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Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer

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Nano Research 2015年第1期8卷 165-174页

作者： Shaoheng Tang mei Chen Nanfeng zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials andDepartment of Chemis try College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian 361005 China

Near-infrared （NIR） photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets （SPNS） has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size （-4.4 nm）, SPNS surface-functionalized with reduced glutathione （GSH） can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.

关键词： photothermal therapy chemotherapy Pd nanosheets drug delivery synergistic effect

Representation Theorem for Generators of Quadratic BSDEs

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Acta Mathematicae Applicatae Sinica 2018年第3期34卷 622-635页

作者： Shi-qiu zheng Shou-mei LI College of Applied Sciences Beijing University of Technology Beijing 100124 China College of Sciences North China University of Science and TechnologyTangshan 063210 China

In this paper, we establish a general representation theorem for generator of backward stochastic differential equation（BSDE）, whose generator has a quadratic growth in z. As some applications, we obtain a general converse comparison theorem of such quadratic BSDEs and uniqueness theorem, translation invariance for quadratic g-expectation.

关键词： backward stochastic differential equation representation theorem of generator converse comparison theorem g-expectation

Secure oblivious transfer protocol from indistinguishability obfuscation

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The Journal of China Universities of Posts and Telecommunications 2016年第3期23卷 1-10页

作者： Yuan zheng Wang mei Feng Xiao Beijing Electronic Science & Technology Institute Beijing 100070 China School of Telecommunications Engineering Xidian University Xi'an 710071 China

A new secure oblivious transfer （OT） protocol from indistinguishability obfuscation （iO） is proposed in this paper. The candidate iO and a dual-mode cryptosystem are the main technical tools of this scheme. Garg et al. introduced a candidate construction of iO in 2013. Following their steps, a new k-out-of-1 OT protocol is presented here, and its realization from decisional Diffie-Hellman （DDH） is described in this paper, in which iO was combined with the dual-mode cryptosystem. The security of the scheme mainly relies on the indistinguishability of the obf-branches （corresponding to the two modes in dual-mode model）. This paper explores a new way for the application of iO.

关键词： indistinguishability obfuscation (iO) oblivious transfer (OT) protocol dual-mode cryptosystem

Nuclear TAR DNA-binding protein 43 A new target for amyotrophic lateral sclerosis treatment

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Neural Regeneration Research 2013年第35期8卷 3284-3295页

作者： mei zheng Yujie Shi Dongsheng Fan Department of Neurology Peking University Third Hospital School of Pharmaceutical Sciences Peking University

Abnormal TAR DNA-binding protein 43 （TDP-43） inclusion bodies can be detected in the degen- erative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 expression reduced in the nuclei and transferred to the cytoplasm. This was accompanied by neuronal death, mimicking the pathological changes in TDP-43 that are seen in patients with amyotrophic lateral sclerosis. Interestingly, in the early stages of the response to malonate treatment, nuclear TDP-43 expression increased, and neurons remained relatively intact, without inclusion bodies or fragmentation. Therefore, we hypothesized that the increase of nuclear TDP-43 expression might be a pro-survival factor against oxidative stress injury. This hypothesis was confirmed by an in vitro transgenic experiment, in which overexpression of wild type mouse TDP-43 in cultured cortical motor neurons significantly reduced malonate-induced neuronal death. Our findings suggest that the loss of function of TDP-43 is an important cause of neuronal degen- eration, and upregulation of nuclear TDP-43 expression might be neuroprotective in amyotrophic lateral sclerosis.

关键词： neural regeneration neurodegenerative disease amyotrophic lateral sclerosis TAR DNA-bindingprotein 43 cortex motor neurons oxidative stress sodium malonate neuroprotection grants-supported paper neurodegeneration

A Novel Product Remaining Useful Life Prediction Approach Considering Fault Effects

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1762-1773页

作者： Jingdong lin zheng lin Guobo Liao Hongpeng Yin School of Automation Chongqing UniversityChongqing 400044China

In this paper,a novel remaining useful life prediction approach considering fault effects is *** Wiener process is used to construct the degradation process of single performance characteristic with the fault *** first passage time based remaining useful life distribution is calculated by assuming fault occurrence moment is a random variable and follows a certain *** maximization algorithm is employed to estimate model parameters,where the fault occurrence moment is considered as a missing ***,a Copula function is used to describe the dependence between the multiple performance characteristics and derive joint remaining useful life(RUL)distribution of product with the fault *** effectiveness of the proposed approach is verified by the experiments of turbofan engines.

关键词： Degradation process fault effects fault occurrence moment(FOM) performance characteristic(PC) remaining useful life(RUL)

A Semilinear Elliptic Equation with Double Resonance

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Acta Mathematica Sinica,English Series 2011年第7期27卷 1233-1246页

作者： mei Yue JIANG Ming zheng SUN LMAM School of Mathematical Sciences Peking University Beijing 100871 P. R. China College of Sciences North China University of Technology Beijing 100144 P. R. China

In this paper, the existence and multiplicity of a class of double resonant semilineax elliptic equations with the Dirichlet boundary value axe studied.

关键词： Semilinear elliptic equation double resonance

Admissible Solutions of Systems of Complex Partial Difference Equations on C^n

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 297-306页

作者： ling-yun GAO Ze-mei zheng Department of Mathematics Jinan University Guangzhou

In a recent papers,some authors applied Nevanlinna theory to prove some results on complex difference equations reminiscent of the classical Malmquist theorem in complex differential equations. We will mainly investigate Malmquist theorem of a type of systems of complex partial difference equations on Cn,improvements and extensions of such results are presented in this paper.

关键词： Malmquist type meromorphic solution value distribution partial difference equations

Land use scenario simulation of mountainous districts based on Dinamica EGO model

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Journal of Mountain Science 2020年第2期17卷 289-303页

作者： CHENG lin-lin LIU mei ZHAN Jia-qi College of Geoscience and Surveying Engineering China University of Mining and Technology (Beijing)

Mountainous area makes up 22% of global land, and rational land use in this area is important for sustainable development. Mentougou district has been positioned as an ecological conservation development zone of Beijing and significant land use changes have taken place since 2004. With the combination of GIS and Dinamica EGO(Environment for Geoprocessing Objects) model, the quantitative structure and spatial distribution of land use in Mentougou from 2006 to 2014 are analyzed in this paper. Considering topography has influence on the action mode of driving factors, the research area is divided into two parts based on elevation, mountainous area above 300 m, plain and shallow mountainous area below 300 m. Based on cellular automata theory, the probability of land use change is calculated by Weights of Evidence method and the spatial distribution of land use is simulated by means of two complementary spatial transition functions: Expander and Patcher. Land use pattern of Menougou in 2030 for three kinds of scenarios: trend development, rapid development and ecological protection are simulated. The comparison shows that the trend development scenario is more reasonable based on social, economic and environmental considerations and other scenarios provide a reference for improving irrational land use.

关键词： Land use change Mountainous districts Dinamica EGO model Scenarios simulation Mentougou district

Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy

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Nano Research 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng Lei Yuan Liang Ran An Yi Wei Shuyu Liu Jianhao zheng Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent *** explosion of ROS will cause oxidative stress,thereby inducing tumor cell ***,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation *** this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is *** reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor *** addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming *** nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible *** agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor *** of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ***,the nanoagents show the ability to effectively treat colon tumors.

关键词： reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy