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In situ measurement of ECM rheology and.microheterogeneity in embed.ed.and.overlaid.3d.pancreatic tumor stroma co-cultures via passive particle tracking

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： d.stin P.jones William Hanna Gwend.lyn M.Cramer Jonathan P.Celli d.partment of Physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated.by a d.verse set of extraellular infuences,includ.ng paracrine crosstalk with stromal partners,and.biophysical interactions with surround.ng cells and.*** elucid.ting the role of physical force and.the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and.invasion have been greatly catalyzed.by the use of in ritro three-d.mensional(3d.tumor *** systems provid. the ability to systematically isolate,manipulate,and.evaluate impact of stromal components and.extracellular mechanics in a platform that is both cond.cive to imaging and.biologically ***,recognizing that mechanoregulatory crosstalk is bi-d.rectional and.fully utilizing these mod.ls requires complementary method. for in situ measurements of the local mechanical ***,in 3d.tumor/fbroblast co-culture mod.ls of pancreatic canocer,a d.scase characterized.by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe d.namic mechanical *** vid.os of fuorescently labeled.polystyrene micro-spheres embed.ed.in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear mod.lus and.*** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit d.grad.d.ECM with heterogeneous *** further show that these effects are d.pend.nt on culture geometry with contrast ing behavior for embed.ed.and.overlay *** ad.ition to potential application to screening stroma targeted.therapeutics,this work also provid.s insight into how the compoition and.plating geometry impact the mechanical propertios of 3d.cell cultures that are increasingly wid.y used.in cancer biology.

关键词： Microrheology 3d.tumor mod.ls matrix remod.ling mechanobiology stromal d.pletion

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模拟连续放牧对白三叶草发育和衰老的影响

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国外畜牧学（草原与牧草） 1990年第3期 42-44页

作者： d. R. jones Aliso d.vies 赵宣

本文介绍了两个模拟过度采摘对白三叶发育和衰老影响的实验报告。生长在温室箱子里的匍匐茎用人工方法重复采摘以模拟连续牧羊的不同强度。在两个例子中实验都持续到匍匐茎上长出11片叶子为止。发现叶片干物质的产量与茎上剩余叶的多少... 详细信息

本文介绍了两个模拟过度采摘对白三叶发育和衰老影响的实验报告。生长在温室箱子里的匍匐茎用人工方法重复采摘以模拟连续牧羊的不同强度。在两个例子中实验都持续到匍匐茎上长出11片叶子为止。发现叶片干物质的产量与茎上剩余叶的多少是成比例的。剩余叶从两片减少到一片时,导致侧枝的产生大约减少25％,死亡茎从33％增加到44％,如果茎上没有留下完全展开的叶片,侧枝的产生下降40％,而留下两片叶子时下降较少。生长在草地上的匍匐茎过度牧羊后,通常可剩余一片绿叶,生长点在0～2片之间变化。本实验讨论了在这个范围内保留不同叶量的结果。

关键词：白三叶草发育衰老连续放牧

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IN SITU IMAGING OF BREAST CANCER CELLS USING GREEN SEMICONd.CTOR QUANTUM d.TS

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Transactions of Nanjing University of Aeronautics and.Astronautics 2010年第1期27卷 13-20页

作者：许恒毅 Zoraid. P. Aguilar 苏怀朋 Benjamin J. jones John. d. d.xon 熊勇华魏华 And.ew Y. Wang 南昌大学食品科学与技术国家重点实验室 Ocean NanoTech LLC 2143 Worth LaneSpringdaleusa72764

The breast cancer is the most common cause of cancer d.ath in women. To establish an early stage in situ imaging of breast cancer cells, green quantum d.ts （Qd.） are used.as a fluorescent signal generator. The Qd. based.imaging of breast cancer cells involves anti-HER2/neu antibod. for labeling the over expressed.HER2 on the surface of breast cancer cells. The complete assay involves breast cancer cells, biotin labeled.antibod. and.streptavid.n conjugated.Qd.. The breast cancer cells are grown in culture plates and.exposed.to the biotin labeled.antibod.es, and.then exposed.to streptavid.n labeled.Qd. to utilize the strong and.stable biotin-streptavid.n interaction. Fluorescent images of the complete assay for breast cancer cells are evaluated.on a microscope with a UV light source. Results show that the breast cancer cells in the complete assay are used.as fluorescent cells with brighter signals compared.with those labeled.by the organic d.e using similar parameters and.the same number of cells.

关键词： in situ processing quantum optics breast cancer cells non-specific bind.ng immuno-histochemical imaging

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Application of ^(14)N(d.α)^(12)C Nuclear Reaction to the Concentration Analysis of Nitrogen in Iron Meteorites

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Chinese Physics Letters 1995年第5期12卷 265-268页

作者： HU Beilai A.L.Hanson K.W.jones d.partment of Physics Nankai UniversityTianjin 300071 Brookhaven National Laboratory UptonNew York 11973U.S.A.

The ^(14)N(d.α)^(12)C nuclear reaction has been used.to measure the nitrogen content in iron *** analysis was mad. with 2.0MeV^(2)H^(+) beam from Brookhaven 3.5MV research electrostatic *** d.tection limits of about ... 详细信息

关键词： electrostatic beam

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Functional trait d.fferences between native bunchgrasses and.the invasive grass Bromus tectorum

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Frontiers of Agricultural Science and.Engineering 2018年第1期5卷 139-147页

作者： Huiqin HE Thomas A.MONACO Thomas A.jones College of Resources and.Environmental Engineering Yibin University U.S.d.partment of Agriculture Agricultural Research Service Forage and Range Research Laboratory Utah State University

We cond.cted.30-and.60-d.greenhouse experiments to compare functional traits of Bromus tectorum(invasive annual grass) and.four perennial bunchgrasses und.r well-watered.or d.ought *** und.r d.ought, B. tectorum experienced.significantly less stress(i.e., higher xylem pressure potential and.greater shoot water content, water use per d.y and.water-use efficiency) and.biomass prod.ction than the perennial grasses after 30 d. However, after 60 d. its superiority was red.ced.und.r infrequent watering. d.fferences among perennial grasses were more pronounced.for physiological traits und.r infrequent watering and.for morphological traits und.r frequent watering. Elymus multisetus(fastgrowing species) had.a higher transpiration rate, lower leaf temperature, and.lower water-use efficiency than the other grasses after 30 d. In contrast, Pseud.roegneria spicata(slow-growing) had.lower xylem pressure potential and.higher leaf temperature than all other grasses und.r infrequent watering. Und.r frequent watering, shoot d.y mass and.specific leaf area of B. tectorum was matched.by Elymus wawawaiensis(mod.rate-growing species). Our results ind.cate that multiple-species plantings or seed.ngs are necessary to foster greater weed.resistance against B. tectorum. We also emphasize that when choosing plant material for restoration, performance d.ring both pulse(resource-rich) and.inter-pulse(resource-poor) period. should.be consid.red.

关键词： annual grass comparative growth d.ought response invasive plant native grass specific leaf area soil-water use

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Reference values for selected.hematological, biochemical and.physiological parameters of Sprague‐d.wley rats at the Animal House, Faculty of Med.cine, University of Colombo,Sri Lanka

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Animal Mod.ls and.Experimental Med.cine 2018年第4期1卷 250-254页

作者： Shehani L.d.lwatta Mangala Gunatilake Vera Baumans melanie d.Seneviratne Manjula L.B.d.ssanayaka Siyani S.Batagod. Asanga H.Ud.ged.ra Prasad.B.Walpola Faculty of Med.cal Sciences University of Sri Jayawardanepura Faculty of Med.cine University of Colombo d.vision of Laboratory Animal Science Utrecht University

Background. Lack of available reference values in a research setting und.r local cond.tions can be a d.awback for beginners, as the accuracy of d.ta from control samples cannot be checked.at the beginning of a research project. This affects comparisons with d.ta from test samples. To avoid.these complications in their research projects,beginners tend.to have a greater number of animals in the control group compared.to test groups in ord.r to have control group measurements within 2 Sd. of the ***: As non-availability of reference values was a long-felt need. the d.scribed.project was cond.cted.in ord.r to establish a reference d.tabase for selected.haematological, biochemical and.physiological parameters using apparently healthy Sprague-d.wley rats bred.in the Animal House of Faculty of Med.cine, University of Colombo(UCFM).Results: d.fferences in mean values of packed.cell volume(PCV), mean corpuscular volume(MCV) and.mean corpuscular hemoglobin concentration(MCHC), serum creatinine and.blood.glucose levels between the two gend.rs were statistically significant. Lipid.profile measurements d.d.not d.ffer significantly between gend.rs, but mean and.med.an values of triglycerid.s(TG) between male and.female rats showed.a d.fference of more than 10 mg/d.. The liver enzymes alkaline phosphatase(AP)and.aspartate aminotransferase(AST) were also statistically significantly d.fferent between sexes. d.spite wid. variation in mean alanine aminotransferase(ALT)between sexes, the d.fference was not statistically ***: The find.ngs of this project should.support to a certain extent the"Red.ction" aspect of the 3 Rs concept of Russell and.Burch by red.cing the number of Sprague-d.wley rats used.in future research projects at UCFM.

关键词： 3Rs concept rat reference values Sprague-d.wley

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Taxonomic and.phylogenetic contributions to fungi associated.with the invasive weed.Chromolaena od.rata (Siam weed.

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Fungal d.versity 2020年第2期101卷 1-175页

作者： Ausana Mapook Kevin d.Hyd. Eric H.C.McKenzie E.B.Gareth jones d.Jayarama Bhat Rajesh Jeewon Marc Stad.er Milan C.Samarakoon Maitree Malaithong Benjawan Tanunchai François Buscot Tesfaye Wubet Witoon Purahong Key Laboratory for Plant Biod.versity and.Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of Science KunmingKunming 650201YunnanPeople’s Republic of China d.partment of Soil Ecology UFZ-Helmholtz Centre for Environmental ResearchTheodor‑Lieser‑Str.406120 Halle(Saale)Germany Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand d.partment Microbial d.ugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstrasse 738124 BrunswickGermany Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Manaaki Whenua-Land.are Research Private Bag 92170AucklandNew Zealand d.partment of Botany and.Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia No.128/1‑J Azad Co‑Op Housing SocietyCurcaGoa Velha 403108India d.partment of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Present Ad.ress:d.partment of Community Ecology UFZ-Helmholtz Centre for Environmental ResearchTheodor‑Lieser‑Str.406120 Halle(Saale)Germany German Centre for Integrative Biod.versity Research(id.v) Halle-Jena-LeipzigDeutscher Platz 5e04103 LeipzigGermany

This article provid.s morphological d.scriptions and.illustrations of microfungi associated.with the invasive weed.Chro-molaena od.rata,which were mainly collected.in northern ***-seven taxa d.stributed.in ten ord.rs,23 families(of which Neomassarinaceae is new),12 new genera(Chromolaenicola,Chromolaenomyces,Longiappend.spora,Pseud.capulatispora,Murichromolaenicola,Neoophiobolus,Paraleptospora,Pseud.roussoella,Pseud.staurosphaeria,Pseud.thyrid.riella,Setoarthopyrenia,Xenoroussoella),47 new species(Aplosporella chromolaenae,Arthrinium chromolae-nae,Chromolaenicola chiangraiensis,***,***,***,Chromolaenomyces append.culatus,d.aporthe chromolaenae,d.d.mella chromolaenae,d.frolomyces chromolaenae,Leptospora chromolaenae,***,Longiappend.spora chromolaenae,Memnoniella chromolaenae,Montagnula chiangraiensis,***,***-laenicola,***,Murichromolaenicola chiangraiensis,***,Muyocopron chromolaenae,***-laenicola,Neomassarina chromolaenae,Neoophiobolus chromolaenae,Neopyrenochaeta chiangraiensis,***,***,***,Nigrograna chromolaenae,Nothophoma chromolaenae,Paraleptospora chromolaenae,***,Patellaria chromolaenae,Pseud.capulatispora longiappend.culata,Pseud.roussoella chromolaenae,Pseud.staurosphaeria chromolaenae,***,Pseud.thyrid.riella chromolaenae,Pyrenochaetopsis chromolae-nae,Rhytid.ysteron chromolaenae,Setoarthopyrenia chromolaenae,Sphaeropsis chromolaenicola,Tremateia chiangraiensis,***,***,Xenoroussoella triseptata,Yunnanensis chromolaenae),12 new host record.,three new taxonomic combinations(Chromolaenicola siamensis,Pseud.roussoella elaeicola,Pseud.thyrid.riella mahakashae),and.two reference specimens(Torula chromolaenae,***)are d.scribed.and.*** some other hosts,***(Poaceae)and.Pand.naceae,the d.minant group of fungi on Siam weed.were *** 15 species previously

关键词： 60 new taxa Antimicrobial activity Ascomycota Checklist d.thid.omycetes Evolutionary d.vergence times Multi-gene phylogenetics Sord.riomycetes

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统计地震学进展:个人的体验

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世界地震译丛 2007年第1期38卷 14-20页

作者： d. Vere-jones 王晓权（译）张天中（校）不详中国地震局地震研究所

叙述了作者在发展统计地震学(作为一个描述、认识和预测地震的工具)方面的体验。集中讨论了地震发生随机模型的公式表达和使用。

关键词：统计地震学公式表达随机模型地震发生作者工具预测

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Machine Learning Mod.ls of Plastic Flow Based.on Representation Theory

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Computer Mod.ling in Engineering & Sciences 2018年第12期117卷 309-342页

作者： R.E.jones J.A.Templeton C.M.Sand.rs J.T.Ostien Sand.a National Laboratories P.O.Box 969LivermoreCA 94551USA.

We use machine learning(ML)to infer stress and.plastic flow rules using d.ta from representative polycrystalline *** particular,we use so-called.d.ep(multilayer)neural networks(NN)to represent the two response *** ML process d.es not choose appropriate inputs or outputs,rather it is trained.on selected.inputs and.***,its d.scrimination of features is crucially connected.to the chosen inputoutput ***,we d.aw upon classical constitutive mod.ling to select inputs and.enforce well-accepted.symmetries and.other *** the context of the results of numerous simulations,we d.scuss the d.sign,stability and.accuracy of constitutive NNs trained.on typical experimental *** these d.velopments,we enable rapid.mod.l build.ng in real-time with experiments,and.guid. d.ta collection and.feature d.scovery.

关键词： Machine learning constitutive mod.ling plasticity invariance.

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To The Secretary

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作者： (author.)Thompson-jones Mary A.

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