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四端硅压力传感器输出电压的解析模型

电子学报 2005年第5期33卷 912-914页

作者：陆生礼柯导明陈军宁孟坚朱德智东南大学国家ASIC工程中心浙江南京210096 安徽大学电子系安徽合肥230039

　本文用摄动法求解了横向压阻效应四端硅压力传感器输出电压的两维偏微分方程,导出了器件的输出电压与器件尺寸的关系;证明了随应力而变的输出电压最大值在器件横向L/2处,并给出了最大输出电压的解析表达式.这些解析公式得到的计算结果... 详细信息

　本文用摄动法求解了横向压阻效应四端硅压力传感器输出电压的两维偏微分方程,导出了器件的输出电压与器件尺寸的关系;证明了随应力而变的输出电压最大值在器件横向L/2处,并给出了最大输出电压的解析表达式.这些解析公式得到的计算结果,都和数值解、实验数据相符合,说明了得到的公式具有高的精度.用所给的解析表达式可以很方便地进行器件设计和模拟.

关键词：四端硅压力传感器正则摄动解析表达式

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放射性核素治疗药物的临床研究进展

药学进展 2024年第3期48卷 186-198页

作者：刘嘉月郭晓轶朱华杨志北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科国家药监局放射性药物研究与评价重点实验室恶性肿瘤发病机制及转化研究教育部重点实验室

放射性核素治疗(RNT)系将放射性核素聚集在病变部位，利用电离辐射生物效应杀伤病变组织。钇-90(90Y)、镥-177(177lu)、铽-161(161Tb)是近年来备受关注的β射线核素，也是RNT中的代表性核素。基于上述核素的RNT药物陆续被研发与转化，已... 详细信息

放射性核素治疗(RNT)系将放射性核素聚集在病变部位，利用电离辐射生物效应杀伤病变组织。钇-90(90Y)、镥-177(177lu)、铽-161(161Tb)是近年来备受关注的β射线核素，也是RNT中的代表性核素。基于上述核素的RNT药物陆续被研发与转化，已有5种药物获批上市，还有多种药物也已进入临床试验。主要对靶向生长抑素受体2、前列腺特异性膜抗原、成纤维细胞激活蛋白的90Y、177lu和161Tb标记的抗肿瘤RNT药物的临床研究进展进行综述。

关键词：钇-90 镥-177 铽-161 放射性核素治疗抗肿瘤

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车载环境的空调器室内机隔振方法

同济大学学报（自然科学版） 2005年第1期33卷 126-129页

作者：杨竹丰吕琳鲁善勇同济大学机电厂上海200092

分析了空调器室内机悬挂系统的耦合振动特点 ,根据地面车辆的运动规律 ,提出并推导了基于有限频域的系统解耦方法 ,通过试验验证和工程应用 ,证明了该方法的有效性 .

关键词：车载空调器悬挂系统耦合振动解耦

MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich Win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

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一种高效的分布式水军群组检测算法

计算机工程 2019年第7期45卷 6-12页

作者：张璐朱海婷南京财经大学信息工程学院南京210046 南京邮电大学物联网学院南京210023

为在电子商务水军群组检测中快速处理真实环境中的大规模用户数据,提出一种分布式水军群组检测算法。设计基于余弦模式挖掘的候选群组提取算法,通过余弦相似度衡量群组成员间的耦合性,以精准提取候选群组并降低后续识别的计算量。结合... 详细信息

为在电子商务水军群组检测中快速处理真实环境中的大规模用户数据,提出一种分布式水军群组检测算法。设计基于余弦模式挖掘的候选群组提取算法,通过余弦相似度衡量群组成员间的耦合性,以精准提取候选群组并降低后续识别的计算量。结合组投影技术与Spark计算框架,提出一种分布式群组提取算法,从而提升群组检测的运行速度。在真实数据集上的实验与案例研究结果表明,该算法能够保证检测准确率,且具有较高的运行效率。

关键词：水军群组检测检测效率余弦模式紧耦合群组组投影分布式计算框架

Meta-analysis and trial sequential analysis on blood uric acid and joint function in gouty arthritis treated with fire needling therapy in comparison with western medication

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World Journal of Acupuncture-Moxibustion 2022年第1期32卷 49-60页

作者： Kai-feng DENG Liang-huizhi LI Ting-zhen PAN Heng NING Hui-ling lu Yuan-xi HUANG Xue LI Xiao-hua YOU Dan-meng zhu Ying zhu Ri-lan CHEN Graduate School of Guangxi University of Chinese Medicine NanningGuangxi Province 530001China Ruikang Affiliated Hospital of Guangxi University of Chinese Medicine NanningGuangxi Province 530001China

Objective:To conduct the meta-analysis and trial sequential analysis(TSA) on clinical trials of fire needling therapy in treatment of gouty arthritis and review systematically the clinical therapeutic effect of fire needling therapy on gouty arthritis so as to provide the medical evidences of the extensive application of this therapy in treatment of gouty ***:The relevant clinical trials of fire needling therapy for treatment of gouty arthritis were searched from China National knowledge Infrastructure,Wanfang Data Knowledge Service Platform,Chinese Science and Technology Journal Database,American Medical Online,Dutch Medical Literature Database and International Evidence-Based Medical *** Review Manager 5.3 software,the quality of the included trials was assessed and meta-analysis was *** TSA v0.9 software,the trial sequential analysis was conduced on the appropriate ***:A total of 10 trials were included with 775 patients *** analysis results showed that compared with the western medication,the total effective rate(RR=1.14’95%CI [1.09,1.20]),the curative rate(RR=1.59’95%CI [1.33,1.89]),the reduced VAS score(MD=-1.44’ 95%CI [-1.93,-0.951]) and the reduced incidence of adverse reaction(RR=0.27’ 95% CI [0.09,0.76]) of the fire needling therapy were different significantly(all P <0.05).Regarding the reduction of blood uric acid(MD=-40.47’ 95%CI [-80.21,-0.72]) and the score of symptoms and physical signs(MD=-1.38’95% CI [-3.71,0.95]),the effect of fire needling therapy was similar to that of western medication group(both P≥0.05).The trial sequential analysis suggested that the result was reliable,in which,the total effective rate of fire needling therapy was much higher than the western ***,it was potentially a false-positive finding,in which,fire needling therapy was much more advantageous at reducing blood uric acid as compared with the western ***:Based on the analytic results,it

关键词： Gouty arthritis Fire needle Blood uric acid Joint function Meta-analysis Trial sequential analysis

Stackelberg博弈下海盗活动地区海军护航选择优化

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交通运输系统工程与信息 2014年第6期14卷 152-157页

作者：朱乐群吕靖李晶大连海事大学交通运输管理学院辽宁大连116026

为了优化海军在海盗活动区域的护航选择决策,更好地保护过往船舶,维护海上运输安全,在对实际护航行动涉及的海军与海盗两方主体博弈关系分析的基础上,建立了一个包括海军和海盗双方在内的非合作非零和Stackelberg博弈对双方行为进行描述... 详细信息

为了优化海军在海盗活动区域的护航选择决策,更好地保护过往船舶,维护海上运输安全,在对实际护航行动涉及的海军与海盗两方主体博弈关系分析的基础上,建立了一个包括海军和海盗双方在内的非合作非零和Stackelberg博弈对双方行为进行描述,并选取双层规划模型将博弈关系进行数学转换.针对该双层规划模型的特点,采用基于灵敏度分析的启发式算法(SAB)对反应函数具体形式进行计算,并进行模型求解算法设计.最后,以索马里海盗活动区域为例进行实例分析,得出海军继续选择亚丁湾进行护航,海盗活动区域将向红海转移的结果,结果也说明了模型与算法的合理性.

关键词：水路运输海军护航优化 Stackelberg博弈海上通道安全双层规划

Zircon U-Pb age, Trace Element, and Hf Isotopic Compositions of Nordmarkite in the Lizhuang Rare Earth Element Deposit in the Western Margin of the Yangtze Block

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 225-240页

作者： ZHOU Jiayun TAN Hongqi GONG Daxin zhu Zhimin luO Liping Institute of Multipurpose Utilization of Mineral Resources Chinese Academy of Geological Sciences Chengdu 610041

The Mianning-Dechang （MD） rare earth element （REE） belt, located in the northern Kangdian axis （KDA） in the western margin of the Yangtze platform, is one of the most economically significant REE mineral belts in China. REE mineralization is associated with Himalayan carbonatite- alkaline complexes. The Lizhuang nordmarkite occurred in the northern part of the MD REE belt. The majority of zircons from the Lizhuang nordmarkite are characterized by pronounced positive Ce yet slightly negative Eu anomalies and high U/Yb. Moreover, all zircons have stable Hf isotopic compositions with initial 176Hf/177Hf ratios ranging from 0.282739 to 0.282808 and an average value of 0.282773. The negative lu/Hf and positive till（t） range from -0.98 to -0.94 （average value of -0.96） and from -0.56 to 1.89 （the majority is positive, with an average of 0.66）, respectively. These characteristics indicate that the rock is derived from an enriched mantle and subducted material. LA-ICP-MS analysis of the zircons from the intrusion yields a weighted mean 2~6pb/23SU age of 28.57~0.61Ma. During this period, the tectonic activity in the KDA is not plate subduction but an intraplate tectonic exhibiting fold-thrust and strike-slip behaviors in the western marginal zone of the Yangtze platform （WMYB）. We suggest the possibility of an existing eastward old slab subduction under WMYB combined with a regional tectonic evolution. The Lizhuang nordmarkite may be derived from an enriched mantle beneath the western part of the Yangtze craton, which originated from the remelting of the Tethys subducting slab, because of the Himalayan strike-slip that formed a special type of REE deposit called strike-slip-type REE deposits.

关键词： nordmarkite REE deposit Hf isotopic characteristics of zircon Lizhuang

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浅谈金安区中生界地层地质灾害发育规律

地下水 2024年第2期46卷 137-140页

作者：朱义田国林黄德国安徽省地质矿产勘查局313地质队安徽六安237000 陕西地矿九Ο八环境地质有限公司陕西西安710600

安徽六安市金安区地质灾害分布于低山丘陵区,而低山丘陵区的主要出露多为中生界地层。对中生界地层地质灾害发育规律进行研究,有利于提高居民对金安区地质灾害的认识,为区域地质灾害的预防与治理提供基础依据。通过收集金安区地质灾害... 详细信息

安徽六安市金安区地质灾害分布于低山丘陵区,而低山丘陵区的主要出露多为中生界地层。对中生界地层地质灾害发育规律进行研究,有利于提高居民对金安区地质灾害的认识,为区域地质灾害的预防与治理提供基础依据。通过收集金安区地质灾害发育基础资料,对研究区中生界地层中发育地质灾害分布情况统计,分析其孕灾地质条件、形成机理与成灾模式,并提出防治措施建议。结果认为:(1)金安区现有地质灾害点32处,其中21处灾害点发育于中生界地层,占灾害点总数的65.63%,其中滑坡17处,崩塌4处,金安区灾害点有一半以上分布于中生界地层中。(2)区内灾害点的治理措施及工艺相对成熟,以“减载工程+支挡工程+排水工程”与“减载工程+防护工程+排水工程”为主;(3)该地层中地质灾害主要受地形地貌、工程地质岩组等控制。金安区中生界地层中仅存在发育滑坡与崩塌地质灾害,两种地质灾害的破坏模式有所不同,滑坡地质灾害破坏模式多为突滑+毁伤模式,崩塌灾害成灾模式主要为滑移或倾倒+毁伤模式和崩落+毁伤模式。(4)结合既有治理区的工程经验及本次研究成果,认为通过加强切坡建房中的防护,做好切坡后相应的排水措施,完善排水系统;对坡面采用植被护坡、种草籽、喷浆等手段,可达到护坡的作用。研究结论对同类型切坡建房灾害的防治可提供一定的指导和借鉴意义。

关键词：中生界地层地质灾害发育规律形成机理防治措施