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Spatial and temporal distribution of American cutaneous leishmaniasis in Acre state,Brazil

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Infectious Diseases of Poverty 2017年第1期6卷 891-899页

作者： Leonardo Augusto Kohara melchior Andreia Fernandes Brilhante Francisco Chiaravalloti-Neto Biological and Nature Science Center Federal University of AcreRio BrancoACBrazil School of Public Health University of Sao PauloSao PauloSPBrazil Department of Epidemiology School of Public HealthUniversity of Sao PauloSao PauloSPBrazil Departamento de Epidemiologia Faculdade de Saude PublicaUniversidade de Sao PauloAv.Dr.Arnaldo715CEP 01246-904Sao PauloSPBrazil

Background:Acre has reported the highest incidence of American cutaneous leishmaniasis(ACL)in Brazil in recent *** present study seeks to identify high and low risk agglomerations of ACL in space and space-time during the period from 2007 to 2013 in Acre,and also to characterize the occurrence of the disease in time and according to sociodemographic ***:This is an ecological study,the study population of which consisted of autochthonous ACL cases notified in the municipalities of Acre by an epidemiological surveillance *** statistics of SaTScan^(TM)software were used to identify spatial and space-time *** addition,the cases were characterized by sex,age,home situation(in a rural or urban area),and temporal ***:Acre reported an incidence rate of 12.4 cases per 10000 inhabitant-years in the study period,with the rates varied greatly(standard deviation of 21.8)among their 22 *** agglomeration of high risk and three of low risk were detected in space and *** of the five micro-regions of Acre presented a stationary temporal *** profile of transmission varied according to the *** speaking,the disease occurred more often among young people,those of male gender,and those living in rural ***:Acre has stood out within the Brazilian national context due to its high rates of ACL incidence in the central region of the Acre *** high rates in the micro-region of Brasileia are related to the disease’s intra/peridomiciliary occurrence,and it would seem that the municipality of Sena Madureira is approaching a transmission pattern similar to that of *** other micro-regions,the profile of the disease’s transmission is mainly related to the forest/sylvatic cycle of ACL.

关键词： Cutaneous leishmaniasis Geographical information system Spatial analysis Scan statistics Acre Brazil

Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders

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World Journal of Gastroenterology 2017年第11期23卷 2029-2036页

作者： Clémence Bildstein Chloémelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin Anne-Marie Leroi INSERM U1073 Service de Physiologie DigestiveCHU Rouen INSERM U1073 Service de Chirurgie DigestiveCHU Rouen EA 3830 Pole 3RCHU RouenGroupe de Recherche sur le Handicap Ventilatoire INSERM CIC 0204

AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for *** The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of *** Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI.

关键词： Neurogenic bowel dysfunction Fecal incontinence Constipation Obstructed defecation Transanal irrigation

大地测量在近代发展的内部地球物理学中的作用

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地球物理学报 1981年第4期24卷 448-454页

作者： P.melchior 李锡其

我们的目的是说明大地测量学的近代发展如何为解决地球动力学的基本问题提供新的工具。例如:1.全球规模的重力场的知识将给出关于地幔中过渡带位置的信息,或关于地核-地幔交界面的地形的资料;2.在地球表面上的高精度定位将允许测量构造... 详细信息

我们的目的是说明大地测量学的近代发展如何为解决地球动力学的基本问题提供新的工具。例如:1.全球规模的重力场的知识将给出关于地幔中过渡带位置的信息,或关于地核-地幔交界面的地形的资料;2.在地球表面上的高精度定位将允许测量构造板块的位移,同时将对地震预报作出贡献;3.用新技术所确定的极移的分析,将能阐明其阻尼问题,维持这一运动的能源问题以及地核-地幔耦合等问题。

关键词：大地测量基础天文学地球内部测绘重力测量重力观测固体潮大地测量学测地学地球动力学超导重力仪张德勒地球物理学地球科学

氨苄青霉素/Brobactam与β-内酰胺类体外活性的比较

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国外医药（抗生素分册） 1992年第5期13卷 356-361页

作者： melchior NH 朱汝锦

产生β—内酰胺酶革兰氏阳性菌和阴性菌是导致世界性β—内酰胺类耐药性提高的主要原因。抗生素失活由于胞外β—内酰胺酶如金葡菌,或产生于革兰氏阴性菌周质中酶所致。因此,任何临床使用β—内酰胺酶抑制剂不仅具有对广范围酶有良好抑... 详细信息

产生β—内酰胺酶革兰氏阳性菌和阴性菌是导致世界性β—内酰胺类耐药性提高的主要原因。抗生素失活由于胞外β—内酰胺酶如金葡菌,或产生于革兰氏阴性菌周质中酶所致。因此,任何临床使用β—内酰胺酶抑制剂不仅具有对广范围酶有良好抑制作用。

关键词：氨苄青霉素 Brobactam β-内酰胺类

Experience of Management of Anorexia Nervosa Patients with Extremely Severe Malnutrition in a Transdisciplinary Clinical Nutrition-Eating Disorders Inpatient Unit

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International Journal of Clinical Medicine 2020年第12期11卷 750-768页

作者： M. Guinhut J. C. melchior N. Godart M. Hanachi Clinical Nutrition Unit Raymond Poincaré Hospital Garches France Paris Descartes University Paris France Paris-Saclay University Paris France Fondation de Santé des Etudiants de France Paris France CESP INSERM UMR 1018 Paris-Saclay University Paris France UMR Micalis Institut INRA Jouy En Josas France

Background: The question of where to hospitalize extremely malnourished patients with anorexia nervosa (AN) is a real dilemma. On one hand, psychiatrists have to deal with severe medical complications that are not within their competences and that justify hospitalization in an internal medicine ward. On the other hand, medical doctors have to face psychic decompensations that would justify admission to a psychiatric ward. In this context, we share our experience of management of severely malnourished AN adult patients in a transdisciplinary specialized eating disorders (ED) unit, referral center for AN associated with somatic severity. Method: First, we described the modalities of care proposed to patients with AN hospitalized in the medical unit. Intensive medical care, both somatic and psychiatric, are provided thanks to a transdisciplinary therapeutic program, where objectives are to: medically stabilize the patient, initiate progressive refeeding and start supportive psychotherapy before being transferred to a psychiatric ED unit. Secondly, we conducted a retrospective descriptive study that included all adult patients with AN admitted for the first time to the unit, between November 1997 and January 2014, for severe malnutrition and/or complications of the ED. Objective was to specify patients’ characteristics: demographic, nutritional status, history of ED, care pathway. Results: Among a cohort of 386 adult patients with AN (21 males and 365 females) admitted for the first time in the unit, mean age was 29.4 (±11.5) years, mean BMI was 12.7 (±2.2) kg/m2. Before being supported in the unit, 78.2% of patients had already been hospitalized in other hospitals. Mean length of stay was 35.2 days. Patients were clinically serious and unstable because of life-threatening somatic complications due to a low BMI. During hospital stay, a temporary transfer to medical intensive care unit was necessary for 25.6%

关键词： Anorexia Nervosa Severe Malnutrition Referral Center Transdisciplinarity

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缓解内存访问的瓶颈

今日电子 2000年第12期 41-43页

作者： Tim melchior 雷天石 Aeroflex UTMC公司

下一代的系统架构将解决CAM和cache不能解决的问题

关键词：内存存取速度计算机系统结构微处理器 CAM

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国际平面设计师丛书米修·英博顿中英文本

国际平面设计师丛书米修·英博顿中英文本

欧洲仔猪氨基酸营养——仔猪低蛋白质高生长性能的氨基酸平衡日粮

2003年

作者：（瑞士）米修·英博顿（melchior Imboden）绘）潘沁

本图集收集了英博顿平面设计作品，包括海报、摄影作品等，其海报运用和谐的色彩，以纯色为主色；摄影作品采用黑白两色。作品表现出简约主义的艺术风格。

关键词：艺术工艺美术各国工艺美术

来源：汇雅图书（南通市图书馆... 评论

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饲料与畜牧（新饲料） 2007年第8期 17-18页

作者： Delphine melchior 陈春梅味之素(法国)有限公司味之素(中国)有限公司

与中国仔猪的断奶日龄相似，欧洲仔猪的平均断奶日龄为21d～28d。仔猪阶段的饲料通常分为3个阶段：（1）教槽料：通常是哺乳仔猪在母猪的引导下采食；（2）开食前的饲料：一般在20日龄时，体重达7kg的小猪，一直采食开食前料直到体重达1... 详细信息

与中国仔猪的断奶日龄相似，欧洲仔猪的平均断奶日龄为21d～28d。仔猪阶段的饲料通常分为3个阶段：（1）教槽料：通常是哺乳仔猪在母猪的引导下采食；（2）开食前的饲料：一般在20日龄时，体重达7kg的小猪，一直采食开食前料直到体重达15kg；（3）开食料：一般小猪断奶后20～50日龄期间采食，体重从15kg到30kg。在法国，平均每头母猪年产仔猪数达20头，采用这种饲养方案的仔猪，

关键词：哺乳仔猪氨基酸营养平衡日粮生长性能低蛋白质欧洲断奶日龄开食料

用CMOS/TTL兼容工艺实现的模拟乘除器

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Journal of Semiconductors 1987年第2期 210-213页

作者：洪志良,Hans melchior 复旦大学微电子学研究所瑞士联邦苏黎世高等理工学院

本文报道首次用发射区自对准CMOS/TTL兼容工艺实现的模拟四象限乘除器.实验测得这种乘除器在输入电压是电源电压1/3范围内具有非线性失真小于1％,偏离电压小至几毫伏和输入动态范围超过电源电压一半等特性.

关键词：双极型管发射区自对准动态范围四象限乘法器 CMOS/TTL TTL 非线性失真谐波失真电源电压