. There is an urgent need to maximize the utilization of spectrum bands in mobile networks. To ascertain the availability of spectrum bands, users should engage in wireless channel sensing and collaboration. However, spectrum sensing data always involves users’ privacy, such as their location. This paper first introduces sensing trajectory inference attack in cognitive vehicular networks and then proposes a data confusion-based privacy-preserving algorithm and a cryptonym array-based privacy-preserving aggregation scheme for spectrum sensing in cognitive vehicular networks. Unlike existing methods, the proposed schemes transmit confused data during the aggregation process. This deliberate obfuscation makes it almost impossible to infer users’ location from the transmitted data. The analysis demonstrates the resilience of the proposed schemes against sensing trajectory inference attack.

关键词： Privacy Data privacy Wireless sensor networks Authentication Data aggregation Throughput Inference algorithms

An Active Deception Defense Model Based on Address Mutation and Fingerprint Camouflage

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China Communications 2024年第7期21卷 212-223页

作者： Wang Shuo Chu Jiang Pei qingqi Shao Feng Yuan Shuai Zhong Xiaoge State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Blockchain and Secure Computing Xidian UniversityXi’an 710071China

The static and predictable characteristics of cyber systems give attackers an asymmetric advantage in gathering useful information and launching *** reverse this asymmetric advantage,a new defense idea,called Moving Target Defense(MTD),has been proposed to provide additional selectable measures to complement traditional ***,MTD is unable to defeat the sophisticated attacker with fingerprint tracking *** overcome this limitation,we go one step beyond and show that the combination of MTD and Deception-based Cyber Defense(DCD)can achieve higher performance than either of *** particular,we first introduce and formalize a novel attacker model named Scan and Foothold Attack(SFA)based on cyber kill ***,we develop probabilistic models for SFA defenses to provide a deeper analysis of the theoretical effect under different defense *** models quantify attack success probability and the probability that the attacker will be deceived under various conditions,such as the size of address space,and the number of hosts,attack analysis ***,the experimental results show that the actual defense effect of each strategy almost perfectly follows its probabilistic ***,the defense strategy of combining address mutation and fingerprint camouflage can achieve a better defense effect than the single address mutation.

关键词： address mutation deception defense fingerprint camouflage moving target defense probabilistic model

A vertical track nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 931-946页

作者： meng LI Hu DING Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai Frontier Science Center of MechanoinformaticsShanghai UniversityShanghai 200444China

Eliminating the effects of gravity and designing nonlinear energy sinks(NESs)that suppress vibration in the vertical direction is a challenging task with numerous damping *** this paper,the dynamic design of a vertical track nonlinear energy sink(VTNES)with zero linear stiffness in the vertical direction is proposed and realized for the first *** motion differential equations of the VTNES coupled with a linear oscillator(LO)are *** the strong nonlinearity considered of the VTNES,the steady-state response of the system is analyzed with the harmonic balance method(HBM),and the accuracy of the HBM is verified *** this basis,the VTNES prototype is manufactured,and its nonlinear stiffness is *** damping effect and dynamic characteristics of the VTNES are studied theoretically and *** results show that the VTNES has better damping effects when strong modulation responses(SMRs)***,even for small-amplitude vibration,the VTNES also has a good vibration suppression *** sum up,in order to suppress the vertical vibration,an NES is designed and developed,which can suppress the vertical vibration within certain ranges of the resonance frequency and the vibration intensity.

关键词： track nonlinear energy sink(TNES) vertical direction gravity nonlinear stiffness harmonic balance method(HBM) vibration control

Nested Saturated Control of Uncertain Complex Cascade Systems Using Mixed Saturation Levels

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1163-1174页

作者： meng Li Zhigang Zeng Wuhan National Laboratory for Optoelectronics Wuhan 430074 School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

This study addresses the problem of global asymptotic stability for uncertain complex cascade systems composed of multiple integrator systems and non-strict feedforward nonlinear systems. To tackle the complexity inherent in such structures, a novel nested saturated control design is proposed that incorporates both constant saturation levels and state-dependent saturation levels. Specifically, a modified differentiable saturation function is proposed to facilitate the saturation reduction analysis of the uncertain complex cascade systems under the presence of mixed saturation levels. In addition, the design of modified differentiable saturation function will help to construct a hierarchical global convergence strategy to improve the robustness of control design scheme. Through calculation of relevant inequalities, time derivative of boundary surface and simple Lyapunov function,saturation reduction analysis and convergence analysis are carried out, and then a set of explicit parameter conditions are provided to ensure global asymptotic stability in the closed-loop systems. Finally, a simplified system of the mechanical model is presented to validate the effectiveness of the proposed method.

关键词： method saturation differentiable

Adaptive admittance tracking control for interactive robot with prescribed performance

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Journal of Systems Engineering and Electronics 2024年第2期35卷 444-450页

作者： meng Qingrui LIN Yan School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100190China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

An adaptive control approach is presented in this paper for tracking desired trajectories in interactive manipulators. The controller design incorporates prescribed performance functions (PPFs) to improve dynamic performance. Notably, the performance of the output error is confined in an envelope characterized by exponential convergence, leading to convergence to zero. This feature ensures a prompt response from admittance control and establishes a reliable safety framework for interactions. Simulation results provide practical insights,demonstrating the viability of the control scheme proposed in this paper.

关键词： prescribed performance admittance control adaptive control robots

Cooperative User-Scheduling and Resource Allocation Optimization for Intelligent Reflecting Surface Enhanced LEO Satellite Communication

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China Communications 2024年第2期21卷 227-244页

作者： meng meng Bo Hu Shanzhi Chen Jianyin Zhang State Key Lab of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Lab of Wireless Mobile Communication China Academy of Telecommunication TechnologyBeijing 100191China Research Institute of China Mobile Beijing 100053China

Lower Earth Orbit(LEO) satellite becomes an important part of complementing terrestrial communication due to its lower orbital altitude and smaller propagation delay than Geostationary satellite. However, the LEO satellite communication system cannot meet the requirements of users when the satellite-terrestrial link is blocked by obstacles. To solve this problem, we introduce Intelligent reflect surface(IRS) for improving the achievable rate of terrestrial users in LEO satellite communication. We investigated joint IRS scheduling, user scheduling, power and bandwidth allocation(JIRPB) optimization algorithm for improving LEO satellite system *** optimization problem of joint user scheduling and resource allocation is formulated as a non-convex optimization problem. To cope with this problem, the nonconvex optimization problem is divided into resource allocation optimization sub-problem and scheduling optimization sub-problem firstly. Second, we optimize the resource allocation sub-problem via alternating direction multiplier method(ADMM) and scheduling sub-problem via Lagrangian dual method ***, we prove that the proposed resource allocation algorithm based ADMM approaches sublinear convergence theoretically. Finally, we demonstrate that the proposed JIRPB optimization algorithm improves the LEO satellite communication system throughput.

关键词： convex optimization intelligent reflecting surface LEO satellite communication OFDM