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Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

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Traditional Medicine Research 2024年第10期9卷 1-9页

作者： Bo-Wen Zhang Di Yang Jin-Tao Li mei-hao peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:Luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

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The flavonoids from Pentorum chinense *** ferroptosis to alleviate sorafenib-induced liver injury in BRL-3A cells

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Traditional Medicine Research 2024年第2期9卷 18-26页

作者： Di Yang Bo-Wen Zhang Shan Lei Jin-Tao Li mei-hao peng Jia-Qing Liao Xue Tang Qi Zhao Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China Chengdu Analytical Applications Center Shimadzu(China)Co.Ltd.Chengdu 610023China

Background:Drug-induced liver damage is a severe medical issue that affects people all over the *** has some side effects that cause liver injury.A dietary medicinal plant called Penthorum chinense Pursh.(PCP)has hepatoprotective *** are currently few reports on PCP’s protective impact and mechanism against sorafenib-induced liver ***:To create a liver injury model,sorafenib was administered to BRL-3A *** viability assays,immunofluorescence tests,Western blotting,real-time quantitative PCR,and high-content imaging systems were utilized to examine PCP’s effect and ***:In this study,PCP treatment mitigated the liver damage caused by sorafenib by enhancing cell survival,lowering lipid reactive oxygen species and malondialdehyde levels,and elevating glutathione *** addition,PCP can enhance the protein expression of cystine/glutamate transporter xCT and glutathione peroxidase 4,reduce iron content and alleviate mitochondrial *** mechanism studies revealed that PCP inhibited ferroptosis by promoting the production of nuclear factor E2-related factor 2 nuclear translocation and subsequently affecting target genes(HO-1 and NQO1).Conclusion:Together,PCP regulates the nuclear factor E2-related factor 2 pathway,which helps to lessen ferroptosis brought on by sorafenib.

关键词： sorafenib Pentorum chinense Pursh. ferroptosis oxidative stress Nrf2

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成组立模成型机模板结构优化设计研究

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机械设计与制造 2024年第4期398卷 379-383页

作者：蔡安江梅浩鹏于海滨西安建筑科技大学机电工程学院陕西西安710055 德州海天机电科技有限公司山东济南250061

混凝土预制构件成组立模成型机(简称成组立模)是一种新型的生产混凝土预制构件的设备。为了提高成组立模台面的振动效果和承载能力,本研究以成组立模模板结构为研究对象,提出了一种拓扑优化新兴设计与响应面法结合的优化设计理论。首先... 详细信息

混凝土预制构件成组立模成型机(简称成组立模)是一种新型的生产混凝土预制构件的设备。为了提高成组立模台面的振动效果和承载能力,本研究以成组立模模板结构为研究对象,提出了一种拓扑优化新兴设计与响应面法结合的优化设计理论。首先,基于变密度法对成组立模模板结构加强筋布局进行拓扑优化设计,得到了加强筋最佳的材料分布形式,以此对成组立模模板结构进行了结构优化设计。为得到最佳的加强筋设计参数,采用中心组合试验设计,建立模板结构最大位移、最大等效应力的响应面模型。利用多目标遗传算法对响应面模型进行优化求解,得出加强筋各参数最优的组合方案。有限元分析结果表明:与初始方案相比,优化设计方案提高了台面的刚度和强度,同时改善了模板结构的振动特性,并提高了混凝土预制构件的成型质量。该研究为进一步推进成组立模的研究提供了理论指导。

关键词：成组立模加强筋布局拓扑优化结构优化设计响应面法有限元分析

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Multiple thermal events recorded in the Acasta Gneiss Complex:Evidence from in-situ dating of zircon, titanite, and apatite

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Science China Earth Sciences 2024年第3期67卷 673-686页

作者： Qingfeng mei Jinhui YANG Jinfeng SUN Qiuli LI Shitou WU Xiaoxiao LING peng peng hao WANG State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China

In-situ dating of the zircons, titanites, and apatites in the rock fragments of approximately 1 cm2in size from the Acasta Gneiss Complex was performed using secondary ion mass spectrometry or laser ablation inductively coupled plasma mass spectrometry to provide constraints on the thermal history of the Acasta Gneiss Complex. The zircons in these rock fragments typically exhibit multiple age populations, reflecting the presence of inherited zircons or the post-crystallization process of zircon overgrowth. Combined with previous studies, our zircon dating results reveal multiple magmatic events that occurred in the Acasta Gneiss Complex, specifically at >3.96, ~3.72, and ~3.57 Ga, respectively. A titanite Pb-Pb isochron age of2911±22 Ma(95% confidence level, MSWD=1.5) for sample AY199 is identified, consistent with the timing of the latest Archean magmatism in the Acasta Gneiss Complex. The titanite U-Pb ages for samples AC478 and AY066 are 1932±270 Ma(95% confidence level, MSWD=2.3) and 1813±45 Ma(95% confidence level, MSWD=2.3), respectively. The apatites in sample P090803-C exhibit a Pb-Pb isochron age of 1833±26 Ma(95% confidence level, MSWD=1.4). The apatite U-Pb ages for samples AC478, AY199, and AY066 are 1850±20 Ma(95% confidence level, MSWD=1.3), 1827±100 Ma(95% confidence level, MSWD=6.3), and 1807±58 Ma(95% confidence level, MSWD=3.9), respectively. Titanites in samples AC478 and AY066, as well as the apatites in all four investigated samples, show a uniform age(Pb-Pb or U-Pb age) of ~1.9–1.8 Ga,indicating U-Pb system reset in these minerals due to the Wopmay orogeny and documenting that the peak temperature condition associated with the Wopmay orogeny exceeded the apatite U-Pb closure temperature and approached or exceeded that of titanite.

关键词： Zircon Titanite Apatite Acasta Gneiss Complex Wopmay Orogen

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Vanadium nitride quantum dots@carbon skeleton anode material synthesized via in situ oxidation initiation strategy

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Tungsten 2024年第3期6卷 561-573页

作者： Yi-Han Fu Yuan-You peng Lei Zhao Tian-Qi He mei-mei Yuan hao Dang Rui Liu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals School of Materials Science and Engineering Lanzhou University of Technology

Vanadium nitride（VN） has received significant attention as a potential negative electrode material due to its remarkable theoretical and physical ***,the electrochemical performance needs to be improved due to its low specific surface area and the issue of being easily dissolved in *** have shown that the composite structure of carbon-coated nano sc ale VN particles could significantly increase the specific surface area of VN,and more importantly,and the carbon matrix can effectively restrain the dissolution of VN particles in the electrolyte,thereby improving its chemical and electrochemical performance,including specific capacity and cycling ***,VN quantum dots are synthesized and protected by uniformly coating the carbon skeleton on its surface via an in situ strategy of oxidation initiation,which initiates dopamine polymerization,forming a crystalline complex of polydopamine and *** heat treatment,the product is a composite material with VN quantum dots embedded in the amorphous carbon *** resulting smallsized and crosslinked carbon particles formed a graded pore structure,more reasonable channels provided for electrolyte ions transport *** the composite material was used as the negative electrode material for supercapacitors,it exhibits the specific capacity of 391.9 F·g-1at a current density of 0.5 A·g-1and excellent capacity retention rate of 83.6% after *** synthesis method of this quantum dot could be applied to other metal compounds and has potential applications in catalysis,environmental protection,and other fields.

关键词： In situ initiation Vanadium nitride Quantum dots Anode Supercapacitors

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SFNet:Stellar Feature Network with CWT for Stellar Spectra Recognition

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Research in Astronomy and Astrophysics 2024年第9期 262-272页

作者： hao Fu peng Liu Xuan Qi Xue mei College of Electrical Engineering and Control Science Nanjing Tech University

Stellar spectral classification is crucial in astronomical data analysis. However, existing studies are often limited by the uneven distribution of stellar samples, posing challenges in practical applications. Even when balancing stellar categories and their numbers, there is room for improvement in classification accuracy. This study introduces a Continuous Wavelet Transform using the Super Morlet wavelet to convert stellar spectra into wavelet images. A novel neural network, the Stellar Feature Network, is proposed for classifying these images. Stellar spectra from Large Sky Area Multi-Object Fiber Spectroscopic Telescope DR9, encompassing five equal categories (B, A, F, G,K), were used. Comparative experiments validate the effectiveness of the proposed methods and network,achieving significant improvements in classification accuracy.

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Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 956-964页

作者： Li-Ying hao Gege Dong Tieshan Li Zhouhua peng the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731the Navigation CollegeDalian Maritime UniversityDalian 116026 the Yangtze Delta Region Institute(Huzhou) Huzhou 313001China

This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external *** surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to *** reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency *** nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external *** using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of *** with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance ***,the comparison results through simulations are given to verify the effectiveness of the proposed method.

关键词： Actuator faults autonomous surface vehicle(ASVs) improved artificial potential function nonlinear state observer obstacle avoidance

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Freeze-induced acceleration of iodide oxidation and consequent iodination of dissolved organic matter to form organoiodine compounds

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Journal of Environmental Sciences 2024年第10期144卷 67-75页

作者： Xuexin Gong mei He Zhineng hao Rusong Zhao Jingfu Liu School of Resources and Environment Yangtze UniversityWuhan 430100China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Qilu University of Technology(Shandong Academy of Sciences) Shandong Analysis and Test CenterKey Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong ProvinceJinan 250014China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Freeze-induced acceleration of I–oxidation and the consequent iodination of dissolved organic matter(DOM)contribute to the formation of organoiodine compounds(OICs)in cold *** formed OICs may be a potentially important source of risk and are very closely with the environment and human ***,we investigated the acceleration effects of the freeze process on I–oxidation and the formation of *** comparison to reactive iodine species(RIS)formed in aqueous solutions,I–oxidation and RIS formation were greatly enhanced in frozen solution and were affected by pH,and the content of I–and ***-thaw process further promoted I–oxidation and the concentration of RIS reached 45.7μmol/L after 6 freeze-thaw *** consequent products of DOM iodination were greatly promoted in terms of both concentration and *** total content of OICs ranged from 0.02 to 2.83μmol/L under various *** 183–1197 OICs were detected by Fourier transform ion cyclotron resonance mass spectrometry,and more than 96.2%contained one or two iodine *** OICs had aromatic structures and were formed via substitution and addition *** findings reveal an important formation pathway for OICs and shed light on the biogeochemical cycling of iodine in the natural aquatic environment.

关键词： Freeze process Dissolved organic matter(DOM) Iodination Organoiodine compounds(OICs) Ultrahigh resolution mass spectrometry

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Acoustic characterization of hydrate formation and decomposition in clay-bearing sediments

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Petroleum Science 2024年第4期21卷 2830-2838页

作者： Yi-Jian Zhu Xiao-mei Yang Xing Huang hao Li Xiao-Hui Wang Yi-Fei Sun peng Xiao Chang-Yu Sun Guang-Jin Chen State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and Environment China University of Petroleum

Understanding the acoustic characteristics of hydrates in various sediments is crucial for hydrate resource detection and safe and efficient exploitation, as hydrate occurrence patterns vary greatly in different sediments. In this work, sediments with different bentonite contents, water saturations, and types were prepared to investigate the characteristics of P-wave velocity(reflecting the magnitude of hydrate saturation in the sediment) and amplitude(reflecting the degree of hydrate-sediment cementation) during hydrate formation and depressurization. During hydrate formation, the P-wave velocity and amplitude have similar trends. As clay content increases, the P-wave velocity increase rates quickened. On the other hand, the increased rate of P-wave velocity slows down with the increase of water saturation in the clay-bearing sediments. Comparing various types of sediment shows that the water absorption and swelling of bentonite reduce the pore space, speeding up the cementation of the hydrate with the sediment and increasing P-wave velocity at a faster rate. Correspondence between P-wave velocity and hydrate saturation is strongly related to sediment type, clay content, and water *** rapidly decreasing amplitude in the early stage of hydrate depressurization indicates that hydrate in clay-bearing sediments is weakly cemented to the sediments, which is prone to stratigraphic *** findings of this study offer guidance for hydrate resource assessments in clay-bearing sediments as well as geologic risk estimations during hydrate mining.

关键词： gas hydrate bentonite illite P-wave velocity amplitude

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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang mei-Yu Lv Xiang-peng Li peng Zhang Yue-Ze Wang Lei Shen Xiu-Hai Wu Bo Fu peng-Yu Guo Zi-Qi Wang Dong-Bing Cheng hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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