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Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?

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World Journal of Gastroenterology 2022年第33期28卷 4861-4874页

作者： Xiu-Cai Fang Wen-Juan Fan Douglas D Drossman Shao-mei Han mei-yun ke Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030Hubei ProvinceChina Center of Functional GI and Motility Disorders University of North CarolinaChapel HillNC 27517United States Center for Education and Practice of Biopsychosocial Care Drossman GastroenterologyDurhamNC 27713United States Rome Foundation Rome FoundationRaleighNC 27614United States Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

BACKGROUND The Rome IV criteria eliminated abdominal discomfort for irritable bowel syndrome(IBS), which was previously included in Rome III. There are questions as to whether IBS patients with abdominal discomfort(seen in Rome III but not Rome IV) are different from those with abdominal pain(Rome IV).AIM To compare bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain &*** We studied IBS patients meeting Rome III criteria. We administered the IBS symptom questionnaire, psychological status, and IBS quality of life. Patients were classified according to the predominant abdominal symptom associated with defecation into an only pain group, only discomfort group, and pain & discomfort group. We compared bowel symptoms, extraintestinal symptoms, IBS quality of life, psychological status and healthcare-seeking behaviors, and efficacy among the three groups. Finally, we tested risk factors for symptom reporting in IBS *** Of the 367 Rome III IBS patients enrolled, 33.8%(124 cases) failed to meet Rome IV criteria for an IBS diagnosis. There were no meaningful differences between the pain group(n = 233) and the discomfort group(n = 83) for the following:(1) Frequency of defecatory abdominal pain or discomfort;(2) Bowel habits;(3) Coexisting extragastrointestinal pain;(4) Comorbid anxiety and depression;and(5) IBS quality of life scores except more patients in the discomfort group reported mild symptom than the pain group(22.9% vs 9.0%). There is a significant tendency for patients to report their defecatory and non-defecatory abdominal symptom as pain alone, or discomfort alone, or pain & discomfort(all P < 0.001).CONCLUSION IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain. IBS symptoms manifesting abdominal pain or discomfort may primarily be due to different sensation and reporting expe

关键词： Irritable bowel syndrome Abdominal pain Abdominal discomfort Diagnosis Psychosocial distress Quality of life

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Visceral response to acute retrograde gastric electrical stimulation in healthy human

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World Journal of Gastroenterology 2005年第29期11卷 4541-4546页

作者： Shu-Kun Yao mei-yun ke Zhi-Feng Wang Da-Bo Xu Yan-Li Zhang Department of Gastroenterology Peking Union Medical College Hospital Beijing 100730 China

AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with ***: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel ***: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in *** frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among ***: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.

关键词： Visceral response Retrograde gastric electrical stimulation Symptom Obesity

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EFFECTS OF ENTERAL AND PARENTERAL NUTRITION ON GASTROENTERIC HORMONES AND GASTRIC MOTILITY AFTER SUBTOTAL GASTRECTOMY

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Chinese Medical Sciences Journal 2008年第2期23卷 113-116页

作者： Wei-ming Kang Jian-chun Yu Qun Zhang mei-yun ke Jia-ming Qian Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Gastroenterology Peking UnionMedical College Hospital Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100730

Objective To investigate the effects of enteral nutrition （EN） and parenteral nutrition （PN） on gastric motility and gastroentefic hormones after subtotal gastrectomy. Methods Forty-one patients underwent gastrectomy were randomly divided into EN group （n=20） and PN group （n=21 ）. From the first postoperative day to the seventh day, patients received either EN （EN group） or PN （PN group） with isocalofic （84.9kJ·kg^-1·d^-1） and isonitrogenous （0.11g·kg^-1·d^-1） intake. Serum gastrin （GAS）, plasma mofilin （MTL）, and plasma cholecystokinin （CCK） were measured on preoperative day, the first and seventh postoperative day. Electrogastrography （EGG） was measured on preoperative day and the seventh postoperative day. Results Compared with preoperafion, blood GAS, MTL, and CCK levels of 41 patients decreased significantly on the first day after subtotal gastrectomy （ P 〈 0. 001 ）, but returned to the preoperative levels one week later. EGG after gastrectomy showed that gastric basal electrical rhythm was significantly restrained （ P 〈 0. 001 ）. On the seventh day after subtotal gastrectomy, plasma MTL and CCK levels in EN group were higher than those in PN group （ P 〈 0.05 ）. There was no difference in GAS level between two groups. EGG in EN group was better than that in PN group postoper- atively. Conclusions The levels of gastroentefitic hormones and the gastric motility decrease significantly after subtotal gastrectomy. In contrast with PN, EN can accelerate the recovery of MTL, CCK, and gastric motility after subtotal gastrectomy.

关键词： enteral nutrition parenteral nutrition gastroenteric hormones gastric motility gastrectomy

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A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation

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World Journal of Gastroenterology 2007年第5期13卷 732-739页

作者： San-Ren Lin mei-yun ke Jin-Yan Luo Yao-Zong Yuan Ji-Yao Wang Shelley diTommaso Verena Walter Jiaqing Huang The 3rd Hospital Beijing Medical University Beijing China Peking Union Medical College Hospital BeijingChina The 2nd Hospital of Xian Jiaotong University Shanxi China Shanghai Ruijin Hospital Shanghai China Shanghai Zhongshan Hospital Shanghai China Novartis Pharma AG Basel Switzerland Novartis Pharmaceuticals Corp East HanoverNew Jersey United States

AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatmentfree baseline period, patients were randomized to receive either tegaserod （6 mg b.i.d.） or placebo （b.i.d.） for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements （CSBMs） during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients＇ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events （AEs）. RESULTS： A total of 607 patients were randomized to receive either tegaserod （n = 304） or placebo （n = 303）. Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo （1.39 vs 0.91, P = 0.0002）. A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 （47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018） and for the absolute number of≥ 3 CSBMs/wk over wk 1-4 （25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021）. Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod （3.6%） compared with placebo （1.7%）. CONCLUSION： Tecjaserod treatment improved multiple symptoms of CC and was associated with a fa

关键词： Chronic constipation tegaserod China Complete spontaneous bowel movement Placebocontrolled Stool

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Gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia

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World Journal of Gastroenterology 2013年第32期19卷 5357-5364页

作者： Jiao Yu Shi Liu Xiu-Cai Fang Jun Zhang Jun Gao Ying-Lian Xiao Li-Ming Zhu Fen-Rong Chen Zhao-Shen Li Pin-Jin Hu mei-yun ke Xiao-Hua Hou Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Division of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences Division of Gastroenterology Second Affiliated Hospital of Medical CollegeXi’an Jiaotong University Division of Gastroenterology Changhai HospitalSecond Military Medical University Division of Gastroenterology First Affiliated Hospital of Sun Yat-sen University

AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi’an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.RESULTS: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.CONCLUSION: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.

关键词： Functional dyspepsia Gastrointestinal symptoms Dyspeptic symptom score Helicobacter pylori infection Postprandial distress syndrome Epigastric pain syndrome Rome III criteria

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不同状态糖尿病患者胃电活动的特点

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世界华人消化杂志 2009年第10期17卷 1033-1037页

作者：陈维娜蓝宇柯美云北京积水潭医院消化科北京大学医学部第四临床医学院北京市100035 北京协和医院消化科北京市100730

目的:观察不同状态糖尿病患者的胃电活动特征,探讨糖尿病胃电紊乱的发展规律.方法:2005-11/2006-05北京协和医院就诊的糖尿病患者54例,根据糖尿病并发症及上消化道症状的有无分为3组:无并发症及上消化道症状组,有并发症而无明显上消化... 详细信息

目的:观察不同状态糖尿病患者的胃电活动特征,探讨糖尿病胃电紊乱的发展规律.方法:2005-11/2006-05北京协和医院就诊的糖尿病患者54例,根据糖尿病并发症及上消化道症状的有无分为3组:无并发症及上消化道症状组,有并发症而无明显上消化道症状组,有并发症及明显上消化道症状组.记录空腹30min和餐后60min的体表胃电活动.结果:糖尿病患者胃电节律异常发生率为74.1%.餐前胃电活动表现为:正常节律(46.3%)、胃动过缓(31.5%)、无节律(14.8%)、胃动过速(7.4%);餐后胃电活动表现为:胃动过缓(37%)、正常节律(35.2%)、无节律(20.4%)、胃动过速(7.4%).有并发症及上消化道症状组的PR值显著高于无并发症及上消化道症状组(1.07±1.17vs0.93±0.14,P=0.022).有并发症及上消化道症状者早饱症状的严重程度和PR值负相关(r=-0.535,P=0.040).结论:糖尿病患者胃电节律紊乱以胃动过缓最常见,不同状态糖尿病患者的胃电活动存在差异.

关键词：糖尿病胃电活动胃电节律胃动过缓胃动过速

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-yun Zhou Xiao Huang Xin-Yue Li Ming-ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： ke Jiang Zhi Chen Ji Yu Chen Zheng Shan Huang Ming Wang Chongqing key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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渗透氢对BCC金属裂纹扩展行为的影响

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原子与分子物理学报 2025年第4期42卷 45-52页

作者：朱云蝶赵可可张吉鼎江晓禹西南交通大学力学与航空航天学院成都611756

在氢环境下,氢原子会吸附在金属材料表面.随着时间推移,氢原子会渗透进入金属内部占据空隙位置.氢原子的聚集会导致应力集中,最终进一步影响材料的力学行为.本文通过分子动力学方法研究氢在裂纹尖端行为的力学响应.研究结果表明,裂纹尖... 详细信息

在氢环境下,氢原子会吸附在金属材料表面.随着时间推移,氢原子会渗透进入金属内部占据空隙位置.氢原子的聚集会导致应力集中,最终进一步影响材料的力学行为.本文通过分子动力学方法研究氢在裂纹尖端行为的力学响应.研究结果表明,裂纹尖端吸附的氢降低了原子间的键合力,导致局部应力集中所需的临界外加载荷减小;使得材料在较低的断裂强度条件下发生破坏,并在很大程度上促进了裂纹的扩展.模拟观察到在外加载荷下吸附氢在裂纹尖端的渗透过程,氢原子会聚集在高应力区域,造成材料塑性降低.另外,渗透进材料的氢原子数目会随着计算时间的增加达到一个最大临界值.当施加应变增大,裂纹尖端渗透氢原子数最大临界值和达到临界值的时间会增加.

关键词：分子动力学裂纹扩展氢渗透塑性损失

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