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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1120-1127页

作者： Da-Wen Wu Fei-Peng Jiang Ge Ge mei-xia zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the association between central serous chorioretinopathy(CSC)and Helicobacter pylori(Hp)by summarizing all available ***:The Scopus,Embase,EBSCO,PubMed,Web of Science,and Cochrane Library databases for all relevant studies published from inception to October 2022 were searched,and manually searched for relevant reference lists as a *** investigating the association between CSC and Hp infection were ***,8 case-control studies were included in the Meta-analysis after study ***:The results showed no significant correlation between Hp infection and CSC[odds ratio(OR)1.89,95%confidential interval(CI)0.58–6.15,I2=96%,P=0.29].After subgroup analysis based on the degree of development of the study(developing/developed countries),it was found that the results of the two subgroups were the same as the whole,and no significant difference between the two subgroups ***-regression showed that the effect of sample size on heterogeneity among studies was more prominent(P<0.01,adjusted R^(2)=89.72%),which can explain 89.72%of the sources of ***:This Meta-analysis reveals no significant correlation between Hp infection and CSC,which still warrants further well-designed extensive sample studies to reach a more reliable conclusion and promote a better understanding of the treatment of CSC.

关键词： central serous chorioretinopathy Helicobacter pylori infection retinal diseases Meta-analysis

Choroidal infarction after internal carotid artery stenting

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1960-1962页

作者： Li zhang Jia-Wei Liu Sheng Gao Tian-Yu Yang mei-xia zhang West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Dear Editor,We present a case of choroidal infarction along with retinal infarction after carotid artery stenting(CAS),which is a rare condition not reported in the *** has increasingly been accepted as the mainstay reconstruction method for carotid artery stenosis compared with carotid endarterectomy(CEA)due to no need for general anesthesia.

关键词： infarction carotid artery

Non-linear relationship between age and subfoveal choroidal thickness in Chinese patients with proliferative diabetic retinopathy

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World Journal of Diabetes 2024年第9期15卷 1903-1915页

作者： Chun-Yan Lei Jiang-Ying Xie Qi-Bo Ran mei-xia zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Sichuan University Operating Room Department of AnesthesiologyWest China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND No study has investigated the change regularity between age and subfoveal choroidal thickness(SFCT)in proliferative diabetic retinopathy(PDR).AIM To investigate the relationship between the SFCT and age in Chinese patients with *** This was a cross-sectional retrospective *** participants were hospitalized individuals with type 2 diabetes who underwent vitrectomy for *** eyes that met the criteria were included in the *** necessary laboratory tests were performed at the time of *** macular thickness(CMT)and SFCT were two quantitative assessments made using enhanced depth imaging optical coherence *** was measured automatically and SFCT was measured manually with digital calipers provided by the Heidelberg Eye Explorer *** The final analysis included a total of 234 individuals with *** average age was 55.60 years old±10.03 years old,and 57.69%of the population was *** analysis revealed a significant negative connection between age and SFCT in patients with PDR[β=-2.44,95%confidence interval(95%CI):-3.46 to-1.42;P<0.0001].In the fully adjusted model,the correlation between SFCT and age remained steady(β=-1.68,95%CI:-2.97 to-0.39;P=0.0117).Spline smoothing showed that the relationship between SFCT and age in patients with PDR was non-linear,with an inflection point at 54 years of *** Our findings suggest that age is a key determinant of choroidal *** non-linear link between SFCT and age in PDR patients should be taken into account.

关键词： Age Subfoveal choroidal thickness Proliferative diabetic retinopathy Optical coherence tomography Central macular thickness

Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 188-200页

作者： Qing-Qing Tang xiang-Gang Yang Hong-Qiu Wang Da-Wen Wu mei-xia zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511400Guangdong ProvinceChina

AIM:To summarize the application of deep learning in detecting ophthalmic disease with ultrawide-field fundus images and analyze the advantages,limitations,and possible solutions common to all ***:We searched three academic databases,including PubMed,Web of Science,and Ovid,with the date of August *** matched and screened according to the target keywords and publication year and retrieved a total of 4358 research papers according to the keywords,of which 23 studies were retrieved on applying deep learning in diagnosing ophthalmic disease with ultrawide-field ***:Deep learning in ultrawide-field images can detect various ophthalmic diseases and achieve great performance,including diabetic retinopathy,glaucoma,age-related macular degeneration,retinal vein occlusions,retinal detachment,and other peripheral retinal *** to fundus images,the ultrawide-field fundus scanning laser ophthalmoscopy enables the capture of the ocular fundus up to 200°in a single exposure,which can observe more areas of the ***:The combination of ultrawide-field fundus images and artificial intelligence will achieve great performance in diagnosing multiple ophthalmic diseases in the future.

关键词： ultrawide-field fundus images deep learning disease diagnosis ophthalmic disease

Dietary Daidzein Enhances Antiapoptotic Effect of 17β-Estradiol (E_2) on Breast Cancer MCF-7 Cells

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Chinese Journal of Cancer Research 2010年第1期22卷 10-16页

作者： xiao-fei Wu Yi-jing Wang Guo-liang xia mei-jia zhang State Key Laboratory for Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China

Objective： To investigate whether dietary daidzein interact with endogenous 17β-Estradiol （E2） to give rise to additive or inhibitory effects on proliferation and apoptosis in breast cancer cells. Methods： Cell cycle distribution and apoptosis induction were analyzed by using flow cytometry when breast cancer cell lines MCF-7 were cotreated with daidzein （1, 5 μmol/L） and E2 （0.1-10 nmol/L） for 5 days. Whether daidzein could alter E2-modulated mRNA expression of estrogen receptor alpha （ERα）, estrogen receptor beta （ERI3） and ERβ-estrogen response element （ERE） dependent transcription was investigated by RT-PCR and luciferase induction assays. The effects of daidzein on E2-modulated expression of proapoptotic p53, bax and antiapoptotic bcl-2 at both mRNA and protein levels were also investigated by RT-PCR and Western blot. Results： Daidzein enhanced the antiapoptotic effect in an Ea dose-dependent manner, but had no effect on E2-induced proliferation. Daidzein antagonized E2-induced ERβ mRNA expression and ERβ-ERE dependent transcription. In addition, daidzein only antagonized E2-upregulated expression of p53 and bax, but had no effect on E2-upregulated expression of bcl-2. Conclusion： Daidzein enhances the antiapoptotic effect of E2 on breast cancer cells by inhibiting E2-mediated p53-bax proapoptotic pathway. These results suggest that dietary daidzein may enhance deleterious effect of endogenous E2 in hormone-dependent breast cancer.

关键词： Daidzein E2 Breast cancer MCF-7 cells Antiapoptotic effect Estrogen receptor (ER)

Analysis of Potential Energy Surface for Butanone Isomerization

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Chinese Journal of Chemical Physics 2013年第5期26卷 519-525,I0003页

作者： Xue Yang Bing Yan Hai-feng Xu Rui-han Zhu mei-xia zhang Da-jun Ding Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China College of Science Jilin Institute of Chemical Technology Jilin 132022 China

The potential energy surfaces for butanone isomerization have been investigated by density function theory calculation. Six main reaction pathways are confirmed using the intrinsic reaction coordinate method, and the corresponding isomerization products are 1-buten-2-ol, 2-buten-2-ol, butanal or 1-buten-l-ol, methyl 1-propenyl ether, methyl allyl ether, and ethyl vinyl ether, respectively. Among them, there are three pathways through butylene oxide, indicating butylene oxide is an important intermediate product during butanone isomer ization. The calculated vertical ionization energies of the reactant and its products are in a good agreement with the experimental values available. From the consideration for the relative energies Of transition states and the number of high-energy barriers we infer that the reaction pathway butanone-＊l-buten-2-ol---2-buten-2-oi is the most competitive. The obtained results are informative for future studies on isomerization of ketone molecules.

关键词： Butanone Isomerization Density function theory Potential energy surface,Vertical ionization energy

Paroxysmal speech disorder as the initial symptom in a young adult with anti-N-methyl-D-aspartate receptor encephalitis: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8648-8655页

作者： Chuan-Chen Hu xiao-Ling Pan mei-xia zhang Hong-Fang Chen Department of Neurology The Affiliated Jinhua HospitalSchool of MedicineZhejiang UniversityJinhua 321000Zhejiang ProvinceChina

BACKGROUND Anti-N-methyl-D-aspartate receptor(anti-NMDAR)encephalitis is a treatable but frequently misdiagnosed autoimmune *** dysfunction,as one of the common manifestations of anti-NMDAR encephalitis,is usually reported as a symptom secondary to psychiatric symptoms or seizures rather than the initial symptom in a paroxysmal *** report a case of anti-NMDAR encephalitis with paroxysmal speech disorder as a rare initial manifestation,and hope that it will contribute to the *** SUMMARY A 39-year-old man with anti-NMDAR encephalitis initially presented with paroxysmal nonfluent aphasia and was misdiagnosed with a transient ischemic attack and cerebral infarction *** patient subsequently presented with seizures,but no abnormalities were found on brain magnetic resonance imaging or *** fluid(CSF)analysis revealed mild pleocytosis and increased protein ***-NMDAR antibodies in serum and CSF were detected for a conclusive *** immunotherapy,the patient made a full *** This case suggests that paroxysmal speech disorder may be the presenting symptom of anti-NMDAR encephalitis in a young patient.

关键词： Anti-N-methyl-D-aspartate receptor encephalitis Autoimmune disease Paroxysmal speech disorder Seizure Immunotherapy Case report

Progression and Regression of Abdominal Aortic Aneurysms in Mice

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Current Medical Science 2021年第5期41卷 901-908页

作者： Yu-chao DING xian-jing zhang Ji-xiu zhang Zi-yi ZHAI mei-xia zhang Bao-hong JIANG Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China The College of Basic Medical Science China Medical UniversityShenyang 110122China

Objective:Abdominal aortic aneurysm(AAA)is a significant medical problem with a high mortality ***,the underlying mechanism for the progression and regression of AAA is ***:Experimental model of AAA was first created by porcine pancreatic elastase incubation around the infrarenal aorta of C57BL/6 ***,AAA progression and regression were evaluated based on the diameter and volume of *** aortas were harvested for hematoxylin-eosin staining(HE),orcein staining,sirius red staining,immunofluorescence analysis and peris’prussian blue staining at the indicated time ***,P-aminopropionitrile monofumarate(BAPN)was used to explore the underlying mechanism of the regression of ***:When we extended the observation period to 100 days,we not only observed an increase in the AAA diameter and volume in the early stage,but also a decrease in the late *** with AAA diameter and volume,the aortic thickness showed the same tendency based on HE *** elastin and collagen content first degraded and then regenerated,which corresponds to the early deterioration and late regression of ***,endogenous up-regulation of lysyl oxidase(LOX)was detected,accompanying the regression of AAA,as detected by an immunofluorescent *** and LOX inhibitor considerably inhibited the regression of AAA,paralleling the degradation of elastin lamella and ***:Taken together,we tentatively conclude that endogenous re-generation of LOX played an influential role in the regression of ***,regulatory factors on the generation of LOX exhibit promising therapeutic potential against AAA.

关键词： abdominal aortic aneurysm disease progression disease regression elastogenesis lysyl oxidase

Spontaneous dislocation of a toric implantable collamer lens resulting in corneal endothelial decompensation:a case report and review of the literature

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 135-138页

作者： Li zhang Yan-Xi Li Chun-Yan Lei Lin Wang mei-xia zhang Sichuan University West China Hospital Chengdu 610041Sichuan ProvinceChina

Dear Editor We present a case of spontaneous dislocation of a toric implantable collamer lens(TICL)resulting in corneal endothelial decompensation 8y after *** 2006,by helping people take off their glasses,the Visian TICL(Staar Surgical Co,Monrovia,CA,USA)have gained popularity in *** complications of intraocular pressure(IOP)elevation,cataract formation and endothelial damage exist as relevant problems,implantable collamer lens(ICL)implantation has been generally accepted as a viable option to correct moderate to high ametropia[1-2].

关键词： dislocation implantation glasses

Role of rotational state-selected for nonadiabatic alignment： OCS molecules in femtosecond laser fields

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Frontiers of physics 2013年第2期8卷 236-240页

作者： Rui-Han Zhu Chun-Cheng Wang Si-Zuo Luo Xue Yang mei-xia zhang Fu-Chun Liu Da-Jun Ding Institute of Atomic and Molecular Physics Jilin UniversityChina Changchun 130012 School of Science Changchun University of Science and TechnologyChina Changchun 130022

Nonadiabatic alignment by intense nonresonant the spatial direction of molecules： By solving the the degree of alignment of the molecules initially laser fields is a versatile technique to manipulate time-dependent SchrSdinger equation numerically in different rotational state are calculated and the results show that the degree of alignment strongly depends on the initial rotational state. Thus, the present study indicates that, for obtaining a high degree of alignment for molecules, appropriate selection of molecular rotational states is necessary.

关键词： nonadiabatic alignment rotational state-selection linear triatomic molecule