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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture

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World Journal of Psychiatry 2024年第6期14卷 838-847页

作者： Wen-Hui Fu Zhi-Long Hu Yuan-Jun Liao Ri-Jiang Chen Jian-Bin Qiu Wu-Tang Que wan-Tao wang Wei-hua Li Wei-Bin Lan Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 361000Fujian ProvinceChina

BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress *** hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is *** speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological *** To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with *** In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were *** analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris *** Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,*** sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,*** specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,***,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consid

关键词： Psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis Correlation

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Production and test of sPHENIX W/SciFiber electromagnetic calorimeter blocks in China

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Nuclear Science and Techniques 2024年第8期35卷 167-176页

作者： Xiao‑Zhou Yu Xi‑Yang wang Wei‑Hu Ma Shi‑Hong Fu Peng‑Fei Sun Jin‑Xing Song wan‑Bing He Yang Shen Long Ma Jin‑Hui Chen huan‑Zhong huang Si‑Guang wang Jing Zhou Xiao‑mei Li Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Fudan UniversityShanghai 200433China Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγ*** EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of *** this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle *** this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are *** selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.

关键词： sPHENIX Tungsten/scintillating fiber electromagnetic calorimeter Cosmic ray test

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Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

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Military Medical Research 2024年第4期11卷 616-619页

作者： Zhi-Wen Luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui Chen Ren-Wen wan Shi-Yi Chen Jie mei Wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)

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Covering corneal stromal lenticule for macular hole in pathological myopia

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1675-1680页

作者： Zi-Yan Tang Gang Qiao Xiao-Juan Zhang Li-Jun Xie Qiang-Xing Zou Chun-mei He Long Zhao hua-Qing Yang Yu Quan Kui Cao Hui Jiang Yu-Kun He wanjiang Eye Hospital of Mianyang Mianyang 621000Sichuan ProvinceChina

AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological ***:This was a prospective non-randomized series case *** eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this *** cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas *** cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were ***:All cases were successfully performed the surgery and the postoperative follow-up was *** surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence *** reattachment of retina was achieved in all 6 eyes(100%,6/6)with *** was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all ***:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary *** it can effectively improve the visual function of *** new technique offers meaningful new ideas for treating refractory MH in pathological myopia.

关键词： corneal stromal lenticule macular hole pathological myopia

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Unloading and successful treatment with bioresorbable stents during percutaneous coronary intervention:A case report

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World Journal of Cardiology 2024年第8期16卷 484-490页

作者： Tao Sun Ming-Xue Zhang Yan Zeng Li-hua Ruan Yi Zhang Cheng-Long Yang Zhang Qin Jing wang Hai-mei Zhu Yun Long Department of Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Teaching and Research Section of Chinese Internal Medicine The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Pain The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND With the development of percutaneous coronary intervention(PCI),the number of interventional procedures without implantation,such as bioresorbable stents(BRS)and drug-coated balloons,has increased *** drug-eluting stent unloading is one of the most common clinical ***,BRS detachment is more concealed and harmful,but has yet to be reported in clinical *** this study,we report a case of BRS unloading and successful *** is a case of a 59-year-old male with the following medical history:“Type 2 diabetes mellitus”for 2 years,maintained with metformin extended-release tablets,1 g PO BID;“hypertension”for 20 years,with long-term use of metoprolol sustained-release tablets,47.5 mg PO QD;“hyperlipidemia”for 20 years,without regular *** was admitted to the emergency department of our hospital due to intermittent chest pain lasting 18 hours,on February 20,2022 at 15:*** results showed sinus rhythm,ST-segment elevation in leads I and avL,and poor R-wave progression in leads V1–***-sensitivity troponin I level was 4.59 ng/mL,indicating an acute high lateral wall myocardial *** patient’s family requested treatment with BRS,without *** PCI,the BRS became unloaded but was successfully *** patient was followed up for 2 years;he had no episodes of angina pectoris and was in generally good *** We describe a case of a 59-year-old male experienced BRS unloading and successful *** analyzing images,the causes of BRS unloading and the treatment plan are discussed to provide insights for BRS release *** discuss preventive measures for BRS unloading.

关键词： Coronary artery diseases Percutaneous coronary intervention Bioresorbable stents Stent unloading Stent release Intravascular ultrasound Case report

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Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program

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World Journal of Clinical Cases 2024年第25期12卷 5713-5719页

作者： Ling-Ling Tao Cai-hua Zeng Wen-Juan mei Yan-Li Zou Blood Purification Room The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their *** study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis *** To evaluate the impact of nursing intervention on sleep quality in hemodialysis *** This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in *** study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor *** identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and ***-intervention,sleep quality was reassessed using the *** The study found that 68.6%of hemodialysis patients were poor *** the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(P<0.001),indicating improved sleep *** demonstrated the effectiveness of the structured nursing intervention in enhancing sleep quality for middle-aged and elderly hemodialysis *** The structured nursing intervention program focusing on sleep hygiene education,relaxation techniques,and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis *** significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient *** findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.

关键词： Hemodialysis patients Nursing intervention Sleep quality Elderly Pittsburgh Sleep Quality Index Patient wellbeing

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Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai wan Hao-Qing Xie Xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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威海小石岛人工鱼礁海域渔获物群落结构特征及其与环境因子相关性

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海洋科学 2016年第11期40卷 34-43页

作者：王新萌唐衍力孙晓梅盛化香万荣中国海洋大学水产学院山东青岛266003

为探究人工鱼礁投放对威海小石岛附近海域渔获物种类组成、渔获量变化、渔获物结构特征的影响,作者于2012~2013年对威海小石岛人工鱼礁区及对照区的渔获物和环境因子进行了调查,并采用聚类分析、单因子相似性分析及相似性百分比分析对... 详细信息

为探究人工鱼礁投放对威海小石岛附近海域渔获物种类组成、渔获量变化、渔获物结构特征的影响,作者于2012~2013年对威海小石岛人工鱼礁区及对照区的渔获物和环境因子进行了调查,并采用聚类分析、单因子相似性分析及相似性百分比分析对渔获物结构特征进行分析,采用典范对应分析（CCA）对礁区主要物种与环境因子的相关性进行分析。结果显示,南、北礁区地笼网调查到渔获物种类数量高于对照区,分别为24、31和18种。南、北礁区鱼类和甲壳类生物资源量高于对照区。南、北礁区全年资源量占优势的种类为日本蟳（Charybdis japonica）和大泷六线鱼（Hexagrammos otakii）,对照区为海刺猬（Glyptocidaris crenularis）和大泷六线鱼。聚类分析和单因子相似性分析表明,渔获物组成结构在季节间差异显著（P〈0.05）,在春季和夏季,人工鱼礁区渔获物组成结构和对照区差异显著（P〈0.05）。典范对应分析表明,水温、叶绿素a和溶解氧是影响礁区主要渔获物种类分布的主要环境因子。投放人工鱼礁改善了威海小石岛礁区水域的渔获物群落结构,并增加主要鱼类、甲壳类经济物种的渔获量。

关键词：人工鱼礁渔业资源群落结构 CCA 环境因子

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整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

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Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye wan-Qiong Li mei-Ling Chen Qian-Kun Shi hua wang Xin-Ling Li Ying-He Li Jie Yang Qiao-Li wang Fang Hu Yan-Feng Gao Shu-Wen Liu Mu-Sheng Zeng Guo-Kai Feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide

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Characteristics and genesis of groundwater salinization in coastal areas of the Lower Reaches of Oujiang Basin

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Journal of Groundwater Science and Engineering 2024年第2期12卷 190-204页

作者： mei-hui Zhang Shi-yang Zhou Dan-dan Liu Ying Zhang Yu-xi Zhang Xi Chen Hui-wei wang Bei Li Wei Kang Bing Yi wan-peng Shi Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Fujian Provincial Key Laboratory of Water Cycling and Eco–Geological Processes Xiamen 361021FujianChina China University of Geosciences(Beijing) Beijing 100083China Changsha Center of Natural Resources Comprehensive Survey China Geological SurveyChangsha 410600China Hydrogeological Environmental Geological Survey Center of China Geological Survey Tianjin 071501China China University of Geosciences Wuhan 430074China

The coastal areas of the lower reaches of Oujiang River Basin are rich in groundwater ***,the unsustainable exploitation and utilization of groundwater have led to significant changes in the groundwater *** the characteristics and genesis of groundwater salinization is crucial for preventing its deterioration and ensuring sustainable *** this study,a comprehensive approach combining the ion ratio method,mineral saturation index method and multivariate statistical analysis was employed to investigate the hydrochemical characteristics and main controlling factors in the study *** findings reveal that:(1)Groundwater samples in study area exhibit a neutral to slightly alkaline *** predominant chemical types of unconfined water are HCO_(3)-Ca·Na,HCO_(3)·Cl-Na·Ca and HCO_(3)·SO_(4)-Ca·Na,while confined water mainly exhibits Cl·HCO_(3)-Na and Cl-Na types.(2)Salinity coefficients indicate an increase in salinity from unconfined to confined ***,Na^(+)and Cl^(–)concentrations show an increasing trend from mountainous to coastal areas in unconfined water,while confined water displays variability in TDS,Na^(+)and Cl^(–)concentrations.(3)Groundwater salinity is mainly influenced by water-rock interactions,including the dissolution of halite and gypsum,cation exchange,and seawater intrusion ***,human activities and carbonate dissolution contribute to salinity in unconfined *** intrusion is identified as the primary factor leading to higher salinity in confined water compared to unconfined water,with increasing cation exchange and seawater interaction observed from unconfined to confined water.

关键词： Hydrochemical Multivariate statistical analysis Seawater intrusion

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