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Science China Earth Sciences 2009年第8期52卷 1115-1126页

作者： qingyong meng AnChun Li TieGang Li FuQing Jiang XiaoJing Zhou Key Lab of Marine Geology & Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

Our rock magnetic analysis of core Ph05 from the West Philippine Sea demonstrates that the core preserves a strong, stable remanent magnetization and meets the magnetic mineral criteria for relative paleointensity (RP... 详细信息

关键词： West Philippine Sea relative paleointensity geomagnetic field

Paleoenvironment evolution of the East Philippine Sea recorded in the new-type ferromanganese crust since the terminal Late Miocene

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Science China Earth Sciences 2007年第8期50卷 1179-1188页

作者： XU ZhaoKai LI AnChun JIANG FuQing LI TieGang meng qingyong JIN Ning Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Graduate University of Chinese Academy of Sciences Beijing 100039China

From systemic research of microstructure, geochemistry, uranium-series and 10Be isotope dating on a new-type deepwater ferromanganese crust from the East Philippine Sea, the paleoenvironment evolu-tion of the target area since the terminal Late Miocene was recovered. The vertical section changes of microstructure and chemical composition are consistent in the studied crust, which indicate three major accretion periods and corresponding paleoenvironment evolution of the crust. The bottom crust zone was formed in the terminal Late Miocene (5.6 Ma) with loose microstructure, high detritus content and high growth rate. Reductions of mineral element content, accretion rate and positive Ce-anomaly degree at 4.6 Ma indicate temporal warming, which went against the crust accretion and finally formed an accretion gap in the terminal Middle Pliocene (2.8―2.7 Ma). The more active Antarctic bottom sea-waters in the Late Pliocene (2.7 Ma) facilitated the fast transfer to the top pure crust zone. Hereafter, with the further apart of volcanic source and the keeping increase of eolian material (1.0 Ma), although surrounding conditions were still favorable, mineral element content still shows an obvious reducing trend. It thereby offers new carrier and data for the unclear paleoceanographic research of the target area since the terminal Late Miocene.

关键词： new-type ferromanganese crust record paleoenvironment evolution uranium-series dating 10Be isotope dating East Philippine Sea

A preliminary study on fingerprinting approach in marine sediment dynamics with the rare earth elements

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Acta Oceanologica Sinica 2010年第4期29卷 62-77页

作者： ZHOU Xiaojing LI Anchun JIANG Fuqing meng qingyong Key Laboratory of Marine Geology ＆ Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Locating the quantitized natural sediment fingerprints is an important work for marine sediment dynamics *** total of 146 sediment samples were collected from the Shelf of the East China Sea and five rivers,including Huanghe （Yellow）,Changjiang （Yangtze）,Qiantang,Ou and Min *** sediment grain size and the contents of rare earth elements （REEs） were measured with laser particle size analyzer and ICP-MS *** results show that absolute REE content （ΣREE） and the concentration ratio of light REEs to heavy REEs （L/HREE） are different in the sediments among those *** are higher REE contents in being less than 2 m and 2–31 μm fractions in the Changjiang Estuary surface *** REE contents of bulk sediment are dominated by the corresponding values of those leading *** of sediment is higher close to the estuaries and declines seaward on the inner shelf of the East China Sea （ECS）.The L/HREE ratio has a tendency of increase southward from 28 ？ *** conditions plays a predominate role on spacial distributions of the surficial sediment’s REE *** some situations,the currents tend to remove the coarser light grains from initial populations,as well as the deposit of the finer heavy mineral *** other situations,the currents will change the ratio of sediment constituents,such as ratio between silts and clays in the *** a result,the various values of REE or L/HREE ratio in different bulk sediments are more affected by the change of size-fractions than source *** the long-term stable hydrodynamic environment,i.e.,the East China Sea Shelf,new sediment transport model based on the size and density gradation concept may help to understand the spatial distribution patterns of REE parameters.

关键词： rare earth elements fingerprints East China Sea Shelf sediment transport

Immunoglobulin superfamily containing leucine-rich repeat(ISLR)negatively regulates osteogenic differentiation through the BMP-Smad signaling pathway

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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao Lan Chang Liu Lei Li YingYing Yu Tongtong Wang Fan Liu Kun Wang Jin Liu qingyong meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment *** an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for *** herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

Melatonin improves the first cleavage of parthenogenetic embryos from vitrified-warmed mouse oocytes potentially by promoting cell cycle progression

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Journal of Animal Science and Biotechnology 2022年第1期13卷 106-122页

作者： Bo Pan Izhar Hyder Qazi Shichao Guo Jingyu Yang Jianpeng Qin Tianyi Lv Shengqin Zang Yan Zhang Changjun Zeng qingyong meng Hongbing Han Guangbin Zhou Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Department of Veterinary Anatomy and Histology Shaheed Benazir Bhutto University of Veterinary and Animal SciencesSakrandSindh 67210Pakistan State Key Laboratory of AgroBiotechnology China Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgricultureBeijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background:This study investigated the effect of melatonin(MT)on cell cycle(G1/S/G2/M)of parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II(MII)oocytes and elucidated the potential mechanism of MT action in the first cleavage of ***:After vitrification and warming,oocytes were parthenogenetically activated(PA)and in vitro cultured(IVC).Then the spindle morphology and chromosome segregation in oocytes,the maternal mRNA levels of genes including Miss,Doc1r,Setd2 and Ythdf2 in activated oocytes,pronuclear formation,the S phase duration in zygotes,mitochondrial function at G1 phase,reactive oxygen species(ROS)level at S phase,DNA damage at G2 phase,early apoptosis in 2-cell embryos,cleavage and blastocyst formation rates were *** results indicated that the vitrification/warming procedures led to following perturbations 1)spindle abnormalities and chromosome misalignment,alteration of maternal mRNAs and delay in pronucleus formation,2)decreased mitochondrial membrane potential(MMP)and lower adenosine triphosphate(ATP)levels,increased ROS production and DNA damage,G1/S and S/G2 phase transition delay,and delayed first cleavage,and 3)increased early apoptosis and lower levels of cleavage and blastocyst *** results further revealed that such negative impacts of oocyte cryopreservation could be alleviated by supplementation of warming,recovery,PA and IVC media with 10^(−9) mol/L MT before the embryos moved into the 2-cell stage of ***:MT might promote cell cycle progression via regulation of MMP,ATP,ROS and maternal mRNA levels,potentially increasing the first cleavage of parthenogenetic zygotes developed from vitrified-warmed mouse oocytes and their subsequent development.

关键词： Cell cycle Cleavage rate Melatonin MetaphaseⅡoocyte Parthenogenetic activation Vitrification

Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330

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Frontiers of Agricultural Science and Engineering 2015年第3期2卷 242-248页

作者： mengxu GE Fei LIU Fei CHANG Zhaolin SUN Jing FEI Ying GUO Yunping DAI Zhengquan YU Yaofeng ZHAO Ning LI qingyong meng State Key Laboratory of Agrobiotechnology College of Biological ScienceChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology Yunnan Agricultural UniversityKunming 650201China

Lactoferrin is a member of the transferrin family of multifunctional iron binding *** numerous physiological functions have been described for lactoferrin,the mechanisms underlying these functions are not *** further study the functions and mechanisms of lactoferrin,we modified the lactoferrin promoter of mice using the CRISPR/Cas9 system to reduce or eliminate lactoferrin *** mice with lactoferrin promoter mutations were obtained with an efficiency of 24%(7/29)by injecting the plasmid pX330,expressing a small guide RNA and human codonoptimized SpCas9,into fertilized eggs of *** integration and off-targeting of pX330 were not *** results confirmed that pronuclear injection of a circular plasmid is a feasible and efficient method for targeted mutagenesis in mice.

关键词： lactoferrin promoter CRISPR/Cas9 plasmid pX330

苏格兰现代学徒制与其他教育类型的联系机理、运行机制及经验启示

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职业技术教育 2019年第27期40卷 73-79页

作者：孟庆永浙江经济职业技术学院物流与供应链管理学院

苏格兰学徒制基于其灵活、特色的学分与资历框架建立了与其他教育纵横沟通的"立交桥"。剖析其运行机制,借鉴其成功经验,我国可通过建立国家资历框架来完善现代学徒制与其他教育的联系机制,在多层面保障企业决策权,维护好企业主体地位,... 详细信息

苏格兰学徒制基于其灵活、特色的学分与资历框架建立了与其他教育纵横沟通的"立交桥"。剖析其运行机制,借鉴其成功经验,我国可通过建立国家资历框架来完善现代学徒制与其他教育的联系机制,在多层面保障企业决策权,维护好企业主体地位,引入市场机制整合多方优质资源参与现代学徒培养,政府部门可采用购买服务或自设机构的形式协调各参与方的利益诉求,转移承接协调成本,同时制定规范合理的补贴机制,降低培养成本。

关键词：苏格兰现代学徒制国家资历框架培养模式课程体系质量保证

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5G技术在煤矿井下应用架构探讨

工矿自动化 2020年第7期46卷 28-33页

作者：孟庆勇煤炭科学技术研究院有限公司北京100013 煤矿应急避险技术装备工程研究中心北京100013 北京市煤矿安全工程技术研究中心北京100013

通过对比、分析5G非独立组网(NSA)和独立组网(SA)架构的网络部署及优缺点,结合煤矿井下4G"一网一站"已普遍应用的现状,提出了基于NSA的煤矿井下4G与5G融合网络架构,利用4G网络实现语音、调度功能,5G网络拓展其他智能化应用,以最大程度... 详细信息

通过对比、分析5G非独立组网(NSA)和独立组网(SA)架构的网络部署及优缺点,结合煤矿井下4G"一网一站"已普遍应用的现状,提出了基于NSA的煤矿井下4G与5G融合网络架构,利用4G网络实现语音、调度功能,5G网络拓展其他智能化应用,以最大程度地减少投资。研究了煤矿井下5G网络传输方式,重点探讨了5G承载网的3种前传组网方案及适用场景:光纤直连方案适用于井下水泵房、变电所等场所的机器人巡检,虚拟现实(VR)/增强现实(AR)培训,无人值守工作面等场景;无源波分复用方案适用于井下网络部署简单、独立维护性强的场景;有源光传送网方案可灵活适应不同场景。探讨了智能巡检机器人、环境监测与安全防护、VR/AR智慧煤矿、井下车辆无人驾驶4种煤矿井下5G网络切片应用场景,分析了不同场景下5G组网架构的应用模式。

关键词：智慧矿山煤矿5G专网 5G组网架构一网一站非独立组网独立组网网络切片

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矿用救援通信系统多终端蓝牙同频干扰方法

煤矿安全 2020年第8期51卷 112-116页

作者：孟庆勇煤炭科学技术研究院有限公司北京100013 煤矿应急避险技术装备工程研究中心北京100013 北京市煤矿安全工程技术研究中心北京100013

针对基于蓝牙传输的矿井应急救援无线通信中出现的同频干扰问题,提出了利用跳频技术实现抗干扰的方法。矿用体征参数传感器与矿用数据采集终端通过蓝牙连接,当频道状态为占用时,数据采集终端控制体征参数传感器采用跳频方式更改频道,数... 详细信息

针对基于蓝牙传输的矿井应急救援无线通信中出现的同频干扰问题,提出了利用跳频技术实现抗干扰的方法。矿用体征参数传感器与矿用数据采集终端通过蓝牙连接,当频道状态为占用时,数据采集终端控制体征参数传感器采用跳频方式更改频道,数据采集终端将根据蓝牙频道状态表按顺序递增搜索未占用的频道,在数据采集终端更改频道后将该频道状态改为占用,并在煤矿井下进行测试实验。测试结果表明:该方法能够有效地将多终端分配到不同的频道,避免同频传输所产生的干扰情况,可有效地提升井下应急通信系统的稳定性和救援能力。

关键词：应急救援蓝牙多终端跳频技术同频干扰

基于RFID的矿用产品安标信息智能管控装备和方法研究

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中国煤炭 2014年第11期40卷 54-58页

作者：孟庆勇煤炭科学技术研究院有限公司北京市朝阳区100013

分析了我国对矿用产品安全管理的主要手段以及存在的主要问题,针对矿用产品种类繁杂以及矿用产品管理难度大等问题,设计了包括专用电子标签和安标信息检查仪等基于RFID的新型矿用产品安标信息智能管控装备,通过电子标签与矿用产品的功... 详细信息

分析了我国对矿用产品安全管理的主要手段以及存在的主要问题,针对矿用产品种类繁杂以及矿用产品管理难度大等问题,设计了包括专用电子标签和安标信息检查仪等基于RFID的新型矿用产品安标信息智能管控装备,通过电子标签与矿用产品的功能输出端连接,避免了假冒和未授权矿用产品的使用,提高安标信息监督检查的效率。

关键词：矿用产品安标信息智能管控电子标签