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Inherently Chiral and Symmetrical Heteroatom-Doped Zigzag-Type Hydrocarbon Belts

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CCS Chemistry 2024年第5期6卷 1198-1210页

作者： Xue-Yuan Wang Xin-Yu Zhang Shuo Tong Qing-Hui Guo mei-Ling Tan cheng-Jun Li mei-Xiang Wang Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084

hydrocarbon belts due to their potential applications in carbon *** contrast,heteroatomembedded zigzag hydrocarbon belts as advanced design strategies with fascinating structures and desirable,unique properties have remained largely unexplored,and inherently chiral ones are ***,we report the synthesis of a diversity of symmetric and highly enantiopure inherently chiral O-and N-doped zigzag-type hydrocarbon belts starting from strainless macrocycles based on fjord-stitching *** readily available pertriflated resorcin[6]arene underwent partial hydrolyses and intramolecular S_(N)Ar reactions to form a calix[3](9H-xanthene)derivative and a prochiral half-belt *** transformations of calix[3](9H-xanthene)into C_(3v)-symmetric molecular belts were achieved by closing the rest of the fjords with triple intramolecular S_(N)Ar reactions and Yamamoto homo coupling reactions,as well as palladiumcatalyzed intermolecular acridination reactions with primary *** prochiral half-belt underwent enantioselective desymmetrizative mono-acridination to afford an inherently chiral N,O_(4)-bridged pseudo-belt with an enantiomeric excess(ee)value of>99%under the catalysis of Pd(OAc)_(2)and(R)-*** closure reactions of the pseudo-belt produced diverse heteroatom-inlayed zigzag-type hydrocarbon belts of inherent ***,we showed the unique cavity structures of the belts and demonstrated interesting chiroptic properties of the inherently enantiopure chiral *** research opens the door for the exploration of novel and sophisticated symmetric and inherently chiral molecular nanobelt structures with outstanding physical and chemical properties,as well as potential applications.

关键词： zigzag-type molecular belt heterocycle chiroptical property fjord-stitching strategy resorcinarene

ATP6AP2,a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei Xiong Hao-Han Guo Jin-Xiu Pan Xiao Ren Daehoon Lee Li Chen Lin mei Wen-cheng Xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2,an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2 in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2 in the OB-lineage cells(Atp6ap2^(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2-KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2-KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2-KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2 is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2-KO *** together,these results support the view for ATP6AP2 as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2 in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs

Dynamic Spacer Installation of Multifunctionalities into Metal-Organic Frameworks for Spontaneous One-Step Ethylene Purification from a Ternary C_(2)-Hydrocarbons Mixture

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CCS Chemistry 2024年第1期6卷 241-254页

作者： Yang-Yang Xiong cheng-Xia Chen Tony Pham Zhang-Wen Wei Katherine A.Forrest mei Pan cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275 Department of Chemistry University of South FloridaTampaFlorida 33620

Simultaneous ethane and acetylene removal from a C_(2)-gases mixture(C_(2)H_(6),C_(2)H_(4),and C_(2)H_(2))through a one-step separation process for ethylene purification is of great importance yet challenging in petrochemical industry,owing to their similar molecule sizes and physical ***,a series of multifunctionalized metal–organic frameworks(MOFs),LIFM-XYY-1∼8(LIFM stands for Lehn Institute of Functional Materials,and XYY are the initials of the first author),are constructed via a dynamic spacer installation(DSI)approach to optimize the pore-nanospaces for efficient C_(2)H_(4) isolation from the ternary C_(2)-gases *** of variable organic-spacers into the prototypical MOFs,LIFM-28 or PCN-700,results in dramatically improved pore volume/surface area,contracted pore size,and functionalized pore surface,which in turn bring out high C_(2)-gases uptake capacities,enhanced C_(2)H_(6) and C_(2)H_(2) adsorption selectivities over C_(2)H_(4),and fast adsorption kinetics,providing an effective strategy to achieve delicate trade-off among these indexes for adequate separation ***,optimized LIFM-XYY-7 presents four-times C_(2)H_(6) and C_(2)H_(2) adsorption capacities than *** breakthrough experiments reveal that poly-grade C_(2)H_(4)(>99.9%)can be obtained from binary or ternary C_(2)-hydrocarbon mixtures through a single separation *** with themolecular simulations,this work demonstrates a promising protocol of porenanospace engineering via multi-functional optimization by the DSI approach to screen out MOFs for a formidable task.

关键词： metal-organic frameworks dynamic spacer installation C_(2)H_(6)/C_(2)H_(2)/C_(2)H_(4)gases separation pore nanospace engineering multi-functional optimization

Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 979-990页

作者： Yi-mei Wang Zheng-Wei Luo Yu-Lin Shu Xiu Zhou Lin-Qing Wang Chun-Hong Liang Chao-qun Wu Chang-Ping Li Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)is the primary risk factor for gastric cancer(GC),the Wnt/β-Catenin signaling pathway is closely linked to *** has a high mortality rate and treatment cost,and there are no drugs to prevent the progression of gastric precancerous lesions to ***,it is necessary to find a novel drug that is inexpensive and preventive to against *** To explore the effects of *** and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC(PLGC).METHODS Mice were divided into the control,N-methyl-N-nitrosourea(MNU),***+MNU,and Moluodan *** first created an *** infection model in the ***+MNU and Moluodan groups.A PLGC model was created in the remaining three groups except for the control *** was fed to mice in the Moloudan group ad *** general condition of mice were observed during the whole experiment *** tissues of mice were grossly and microscopically *** quantitative real-time PCR(qRT-PCR)and Western blotting analysis,the expression of relevant genes were *** Mice in the ***+MNU group showed the worst performance in general condition,gastric tissue visual and microscopic observation,followed by the MNU group,Moluodan group and the control ***-PCR and Western blotting analysis were used to detect the expression of relevant genes,the results showed that the ***+MNU group had the highest expression,followed by the MNU group,Moluodan group and the control *** *** can activate the Wnt/β-catenin signaling pathway,thereby facilitating the development and progression of *** suppressed the activation of the Wnt/β-catenin signaling pathway,thereby decreasing the progression of PLGC.

关键词： Helicobacter pylori Gastric cancer Wnt/β-catenin signaling pathway Moluodan

A new infrageneric classification of Gastrochilus(Orchidaceae:Epidendroideae)based on molecular and morphological data

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Plant Diversity 2024年第4期46卷 435-447页

作者： Jun-Yi Zhang Yue-Hong cheng Min Liao Yu Feng Sen-Long Jin Ting-mei He Hai He Bo Xu China-Croatia“Belt and Road”Joint Laboratory on Biodiversity and Ecosystem Services CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesP.O.Box 416Chengdu 610041SichuanChina College of Life Sciences Chongqing Normal UniversityChongqing 401331China Wolong National Natural Reserve Administration Bureau Wenchuan 623006SichuanChina University of Chinese Academy of Sciences Beijing 100049China

Gastrochilus is an orchid genus containing 73 species of mainly epiphytic on trees or rocks in mountain forests of tropical and subtropical *** phylogenetic analyses and morphological assessments have failed to produce a well-resolved phylogeny at the infrageneric *** the present study,a new infrageneric classification of Gastrochilus is proposed based on thoroughly morphological and phylogenetic analyses based on 52 *** phylogenetic analysis divided the genus into six sections including three new sections,***,*** and *** also reinstate *** to the specific ***,two new species,*** Jun ***,***&Yue *** and *** Jun ***,***&Yue ***,are described and illustrated.A key to six sections of the genus is presented.

关键词： Gastrochilus Phylogeny Character evolution Taxonomy New species

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu mei SHAN Hui TAN Jin Feng ZHOU Jian SONG Yuan Jin LI Si Qi LIU Chen XU Dong qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

Detection of astrophysical gravitational wave sources by TianQin and LISA

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 123-163页

作者： Alejandro Torres-Orjuela Shun-Jia Huang Zheng-cheng Liang Shuai Liu Hai-Tian Wang Chang-Qing Ye Yi-Ming Hu Jianwei mei MOE Key Laboratory of Tian Qin Mission Tian Qin Research Center for Gravitational PhysicsSchool of Physics and AstronomyFrontiers Science Center for Tian QinGravitational Wave Research Center of CNSASun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China Department of Physics The University of Hong KongHong Kong 999077China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing100871China

TianQin and LISA are space-based laser interferometer gravitational wave(GW)detectors planned to be launched in the *** detectors will detect low-frequency GWs around 10^(-2)Hz;however,Tian Qin is more sensitive to frequencies above this common sweet-spot while LISA is more sensitive to frequencies below 10^(-2)***,Tian Qin and LISA will be able to detect the same sources but with different accuracy depending on the source and its *** consider some of the most important astrophysical sources—massive black hole binaries,stellar-mass black hole binaries,double white dwarfs,extreme mass ratio inspirals,light and heavy intermediate mass ratio inspirals,as well as the stochastic gravitational background of astrophysical origin—that Tian Qin and LISA will be able to *** each of these sources,we analyze how far they can be detected(detection distance)and how well their parameters can be measured(detection accuracy)using a Fisher Matrix *** compare the results obtained by the three detection scenarios(Tian Qin alone,LISA alone,and joint detection by LISA and Tian Qin)highlighting the gains from joint detection as well as the contribution of Tian Qin and LISA to a combined study of astrophysical *** particular,we consider the different orientations,lifetimes,and duty cycles of the two detectors to explore how they can give a more complete picture when working together.

关键词： wave extreme stochastic

Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury

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World Journal of Stem Cells 2024年第8期16卷 799-810页

作者： Xiong-Fei Zou Bao-Zhong Zhang Wen-Wei Qian Florence mei cheng Department of Orthopedic Surgery Peking Union Medical College HospitalBeijing 100730China College of Nursing The Ohio State UniversityOhioOH 43210United States

Peripheral nerve injury(PNI)is a common neurological disorder and complete functional recovery is difficult to *** recent years,bone marrow mesenchymal stem cells(BMSCs)have emerged as ideal seed cells for PNI treatment due to their strong differentiation potential and autologous trans-plantation *** review aims to summarize the molecular mechanisms by which BMSCs mediate nerve repair in *** key mechanisms discussed include the differentiation of BMSCs into multiple types of nerve cells to promote repair of nerve *** also create a microenvironment suitable for neuronal survival and regeneration through the secretion of neurotrophic factors,extracellular matrix molecules,and adhesion ***,BMSCs release pro-angiogenic factors to promote the formation of new blood *** modulate cytokine expression and regulate macrophage polarization,leading to ***,BMSCs synthesize and release proteins related to myelin sheath formation and axonal regeneration,thereby promoting neuronal repair and ***,this review explores methods of applying BMSCs in PNI treatment,including direct cell trans-plantation into the injured neural tissue,implantation of BMSCs into nerve conduits providing support,and the application of genetically modified BMSCs,among *** findings confirm the potential of BMSCs in treating ***,with the development of this field,it is crucial to address issues related to BMSC therapy,including establishing standards for extracting,identifying,and cultivating BMSCs,as well as selecting application methods for BMSCs in PNI such as direct transplantation,tissue engineering,and genetic *** these issues will help translate current preclinical research results into clinical practice,providing new and effective treatment strategies for patients with PNI.

关键词： Bone marrow mesenchymal stem cells Peripheral nerve injury Schwann cells Myelin sheath Tissue engineering

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun Zhang Yue-mei Zhao Lei Chen Jin-Lin Zhang Bao-cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation