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Factors associated with concussion-symptom knowledge and attitudes toward concussion care seeking in a national survey of parents of middle-school children in the US

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Journal of Sport and Health Science 2021年第2期10卷 113-121页

作者： Zachary Y.Kerr Aliza K.Nedimyer melissa c.kay Avinash chandran Paula Gildner K.Hunter Byrd Juliet K.Haarbauer-Krupa Johna K.Register-Mihalik Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599-8700USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research center University of North CarolinaChapel HillNC 27599-8700USA Injury Prevention Research center University of North CarolinaChapel HillNC 27510USA Human Movement Science curriculum University of North CarolinaChapel HillNC 27599-8700USA School of Health Professions University of Southern MississippiHattiesburgMS 39406USA Datalys center for Sports Injury Research and Prevention IndianapolisIN 46202USA National center for Injury Prevention and control Centers for Disease Control and PreventionAtlantaGA 30341USA

Background:Developing appropriate concussion prevention and management paradigms in middle school(MS)settings requires understanding parents’general levels of concussion-related knowledge and *** study examined factors associated with concussion-symptom knowledge and care-seeking attitudes among parents of MS children(aged 10-15 years).Methods:A panel of 1224 randomly selected ***,aged ≥18 years and identifying as parents of MS children,completed an online questionnaire capturing parental and child *** parents’concussion-symptom knowledge was measured using 25 questions,with possible answers being“yes”,“maybe”,and“no”.correct answers earned 2 points,“maybe”answers earned 1 point,and incorrect answers earned 0 point(range:0-50;higher scores=better knowledge).concussion care-seeking attitudes were also collected using five 7-point scale items(range:5-35;higher scores=more positive attitudes).Multivariable ordinal logistic regression models identified predictors of higher *** met proportional odds *** odds ratios(aORs)with 95%confidence intervals(95%cIs)(excluding 1.00)were deemed statistically ***:Median scores were 39(interquartile range:32-44)for symptom knowledge and 32(interquartile range:28-35)for care-seeking *** multivariable models,odds of better symptom knowledge were higher in women ***(aOR=2.28;95%cI:1.71-3.05),white/non-Hispanics *** racial or ethnic groups(aOR=1.88;95%cI:1.42-2.49),higher parental age(10-year-increase aOR=1.47;95%cI:1.26-1.71),and greater competitiveness(10%-scale-increase aOR=1.24;95%cI:1.13-1.36).Odds of more positive care-seeking attitudes were higher in white/non-Hispanics *** racial or ethnic groups(aOR=1.45;95%cI:1.06-1.99)and in older parental age(10-year-increase aOR=1.24;95%cI:1.05-1.47).conclusion:characteristics of middle school children’s parents(e.g.,sex,race or ethnicity,age)are associated with their concussion-symptom knowle

关键词： Pediatrics Traumatic brain injury Youth

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Journal of Sport and Health Science 2022年第6期11卷 716-724页

作者： Zachary Yukio Kerr Avinash chandran Aliza K.Nedimyer Allison E.Rothschild melissa c.kay Paula Gildner K.Hunter Byrd Juliet K Haarbauer-Krupa Johna K.Register-Mihalik Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599-8700USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research center University of North CarolinaChapel HillNC 27599-8700USA Injury Prevention Research center University of North CarolinaChapel HillNC 27510USA Human Movement Science curriculum University of North CarolinaChapel HillNC 27599-8700USA Department of Health Behavior Gillings School of Public HealthUniversity of North CarolinaChapel HillNC 27599-7400USA School of Health Professions University of Southern MississippiHattiesburgMS 39406USA National center for Injury Prevention and control Centers for Disease Control and PreventionAtlantaGA 30341USA

Objective:Parents may use various information sources to obtain information about sport-related concussions(SRc).This study examined SRcrelated information sources used by parents of United States middle school children(age:10-15 years).Methods:A panel of 1083 randomly selected ***,aged≥18 years and identifying as parents of middle school children,completed an online questionnaire capturing parental and child characteristics,and utilization and perceived trustworthiness of various sources of SRc-related *** logistic regression models identified factors associated with utilizing each *** odds ratios(OR)with 95%confidence intervals(95%cIs)excluding 1.00 were deemed ***:Doctors/healthcare providers(49.9%)and other healthcare-related resources(e.g.,centers for Disease control and Prevention,WebMD)(37.8%)were common SRc-related information sources;64.0%of parents utilized≥1 of these *** sources were considered“very”or“extremely”trustworthy for SRc-related information among parents using these sources(doctors/healthcare providers:89.8%;other healthcare-related resources:70.9%).A 10-year increase in parental age was associated with higher odds of utilizing doctors/healthcare providers(adjusted odd ratio(OR_(adjusted))=1.09,95%cI:1.02-1.16)and other healthcare-related resources(OR_(adjusted)=1.11,95%cI:1.03-1.19).The odds of utilizing doctors/healthcare providers(OR_(adjusted)=0.58,95%cI:0.40-0.84)and other healthcare-related resources(OR_(adjusted)=0.64,95%cI:0.44-0.93)were lower among parents whose middle school children had concussion histories versus the parents of children who did not have concussion ***:One-third of parents did not report using doctors/healthcare providers or other healthcare-related resources for SRc-related *** associated with underutilization of these sources may be targets for future *** education for healthcare providers and e

关键词： Information seeking Media use Traumatic brain injury

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Factors and expectations influencing concussion disclosure within NcAA DivisionⅠathletes:A mixed methodological approach

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Journal of Sport and Health Science 2023年第3期12卷 388-397页

作者： melissa c.kay Heidi Hennink-Kaminski Zachary Y.Kerr Paula Gildner Brittany M.Ingram Kenneth L.cameron Megan N.Houston Laura A.Linnan Stephen W.Marshall Karen Y.Peck Johna K.Register-Mihalik School of Health Professions College of Nursing and Health ProfessionsUniversity of Southern MississippiHattiesburgMS 39406USA School of Media and Journalism University of North Carolina at Chapel HillChapel HillNC 27599USA Injury Prevention Research center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Exercise and Sport Science College of Arts and SciencesUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research center University of North Carolina at Chapel HillChapel HillNC 27599USA center for the Study of Retired Athletes University of North Carolina at Chapel HillChapel HillNC 27599USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA Departments of Physical Medicine and Rehabilitation and Surgery Uniformed Services University of the Health SciencesBethesdaMD 20814USA Department of Health Behavior School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Epidemiology School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Participation in sports is associated with many benefits to all aspects of health;however,it also comes with the risk of injury,particularly ***-disclosure and care seeking following a concussion are especially important because of the lack of outwardly visible signs and/or *** recent research has explored factors affecting concussion disclosure,use of isolated methodologies limits the ability to contextualize how disclosure or nondisclosure ***,the purpose of this study was to describe the factors and expectations of National collegiate Athletic Association(NcAA)athletes that may influence concussion ***:This mixed-methods convergent parallel research study included 25 NcAA Division I athletes representing 13 sports,all of whom completed a concussion-education session with pre-/post-test surveys and a semistructured *** athletes were at least 18 years old and on an NcAA *** surveys focused on previous concussion-related disclosure behaviors,knowledge,attitudes,beliefs,norms,and intentions about disclosing *** focused on the athletes’experiences related to concussion *** data were analyzed using descriptive statistics and Mann-Whitney U *** were analyzed using a consensual Qualitative Research ***:Participants had good concussion knowledge(median=46.0),positive attitudes(median=38.0),strong beliefs(median=13.0),and strong intentions to disclose concussion symptoms(median=7.0).None of the constructs differed by participants’*** quantitative findings were mostly positive,interview data highlighted factors that may explain why some participants are successful in disclosing concussions and why others may find disclosure *** efforts,sport culture,and medical professional presence were the primary facilitators discussed by ***,pressure,and a lack of team support were perceived as di

关键词： Education Medical professional presence Mixed methodological research Reporting Sport culture

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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal cOVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven D Morley kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter c Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BAcKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(cOVID-19),while preexisting MASLD increases the risk of LI and the development of cOVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-coV-2)which causes cOVID-19,uses angiotensin-converting expression enzyme 2(AcE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic AcE2 levels are altered during progression of MASLD and in patients who died with severe *** AcE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe cOVID-19,using AcE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** AcE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,AcE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but AcE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry cOVID-19 cOVID-19-associated cholangiopathy

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Quantitative and qualitative subgenomic RNA profiles of SARS-coV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOc-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung chit chow Siaw Shi Boon Wendy c.S.Ho Maggie Haitian Wang Renee Wan Yi chan Albert Martin Li David Shu cheong Hui Paul kay Sheung chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey club School of Public Health and Primary care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-coV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOc)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOcD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUc¼0.91,95%cI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： coronavirus SARS-coV-2 Omicron BA.2 Non-VOc-D614G RNA-seq Subgenomic RNA(sgRNA)

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MORPHOLOGY, SEDIMENTARY BEDFORMS AND SAND TRANSPORT AcROSS A RIDGE-AND-RUNNEL BEAcH UNDER THE AcTION OF SUMMER WAVES

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chinese Journal of Oceanology and Limnology 1990年第3期8卷 197-212页

作者： christopher E.Vincent Robert c.kay 陈承惠李立 JackJarvis School of Environmental Sciences University of East Anglia U.K. 3rd Institute of Oceanography SOA Xiamen China Department of Geography University of St. Andrews Scotland

As part of a collaborative study between the 3rd Institute of Oceanography, Xiamen, and the U-K. Universities of East Anglia and St. Andrews, a 4-day experiment was conducted on a ridge- and -runnel beach of north Norfolk on the North Sea coast- Detailed surveys were made of every low water of an area 10m by 30m and electromagnetic current meters were used to measure wave- induced currents over the ridge and in the runnel- The locations of bedform fields were noted, fluorescent sand was used to follow the sand movement and, at the end of the experiment, lacquer peels were taken of the top 0-2 m of a vertical section through the ridge- and- runnel-During the 4 days 0-75 m3 of sand per metre width of beach accreted in the runnel and a similar volume was eroded from the upper foreshore. The dominant shoreward transport, identified qualitatively by the movement of the fluorescent sand, suggests the ridge- and- runnel system migrated shorewards up the general beach slope of 1 by 2 - 3 m. The wave orbital

关键词： beach currents shore collaborative Andrews north Xiamen metre sands AcTION

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A literature review of genetics and epigenetics of HcV-related hepatocellular carcinoma: translational impact

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 650-661页

作者： Ziyan Pan Wai-kay Seto chun-Jen Liu Yilei Mao Saleh A.Alqahtani Mohammed Eslam Storr Liver centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Internal Medicine National Taiwan University HospitalTaipei Hepatitis Research center National Taiwan University HospitalTaipei Graduate Institute of clinical Medicine National Taiwan University College of MedicineTaipei Department of Liver Surgery Peking Union Medical College(PUMC)HospitalPUMC&Chinese Academy of Medical SciencesBeijingChina Organ Transplant center of Excellence King Faisal Specialist Hospital&Research CenterRiyadhSaudi Arabia Division of Gastroenterology&Hepatology Johns Hopkins UniversityBaltimoreMDUSA

Background and Objective:Hepatocellular carcinoma(Hcc)poses a significant global health burden and ranks as the fifth most prevalent cancer on a global *** c virus(HcV)infection remains one of the major risk factors for Hcc *** is a heterogeneous disease,and the development of Hcc caused by HcV is intricate and involves various factors,including genetic susceptibility,viral factors,immune response due to chronic inflammation,alcohol abuse,and metabolic dysfunction associated with fatty liver *** this review,we provide a comprehensive and updated review of research on the genetics and epigenetic mechanisms implicated in developing Hcc associated with HcV *** also discuss the potential translational implications,including novel biomarkers and drugs for ***:A comprehensive literature search was conducted in June 2023 in PubMed and Embase *** content and Findings:Recent findings indicate that a variety of genetic and epigenetic processes are involved in the pathogenesis and continue to exist even after the complete elimination of *** deregulation of the epigenome has been identified as a significant factor in the deletrious effects of liver disease,especially during the initial stages when genetic alterations are *** enduring“epigenetic memory”of gene expression is believed to be regulated by epigenetic mechanisms,indicating that alterations caused by HcV infection continue to exist and are linked to the risk of development of liver cancer even after successful *** biology analytical methods will be required to delineate the magnitude and significance of both genetic and epigenomic alterations in tumor ***:By facilitating a more profound understanding of these aspects,this will ultimately foster the advancement of novel therapies and ultimately improve outcomes for patients.

关键词： Epigenetics genetics hepatitis c virus-related hepatocellular carcinoma(HcV-related Hcc) translational implications

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Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： chao Sun George Boon-Bee Goh Wan-cheng chow Wah-Kheong chan Grace Lai-Hung Wong Wai-kay Seto Yi-Hsiang Huang Han-chieh Lin I-cheng Lee Hye Won Lee Seung Up Kim Vincent Wai-Sun Wong Jian-Gao Fan center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(cKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofctively,as estimated by the cKD-Epidemiology collaboration(cKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and cKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for cKD(Pcreased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Pcompared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Pconclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

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Diploidy in evolutionary algorithms for dynamic optimization problems A best-chromosome-wins dominance mechanism

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International Journal of Intelligent computing and cybernetics 2015年第4期8卷 312-329页

作者： Boris Shabash kay c.Wiese School of computing Science Simon Fraser UniversityBurnabyCanada

Purpose–In this work,the authors show the performance of the proposed diploid scheme(a representation where each individual contains two genotypes)with respect to two dynamic optimization problems,while addressing drawbacks the authors have identified in previous works which compare diploid evolutionary algorithms(EAs)to standard *** paper aims to discuss this ***/methodology/approach–In the proposed diploid representation of EA,each individual possesses two copies of the *** order to convert this pair of genotypes to a single phenotype,each genotype is individually evaluated in relation to the fitness function and the best genotype is presented as the *** order to provide a fair and objective comparison,the authors make sure to compare populations which contain the same amount of genetic information,where the only difference is the arrangement and interpretation of the *** two representations are compared using two shifting fitness functions which change at regular intervals to displace the global optimum to a new ***–For small fitness landscapes the haploid(standard)and diploid algorithms perform comparably and are able to find the global optimum very ***,as the search space increases,rediscovering the global optimum becomes more difficult and the diploid algorithm outperforms the haploid algorithm with respect to how fast it relocates the new *** both algorithms use the same amount of genetic information,it is only fair to conclude it is the unique arrangement of the diploid algorithm that allows it to explore the search space ***/value–The diploid representation presented here is novel in that instead of adopting a dominance scheme for each allele(value)in the vector of values that is the genotype,dominance is adopted across the entire genotype in relation to its *** a result,this representation can be extended across any alphabet,for any optimization function.

关键词： Evolutionary computation Genetic algorithms Diploidy Dynamic optimization

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A study of different annealing schedules in SARNA-predict A permutation based SA algorithm for RNA folding

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International Journal of Intelligent computing and cybernetics 2015年第2期8卷 152-171页

作者： Herbert H.Tsang kay c.Wiese Applied Research Lab Trinity Western UniversityLangleyCanada School of computing Science Simon Fraser UniversitySurreyCanada

Purpose–The purpose of this paper is to present a study of the effect of different types of annealing schedules for a ribonucleic acid(RNA)secondary structure prediction algorithm based on simulated annealing(SA).Design/methodology/approach–An RNA folding algorithm was implemented that assembles the final structure from potential substructures(helixes).Structures are encoded as a permutation of *** SA searches this space of *** and annealing schedules were studied and fine-tuned to optimize algorithm ***–In comparing with mfold,the SA algorithm shows comparable results(in terms of F-measure)even with a less sophisticated thermodynamic *** terms of average specificity,the SA algorithm has provided surpassing *** limitations/implications–Most of the underlying thermodynamic models are too simplistic and incomplete to accurately model the free energy for larger *** is the largest limitation of free energy-based RNA folding algorithms in *** implications–The algorithm offers a different approach that can be used in practice to fold RNA sequences ***/value–The algorithm is one of only two SA-based RNA folding *** authors use a very different encoding,based on permutation of candidate *** in depth study of annealing schedules and other parameters makes the algorithm a strong *** benefit is that new thermodynamic models can be incorporated with relative ease(which is not the case for algorithms based on dynamic programming).

关键词： Annealing schedule Simulated annealing RNA secondary structure prediction Ribonucleic acid RNA folding Permutation

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