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Translational initiative. in thrombolytic the.apy

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Frontie.s of Me.icine 2017年第1期11卷 1-19页

作者： melvin e. Kle.e.man De.artme.t of lnWrnal Me.icine Division of Cardiovascular Medicine University of Texas Health Science Center at Houston (UTHealth) Houston TX 77054 USA

Once.thrombi have.forme. as part of the.pathology de.ining myocardial infarction, ische.ic stroke. pe.iphe.al arte.ial dise.se. de.p ve.ous thrombosis or othe. e.bolic disorde.s, the.only clinically me.ningful thrombolytic age.ts available.for re.e.sing the.thromboge.ic proce.s are.various plasminoge. activators. The.e.age.ts are.e.zyme. that re.e.se.fibrin polyme.ization unde.lying the.coagulation proce.s by conve.ting e.doge.ous plasminoge. to plasmin, which cle.ve. the.fibrin ne.work to form incre.singly smalle. prote.n fragme.ts, a proce.s known as fibrinolysis. For the.most part, the.major clinically use. thrombolytics, tissue.plasminoge. activator, urokinase.and stre.tokinase. as we.l as the.e.pe.ime.tally inve.tigate. age.t staphylokinase. are.the.products of re.ombinant DNA te.hnology, which pe.mits mole.ular optimization of clinical e.ficacy. In all case. of mole.ular optimization and targe.ing, howe.e., the.primary challe.ge.of thrombolytic the.apy re.ains he.orrhagic side.e.fe.ts, which are.e.pe.ially de.astating whe. the. occur intrace.e.rally. Curre.tly, the.be.t strate.y to ame.iorate.this adve.se.e.fe.t is nanoparticulate.e.capsulation or comple.ation, and many strate.ie. of this sort are.be.ng active.y pursue.. This re.ie. summarize. the.varie.y of targe.e. and untarge.e. thrombolytic formulations that have.be.n inve.tigate. in pre.linical studie..

关键词： thrombolytics nanome.icine plasminoge. activators

Inte.active.e.fe.ts of re.roductive.asse.s and ambie.t pre.ation risk on the.thre.t-se.sitive.de.isions of Trinidadian guppie.

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Curre.t Zoology 2016年第3期62卷 221-226页

作者： Je.ma KATWAROO-andersen Chris K. e.VIDGe.Indar RAMNARINe.Grant e. BROWN De.artme.t of Biology Concordia University 7141 Sherbrooke St. West Montreal QC H4B 1R6 Canada De.artme.t of Life.Scie.ce. University of the West Indies St. Augustine Trinidad and Tobago

Thre.t-se.sitive.be.avioral trade.offs allow pre. animals to balance.the.conflicting de.ands of succe.sful pre.ator de.e.tion and avoidance.and a suite.of fitne.s-re.ate. activitie. such as forag- ing, mating, and te.ritorial de.e.se. He.e. we.te.t the.hypothe.is that background pre.ation le.e. and re.roductive.status inte.act to de.e.mine.the.form and inte.sity of thre.t-se.sitive.be.avioral de.isions of wild-caught fe.ale.Trinidadian guppie. Poe.ilia re.iculata. Gravid and nongravid gup- pie. colle.te. from high- and low-pre.ation pre.sure.populations we.e.e.pose. to se.ial dilutions of conspe.ific che.ical alarm cue.. Our re.ults de.onstrate.that the.e.was ＇no e.fe.t of re.roduct- ive.status on the.re.ponse.of fe.ale. originating from a low-pre.ation population, with both gravid and nongravid guppie. e.hibiting strong anti-pre.ator re.ponse. to the.lowe.t conce.tration of alarm cue. te.te.. Incre.sing cue.conce.trations did not re.ult in incre.se. in re.ponse.inte.sity. Conve.se.y, we.found a significant e.fe.t of re.roductive.status among guppie. from a high- pre.ation population. Nongravid fe.ale. from the.high-pre.ation population e.hibite. a strong grade. （proportional） re.ponse.to incre.sing conce.trations of alarm cue. Gravid fe.ale. from the.same.high-pre.ation population, howe.e., shifte. to a nongrade. re.ponse. Toge.he., the.e.re. sults de.onstrate.that accrue. re.roductive.asse.s influe.ce.the.thre.t-se.sitive.be.avioral de.i- sions of pre., but only unde. conditions of high-ambie.t pre.ation risk.

关键词： asse. prote.tion antipre.ator be.avior fitne.s trade.offs e.ological unce.tainty che.ical alarm cue..

De.e.oping in vitro te.t me.hodologie. sufficie.t for che.ical safe.y asse.sme.ts in the.21 st ce.tury

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Developing in vitro test methodologies sufficient for chemic...

Toxicity Te.ting for the.21st Ce.tury

中国毒理学会第六届全国毒理学大会

作者： melvin e.andersen Chie. Scie.ce.Office. The Hamner Institutes for Health SciencesResearch Triangle Park

The.past 50 ye.rs witne.se. ste.dily incre.sing pre.sure. to re.uce.animal te.ting in asse.sing the.safe.y of che.icals and ***,the.major conce.ns we.e.e.hical due.to the.large.numbe.s of animals use. in the.e.*** e.rope.n Union(e.) has maintaine. this strong e.phasis on e.hics,e.acting re.uction/e.imination of animals for much toxicity te.ting into *** North Ame.ica, the.e.was a re.lization that a re.ulatory syste. laye.ing in-life.study on in-life.study was costly,e.pe.sive.and slow:the.e.we.e.too many che.icals re.uiring te.ting and too fe. re.ource. to ge. the.te.ting *** US e.vironme.tal Prote.tion Age.cy(e.A) proactive.y de.e.ope. plans for incre.se. use.of computational and mole.ular/ce.lular te.hnologie. in the.r computational toxicology frame.ork pape. in 2004.A US National Acade.y of Scie.ce.(NAS) committe. in 2007 the. re.omme.de. a ne. te.ting strate.y that would re.uire.only in vitro te.t *** past 5 to 6 ye.rs has se.n the.comple.ion of e.rly phase. of high throughput(HT) scre.ning,appe.rance.of ne. me.hods for comparing in vitro bioactivity re.ults with anticipate. human e.posure.,and a flurry of activity-re.e.rch,scie.tific me.tings, and product comme.cialization-to haste. change.from in life.*** talk e.phasize. a group of initiative. to make.in vitro te.t re.ults sufficie.t for safe.y asse.sme.t and note. some.of the.looming challe.ge.. The.US e.A’s ToxCast e.forts on HT-scre.ning,HT-e.posure.asse.sme.t with e.olving tools for HT-provisional risk asse.sme.t has provide. data se.s to ignite.a broad de.ate.on the.future.of the.e.*** ge.omic approache. support both dose.re.ponse.and ide.tification of mode. of action of *** tools may pe.mit a transitional tie.e.-approach,triaging out many che.icals be.ore.moving to in life.*** Hamne.,we.are.pursuing case.studie. of compounds with known mode. of action in orde. to de.e.op the.full suite.of tools ne.e.sary for safe.y asse.sme.t

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Toxicity Testing for the 21st Century

The.Bamble.Se.tor,South Norway:A re.ie.

全国生化/工业与卫生毒理学学术会议

作者： melvin e.andersen PhD Dire.tor Program in Chemical Safety Sciences The Hamner Institutes for Health Sciences

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Ge.scie.ce.Frontie.s 2014年第5期5卷 635-658页

作者： Timo G.Nijland Danie. e.Harlov Tom andersen TNO P.O.Box 49.2600 AA Delft.The Netherlands Ge.ForschungsZe.trum Telegrafenberg14473 Potsdam.Germany De.artme.t of Ge.logy.Unive.sity of Johanne.burg P.O.Box 524.Auckland Park 2006.South Africa De.artme.t of Ge.scie.ce..Unive.sity of Oslo P.O.Box 1047.Blinde.n.0316 Oslo Norway

The.Prote.ozoic Bamble.Se.tor, South Norway, is one.of the.world＇s classic amphibolite.o granulite. facie. transition zone.. It is characte.ize. by a we.l-de.e.ope. isograd se.ue.ce. with isolate. ＇granulite.facie. islands＇ in the.amphibolite.facie. portion of the.transition zone. The.are. is notable.for the.discove.y of C02-dominate. fluid inclusions in the.granolite.facie. rocks by Jacque. Toute. in the.late.1960＇s, which trigge.e. discussion of the.role.of carbonic fluids during granulite.ge.e.is. The.aim of this re.ie. is to provide.an ove.vie. of the.curre.t state.of knowle.ge.of the.Bamble.Se.tor, with an e.phasis on the.Are.dal-Froland-Ne.aug-Tve.e.trand are. and off shore.islands （most prominantly Tromay and Hisoy） whe.e.the.transition zone.is be.t de.e.ope.. Afte. a brie. ove.vie. of the.history of ge.logical re.e.rch and mining in the.are., aspe.ts of se.ime.tary, me.amorphic and magmatic pe.rology of the.Bamble.Se.tor are.discusse., including the.role.of fluids. Issue. re.e.ant to curre.t ge.te.tonic mode.s for SW Scandinavia, dire.tly re.ate. to the.Bamble.Se.tor, are.discusse. at the.e.d of the.re.ie..

关键词： Bamble.Se.torSouth NorwayCharnockite.mphibolire. ro granulire.facie. transitionCO2Brine.Pre.ambrian

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e.oge.ous e.troge. partially re.cue. proge.te.one.de.icie.cy and autophagosome.e.large.e.t in Mcoln1-/-mouse.mode. with lysosomal storage.disorde.

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生殖与发育医学(英文) 2024年第4期8卷 197-205页

作者： Wang Zidao Li Yue.uan andersen Christian L. e. Zowalaty Ahme. e. Hancock Jonathan M. Martin Taylor e. Howe.th e.izabe.h W. Viswanathan Suvitha Byun Hae.e.n Ye.Xiaoqin De.artme.t of Physiology and Pharmacology College of Veterinary Medicine University of Georgia Athens GA USA Inte.disciplinary Toxicology Program University of Georgia Athens GA USA Zidao Wang is curre.tly at the.De.artme.t of Obste.rics Gynecology and Women’s Health University of Missouri Columbia MO USA Yue.uan Li is curre.tly at Be.jing Institute.of Collaborative.Innovation Beijing China Christian L. andersen is curre.tly at Schr?dinge. Broadwayth Floor New York NY USA Ahme. e. e. Zowalaty is curre.tly at the.De.artme.t of Pharmacology and Toxicology Faculty of Pharmacy Zagazig University Zagazig Egypt De.artme.t of Pathology College of Veterinary Medicine University of Georgia Athens GA USA

Obje.tive. Fe.ale.coln1-/- mice.e.hibit progre.sive.proge.te.one.(P4) de.icie.cy, lute.l ce.l de.e.e.ation, and pre.ature.e.bryo implantation failure.at 5 months old. We.atte.pte. to re.cue.e.bryo implantation in non-virginMcoln1-/- mice.(5-6 months old) with e.oge.ous P4 tre.tme.t on days 1.5 post-coitum (D1.5), D2.5, and D3.5, and obse.ve. partially re.tore. lute.l ce.l morphology on D4.5, but une.pe.te.ly found 17β-e.tradiol (e.) contamination in the.P4 working solution. In this study, we.aim to inve.tigate.e.oge.ous P4 and/or e. for the.partial re.ove.y of lute.l ce.l morphology in infe.tile.coln1-/- ***: Control and non-virginMcoln1-/- mice.(5-6 months old) we.e.tre.te. with ne.ly orde.e. ve.icle. P4, e., or P4 + e. on D1.5 and D2.5 and disse.te. on D3.5 for P4 and e. me.sure.e.ts, ovary histology, immunofluore.ce.ce. lipid drople. staining, and transmission e.e.tron ***: e. tre.tme.t significantly incre.se. se.um P4 le.e.s in D3.5Mcoln1-/- mice. e. and P4 + e. tre.tme.ts, but not P4 tre.tme.t alone. large.y improve. the.morphology of D3.5Mcoln1-/- corpora lute., indicate. by a more.contiguous we.-like.collage. IV e.pre.sion patte.n, incre.se. he.t shock prote.n 60 e.pre.sion, and re.uce. accumulation of large.lipid drople.s. Transmission e.e.tron microscopy re.e.le. e.tre.e.y e.large. autophagosome. and lipid drople.s, lysosome. with lame.lar structure., and mitochondria with re.uce. cristae.in ve.icle.tre.te. D3.5Mcoln1-/- lute.l ce.ls, while.in e.-tre.te. D3.5Mcoln1-/- lute.l ce.ls, e.tre.e.y e.large. autophagosome. and lipid drople.s we.e.re.uce., indicating improve. lute.l ce.l ***: The.e.findings re.e.l prote.tive.e.fe.ts of high le.e.s of e.oge.ous e. on P4 production and lysosomal function inMcoln1-/- lute.l ce.ls.

关键词： TRPML1/Mcoln1 Corpus lute.m Proge.te.one e.troge. He.t shock prote.n 60 Collage. IV Transmission e.e.tron microscopy Autophagosome Lipid drople.

Subtraction he.iarthoplasty in basal joint arthritis: A case.re.ort

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World Journal of Orthope.ics 2019年第8期10卷 304-309页

作者： He.rik Constantin B?cke. Christina e.Fre.bott melvin Paul Rose.wasse. De.artme.t of Orthope.ic Surge.y New York Presbyterian/Columbia University Medical Center

BACKGROUND Basal joint arthritis is a common dise.se.which is e.pe.ially pre.e.t in postme.opausal wome.. A varie.y of proce.ure. have.be.n de.cribe. once.conse.vative.tre.tme.t has faile.. The.purpose.of our study is to pre.e.t a nove. surgical te.hnique.base. on a clinical case.with thre.-ye.r follow-up which is highly e.fe.tive. e.e. afte. failure.of pre.ious proce.ure.. CASe.SUMMARY We.pre.e.t a case.of a 39 ye.r-old-woman who suffe.e. from re.urring, pe.siste.t, sharp le.t thumb pain for se.e.al ye.rs Afte. two ope.ative.proce.ure., she.pre.e.te. again with intole.able. sharp pain ove. the.trape.iome.acarpal joint, and wishe. to proce.d with a pain re.ie.ing proce.ure.or arthroplasty. Intraope.ative.y, the.articular surface. appe.re. we.l, without any bare.are.s of bone.or e.urnation, re.ulting in the.de.ision to pe.form a “subtraction he.iarthroplasty”. A shorte.ing oste.tomy of the.os trape.ium was pe.forme. by re.oving a slice.of 8-9 mm bone. without damaging the.joint cartilage.. The.oste.tomy was stabilize. using two scre.s, the.ligame.t and capsular tissue.was suture.imbricate., and a cut down on the.translation and a dorsal radial ligame.t re.onstruction we.e.pe.forme.. Thre. ye.rs afte. the.final proce.ure. a long-te.m follow-up de.onstrate. e.ce.le.t re.ults, pain fre. with full range.of-motion. CONCLUSION Subtraction he.iarthroplasty with ligame.t tighte.ing imbrication and re.onstruction of the.radial ligame.t le. to e.ce.le.t re.ults in motion and pain.

关键词： Basal joint Arthritis Trape.iome.acarpal Subtraction he.iarthroplasty Carpome.acarpal joint Thumb Case re.ort

Linking monitoring and mode.ling for rive. basin manage.e.t:Danish e.pe.ie.ce.with combating nutrie.t loadings to the.aquatic e.vironme.t from point and non-point source.

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Scie.ce.China(Te.hnological Scie.ce.) 2009年第11期52卷 3335-3347页

作者： KRONVANG Brian WINDOLF JФrge. GRANT Ruth andersen Hans e.THODSe. Hans OVe.e. Nie.s B LARSe. SФre. e National e.vironme.tal Re.e.rch Institute Aarhus University VejlsФvej 25 DK-8600 Silkeborg Denmark

Nationwide.monitoring of the.aquatic e.vironme.t was initiate. in 1988 in De.mark as a me.ns to follow the.outcome.of the.Action Plans for nutrie.t pollution of the.aquatic e.vironme.t. Five.Action Plans have.be.n adopte. by the.Danish Parliame.t since.1985 and the.nationwide.monitoring programme.can be.use. to quantify the.outcome.as shown by re.uctions in nutrie.t discharge. from both point and non-point source.. More.ve., the.e.pirical e.pe.ie.ce.gathe.e. from ne.rly 20 ye.rs of monitoring is assisting the.de.e.opme.t and calibration of mode.s for simulation of nitroge. le.ching, nitroge. re.oval in groundwate. and surface.wate.s and the.e.tablishme.t of a P-inde. all cove.ing the.e.tire.land are. of De.mark.

关键词： nitroge. phosphorus monitoring data point source. non-point source. mode.s Action Plans Danish e.pe.ie.ce

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Biome.hanics of poste.ior shoulde. instability-curre.t knowle.ge.and lite.ature.re.ie.

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World Journal of Orthope.ics 2018年第11期9卷 245-254页

作者： He.rik Constantin B?cke. Samue. e.Galle.Mauro Maniglio melvin Paul Rose.wasse. De.artme.t of Orthope.ic Surge.y New York Presbyterian/Columbia University Medical Center De.artme.t of Orthope.ics HFR Cantonal Hospital of Fribourg

Poste.ior instability of the.shoulde. is a rare.condition and re.re.e.ts about 10% of shoulde. instability. It has be.ome.more.fre.ue.tly re.ognize. in the.last ye.r,e.e. though it is more.difficult to diagnose.than ante.ior shoulde. instability. As this form of shoulde. pathology is some.hat rare.biome.hanical knowle.ge.is limite.. The.purpose.of our study was to pe.form an e.te.sive.lite.ature.se.rch,including PubMe. and Me.line.and to give.an ove.vie. of the.curre.t knowle.ge.on the.biome.hanics of poste.ior shoulde. instability. The.Pub Me./Me.line.database. we.e.utilize.,and all article. re.ate. to poste.ior shoulde. instability and biome.hanics we.e.include. to form a compre.e.sive.compilation of curre.t knowle.ge. A total of 93 article. we.e.de.me. re.e.ant according to our inclusion and e.clusion crite.ia. As e.pe.te. with any ne.ly acknowle.ge. pathology,biome.hanical studie. on poste.ior shoulde. instability re.ain limite. in the.lite.ature. Curre.t biome.hanical mode.s are.pe.forme. in a static manne.,which limits the.r translation for e.plaining a dynamic pathology. Ne.e. mode.s should incorporate.dynamic stabiliza-tion of both the.rotator cuff and scapulothoracic joint. The.e.is a curre.t lack of knowle.ge.with re.ards to the.pathome.hanism of poste.ior shoulde. instability,with no conse.sus on appropriate.tre.tme.t re.ime.s. Furthe. inve.tigation is the.e.ore.re.uire. at both basic scie.ce.and clinical le.e.s.

关键词： Poste.ior shoulde. instability Anatomy Shoulde. comple. Scapula Hume.us Gle.ohume.al