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Microalbuminuria and Kidney Disease Risk in HIV Patients Taking Combined Antiretroviral Therapy

World Journal of AIDS 2014年第2期4卷 242-248页

作者： Huylmer Lucena Chaves Mayanna Pinho Batista Adriana de Menezes Gomes Amanda Antunes Costa André Tigre Lima Vinícius Diniz Arcelino do Ceará Pedro Rubens Araújo Carvalho Linna Albuquerque Sampaio Fabrício de Maicy Bezerra melissa soares medeiros Medicine School Unichristus Fortaleza Brazil

Objectives: This study proposes to evaluate risk factors for kidney disease in HIV patients treated chronically and correlate with microalbuminuria measurements. Methods: Review charts and analyses of microalbuminuria in subgroup of HIV patients treated at Ceara/Brazil. Results: 149 patients, 69.1% male, mean 38.5 years old, infection mean 86.8 months. Mean Creatinine Clearance 110.2%, Creatinine 0.97, Urea 27.76 mg/dl, CD4+ 600.37 cels/mm3 and detectable viral load 530.59 copies with 61.7% undetectable. Mean Dosages of microalbuminuria/24h 147, 46 ± 820, 45 (N = 48) and microalbuminuria (mg/dl) 32.05 ± 85.25 (N = 43). Kidney Diseases Classification analyses evidenced 6.4% patients in stages ≥3 and 6.2% presented altered Microalbuminuria/24h. Patients using Tenofovir (TDF) 27.27% had Stage 2 and protease inhibitors (PI) had 4.1% in Stage 3. Proteinuria was observed in 5% stage ≥3. Association PI/TDF had 4.1% in Stage 3. No statistical difference between CD4 > or 3 and microalbuminuria/24h > 300 mg (p = 0.69);detectable/undetectable viral load and microalbuminuria/24h (p = 0.63) or stage ≥3 (p = 0.17);relation to Diabetes or arterial hypertension and microalbuminuria 24 h (p = 0.5 and p = 0.21);relation stage ≥3 and microalbuminuria/24h (p = 0.33);relation HIV diagnoses >/ or or < 50 years and microalbuminuria/24h (p = 0.55) or microalbuminuria mg/d (p = 0.32). Relating comorbidities risk (Diabetes Mellitus plus Systemic Arterial Hypertension) to Kidney Diseases, it was found that 55.5% patients in Stage 3 or above with comorbidities compared with 15% with comorbidities in lower stages (P = 0.005). Nevertheless, comorbidities presence was not associated with microalbuminuria (p = 0.08). Conclusion: Kidney disease is a real risk for HIV patients and stages ≥

关键词： HIV AIDS Antiretroviral Kidney Disease Microalbuminuria

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Vitamin D and Secondary Hyperparathyroidism in HIV Infected Patients Taking Antiretroviral Therapy

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World Journal of AIDS 2014年第4期4卷 430-437页

作者： Huylmer Lucena Chaves Henrique Pires Moreira Hayato Augusto Hossoe Correa William Browne de Oliveira Machado Rian Brito Teles Lucigleyson Ribeiro do Nascimento Janedson Baima Bezerra Filho Camilla Camuza Coelho Rabelo Queiroz Danilo Goncalves Nobrega Ana Carolina Vasconcelos Moreira Maria Carolina Nunes Albano de Meneses Fabricio de Maicy Bezerra melissa soares medeiros Medicine School UNICHRISTUSFortalezaBrazil Fortaleza General Hospital FortalezaBrazil Sso Jose Hospital of Infectious Diseases FortalezaBrazil

Objective: Due to the lack of studies assessing hypovitaminosis D and secondary hyperparathyroidism in Brazilian HIV-infected population, especially in the northeastern population, this study aimed to determine the profile of these conditions in patients infected with HIV and its correlation with immuno-virological, sociodemographic data and associated comorbidities. Methods: Comparison studies were obtained from routine clinical samples of HIV infected patients submitted for 25-OH Vitamin D, PTH and alkaline phosphatase determination. Results: A total of 78 patients were included, 42 (53.8%) males, mean age 45.7 years. Antiretroviral regimens most used in this study were Zidovudine/Lamivudine/Efavirenz 17.9%, Tenofovir/Lamivudine/Efavirenz 17.9%,Tenofovir/Lamivudine/Atazanavir-r 15.4%. The mean value CD4 count was 592.1 ± 247.2 cells/mm3, CD8 cell count was 1026.5 ± 467.3 cells/mm3, mean detectable viral load was 2220 ± 15703 copies and CD4/CD8 ratio was 0.63 ± 0.33. A total of 34 vitamin D dosages were collected with 41.2% representing sufficient amount and 58.8% insufficient. Alkaline Phosphatase (ALP) dosage was elevated in 49.3% (N=35) of the patients. Parathormone (PTH) was elevated in 18% (N = 11). Among patients with elevated PTH levels, 81.9% had elevated levels of ALP (p = 0.01). In the group of patients with high levels of ALP, 45.7% had a CD4 count 3 (p = 0.02). There was no significant difference in vitamin D related to gender (p = 0.21), age (p = 0.23), CD4 count (p = 0.26), suppressed viral load (p = 0.44) or blood glucose (p = 0.45). Conclusions: This study evidenced a high prevalence of Vitamin D insufficiency in Northeast Brazil, which suggests HIV infection correlation. A high prevalence of Hyperparathyroidism was detected and related with inflammatory condition persistence and low CD4 count. We suggest improve vitamin D follow up and measurements in this population with better CD4 count control to avoid future osteoarticular complications of HIV

关键词： HIV Hyperparathyroidism Vitamin D Antiretroviral Therapy

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Analysis of the （Im）Possibility of Social Retrogression in the Brazilian Constitutional Order

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Sociology Study 2015年第11期5卷 875-882页

作者： Matheus medeiros Maia Rafael soares Duarte Moura Faculdade de Direito Santo Agostinho (FADISA) Brazil

The subject of this research is the study of the principle of non-retrogression, implicitly confirmed in the Constitution of the Federative Republic of Brazil in 1988. Because of the economic and financial crisis context Brazil is going through, the public resources directed to the materialization of constitutionally assured social rights started to be rationalized, with reflections at the legislative level with the amendment of laws that receded in terms of social order. In this scenario, the principle of non-retrogression is put under analysis as constitutional norm it is, with its absolute or relative nature. By employing a scientific-deductive method and a bibliographic procedure, it is concluded that the non-retrogression principle must not have an absolute nature, but rather a relative one. Therefore, in order for a norm to result in a legitimate social retrogression, it has to be bound to the sieves of reasonability and proportionality, due legislative process and to the protective sphere of the existential minimum for citizens.

关键词： Non-retrogression principle Constitution of the Federative Republic of Brazil 1988 (CFRB/88) proportionality andreasonability

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SOME FURTHER NOTES ON THE MATRIX EQUATIONS A^TXB+B^TX^TA=C AND A^TXB+B^TXA=C

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Acta Mathematica Scientia 2015年第1期35卷 275-280页

作者： G.soares Center of Mathematics University of Trás-os-Montes of Alto Douro

Dehghan and Hajarian, [4], investigated the matrix equations A^TXB＋B^TX^TA = C and A^TXB ＋ B^TXA = C providing inequalities for the determinant of the solutions of these equations. In the same paper, the authors presented a lower bound for the product of the eigenvalues of the solutions to these matrix equations. Inspired by their work, we give some generalizations of Dehghan and Hajarian results. Using the theory of the numerical ranges, we present an inequality involving the trace of C when A, B, X are normal matrices satisfying A^T B = BA^T.

关键词： matrix equation eigenvalue trace permutation matrix

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Irritable bowel syndrome:A clinical review

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World Journal of Gastroenterology 2014年第34期20卷 12144-12160页

作者： Rosa LS soares Internal Medicine Department Faculty of MedicineFederal Fluminense UniversityRio de Janeiro 24030-210Brazil

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21st century. It’s the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics. Its can affect up to one in five people at some point in their lives, and has a significantly impact of life quality and health care utilization. The prevalence varies according to country and criteria used to define IBS. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria III is the current gold-standard for the diagnoses of IBS. Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis. There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS. However, a number of different changes in IBS patients were demonstrated in recent years, some of which can be used in the future as a diagnostic support. IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs, stressor conditions and changes in dietary *** traditional pharmacologic management of IBS has been symptom based and several drugs have been used. However, the cornerstone of its therapy is a solid patient physician relationship. This review will provide a summary of pathophysiology, diagnostic criteria and current and emerging therapies for IBS.

关键词： Irritable bowel syndrome Clinical review Pathogenesis Diagnostic Treatment Biopsychosocial model

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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

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Neural Regeneration Research 2022年第10期17卷 2223-2224页

作者： Suellen Alessandra soares de Moraes Faculdade de Fisioterapia e Terapia Ocupacional Universidade Federal do ParáBelémParáBrazil

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon *** involve inflammation and lead to loss of *** chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical *** term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).

关键词： tendon injuries Acute

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Wastewater treatment in 2050:Challenges ahead and future vision in a European context

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Environmental Science and Ecotechnology 2020年第2期2卷 72-75页

作者： Ana soares Cranfield Water Science Institute Cranfield UniversityCranfieldMK430ALUK

*** The current state of the wastewater industry is one of *** Europe,in the last 2 decades,we have seen a significant improvement on river water quality after implementation of the Urban Waste Water Treatment European Directive(91/271/EEC)[1],and the European Water Framework Directive[2].Up to 97% of the population have now access to safely managed wastewater treatment services.

关键词： Green housegas emissions Gas recovery anMBR Nitrification Full-scale implementation Water Industry

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迷失丛林 Sonora鸡尾酒吧

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室内设计与装修 2025年第1期 148-149页

作者：无 Ricard Fabregat Rafaela Aranzaens Michele soares Yesica Pena Maria di Bello Adria Goula(摄影) 夏花(编译) EL EQUIPO CREATIVO 不详

Sonora鸡尾酒吧位于阿姆斯特丹Nhow酒店的顶层。其三角形的布局让空间更显紧凑,由OMA建筑事务所及建筑师RemKoolhaas设计的落地玻璃幕墙,提供了欣赏阿姆斯特丹新区壮丽景观的机会。设计师面临的挑战在于,要如何让鸡尾酒吧在与这些美景... 详细信息

Sonora鸡尾酒吧位于阿姆斯特丹Nhow酒店的顶层。其三角形的布局让空间更显紧凑,由OMA建筑事务所及建筑师RemKoolhaas设计的落地玻璃幕墙,提供了欣赏阿姆斯特丹新区壮丽景观的机会。设计师面临的挑战在于,要如何让鸡尾酒吧在与这些美景的竞争中脱颖而出。

关键词：建筑事务所玻璃幕墙阿姆斯特丹鸡尾酒建筑师三角形酒店

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Modified Joint Distribution of Wave Heights and Periods

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China Ocean Engineering 2016年第3期30卷 359-374页

作者： H.D.Zhang C.Guedes soares Centre for Marine Technology and Ocean Engineering (CENTEC) Instituto Superior Técnico Universidade de Lisboa

The modified versions of the linear theoretical model of Longuet-Higgins （1983） are derived in this work and also compared with the laboratory experiments carried out in MAR1NTEK. The main feature of modifications is to replace the mean frequency in the formulation with the peak frequency of the wave spectrum. These two alternative forms of joint distributions are checked in three typical random sea states characterized by the initial wave steepness. In order to further explore the properties ＆these models, the associated marginal distributions of wave heights and wave periods are also researched with the observed statistics and some encouraging results are obtained.

关键词： Longuet-Higgins joint distribution mixed sea state nonlinear wave series wave height wave period

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Experimental and numerical analysis of multi-chamber oscillating water column devices

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Journal of Hydrodynamics 2024年第3期36卷 492-503页

作者： Jorge Gadelho Kourosh Rezanejad C.Guedes soares Centre for Marine Technology and Ocean Engineering(CENTEC) Instituto Superior TécnicoUniversidade de LisboaAvenida Rovisco PaisLisboaPortugal

A review of multi-chamber oscillating water column(OWC)device designs is *** significant variations of these devices are discussed,onshore OWC(OOWC)and a floating OWC(FOWC).The efficiency results of several theoretical studies based on low-and high-fidelity numerical models are presented and compared with the model scale ***,low-fidelity numerical models are very fast to run,but their accuracy is limited compared with high-fidelity numerical *** model experiments usually give results much more accurate than numerical models,but they need adequate facilities and are very *** the case of the OOWC,all models show a similar trend of total efficiency,but while the analytical model shows a maximum value of around 90%efficiency,the CFD model shows 60%,and the experiments only go up to 40%.The main reason is connected with the mathematical simplifications and assumptions that do not represent all the hydrodynamic and aerodynamic processes between the water,air,and *** the case of the FOWC,interestingly,the experimental results show a maximum efficiency of almost 100%,while the analytical model only predicts a maximum of 80%.The efficiency seems highly dependent on the heave motion resonance of the entire device,where the analytical model fails to predict this natural frequency.

关键词： Wave energy converters oscillating water column(OWC) multi-chambers experimental modelling numerical modelling

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