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Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis

World Journal of Gastroenterology 2008年第28期14卷 4558-4561页

作者： Li-Hui Deng Ping Xue Qing Xia Xiao-Nan Yang mei-hua wan Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM： To investigate the effect of admission hypertriglyceridemia （HTG） on the episodes of severe acute pancreatitis （SAP）. METHODS： One hundred and seventy-six patients with SAP were divided into HTG group （n = 45） and control group （n = 131） according to admission triglyceride （TG） ≥ 5.65 mmol/L and 〈 5.65 retool/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson＇ s score, acute physiology and chronic heath evaluation Ⅱ （APACHE Ⅱ） score, Balthazar＇s computed tomography （CT） score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE Ⅱ score was analyzed. RESULTS： SAP patients with HTG were younger （40.8 ± 9.3 years vs 52.6 ± 13.4 years, P 〈 0.05） with higher etiology rate of overeating, high-fat diet （40.0% vs 14.5%, P 〈 0.05） and alcohol abuse （46.7% vs 23.7%, P 〈 0.01）, incidence rate of hypocalcemia （86.7% vs 63.4%, P 〈 0.01） and hypoalbuminemia （84.4% vs 60.3%, P 〈 0.01）, 24-h APACHE Ⅱ score （13.6 ± 5.7 vs 10.7 ± 4.6, P 〈 0.01） and admission serum glucose （17.7 ± 7.7 vs 13.4 ± 6.1, P 〈 0.01）, complication rate of renal failure （51.1% vs 16.8%, P 〈 0.01）, shock （37.9% vs 14.5%, P 〈 0.01） and infection （37.4% vs 18.3%, P 〈 0.01） and mortality （13.1% vs 9.1%, P 〈 0.01）. Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE Ⅱ score （r = 0.509, P = 0.004）.CONCLUSION： The clinical features of SAP patients with HTG are largely consistent with previous studies, HTG aggravates the episodes of SAP.

关键词： Clinical study Hypertriglyceridemia Severe acute pancreatitis Clinical features Outcome

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Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis

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Chinese Medical Journal 2020年第12期133卷 1510-1512页

作者： Qiu-Ting Wu huan Chen Jin Xiang Wen-Fu Tang mei-hua wan Department of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengduSichuan 610041China GCP Center of West China Hospital Sichuan UniversityChengduSichuan 610041China

To the Editor:Acute pancreatitis(AP)is a common digestive systemdisease without specialized treatment until *** function plays essential role in AP treatment and could be restored with Da-Cheng-Qi decoction(DCQD)as evidenced by our previous clinical study.[1]Based on the formula composing principles and our clinical experience,according to the traditional Chinese medicine theory that the lung and the large intestine are internal and externally related,Huzhang and Gualoupi were added into DCQD to form a new formula named Hu-Pi-Cheng-Qi decoction(HPCQD)which could increase the effects of purging Fu-Organ and ventilating *** with HPCQDis effective against AP in clinical practice;however,the pharmacokinetic parameters of HPCQD after enema administration in AP is *** to formula tissue pharmacology,prescription compatibility is based on its ***,the active ingredients types absorbed into the body and the metabolic process could be significantly affected by different compatibility.[2]Therefore,our purpose was to elucidate the pharmacokinetic parameters when HPCQD is absorbed into blood circulation through the rectum,the effective components and the distribution of HPCQD via enema administration on AP rats.

关键词： decoction pancreatitis lung

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Therapeutic Effect of Chinese Herbal Ointment Liu-He-Dan in Patients with Acute Pancreatitis

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Chinese Medical Journal 2016年第9期129卷 1128-1130页

作者： mei-hua wan Xian-Lin Zhao Wei-Wei Chen Juan Li Hui Guo Qing Xia Wen-Fu Tang Department of Integrated Traditional Chinese and Western Medicine Sichuan Provincial Pancreatitis Center West China Hospital Sichuan University Chengdu Sichuan 610041 China

INTRODUCTION Severe acute pancreatitis （AP） remains a challenge in clinical practice, and there are no internationally agreed specific therapies. Severe AP typically presents with epigastric pain, abdominal distention, vomiting, and constipation at the early stage and is similar to the Yangming-Fushi syndrome of traditional Chinese medicine （TCM）. The Chinese herbal ointment Liu-He-Dan （LHD） has been adapted for the treatment of AP with Yangming-Fushi syndrome externally on belly for many years in our hospital. However, the potential mechanism of LHD in the treatment of severe AP has not been elucidated. Therefore, the present study sought to evaluate the effect of LHD on AP patients and preliminarily investigate its anti-inflammatory mechanism.

关键词： Acute Pancreatitis Chinese Herbal Liu-He-Dan Proinflammatory Cytokines

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Extracellular vesicles in the pathogenesis and treatment of acute lung injury

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军事医学研究:英文版 2023年第4期10卷 478-498页

作者： Qian Hu Shu Zhang Yue Yang Jia‑Qi Yao Wen‑Fu Tang Christopher J.Lyon Tony Ye Hu mei‑hua wan Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610041China Department of Emergency Medicine Emergency Medical LaboratoryWest China Hospital of Sichuan UniversityChengdu 610041China Center of Cellular and Molecular Diagnosis Tulane University School of Medicine1430 Tulane Ave.New OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane Ave.New OrleansLA 70112USA West China Hospital(Airport)of Sichuan University Chengdu 610299China

Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe *** have high mortality rates,and despite decades of research on clinical ALI/ARDS,there are no effective therapeutic *** of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and ***,studies on the role of extracellular vesicles(EVs)in regulating normal and pathophysiologic cell activities,including inflammation and injury responses,have attracted *** and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes,which can be used to diagnose and predict the development of ALI/*** secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function,and thereby promote cell proliferation and tissue *** review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation,particularly ALI/ARDS.

关键词： Acute lung injury(ALI) Acute respiratory distress syndrome(ARDS) Extracellular vesicles(EVs) Pulmonary inflammation Mesenchymal stem cells(MSCs)

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Effect of Chaiqinchengqi decoction on sarco/endoplasmic reticulum Ca^(2+)-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats

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World Journal of Gastroenterology 2008年第15期14卷 2343-2348页

作者： Ping Xue Li-Hui Deng Zhao-Da Zhang Xiao-Nan Yang Qing Xia Da-Kai Xiang Lei huang mei-hua wan Departnaent of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of General Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM: To investigate the effect of Chaiqinchengqi decoction (CQCQD) on sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) mRNA expression of pancreatic tissues in acute pancreatitis (AP) rats. METHODS: Thirty Sprague-Dawley (SD) rats were randomized into control group, AP group and CQCQD group (n = 3 × 10). The rats in the CQCQD group were intragastrically administered with CQCQD (10 mL/kg every 2 h) after induction of AP by intraperitoneal injection of caerulein (50 μg/kg.h × 5) within 4 h. At 6 h after the induction of AP model, pancreatic tissues were collected for the pathological observation, mRNA extraction for determination of SERCA1 and SERCA2 mRNA expression or pancreatic acinar cell isolation for measurement of fluorescence intensity (FI) of intracellular calcium ion concentration [Ca2+]i. RESULTS: There was no expression of pancreatic SERCA1 mRNA in the control group and the AP group. The expression of pancreatic SERCA2 mRNA in the AP group was down-regulated (expression ratio = 0.536; P = 0.001) compared with the control group, while that in the CQCQD group was up-regulated (expression ratio= 2.00; P = 0.012) compared with AP group. The FI of intracellular [Ca2+] of pancreatic acinar cells in the AP group (138.2 ± 23.1) was higher than the C group (111.0 ± 18.4) and the CQCQD group (118.7 ± 15.2 ) (P < 0.05) and the pancreatic pathological score in the CQCQD group was lower than that in the AP group (5.7 ± 1.9 vs 9.2 ± 2.7, P < 0.05).CONCLUSION: CQCQD can up-regulate the expression of SERCA2 mRNA of pancreatic tissues, reduce intracellular calcium overload and relieve pancreatic tissue lesions.

关键词： Chaiqinchengqi decoction Pancreatitis Calciumoverload Sarco/endoplasmic reticulum Ca^2+-ATPase

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Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

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World Journal of Gastroenterology 2020年第43期26卷 6810-6821页

作者： Jing Hu Yu-mei Zhang Yi-Fan Miao Lv Zhu Xiao-Lin Yi huan Chen Xi-Jing Yang mei-hua wan Wen-Fu Tang Department of Integrative Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Traditional Chinese Medicine Xiang’an Hospital of Xiamen UniversityXiamen 361101Fujian ProvinceChina Animal Experiment Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis(SAP).These two complications can both lead to water metabolism and acid-base balance disorders,which could act as additional critical factors affecting the disease ***(AQPs),which can regulate the transmembrane water transport,have been proved to participate in the pathophysiological process of SAP and the associated complications,such as acute lung injury and acute kidney ***,exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this *** To determine whether Yue-Bi-Tang(YBT)can regulate the water metabolism in rats with severe acute pancreatitis via regulating the expression of *** Sprague-Dawley rats were randomly divided into three groups,sham operation group(SOG),model group(MG),and treatment group(TG).SAP was induced with 3.5%sodium taurocholate in the MG and *** in the TG were administered with YBT while SOG and MG rats were given the same volume of *** and tissue samples were harvested to detect serum inflammatory cytokines,histopathological changes,malondialdehyde and superoxide dismutase in the lung,and protein and mRNA expression of kidney injury molecule-1,α-smooth muscle actin,and vimentin in the kidney,and AQP1 and 4 in the lung,pancreas,and *** The serum interleukin-10,tumor necrosis factorα,and creatinine levels were higher in the MG than in the *** necrosis factorαlevel in the TG was lower than that in the *** level in lung tissues was higher than in the *** pathological scores and edema scores of the pancreas,lung,and kidney tissues in the MG were all higher than those in the SOG and *** protein expression of AQP4 in lung tissues and AQP1 in kidney tissues in the MG were higher than those in the SOG and *** expression of vimentin was s

关键词： Yue-Bi-Tang Aquaporins Sever acute pancreatitis Acute lung injury Acute kidney injury Water metabolism

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Optimal timing for the oral administration of DaCheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis

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World Journal of Gastroenterology 2017年第39期23卷 7098-7109页

作者： Yu-mei Zhang Lin Zhu Xian-Lin Zhao huan Chen Hong-Xin Kang Jian-Lei Zhao mei-hua wan Juan Li Lv Zhu Wen-Fu Tang Department of Integrative Medicine West China Hospital Sichuan University Digestive System Department Sichuan Integrative Medicine Hospital Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital Department of Pharmacology School of Preclinical and Forensic Medicine West China Medical Center Sichuan University

AIM To identify the optimal oral dosing time of Da-Cheng-Qi decoction(DCQD) in rats with acute pancreatitis(AP) based on the pharmacokinetic and pharmacodynamic *** First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4 h G(a), 12 h G(a) and 24 h G(a)]. The NG(a) and model groups were administered DCQD(10 g/***) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate. Plasma samples were collected from the tails at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after a single dosing with DCQD. Plasma and pancreatic tissue concentrations of the major components of DCQD were determined by high-performance liquid chromatography tandem mass spectroscopy. The pharmacokinetic parameters and serum amylase were detected and compared. Second, rats were divided into a sham-operated group [NG(b)] and three treatment groups [4 h G(b), 12 h G(b) and 24 h G(b)] with three corresponding control groups [MG(b)s]. Blood and pancreatic tissues were collected 24 h after a single dosing with DCQD. Serum amylase, inflammatory cytokines and pathological scores of pancreatic tissues were detected and *** The concentrations of emodin, naringin, honokiol, naringenin, aloe-emodin, chrysophanol and rheochrysidin in the 12 h G(a) group were higher than those in the 4 h G(a) group in the pancreatic tissues(P < 0.05). The area under the plasma concentration-time curve from time 0 to the time of the last measurable concentration values(AUC0→t) for rhein, chrysophanol, magnolol and naringin in the 12 h G(a) group were larger than those in the 4 h G(a) or 24 h G(a) groups. The 12 h G(a) group had a higher Cmax than the other two model groups. The IL-10 levels in the 12 h G(b) and 24 h G(b) groups were higher than in the MG(b)s(96.55 ± 7.84 vs 77.46 ± 7.42, 251.22 ± 16.15 vs 99.72 ± 4.7 respectively, P < 0.05), while in the 24 h G(b) group, the IL-10 leve

关键词： Da-Cheng-Qi decoction Acute pancreatitis Pharmacokinetics Oral dosing time Pharmacodynamics

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Sheng-jiang powder ameliorates obesity-induced pancreatic inflammatory injury via stimulating activation of the AMPK signalling pathway in rats

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World Journal of Gastroenterology 2018年第39期24卷 4448-4461页

作者： Yi-Fan Miao Juan Li Yu-mei Zhang Lv Zhu huan Chen Ling Yuan Jing Hu Xiao-Lin Yi Qiu-Ting Wu mei-hua wan Wen-Fu Tang Department of Integrative Medicine West China HospitalSichuan University

AIM To investigate the mechanisms by which Sheng-jiang powder(SJP) ameliorates obesity-induced pancreatic inflammatory *** Sprague-Dawley rats were randomized into three groups: normal group(NG), obese group(HLG), or SJP treatment group(HSG). Obesity was induced by feeding a high-fat diet in the HLG and HSG, while the NG received standard chow. Rats were euthanized after 12 wk, and blood and pancreatic tissues were collected for histopathological analyses. Nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB) and transforming growth factor beta(TGF-β) expression, serum triglyceride and adiponectin levels, and apoptosis in pancreatic acinar cells were assessed. A high-fat AR42 J acinar cell injury model was established using very low-density lipoprotein(VLDL). AR42 J acinar cell culture supernatant, treated with different interventions, was applied to seven groups of pancreatic stellate cells(PSCs). The proliferation of PSCs and the expression of fibronectin and type I collagenase were *** Compared with the NG, we found higher pathological scores for pancreatic tissues, lower serum adiponectin levels, higher expression levels of NF-κB in pancreatic tissues and TGF-β in pancreatic inflammatory cells, and increased apoptosis among pancreatic acinar cells for the HLG(P < 0.05). Compared with the HLG, we found reduced body weight, Lee's index scores, serum triglyceride levels, and pathological scores for pancreatic tissues; higher serum adiponectin levels; and lower expression levels of NF-κB, in pancreatic tissue and TGF-β in pancreatic inflammatory cells for the HSG(P < 0.05). The in vitro studies showed enhanced PSC activation and increased expression levels of fibronectin and type I collagenase after SJP treatment. An adenosine 5‘-monophosphate-activated protein kinase(AMPK) inhibitor inhibited PSC *** SJP may ameliorate obesity-induced pancreatic inflammatory injury in rats by regulating key molecules of the

关键词： Obesity Sheng-jiang powder Adiponectin Adenosine 5’-monophosphate-activated protein kinase Pancreatic inflammatory injury

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Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet

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World Journal of Gastroenterology 2019年第6期25卷 683-695页

作者： Yi-Fan Miao Hong-Xin Kang Juan Li Yu-mei Zhang Hong-Yu Ren Lv Zhu huan Chen Ling Yuan Hang Su mei-hua wan Wen-Fu Tang Department of Integrative Medicine West China Hospital Sichuan University

BACKGROUND Obesity worsens inflammatory organ injury in acute pancreatitis(AP), but there is no effective preventive strategy. Sheng-jiang powder(SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat *** To explore how obesity may contribute to aggravating inflammatory organ injury in AP in rats and observe the effect of SJP on multiple-organ inflammatory injury in AP in rats fed a high-fat *** Rats were randomly assigned to a control group(CG), an obese group(OG), and an SJP treatment group(SG), with eight rats per group. The rats in the OG and SG were fed a high-fat diet. From the third week, the rats in the SG were given oral doses of SJP(5 g/kg of body weight). After 12 wk, AP was induced in the three groups. Serum amylase level, body weight, Lee's index, serum biochemistry parameters, and serum inflammatory cytokine and tissue cytokine levels were assessed, and the tissue histopathological scores were evaluated and *** Compared with the CG, serum triglyceride, total cholesterol, interleukin-6, and interleukin-10 levels were significantly higher in the OG, and serum high-density lipoprotein cholesterol level was significantly lower in the OG. Moreover,enhanced oxidative damage was observed in the pancreas, heart, spleen, lung,intestine, liver, and kidney. Evidence of an imbalanced antioxidant defense system, especially in the pancreas, spleen, and intestine, was observed in the obese AP rats. Compared with the OG, serum high-density lipoprotein cholesterol, interleukin-10, and superoxide dismutase expression levels in the pancreas, spleen, and intestine were increased in the SG. Additionally, SJP intervention led to a decrease in the following parameters: body weight; Lee's index; serum triglyceride levels; serum total cholesterol levels; malondialdehyde expression levels

关键词： Obesity Acute pancreatitis Sheng-jiang powder Multiple-organ inflammatory injury Oxidative stress

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A Reliable Iteration Algorithm for One-Bit Compressive Sensing on the Unit Sphere

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 801-822页

作者： Yan-cheng LU Ning BI An-hua wan School of Mathematics Sun Yat-sen UniversityGuangzhou 510275China

The one-bit compressed sensing problem is of fundamental importance in many areas,such as wireless communication,statistics,and so ***,the optimization of one-bit problem coustrained on the unit sphere lacks an algorithm with rigorous mathematical proof of convergence and *** this paper,an iteration algorithm is established based on difference-of-convex algorithm for the one-bit compressed sensing problem constrained on the unit sphere,with iterating formula■,where C is the convex cone generated by the one-bit measurements andη_(1)>η_(2)>1/*** new algorithm is proved to converge as long as the initial point is on the unit sphere and accords with the measurements,and the convergence to the global minimum point of the l_(1)norm is discussed.

关键词： one-bit compressed sensing difference of convex algorithm iteration algorithm ■1-minimization

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