检索结果-南通市图书馆

Reshaping of the Arabidopsis thaliana Proteome Landscape and Co-regulation of Proteins in Development and Immunity

Molecular Plant 2020年第12期13卷 1709-1732页

作者： Mona Bassal Mohammad Abukhalaf Petra Majovsky Domenika Thieme Tobias Herr Mohamed Ayash Naheed Tabassum MHD Rami Al Shweiki Carsten Proksch Ali Hmedat Jorg Ziegler Justin Lee Steffen neumann Wolfgang Hoehenwarter Leibniz Institute of Plant Biochemistry Biochemistry of Plant Interactions DepartmentProteome Biology of Plant Interactions Research GroupWeinberg 3Halle/Saale D-06120Germany Früh Verpackungstechnik AG FehrarltorfSwitzerland King Abdullah University of Science and Technology ThuwalSaudi Arabia Ulm University UlmGermany Universitatsklinikum Halle(Saale) Sektion TumorbiologieHalle/SaaleGermany Molecular Signal Integration Department HalleGermany

Proteome remodeling is a fundamental adaptive response,and proteins in complexes and functionally related proteins are often *** a deep sampling strategy we define core proteomes of Arabidopsis thaliana tissues with around 10 000 proteins per tissue,and absolutely quantify(copy numbers per cell)nearly 16 000 proteins throughout the plant lifecycle.A proteome-wide survey of global post-trans-lational modification revealed amino acid exchanges pointing to potential conservation of translational infi-delity in *** analysis of protein abundance uncovered potentially new tissue-and age-specific roles of entire signaling modules regulating transcription in photosynthesis,seed development,and senescence and *** others,the data suggest a potential function of RD26 and other NAC transcription factors in seed development related to desiccation tolerance as well as a possible function of cysteine-rich receptor-like kinases(CRKs)as ROS sensors in *** of the components of ribo-some biogenesis factor(RBF)complexes were found to be co-expressed in a tissue-and age-specific manner,indicating functional promiscuity in the assembly of these less-studied protein complexes in ***,we characterized detailed proteome remodeling in basalimmunity bytreatingAra-bidopsis seeldings with *** simultaneously monitoring phytohormone and transcript changes upon flg22 treatment,we obtained strong evidence of suppression of jasmonate(JA)and JA-isoleucine(JA-Ile)levels by deconjugation and hydroxylation by IAA-ALA RESISTANT3(IAR3)and JASMONATE-INDUCED OXYGENASE 2(JOX2),respectively,under the control of JASMONATE INSENSITIVE 1(MYC2),sug-gesting an unrecognized role of a new JA regulatory switch in pattern-triggered *** together,the datasets generated in this study present extensive coverage of theArabidopsis proteome in various bio-logical scenarios,providing a rich resource available to the whole plant s

关键词： Arabidopsis deep proteomics protein co-expression plant immunity jasmonate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Guidelines to Quantum Field Interactions in Vacuum

引用

Journal of Modern Physics 2017年第3期8卷 382-424页

作者： Frédéric Schuller Michael neumann-Spallart Renaud Savalle Laboratoire de Physique des Lasers Villetaneuse France Groupe d’Etude de la Matière Condensée CNRS/Université de Versailles/Université de Paris-Saclay Paris France CNRS/Observatoire de Paris-Meudon Paris France

In this treatise we stress the analogy between strongly interacting many-body systems and elementary particle physics in the context of Quantum Field Theory (QFT). The common denominator between these two branches of theoretical physics is the Green’s function or propagator, which is the key for solving specific problems. Here we are concentrating on the vacuum, its excitations and its interaction with electron and photon fields.

关键词： Quantum Vacuum Quantum Electrodynamics Quantum Field Theory Relativistic Quantum Mechanics Feynman Diagrams

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Whole-genome amplification/preimplantation genetic testing for propionic acidemia of successful pregnancy in an obligate carrier Mexican couple:A case report

引用

World Journal of Clinical Cases 2021年第29期9卷 8797-8803页

作者： Adina neumann Miguel Angel Alcantara-Ortigoza Ariadna González-del Angel Nestor Alejandro Zarate Díaz Javier Sam Santana Leonardo M Porchia Esther López-Bayghen Laboratorio de Investigación y Diagnóstico Molecular IngenesMexico City 05320Mexico Laboratorio de Biología Molecular Subdirección de Investigación MédicaInstituto Nacional de PediatríaMexico City 04530Mexico DNA-GEN S.C.Centro de Alta Especialidad en Genética Humana Mexico City 14070Mexico Investigación Clínica IngenesPuebla 72820Mexico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico

BACKGROUND Identifying a potential single monogenetic disorder in healthy couples is costly due to the Assisted Reproduction facilities'current methodology for screening,which focuses on the detecting multiple genetic disorders at ***,we report the successful application of a low-cost and fast preimplantation genetic testing for monogenic/single gene defects(PGT-M)approach for detecting propionic acidemia(PA)in embryos obtained from a confirmed heterozygous propionyl-CoA carboxylase alpha subunit(PCCA)*** SUMMARY A fertile 32-years old Mexican couple with denied consanguinity sought antenatal genetic *** were suspected obligate PA carriers due to a previous deceased PA male newborn with an unknown PCCA/propionyl-CoA carboxylase beta subunit(PCCB)***-Generation Sequencing revealed a heterozygous genotype for a pathogenic PCCA variant(c.2041-1G>T,ClinVar:RCV-000802701.1;dbSNP:rs1367867218)in both *** couple requested in vitro fertilization(IVF)and PGT-M for *** IVF,12 oocytes were collected and fertilized,of which two resulted in high-quality *** biopsies and Whole Genome Amplification by a fragmentation/amplification-based method were performed and revealed that the two embryos were *** polymerase chain reaction and further Sanger sequencing of the exon-intron borders revealed a wild-type PCCA male embryo and a heterozygous c.2041-1G>T female *** embryos were transferred,resulting in a clinical pregnancy and the delivery of a healthy male newborn(38 wk,weight:4080 g,length:49 cm,APGAR 9/9).The absence of PA was confirmed by expanded newborn *** We show that using PGT-M with Whole Genome Amplification templates,coupled with IVF,can reduce the transmission of a pathogenic variant of the PCCA gene.

关键词： Propionic acidemia Autosomal recessive Propionyl-CoA carboxylase alpha subunit(PCCA)gene Preimplantation genetic testing Next-generation sequencing Embryo transfer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drinking Water Quality in the Sagarmatha National Park, Nepal

引用

Journal of Geoscience and Environment Protection 2016年第4期4卷 43-53页

作者： Kirsten Nicholson Emily Hayes Klaus neumann Carolyn Dowling Subodh Sharma Department of Geological Sciences Ball State University Muncie USA Department of Environmental Science & Engineering Kathmandu University Dhulikhel Nepal

In 2014 we began the first systematic study of water quality, specifically fecal contamination of drinking water in the Khumbu Valley, Sagarmatha National Park (SNP, Mt. Everest region), Nepal. Our goal was to identify coliform bacteria and E. coli in drinking water and groundwater-fed springs to generate a data set that will function as a base for potable water supplies and further monitoring. Sampling occurred in May (pre-monsoon summer) and early November (post-monsoon early winter) 2014. Sample sites were selected based on proximity to villages and primary use as a drinking water source. Overall, the data presented a predictable correlation between fecal contamination and both elevation and increasing population/tourist traffic. Drinking water within the study area met current World Health Organization drinking water standards for the physical properties of temperature (2.8°C - 13°C), pH (5.27 - 7.24), conductivity (14.5 - 133 mS) and TDS (7.24 - 65.5 ppm). Samples from the more populated, lower altitude areas had higher levels of E. coli. Samples collected and analyzed in May (pre-monsoon summer) had a higher level of E. coli and coliform bacteria than samples collected in November (post-monsoon early winter) suggesting a seasonal dependence overlaid on the population signature. Surface water typically had higher E. coli values than groundwater-fed springs. Temperature, total dissolved solids and conductivity generally decreased with increasing elevation, whereas pH increased with increasing elevation. There appears to be significant presence of fecal contamination of water sources due to a combination of tourism, elevation and seasons.

关键词： Fecal Coliform E. coli Mt. Everest Drinking Water

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy

引用

World Journal of Gastroenterology 2006年第45期12卷 7271-7277页

作者： José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho Hepatology Branch Department of Gastroenterology University of So Paulo School of Medicine So Paulo Brazil Viral Immu-nology Laboratory Instituto Butantan So Paulo Brazil Hepatology Branch Department of Gastroenterology University of S?o Paulo School of Medicine So Paulo Brazil Faculty of Life Sciences Bar-Ilan Univer-sity Ramat-Gan Israel Virology Branch Instituto Adolfo Lutz So Paulo Brazil

AIM： TO evaluate the impact of hepatitis C virus （HCV） infection with genotype 1 or 3 and the presence or absence of liver cirrhosis （LC） in the early viral kinetics response to treatment. METHODS： Naive patients （n = 46） treated with interferon-α （IFN-α） and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 （n = 28, 7 with LC） or 3 （n = 18, 5 with LC）. RESULTS： The first phase decline was larger in genotype 3 patients than in genotype 1 patients （1.72 vs 0.95 log IU/mL, P 〈 0.001）. The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients （0.87 vs 0.15 log/wk, P 〈 0.001）. Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2^nd phase slope than non-cirrhotic patients （0.06 vs 0.18 log/wk, P 〈 0,02）. None of genotype 1 cirrhotic patients had a 1^st phase decline larger than 1 log （non-cirrhotic patients： 55%, P 〈 0.02）. A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic patients but the 1^st phase slope decline was not different. Sustained viral response was higher in genotype 3 patients than in genotype 1 patients ,（72% vs 14%, P 〈 0.001） and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients （19% vs 0%）. A second phase decline slower than 0.3 log per week was predictive of non-response in all groups. CONCLUSION： Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1^st phase slope decline in genotype 1 patients.

关键词： Hepatitis C virus Treatment Early kinetics Cirrhosis Genotypes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt

引用

World Journal of Hepatology 2013年第1期5卷 38-42页

作者： Anders Bay neumann Stine Degn Andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk Department of Medicine V (Gastroenterology and Hepatology) Aarhus University HospitalDK-8000 Aarhus CDenmark Department of Radiology R Aarhus University HospitalDK-8000 Aarhus CDenmark

AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) ***:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian *** consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of ***:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) *** percents had symptoms for less than one week with ascites as the most prevalent *** (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and *** median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver *** control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered *** died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to ***:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation.

关键词： Ascites Budd-Chiari syndrome Myeloproliferative disorder Thrombophilia Thrombosis Transjugular intrahepatic portosystemic shunt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature

引用

World Journal of Gastroenterology 2006年第14期12卷 2293-2296页

作者： Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P neumann Sven Jonas Jan M Langrehr Peter Neuhaus Department of General Visceral and Transplantation Surgery Charitè-Universitatsmedizin BerlinCampus Virchow KlinikumAugustenburger Platz 113353 BerlinGermany Department of Radiology Charitè-Universitatsmedizin Berlin Campus Virchow KlinikumAugustenburger Platz 113353 BerlinGermany

Xanthogranulomatous cholecystitis （XGC） is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. The diagnosis is usually possible only after pathological examination. A 46 year-old woman was referred to our center for suspected gallbladder cancer involving the liver hilum, right liver lobe, right colonic flexure, and duodenum. Brushing cytology obtained by endoscopic retrograde cholangiography （ERC） showed high-grade dysplasia. The patient underwent an en-bloc resection of the mass, consisting of right Iobectomy, right hemicolectomy, and a partial duodenal resection. Pathological examination unexpectedly revealed an XGC. Only six cases of extended surgical resections for XGC with direct involvement of adjacent organs have been reported so far. In these cases, given the possible coexistence of XGC with carcinoma, malignancy cannot be excluded, even after cytology and intraoperative frozen section investigation. In conclusion, due to the poor prognosis of gallbladder carcinoma on one side and possible complications deriving from highly aggressive inflammatory invasion of surrounding organs on the other side, it seems these cases should be treated as malignant tumors until proven otherwise. Clinicians should include XGC among the possible differential diagnoses of masses in liver hilum.

关键词： Xanthogranulomatous cholecystitis Gallbladder cancer Gallbladder carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

复苏时使用晶体液与胶体液的现代观点

引用

国外医学（麻醉学与复苏分册） 1992年第2期13卷 91-94页

作者： neumann M Demling RH 李彦节

10年来关于治疗低容量休克应该选用晶体液还是胶体液尚有争议。过去研究创伤、择期血管外科、感染和ARDS病人的结果,发现与胶体液相比,使用晶体液量大于3倍失血量,复苏就可能“成功”,但常伴发周围水肿,然而从病人的转归来看无证据能说... 详细信息

10年来关于治疗低容量休克应该选用晶体液还是胶体液尚有争议。过去研究创伤、择期血管外科、感染和ARDS病人的结果,发现与胶体液相比,使用晶体液量大于3倍失血量,复苏就可能“成功”,但常伴发周围水肿,然而从病人的转归来看无证据能说明晶体液和胶体液对引起肺功能不良反应方面有何差别。因此在复苏时,不少人认为只要输晶体液适量,恢复循环动力“稳定”,就不必用昂贵的白蛋白或胶体液。

关键词：复苏晶体液胶体液

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

气体绝缘管道输电线和气体绝缘组合电器在电厂中的应用

引用

电力建设 2004年第6期25卷 4-7页

作者： G.Schoeffner T.neumann 西门子股份公司德国

电厂中每个元件的可靠性对于其运行的经济性非常重要。在开关系统使用GIS以及在输电系统使用GIL能够最大限度地实现电力传输系统的可靠性。这 2种技术综合应用保证了输电系统的高效率。如果考虑到这类系统的停运费用 ,还会导致低寿命周... 详细信息

电厂中每个元件的可靠性对于其运行的经济性非常重要。在开关系统使用GIS以及在输电系统使用GIL能够最大限度地实现电力传输系统的可靠性。这 2种技术综合应用保证了输电系统的高效率。如果考虑到这类系统的停运费用 ,还会导致低寿命周期成本。

关键词：气体绝缘管道输电线(GIL) 气体绝缘组合电器(GIS) 电厂可靠性寿命周期费用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi‐energy system horizon planning:Early decarbonisation in China avoids stranded assets

引用

Energy Internet 2024年第1期1卷 81-98页

作者： Xiaowei Zhou Kai Strunz Tom Brown Hongbin Sun Fabian neumann Department of Sustainable Electric Networks and Sources of Energy Technische Universität BerlinBerlinGermany Department of Digital Transformation in Energy Systems Technische Universität BerlinBerlinGermany Department of Electrical Engineering Tsinghua UniversityBeijingChina

An appropriate decarbonisation pathway is crucial to achieving carbon neutrality in China before *** paper studies decarbonisation pathways for China's energy system between 2020 and 2060 using an open,provincial,and hourly resolved,networked model within the context of multi‐period planning with myopic investment *** representative decarbonisation pathways are compared,with particular attention to the synergies of coupling the electricity and heating *** early and steady path in which emissions are strongly reduced in the first decade is more cost‐effective than following a late and rapid *** decarbonisation in the electricity sector avoids stranded in-vestments in fossil infrastructure and preserves the carbon budget for later emissions in the difficult‐to‐decarbonise heating *** the existing coal power plants by adding carbon capture facilities is cost‐effective in both decarbonisation *** hourly and non‐interrupted resolution for a full weather year reveals the balancing strategies of highly renewable,sector‐coupled *** significant seasonal variation of heat demand dominates long‐term storage behaviours.

关键词： system horizon sector

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：