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受偿意愿在确定生态补偿标准上下限中的作用

中国环境科学 2021年第4期41卷 1932-1939页

作者：潘美晨宋波北京科技大学能源与环境工程学院北京100083

受偿意愿(WTA)是制定生态补偿标准的常用依据之一,能否正确使用WTA对于制定合理的补偿标准具有重要影响.本文梳理了国内近12a的相关文献,发现在WTA应作为生态补偿标准的上限还是下限问题上尚无定论,尽管大多数研究将WTA作为补偿标准下限... 详细信息

受偿意愿(WTA)是制定生态补偿标准的常用依据之一,能否正确使用WTA对于制定合理的补偿标准具有重要影响.本文梳理了国内近12a的相关文献,发现在WTA应作为生态补偿标准的上限还是下限问题上尚无定论,尽管大多数研究将WTA作为补偿标准下限,但背后的逻辑并不严谨.本文认为生态补偿标准制定过程可视为受偿方和支付方的讨价还价过程,因此WTA实际上是受偿方的出价,应作为补偿标准上限.另外,本文从WTA、支付意愿(WTP)是区间的角度进行分析,判断补偿标准可取的范围,发现当调查得到的WTA大于WTP时,仍存在谈成的可能性;当调查得到的WTA小于WTP时,实际达成空间大于表面达成空间,决策者拥有更大的选择空间.

关键词：生态补偿条件价值评估法受偿意愿生态补偿标准

Prediction and analysis of albumin-bilirubin score combined with liver function index and carcinoembryonic antigen on liver metastasis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1670-1680页

作者： Zhan-mei Wang Shu-Ping pan Jing-Jing Zhang Jun Zhou Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Gastroenterology Feicheng People’s HospitalFeicheng 271600Shandong ProvinceChina Department of Anus and Intestine Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a common malignant tumor,and liver metastasis is one of the main recurrence and metastasis modes that seriously affect patients’survival rate and quality of *** such as albumin bilirubin(ALBI)score,liver function index,and carcinoembryonic antigen(CEA)have shown some potential in the prediction of liver metastasis but have not been fully *** To evaluate its predictive value for liver metastasis of CRC by conducting the combined analysis of ALBI,liver function index,and CEA,and to provide a more accurate liver metastasis risk assessment tool for clinical treatment *** This study retrospectively analyzed the clinical data of patients with CRC who received surgical treatment in our hospital from January 2018 to July 2023 and were followed up for 24 *** to the follow-up results,the enrolled patients were divided into a liver metastasis group and a nonliver metastasis group and randomly divided into a modeling group and a verification group at a ratio of 2:*** risk factors for liver metastasis in patients with CRC were analyzed,a prediction model was constructed by least absolute shrinkage and selection operator(LASSO)logistic regression,internal validation was performed by the bootstrap method,the reliability of the prediction model was evaluated by subject-work characteristic curves,calibration curves,and clinical decision curves,and a column graph was drawn to show the prediction *** Of 130 patients were enrolled in the modeling group and 65 patients were enrolled in the verification group out of the 195 patients with CRC who fulfilled the inclusion and exclusion *** LASSO regression variable screening and logistic regression *** ALBI score,alanine aminotransferase(ALT),and CEA were found to be independent predictors of liver metastases in CRC patients[odds ratio(OR)=8.062,95%confidence interval(CI):2.545-25.540],(OR=1.037,95%CI:1.004-1.071)and(OR=1.0

关键词： Albumin-bilirubin Carcinoembryonic antigen Colorectal cancer Tumor metastasis Prediction model

斑蝥酸钠在诱导人宫颈癌Hela细胞凋亡相关基因表达中的作用机制研究

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临床医药实践 2024年第7期33卷 487-491页

作者：华金仁程慧明黄雪媚陈瑾涂云霞汪利群潘玫江西省妇幼保健院江西南昌330006 景德镇市中医院江西景德镇333000

目的:探讨斑蝥酸钠在诱导人宫颈癌Hela细胞凋亡相关基因表达中的作用机制。方法:2023年1月—2023年12月购买1株人宫颈癌Hela细胞,培养至对数生长期后开始实验,将其分为4组,分别加斑蝥酸钠0μmol/L(空白对照组)、4μmol/L(4μmol/L组)、8... 详细信息

目的:探讨斑蝥酸钠在诱导人宫颈癌Hela细胞凋亡相关基因表达中的作用机制。方法:2023年1月—2023年12月购买1株人宫颈癌Hela细胞,培养至对数生长期后开始实验,将其分为4组,分别加斑蝥酸钠0μmol/L(空白对照组)、4μmol/L(4μmol/L组)、8μmol/L(8μmol/L组)和16μmol/L(16μmol/L组),每个浓度分别设置5个复孔(每组样本量为5),以细胞活力试验(CCK-8)检测细胞增殖情况,以流式细胞仪检测细胞凋亡情况,以实时荧光定量多聚核苷酸链式反应(Real-time PCR)检测B淋巴细胞瘤2(BCL-2)、人细胞凋亡调节因子(Bax)、人半胱氨酸蛋白酶3(Caspase-3)的表达情况。结果:4μmol/L组、8μmol/L组和16μmol/L组的细胞增殖抑制率、凋亡率和Caspase-3相对表达量水平均高于空白对照组,BCL-2/Bax相对表达量水平低于空白对照组,差异均有统计学意义(P<0.05)。随着斑蝥酸钠浓度的升高,人宫颈癌Hela细胞增殖抑制率、凋亡率和Caspase-3随之也升高,BCL-2/Bax相对表达量逐渐下降,差异均有统计学意义(P<0.05)。经斑蝥酸钠处理后可见细胞皱缩、变圆,细胞边缘出芽形成多花环结构的凋亡小体。结论:斑蝥酸钠具有抑制人宫颈癌Hela细胞增殖、促进其凋亡的作用,具有剂量依赖性,其对细胞凋亡的调控作用可能与调控BCL-2,Bax和Caspase-3表达有关。

关键词：人宫颈癌Hela细胞斑蝥酸钠细胞凋亡细胞增殖抑制率

New polychlorinated bibenzyls from Rhododendron minutiflorum

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Natural Products and Bioprospecting 2023年第1期13卷 709-717页

作者： Yang-Li Zhu Li Deng Yu Tang Xian-Zhe Fan Yang Han mei pan Li-Jun Zhang Hai-Bing Liao State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004People’s Republic of China Guangxi Key Laboratory of Citrus Biology Guangxi Academy of Specialty CropsGuilin 541004People’s Republic of China Guilin Pharma Company Guilin 541007People’s Republic of China

Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron *** chemical structures of all the isolates were determined by spectroscopic methods,and compounds 1 and 2 were further verified by single-crystal X-ray diffraction *** 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical ***-cally,compounds 2,5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid(Diaphorina citri)with LD_(50) values 27.15,17.02 and 16.20 mg/L,*** values were comparable to the positive control matrine(LD_(50)=11.86 mg/L),which were calculated using observations on day ***,compound 4 hadα-glucosidase inhibitory activity with IC_(50) value of 17.87±0.74μM.

关键词： Rhododendron minutiflorum Polychlorinated bibenzyls Matrine Insecticidal activity Diaphorina citri α-Glucosidase inhibitory activity Acarbose

Dynamic Fluorescence Quenching of Pd6（RuL3）8 Metal-Organic Cages（MOCs） by Ferrocene Derivatives

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Dynamic Fluorescence Quenching of Pd6（RuL3）8 Metal-Organic...

Highly Efficient DCL, UCL, and TPEF in Hybridized Ln-Complexes from Ir-Metalloligand

第七届全国物理无机化学学术会议

作者： Kai Wu mei pan Cheng-Yong Su School of Chemistry and Chemical Engineering Sun Yat-sen University

＜正＞Coordination driven assembly of metal-organic cages with well-defined shapes and unique cavities is emerging as an appealing approach in supramolecular chemistry during the past *** to their beautiful structures,intriguing host-guest properties and potentials in chiral recognition,catalysis,as well as drug delivery and release,metal-organic cages（MOCs）have received considerable *** goup

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CCS Chemistry 2021年第2期3卷 729-738页

作者： Jun-Ting Mo Zheng Wang Peng-Yan Fu Lu-Yin Zhang Ya-Nan Fan mei pan Cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275 State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730050 State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

In molecular level lanthanide complexes,it is still challenging to achieve near-infrared(NIR)down-conversion luminescence(DCL)and visible up-conversion luminescence(UCL)efficiently under ambient *** delicate design of hybridized iridium−europium−ytterbium(Ir–Eu–Yb)trimetallic complexes from an Ir-metalloligand,DCL and UCL emissions with opposite photon conversion pathways were achieved simultaneously in one integrated *** detail,three different types of energy transfer(ET)and photoluminescence(PL)were detected,as follows:(1)Highly sensitized NIR-DCL from Yb(III)center via ETIr→Eu→Yb,which gave the longest decay lifetime(553μs)at room temperature ever reported in solid-state Yb-complexes.(2)Unprecedented UCL red emission from Eu(III)center via ETYb→Eu using 980 nm continuous wavelength(CW)laser excitation,which required ultralow energy threshold(0.616W/cm2).(3)Two-photon excited fluorescence(TPEF)via ETIr→Eu using femtosecond pulsed laser *** exquisite module of“one stone,three birds”provides a new stimulus in the design and application of multifunctional UCL/DCL/TPEF optical materials under ambient conditions.

关键词： NIR up-conversion down-conversion,two-photon d–f heteronuclear

Design,preparation,microstructure and mechanical property of the lightweight radiation-shielding Mg-Ta-Al composites basing differential temperature hot rolling

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Journal of Magnesium and Alloys 2024年第6期12卷 2433-2446页

作者： Wenbo Luo Songya Feng Xiuzhu Han Li Zhou Qinke Kong Zhiyong Xue Jianzhao Wang mei Zhan Xianhua Chen Fusheng pan Institute for Advanced Materials North China Electric Power UniversityBeijing 102206China Beijing Institute of Spacecraft System Engineering Beijing 100094China Sinosteel Equipment&Engineering Co Ltd.Beijing100080China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Inner Mongolia 014030China School of Materials Science Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China

A novel lightweight,radiation-shielding Mg-Ta-Al layered metal-matrix composite(LMC)was successful designed by doping the extremely refractory metal(Ta)into Mg *** Mg-based LMCs sheets shows excellent radiation-dose shield effect,about 145 krad·a^(−1),which is about 17 times of traditional Mg alloy,while its surface density is only about 0.9 g·cm^(−2),reducing by 60%than that of pure *** quantitate relationship between radiation-dose and the materials’thickness was also confirmed to the logistic function when the surface density is in the range of 0.6-1.5 g·cm^(−2).Meantime,the rolling parameters,interface microstructure and mechanical properties in both as-rolled and annealing treated samples were *** sheets possess a special dissimilar atoms diffusion transitional zone containing an obvious inter-diffusion Mg-Al interface and the unique micro-corrugated Ta-Al interface,as well as a thin Al film with a thickness of about 10μ*** special zone could reduce the stress concentration and enhance the strength of Mg-Ta-Al *** interface bonding strength reaches up to 54-76 *** ultimate tensile strength(UTS)and yield strength(TYS)of the Mg-Ta-Al sheet were high to 413 MPa and 263 MPa,respectively,along with an elongation of 5.8%.The molecular dynamics(MD)analysis results show that the two interfaces exhibit different formation mechanism,the Mg-Al interface primarily depended on Mg/Al atoms diffusion basing point defects movement,while the Ta-Al interface with a micro-interlock pining shape formed by close-packed planes slipping during high temperature strain-induced deformation process.

关键词： Dissimilar metals composites Mg based alloys Radiation shielding Hot rolling Lightweight

子宫内膜癌腹腔液细胞学阳性及相关因素与预后关系的研究

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中华肿瘤防治杂志 2010年第7期17卷 538-540页

作者：潘玫江西省妇幼保健院肿瘤科江西南昌330006

目的:探讨腹腔液细胞学检查阳性与子宫内膜癌分期及各项危险因素之间关系,评估腹腔液细胞学检查对预后意义影响。方法:对93例接受手术治疗临床Ⅰ、Ⅱ期子宫内膜癌患者的临床资料进行回顾性分析。结果:93例手术中腹腔液细胞学检查患者中... 详细信息

目的:探讨腹腔液细胞学检查阳性与子宫内膜癌分期及各项危险因素之间关系,评估腹腔液细胞学检查对预后意义影响。方法:对93例接受手术治疗临床Ⅰ、Ⅱ期子宫内膜癌患者的临床资料进行回顾性分析。结果:93例手术中腹腔液细胞学检查患者中,阳性14例,检出率15.1%,Ⅰ期检出率11.1%(7/63),因腹腔液细胞学阳性所致分期变更Ⅰ、Ⅱ期分别为11.1%和34.1%,93例手术患者随访71例,16例死亡,死亡时间术后2～60个月,3例非癌症死亡,死亡病例中腹腔液阳性2例。单纯腹腔液阳性患者生存期>5年,2例腹腔液阳性死亡患者,同时合并宫外转移和淋巴转移。腹腔液阳性与阴性患者比较,5年生存率分别为85.7%和80.7%,差异无统计学意义。结论:单纯腹腔液阳性与预后无显著相关性,腹腔液阳性与宫外转移、不良病理分级、深肌层浸润等危险因素有相关性,当腹腔液阳性患者合并宫外转移、深肌层浸润需重视,并给予积极处理。

关键词：子宫内膜肿瘤细胞学技术预后

ATP6AP2,a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei Xiong Hao-Han Guo Jin-Xiu pan Xiao Ren Daehoon Lee Li Chen Lin mei Wen-Cheng Xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2,an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2 in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2 in the OB-lineage cells(Atp6ap2^(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2-KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2-KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2-KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2 is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2-KO *** together,these results support the view for ATP6AP2 as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2 in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs