检索结果-南通市图书馆

Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian Zhang Kejia Zhao Wenjing Zhou Ran Kang Shiyou Wei Yueli Shu cheng Yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

惯性增强动力吸振器-浮置板轨道低频减振性能研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铁道学报 2024年第8期46卷 102-111页

作者：张群程志宝石志飞北京交通大学土木建筑工程学院智能材料与结构研究所北京100044 北京交通大学结构风工程与城市风环境北京市重点实验室北京100044 中国建筑科学研究院有限公司北京构力科技有限公司北京100013

浮置板轨道(floating slab track, FST)对低频车轨耦合振动具有放大作用,由此引起的低频环境振动难以解决。引入惯性增强动力吸振系统(inerter enhanced dynamic vibration absorber, IDVA),提出带有IDVA的FST,即FST-IDVA,以减小列车移... 详细信息

浮置板轨道(floating slab track, FST)对低频车轨耦合振动具有放大作用,由此引起的低频环境振动难以解决。引入惯性增强动力吸振系统(inerter enhanced dynamic vibration absorber, IDVA),提出带有IDVA的FST,即FST-IDVA,以减小列车移动荷载下的低频振动影响。理论分析给出浮置板轨道结构等效单自由度系统;考虑轮轨激励随机性,应用H_(2)优化理论给出IDVA的设计参数理论解;开发一种Matlab-Ansys联合仿真技术,应用该技术计算8编组列车运行过程中的车轨耦合动力响应。对比无动力吸振器和普通动力吸振器,验证惯性增强动力吸振器对浮置板轨道低频振动的抑制性能。研究结果表明,移动车辆荷载作用下,应用惯性增强动力吸振器后,FST板在其基频处加速度响应、钢弹簧支反力、单块板传往基础的合力均得到有效减小。惯容器的动态质量效果使吸振器与FST之间的相对位移减小大于50%。该技术可在浮置板轨道有限空间内实现更好的低频减振性能。

关键词：浮置板轨道动力吸振器惯容器车轨耦合低频减振

同方期刊数据库

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU mei-zhu cheng Ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： Hua-Chuan Song Hang-cheng Zhou Ping Gu Bing Bao Quan Sun Tian-Ming mei Wei Cui Kang Yao Huan-Zhang Yao Shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

Fourier-domain-compressed optical time-stretch quantitative phase imaging flow cytometry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第8期12卷 1627-1639页

作者： RUBING LI YUEYUN WENG SHUBIN WEI SIYUAN LIN JIN HUANG CONGKUAN SONG HUI SHEN JINXUAN HOU YU XU LIYE mei DU WANG YUJIE ZOU TAILANG YIN FULING ZHOU QING GENG SHENG LIU cheng LEI Institute of Technological Sciences Wuhan University School of Power and Mechanical Engineering Wuhan University Department of Thoracic Surgery Renmin HospitalWuhan University Department of Hematology Zhongnan HospitalWuhan University Department of Thyroid and Breast Surgery Zhongnan HospitalWuhan University Department of Radiation and Medical Oncology Zhongnan HospitalWuhan University School of Computer Science Hubei University of Technology Reproductive Medical Center Renmin HospitalWuhan University Suzhou Institute of Wuhan University Shenzhen Institute of Wuhan University

Optical time-stretch (OTS) imaging flow cytometry offers a promising solution for high-throughput and highprecision cell analysis due to its capabilities of high-speed, high-quality, and continuous imaging. Compressed sensing (CS) makes it practically applicable by significantly reducing the data volume while maintaining its highspeed and high-quality imaging properties. To enrich the information of the images acquired with CS-equipped OTS imaging flow cytometry, in this work we propose and experimentally demonstrate Fourier-domaincompressed OTS quantitative phase imaging flow cytometry. It is capable of acquiring intensity and quantitative phase images of cells simultaneously from the compressed data. To evaluate the performance of our method, static microparticles and a corn root cross section are experimentally measured under various compression ***, to show how our method can be applied in practice, we utilize it in the drug response analysis of breast cancer cells. Experimental results show that our method can acquire high-quality intensity and quantitative phase images of flowing cells at a flowing speed of 1 m/s and a compression ratio of 30%. Combined with machine-learning-based image analysis, it can distinguish drug-treated and drug-untreated cells with an accuracy of over 95%. We believe our method can facilitate cell analysis in both scientific research and clinical settings where both high-throughput and high-content cell analysis is required.

关键词： Image sensors Imaging systems Imaging techniques Phase imaging Refractive index Spatial resolution

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi cheng Niang-mei LIU Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第24期12卷 5502-5512页

作者： Li-Fen mei Quan Gan Jing Hu Yun-Xiang Li Rui Tian cheng-Jian Shi Department of Critical Care Medicine Maternal and Child Health Hospital of Hubei ProvinceWuhan 430000Hubei ProvinceChina Department of Biliary-Pancreatic Surgery Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy(APIP)is a rare and serious condition,and severe APIP(SAPIP)can lead to pancreatic necrosis,abscess,multiple organ dysfunction,and other adverse maternal and infant ***,early identification or prediction of SAPIP is *** To assess factors for early identification or prediction of *** The clinical data of patients with APIP were retrospectively *** were classified with mild acute pancreatitis or severe acute pancreatitis,and the clinical characteristics and laboratory biochemical indexes were compared between the two *** regression and receiver operating characteristic curve analyses were performed to assess the efficacy of the factors for identification or prediction of *** A total of 45 APIP patients were *** with the mild acute pancreatitis group,the severe acute pancreatitis group had significantly increased(P<0.01)heart rate(HR),hemoglobin,neutrophil ratio(NEUT%),and neutrophil–lymphocyte ratio(NLR),while lymphocytes were significantly decreased(P<0.01).Logical regression analysis showed that HR,NEUT%,NLR,and lymphocyte count differed significantly(P<0.01)between the *** may be factors for early identification or prediction of *** area under the curve of HR,NEUT%,NLR,and lymphocyte count in the receiver operating characteristic curve analysis was 0.748,0.732,0.821,and 0.774,*** combined analysis showed that the area under the curve,sensitivity,and specificity were 0.869,90.5%,and 70.8%,*** HR,NEUT%,NLR,and lymphocyte count can be used for early identification or prediction of SAPIP,and the combination of the four factors is expected to improve identification or prediction of SAPIP.

关键词： Severe acute pancreatitis in pregnancy Early identification factors Early predictive factors Clinical features Laboratory biochemical index

深圳市2015~2021年雨源型河流水质时空变化及其对降雨的响应

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境科学 2024年第2期45卷 780-791页

作者：韦必颖成建梅苏晓煜程天舜中国地质大学(武汉)环境学院武汉430078 广东省深圳生态环境监测中心站深圳518049 广东省深圳市水务规划设计院深圳518001

雨源型城市河流水容量偏小,缺乏动态补充水源,易受污染.基于深圳市2015~2021年全市(不含深汕)9大流域的21个水质指标数据和逐日降雨数据,利用单因子指数评价、综合污染指数、层次聚类分析和Pearson相关分析等方法,研究深圳市河流水质时... 详细信息

雨源型城市河流水容量偏小,缺乏动态补充水源,易受污染.基于深圳市2015~2021年全市(不含深汕)9大流域的21个水质指标数据和逐日降雨数据,利用单因子指数评价、综合污染指数、层次聚类分析和Pearson相关分析等方法,研究深圳市河流水质时空分布特征及特征污染物对降雨的响应关系.结果表明:①2015年全区大部分断面水质都是劣Ⅴ类水,2018年10月后河流水质总体得到大幅度改善,与2018年深圳市开展治水专项活动背景一致,到2021年约62%的断面水质达Ⅰ~Ⅲ类水标准;②深圳市(不含深汕)西部人口稠密地区的水质污染较东部更严重,河口和支流下游水质污染较上游更严重;③深圳市坪山河、龙岗河、茅洲河和深圳河的水质受降雨的影响显著;④深圳市河流的主要特征污染指标是DO、COD、BOD5、NH_(4)^(+)-N、TP、高锰酸盐指数、石油类和阴离子表面活性剂;对于坪山河和龙岗河,降雨使TP和NH_(4)^(+)-N指标浓度升高;对于茅洲河,降雨使TP和COD指标浓度升高;对于深圳河,降雨使COD、TP和NH_(4)^(+)-N指标浓度升高.以上结果能够揭示深圳市雨源型河流水质时空变化情况及其对降雨事件引发的非点源污染的响应关系,为深圳市打造更高品质水环境提供科学参考.

关键词：水质评价雨源型河流降雨时空分布深圳市

InSb光栅耦合的太赫兹表面等离激元共振传感方法

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第9期73卷 287-296页

作者：陈钇成张成龙张丽超祁志美中国科学院空天信息创新研究院传感技术国家重点实验室北京100190 中国科学院大学电子电气与通信工程学院北京100049 中国科学院大学材料科学与光电技术学院北京100049

仿真设计了一种光栅耦合型太赫兹(THz)表面等离激元(SPP)共振生化传感结构,该结构通过在锑化铟(InSb)基底表面刻蚀亚毫米光栅形成.基于波矢匹配方程的仿真结果表明,当TM偏振的THz平行波束以30°入射角照射到光栅区间时,光栅的–1和+1级... 详细信息

仿真设计了一种光栅耦合型太赫兹(THz)表面等离激元(SPP)共振生化传感结构,该结构通过在锑化铟(InSb)基底表面刻蚀亚毫米光栅形成.基于波矢匹配方程的仿真结果表明,当TM偏振的THz平行波束以30°入射角照射到光栅区间时,光栅的–1和+1级THz衍射波束能够分别激励传播方向相反的低频SPP和高频SPP.由于采用商业THz时域谱装置可以准确测量低频SPP,本文系统地分析了低频SPP的共振和传感特性对光栅结构参数的依赖关系.仿真结果表明:InSb光栅耦合的THz-SPP共振传感芯片的折射率灵敏度随光栅周期的增大而减小;当光栅周期为120μm、入射角为30°时,折射率灵敏度为1.05 THz/RIU,在此条件下,传感芯片不能对生物分子单分子吸附层作出可探测的响应,究其原因是,低频SPP的消逝场穿透深度远大于生物分子尺寸,致使两者相互作用不足.为了探测生物分子,仿真分析了多孔薄膜覆盖InSb光栅的增敏方法.多孔薄膜具有分子富集作用,能够将THz表面波与生物靶标的相互作用从单分子尺度扩展至整个薄膜厚度,从而提高传感器的生物检测灵敏度.以酪氨酸吸附为例的仿真结果表明,当InSb光栅表面覆盖厚度为120μm、孔隙率为0.4的多孔聚甲基丙烯酸甲酯(PMMA)薄膜后,其吸附灵敏度为0.39 THz/单位体积分数.

关键词：太赫兹表面等离激元共振 InSb光栅生化传感多孔材料

维普期刊数据库博看期刊

气溶胶光学特性对宽谱差分吸收激光雷达NO_(2)质量浓度反演结果的影响

在线全文

学校读者我要写书评

暂无评论

光学学报 2024年第6期44卷 175-187页

作者：成远余纪恒宫振峰梅亮大连理工大学光电工程与仪器科学学院辽宁大连116024

针对宽谱连续波差分吸收激光雷达(DIAL)的特点,通过仿真不同大气条件下的激光雷达信号,计算分析宽谱DIAL气溶胶消光和后向散射效应引起的二氧化氮(NO_(2))质量浓度反演误差。研究结果表明:当大气气溶胶均匀分布时,NO_(2)质量浓度反演误... 详细信息

针对宽谱连续波差分吸收激光雷达(DIAL)的特点,通过仿真不同大气条件下的激光雷达信号,计算分析宽谱DIAL气溶胶消光和后向散射效应引起的二氧化氮(NO_(2))质量浓度反演误差。研究结果表明:当大气气溶胶均匀分布时,NO_(2)质量浓度反演误差主要取决于气溶胶消光效应,而后向散射效应引起的NO_(2)质量浓度反演误差一般可忽略不计;当大气气溶胶非均匀分布时,气溶胶后向散射效应引起的NO_(2)质量浓度反演误差依赖于气溶胶非均匀分布程度,且与波长指数成反比。此外,适当增大分段拟合距离可有效降低气溶胶后向散射效应引起的NO_(2)质量浓度反演误差。利用光谱近似得到宽谱NO_(2)-DIAL气溶胶消光和后向散射效应引起的NO_(2)质量浓度反演误差的近似模型,通过对比模拟计算的结果,验证了近似模型评估NO_(2)质量浓度反演误差的可行性。

关键词：大气光学宽谱差分吸收激光雷达沙氏成像原理二氧化氮气溶胶光学特性