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Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma

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World Journal of Gastroenterology 2005年第42期11卷 6716-6721页

作者： Xiu-mei Ma ying liu Jian-Wen Guo Jiang-Hui liu Lian-Fu Zuo The Fourth Affiliated Hospital of Hebei Medical University Shijiazhuang 050011 Hebei Province China

AIM： TO investigate the significance of S phase kinase- associated protein 2 （Skp2） expression in human gastric carcinoma and the relation between expressions of Skp2, p27 and PTEN. METHODS： Immunohistochemical analysis was performed on 138 gastric carcinoma specimens, their paired adjacent mucosa specimens, 102 paired lymphatic metastatic carcinoma tissue specimens, 30 dysplasia specimens, 30 intestinal metaplasia specimens, 10 chronic superficial gastritis specimens and 5 normal gastric mucosa specimens for Skp2 expression and on 138 gastric carcinoma specimens for p27 and PTEN expression. RESULTS： Skp2 labeling frequency was significantly higher in intestinal rnetaplasia （12.68±0.86） and adjacent rnucosa （19.324±1.22） than in normal gastric rnucosa （0.53±0.13） and chronic superficial gastritis （0.47±0.19）（P = 0.000）, in dysplasia （16.74±0.82）than in intestinal metaplasia （P = 0.000）; in gastric primary carcinoma （31.34±2.17） than in dysplasia and adjacent rnucosa （P = 0.000）, in metastasis gastric carcinoma in lymph nodes （39.76±2.00） than in primary gastric carcinoma （P = 0.037）, respectively. Skp2 labeling frequency was positively associated with differentiation degree （rho = 0.315, P = 0.000）, vessel invasion （rho = 0.303, P = 0.000） and lymph node metastasis （rho = 0.254, P = 0.000） of gastric cancer. Expression of Skp2 was negatively associated with p27 （rho = -0.451, P = 0.000） and PTEN （rho = -0.480, P = 0.000） expression in gastric carcinoma, p27 expression was positively associated with PTEN expression in gastric carcinoma （rho = 0.642, P = 0.000）.CONCLUSION： Skp2 overexpression may be involvedin carcinogenesis and progression of human gastric carcinoma in vivo, possibly via p27 proteolysis. PTEN may regulate the expression of p27 by negatively regulating Skp2 expression.

关键词： Gastric carcinoma Skp2 p27 PTEN

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Modification of physical properties of Ba(Ni_(1/3)Nb_(2/3))O_(3) ceramics through ordered domain engineering

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Journal of Materiomics 2022年第4期8卷 815-822页

作者： Rui Da Shi mei ying liu Xiao Li Zhu Xiang Ming Chen Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang University38 Zheda RoadHangzhou310027China

Ordered domain engineering has been further developed for modifying and improving physical prop-erties in complex perovskite ceramics. In the present work, Ba(Ni_(1/3)Nb_(2/3))O_(3) ceramic is taken as a typicalexample for ordered domain engineering, in which the sintering temperature lies above the order-disorder transition temperature. Though the well-ordered structure could not be obtained in as-sintered samples, high ordering degree could be achieved together with preferred ordered domainstructures in Ba(Ni_(1/3)Nb_(2/3))O_(3) ceramics through long-time annealing, and subsequently the physicalproperties such as electrical resistivity, thermal conductivity, dielectric strength and energy storagedensity are significantly enhanced, where the ordering degree, ordered domain structure and ordereddomain boundary play the critical rules. The present work provides an effective approach for developingcomplex perovskite dielectric ceramics with superior physical properties.

关键词： Complex perovskite Ordered domain engineering Electrical resistivity Thermal conductivity Dielectric strength

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Combination of fire needle and filiform needle for frozen shoulder in different clinical stages

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 119-122页

作者： Yan GAO mei-ying liu Shuang WANG Yue-hui CHEN Jie-ping XIE mei-qi JI Party School of the Central Committee of CP.C (National Academy of Governance) Beijing 100091China Community Health Service Center Exhibition Road of Xicheng DistrictBeijing 100037 China School of Acupuncture-Moxibustion. Beijing University of Chinese Medicine Beijing 100029 China

Objective:To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders,and to choose the best treatment opportunity for clinical treatment of frozen ***:120 patients with frozen shoulders who met the inclusion criteria were numbered according to the visiting *** were randomized into control group(60 cases)and treatment group(60 cases)according to the random number *** groups were treated with filiform needles once every other day and 3 times a week,and a course of treatment included 6 times and 2 courses were *** treatment group was treated by applying a fire needling point bloodletting on the local tender points once a ***ānyú(肩髃 LI 15),Jiānliáo(肩髎 TE 14),Jiānzhēn(肩贞 SI 9),Tiáokǒu(条口 ST 38),and local tender points were taken according to different meridian *** clinical efficacy of the frozen shoulder patients in the two groups in different clinical stages was *** evaluation indicators were scores of pain,joint activity range and activities of daily living,as well as clinical efficacy of traditional Chinese ***:After treatment,the total scores of hundred-mark five-grade in both groups were significantly higher than those before treatment,and the differences were statistically significant(Treatment group82.02 ± 14.23 vs 43.37 ± 22.10,Control group 66.80 ± 18.98 vs 42.67 ± 23.03,both P<0.01),and the total score of the treatment group was significantly higher than the control group(P<0.01).The hundred-mark five-grade assessment scores after treatment in the treatment group during the frozen stage were significantly higher than the control group(77.2± 14.40 vs 68.43 ± 16.94,P<0.01);as to the clinical efficacy,the total effective rate of the treatment group was higher than the control group,and the difference was statistically significant(91.67% vs 76.67%,P<0.01);The total effective rate of the control group in the acute stage and functional rec

关键词： Periarthritis of the shoulder Clinical stage Fire needle Filiform needle

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A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis

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Chinese Medical Journal 2017年第17期130卷 2128-2129页

作者： Teng Han ying-mei liu Ting Yang Hua-Ping Dai Xiao-Lei Zhang Center for Respiratory Diseases China-Japan Friendship Hospital Beijing 100029 China Department of Pulmonary and Critical Care Medicine China-Japan Friendship Hospital Beijing 100029 China National Clinical Research Center for Respiratory Diseases Beijing 100029 China

Pulmonary nocardiosis is an opportunistic infection,especially in immunocompromised *** lymphohistiocytosis （HLH） is a rare but potentially fatal *** report a case of pulmonary nocardiosis with secondary HLH.

关键词： Hemophagocytic Lymphohistiocytosis Infection Pulmonary Nocardiosis

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Analysis of cost and effectiveness of treatment in benign paroxysmal positional vertigo

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Chinese Medical Journal 2019年第3期132卷 342-345页

作者： Ya-Li Wang Min-Ya Wu Pei-Li Cheng Shao-Fang Pei Yi liu ying-mei liu Department of Neurology the Northern Area of Suzhou Municipal HospitalSuzhouJiangsu 215000China

To the Editor: Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of vertigo. Recently, the diagnosis and treatment of BPPV have become areas of increased interest. As such, the levels of clinical diagnosis and treatment have greatly improved. While studies have been conducted worldwide examining the pathogenesis and pathophysiology of BPPV, very few have focused on the cost of diagnosis and treatment of BPPV. Therefore, the current study was designed to analyze the effects and expenditure of the different treatment strategies for BPPV, according to the effective screening of BPPV patients, and vertigo classification.

关键词： positional vertigo Benign paroxysmal positional vertigo (BPPV) clinical diagnosis

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Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 295-298页

作者： Xiong Ding, Chang-You Lu, ying mei, Chang-An liu and Yu-Jun Shi Chongqing, China Department of Hepatobiliary Surgery, Second Clinical College, Chongqing Medical University, Chongqing 400010, China Department of Hepatobiliary Surgery the Second Clinical College Chongqing Medical University 74 Linjiang Road Chongqing 400010China. dingpanda@***

BACKGROUND: The incidence of gallstone is higher in patients with diabetes mellitus than in general population because of hypomotility and lowered emptying function. The aim of this study was to investigate the gene expression of cholecystokinin-A ( CCK-A) receptor in patients with gallstones and diabetes mellitus and its correlation with the hypomotility of the gallbladder. METHODS: Smooth muscle was taken from the gallbladder after cholecystectomy and total RNA was extracted from it by Trizol reagent to compose cDNA. CCK-A receptor was enlarged by reverse transcription-polymerase chain reaction (RT-PCR) and identified by electrophoresis. Based on the analysis of images, the relative expression of the CCK-A re- ceptor was obtained after comparison of the CCK-A recep- tor and β-action. The emptying function of the gallbladder was measured with B ultrasound before operation. RESULTS: Gallbladder ejetion fraction ( GBEF2 ) (%) (24.9±12.7) decreased more significantly in patients with gallstones and diabetes mellitus than in those with simple gallstone (61.5±8.5) (P <0.01). In the two groups, a frac- tion of 540bp of CCK-A receptor could be testified respec- tively, but the relative expression was different. Compared to the expression of β-action, it was 0. 400 ±0.068 in pa- tients with gallstones and diabetes mellitus, but 0. 622 ± 0.070 in those with gallstone only (F =7.169, P <0.01). The result was consistent with the decreased contractility. CONCLUSIONS: The gene expression of CCK-A receptor on the smooth muscle of the gallbladder may decrease more significantly in patients with gallstone and diabetes mellitus than in those with gallstone only; this result is con- sistent with the decreased motih'ty. Thus the lowered ex- pression of CCK-A receptor is probably the cause of hypo-motility in patients with gallstones and diabetes mellitus.

关键词： gallbladder diabetes mellitus CCK-A gene

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Late-stage Use of Low-dose Corticosteroids Aid Recovery of Severe H1N1 Viral Pneumonia

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国际感染病学（电子版） 2013年第3期2卷 132-136页

作者： Bin Cao Li Gu Xiao-min Yu Yu-Dong Yin Chen Ma ying-mei liu Department of Infectious Diseases and Clinical Microbiology Beijing Chao-Yang Hospital (Beijing Institute of Respiratory Medicine)Capital Medical University

The role of corticosteroids in the management of severely ill patients with inlfuenza A (H1N1) viral infection is unclear and controversial. Two critically ill cases with influenza A (H1N1) infections complicated with organizing pneumonia (OP) in 2011 successfully treated with low dose corticosteroids were reported here. After initial clinical improvement, the condition of both patients aggravated 20-23 days after the onset of illness. Chest X-ray and computed tomographies (CT) showed an increment of lung infiltrates. Cultures of blood, pleural lfuid and transbronchial aspirate were negative for bacteria and fungi. Organizing pneumonia was diagnosed clinically and both patients were successfully treated with low-dose corticosteroids. Low-dose corticosteroids initiated during convalescence may be beneficial for severe swine-origin influenza A H1N1 pandemic 2009 virus (S-OIV) infections.

关键词： H1N1 Pneumonia Corticosteroids

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乙交酯与2-氢-2-氧-1,3,2-二氧磷杂环己烷的开环共聚研究

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高等学校化学学报 1998年第5期 165-167页

作者： FAN Chang Lie *, mei ying, liu Zhen Hua, ZHUO Ren Xi (Department of Chemistry,Wuhan University, Wuhan, 430072)

聚乙醇酸及其与乳酸的共聚物是一类无毒、有良好的生物相容性和生物可降解材料，它们广泛地用作药物控释体系的载体，牙科植入材料［１，２］．但由于聚乙醇酸的高度可结晶性，使其不溶于包括三氟乙酸在内的几乎所有的有机溶剂，因此通... 详细信息

聚乙醇酸及其与乳酸的共聚物是一类无毒、有良好的生物相容性和生物可降解材料，它们广泛地用作药物控释体系的载体，牙科植入材料［１，２］．但由于聚乙醇酸的高度可结晶性，使其不溶于包括三氟乙酸在内的几乎所有的有机溶剂，因此通过共聚来改进其物化性质的研究一直方...

关键词：乙交酯 2-氢-2-氧-1`3`2-二氧磷杂环己烷开环聚合

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泪道探通术治疗婴儿泪囊炎的疗效

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国际眼科杂志 2012年第4期12卷 796-797页

作者：刘梅莹邱铭晖广东省中西医结合医院眼科中国广东省佛山市528200

目的:探讨小儿先天性泪囊炎方便、有效的治疗方法及泪道探通术的治疗时机。方法:对52例65眼小儿先天性泪囊炎按月龄分为3组,每组均在表面麻醉下用一次性泪道冲冼针头行泪道冲冼,然后直接进行泪道探通术。结果:月龄1～3mo组27例32眼,一... 详细信息

目的:探讨小儿先天性泪囊炎方便、有效的治疗方法及泪道探通术的治疗时机。方法:对52例65眼小儿先天性泪囊炎按月龄分为3组,每组均在表面麻醉下用一次性泪道冲冼针头行泪道冲冼,然后直接进行泪道探通术。结果:月龄1～3mo组27例32眼,一次探通治愈30眼(94%);4～6mo组13例20眼,一次探通治愈16眼(80%);7～11mo组12例13眼,一次探通治愈6眼(46%)。结论:使用一次性无菌冲洗针行泪道探通术是治疗婴幼儿泪囊炎的一种有效、安全、简便的方法。

关键词：泪道探通术婴儿泪囊炎

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白内障超声乳化术中高眼压的处理及原因分析

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国际眼科杂志 2012年第9期12卷 1767-1768页

作者：刘梅莹李晓凤广东省中西医结合医院眼科中国广东省佛山市528200

目的:分析白内障超声乳化术中出现高眼压的处理方法及发病原因。方法:回顾分析白内障超声乳化手术患者408例557眼,共收集术中出现高眼压患者3例3眼。术中快速静脉滴注200g/L甘露醇250mL,其中2例2眼高血压患者分别给予降血压对症处理。... 详细信息

目的:分析白内障超声乳化术中出现高眼压的处理方法及发病原因。方法:回顾分析白内障超声乳化手术患者408例557眼,共收集术中出现高眼压患者3例3眼。术中快速静脉滴注200g/L甘露醇250mL,其中2例2眼高血压患者分别给予降血压对症处理。观察术后第1d,1wk术眼矫正视力、眼压、角膜水肿情况。结果:囊袋阻滞综合征患者1例1眼及灌注液迷流综合征患者2例2眼用药后眼压下降,前房形成,均顺利完成超声乳化并人工晶状体植入术。3例患者术后视力均有提高;眼压均在正常范围;角膜水肿术后第1d为2级,术后1wk为0级。结论:静脉给予高渗剂是白内障超声乳化术中出现高眼压、前房形成困难的有效治疗措施。

关键词：白内障超声乳化摘除术高眼压灌注液迷流综合征囊袋阻滞综合征

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