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Antimicrobial resistance crisis:could artificial intelligence be the solution?

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Military Medical Research 2025年第1期12卷 72-95页

作者： Guang-yu Liu dan yu mei-mei Fan Xu Zhang Ze-yu Jin Christoph Tang Xiao-Fen Liu Department of Immunology and Pathogen Biology School of Basic Medical SciencesHangzhou Normal UniversityKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceKey Laboratory of Inflammation and Immunoregulation of HangzhouHangzhou Normal UniversityHangzhou 311121China National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education Laboratory of DermatologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Robert and Arlene Kogod Center on Aging Mayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Institute of Antibiotics Huashan HospitalFudan UniversityKey Laboratory of Clinical Pharmacology of AntibioticsNational Health Commission of the People’s Republic of ChinaNational Clinical Research Centre for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

Antimicrobial resistance is a global public health threat,and the World Health Organization(WHO)has announced a priority list of the most threatening pathogens against which novel antibiotics need to be *** discovery and introduction of novel antibiotics are time-consuming and *** to WHO’s report of antibacterial agents in clinical development,only 18 novel antibiotics have been approved since ***,novel antibiotics are critically *** intelligence(AI)has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel ***,we first summarized recently marketed novel antibiotics,and antibiotic candidates in clinical *** addition,we systematically reviewed the involvement of AI in antibacterial drug development and utilization,including small molecules,antimicrobial peptides,phage therapy,essential oils,as well as resistance mechanism prediction,and antibiotic stewardship.

关键词： Antibiotic Artificial intelligence(AI) Clinical development Machine learning(ML) Antimicrobial peptide Phage therapy Antibiotic stewardship

Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： yu-mei Wang mei-Xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina Guo-Hong Ning dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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A revised classification of Dryopteridaceae based on plastome phylogenomics and morphological evidence,with the description of a new genus,Pseudarachniodes

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Plant Diversity 2025年第1期47卷 34-52页

作者： Zheng-yu Zuo Germinal Rouhan Shi-Yong Dong Hong-mei Liu Xin-yu Du Li-Bing Zhang Jin-mei Lu Germplasm Bank of Wild Species and Yunnan Key Laboratory of Crop Wild Relatives OmicsKunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Institut de Systematique EvolutionBiodiversite(ISYEB)Museum National d’Histoire NaturelleCNRSSorbonne UniversiteEcole Pratique des Hautes EtudesUniversite des AntillesCP3957 rue Cuvier 75005ParisFrance Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650GuangdongChina Center for Integrative Conservation&yunnan Key Laboratory for Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun 666303YunnanChina Missouri Botanical Garden 4344 Shaw BlvdSt Louis 63110MOUSA Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina

Dryopteridaceae are the largest fern family and include nearly 20%of extant fern diversity,with 24 currently recognized *** and delineation of genera within this family have varied *** three-subfamily classification of Dryopteridaceae was based primarily on molecular phylogenetic relationships but lacked morphological evidence,and the phylogenetic relationships of the subfamilies and genera of Dryopteridaceae are only partially resolved.A comprehensive and robust phylogeny is urgently *** heterogeneous morphology of the current members of Dryopteridaceae makes the family and its subfamilies difficult to define by single morphological characteristics or even character *** carried out phylogenetic analyses to reconstruct a highly supported phylogeny of *** analyses recovered 24 strongly supported clades grouped into seven major clades of *** morphological characters including habit,rhizome shape,frond morphology,rachis-costae architecture,appendages on stipe base and lamina,and soral arrangement were found to be informative for identifying different major clades and clades in *** on phylogenetic reconstruction and morphological analysis,we presented an updated infra-familial classification of Dryopteridaceae with seven subfamilies and 24 genera including four newly proposed subfamilies(Ctenitidoideae,Lastreopsidoideae,Pleocnemioideae,and Polystichopsidoideae).Morphological character combinations of each subfamily are summarized,and a key is *** genera sensu PPG I are recognized,with Stigmatopetris reclassified into Dryopteridoideae and Arthrobotrya considered a synonym of Teratophyllum.A new genus Pseudarachniodes is *** revised classification will serve as a foundational framework for future investigations on taxonomy,biogeography,and diversification of the most species-rich Dryopteridaceae in ferns.

关键词： Ctenitidoideae Infra-familial Morphological diagnostic characters Phylogenomics Rachis-costae architecture Stigmatopetris

Nonlinear waves for a variable-coefficient modified Kadomtsev-Petviashvili system in plasma physics and electrodynamics

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Communications in Theoretical Physics 2025年第1期77卷 23-34页

作者： Guang-mei Wei yu-Xin Song Tian-Chi Xing Shu Miao School of Mathematical Sciences Beihang University100191 BeijingChina

In this paper,a variable-coefficient modified Kadomtsev-Petviashvili(vcm KP)system is investigated by modeling the propagation of electromagnetic waves in an isotropic charge-free infinite ferromagnetic thin film and nonlinear waves in plasma physics and ***éanalysis is given out,and an auto-B?cklund transformation is constructed via the truncated Painlevé*** on the auto-B?cklund transformation,analytic solutions are given,including the solitonic,periodic and rational *** the Lie symmetry approach,infinitesimal generators and symmetry groups are *** the Lagrangian,the vcm KP equation is shown to be nonlinearly ***,conservation laws for the vcm KP equation are derived by means of a general conservation ***,the physical characteristics of the influences of the coefficient parameters on the solutions are discussed *** solutions have comprehensive implications for the propagation of solitary waves in nonuniform backgrounds.

关键词： modified Kadomtsev-Petviashvili equation Lie symmetry optimal system nonlinear self-adjointness conservation law symbolic computation

Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury

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CHINESE JOURNAL OF INTEGRATIVE MEDICINE 2025年第3期31卷 270-280页

作者： Chen, yu-qing Zhang, Yan-xian Zhang, Xu Lyu, Yong-mei Miao, Zeng-li Liu, Xiao-yu Duan, Xu-chu Nantong Univ Nantong Lab Dev & Dis Key Lab Neuroregenerat Jiangsu Sch Life SciAffiliated Hosp Nantong 226019 Jiangsu Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Minist Educ Nantong 226019 Jiangsu Peoples R China Nantong Univ Dept Pharm Dept Endocrine Affiliated Hosp Nantong 226006 Jiangsu Peoples R China Xuzhou Med Univ Jiangsu Key Lab New Drug Res & Clin Pharm Xuzhou 221004 Jiangsu Peoples R China Nantong Univ Affiliated Wuxi Clin Coll Wuxi 2 Peolpes Hosp Clin Med Res CtrMed CtrDept NeurosurgJiangnan U Wuxi 214002 Jiangsu Peoples R China Yancheng Inst Technol Sch Marine & Bioengn Yancheng 224007 Jiangsu Peoples R China

Peripheral nerve injury (PNI) encompasses damage to nerves located outside the central nervous system, adversely affecting both motor and sensory functions. Although peripheral nerves possess an intrinsic capacity for self-repair, severe injuries frequently result in significant tissue loss and erroneous axonal junctions, thereby impeding complete recovery and potentially causing neuropathic pain. Various therapeutic strategies, including surgical interventions, biomaterials, and pharmacological agents, have been developed to enhance nerve repair processes. While preclinical studies in animal models have demonstrated the efficacy of certain pharmacological agents in promoting nerve regeneration and mitigating inflammation, only a limited number of these agents have been translated into clinical practice to expedite nerve regeneration. Chinese herb medicine (CHM) possesses a longstanding history in the treatment of various ailments and demonstrates potential efficacy in addressing PNI through its distinctive, cost-effective, and multifaceted methodologies. This review critically examines the advancements in the application of CHM for PNI treatment and nerve regeneration. In particular, we have summarized the most commonly employed and rigorously investigated CHM prescriptions, individual herbs, and natural products, elucidating their respective functions and underlying mechanisms in the context of PNI treatment. Furthermore, we have deliberated on the prospective development of CHM in both clinical practice and fundamental research.

关键词： peripheral nerve injury peripheral nerve regeneration Chinese herb medicine natural product mechanism

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紫杉醇长循环肝靶向脂质体的制备

军事医学科学院院刊 2008年第4期32卷 359-361页

作者：杨瑞梅丹宇杨媛梅兴国军事医学科学院毒物药物研究所北京100850

目的:制备紫杉醇长循环肝靶向脂质体(pac-GLs),并对制备的脂质体的性质进行评价。方法:用薄膜水化-高压均质法制备紫杉醇长循环肝靶向脂质体,纳米粒度测定仪测定其粒径,高效液相法测定其包封率。结果:制备的紫杉醇长循环肝靶向脂质体中... 详细信息

目的:制备紫杉醇长循环肝靶向脂质体(pac-GLs),并对制备的脂质体的性质进行评价。方法:用薄膜水化-高压均质法制备紫杉醇长循环肝靶向脂质体,纳米粒度测定仪测定其粒径,高效液相法测定其包封率。结果:制备的紫杉醇长循环肝靶向脂质体中的药物浓度为(1.00±0.10)mg/m l,包封率为(94±3)%。结论:本研究制备的紫杉醇长循环肝靶向脂质体包封率较高,质量可控,重复性好。

关键词：紫杉醇肝靶向脂质体制备

橙皮素抑制P-选择素诱导的乳腺癌转移作用机制研究

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中草药 2017年第4期48卷 714-721页

作者：毛晨梅郁丹红桂环苏州大学附属儿童医院江苏苏州215000

目的探究橙皮素对P-选择素介导的MDA-MB-231乳腺癌细胞转移的影响及其作用机制。方法运用计算机虚拟对接技术体外评价橙皮素与P-选择素的结合能力;采用MDA-MB-231乳腺癌细胞为模型,MTS法观察不同浓度的橙皮素/P-选择素对MDA-MB-231生长... 详细信息

目的探究橙皮素对P-选择素介导的MDA-MB-231乳腺癌细胞转移的影响及其作用机制。方法运用计算机虚拟对接技术体外评价橙皮素与P-选择素的结合能力;采用MDA-MB-231乳腺癌细胞为模型,MTS法观察不同浓度的橙皮素/P-选择素对MDA-MB-231生长能力的影响;ELISA法检测橙皮素对活化的血小板表面P-选择素分泌的影响;黏附实验考察橙皮素对P-选择素介导的MDA-MB-231与内皮细胞黏附的影响;Transwell实验分析橙皮素对P-选择素促进MDA-MB-231乳腺癌细胞迁移的影响;采用Western blotting法考察橙皮素对MDA-MB-231细胞表面糖蛋白(Mucin-1)、整合素(Integrinβ3、β1)及基质金属蛋白酶(MMP-2、MMP-9)蛋白表达的影响;进一步分析橙皮素对MDA-MB-231细胞Integrin-MMP信号通路的影响,阐明橙皮素抗肿瘤转移的作用机制。结果计算机虚拟对接技术证实橙皮素与P-选择素有较好的结合能力;在体外橙皮素能剂量依赖性抑制MDA-MB-231增殖及其与内皮细胞的黏附;橙皮素能降低活化的血小板表面P-选择素的分泌;迁移实验中橙皮素能显著抑制P-选择素介导的MDA-MB-231乳腺癌细胞迁移;降低P-选择素诱导的细胞表面糖蛋白Mucin-1、Integrinβ3、Integrinβ1及MMP-2、MMP-9蛋白的表达。结论橙皮素具有抑制MDA-MB-231乳腺癌细胞生长能力,阻断P-选择素诱导的乳腺癌MDA-MB-231肿瘤细胞迁移以及其与内皮细胞的黏附,其机制为橙皮素通过竞争性结合P-选择素,阻断其与Mucin-1的结合,抑制PI3K-AKT-Paxillin-FAK-Src信号通路,下调P-选择素调控的Integrins及MMP-2、MMP-9表达。

关键词：橙皮素 P-选择素计算机虚拟对接 MDA-MB-231 肿瘤转移基质金属蛋白酶整合素

Predicting Lactobacillus delbrueckii ***-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method

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Science China(Life Sciences) 2025年第2期68卷 558-574页

作者： Shujuan Yang mei Bai Weichi Liu Weicheng Li Zhi Zhong Lai-yu Kwok Gaifang Dong Zhihong Sun Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China College of Computer and Information Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application of Agriculture and Animal Husbandry Hohhot 010018China

Lactobacillus delbrueckii ***(***)and Streptococcus thermophilus(***)are commonly used starters in milk *** experiments revealed that *** interactions(Lb St I)substantially impact dairy product quality and *** biological humidity experiments are time-consuming and labor-intensive in screening interaction combinations,an artificial intelligence-based method for screening interactive starter combinations is ***,in the current research on artificial intelligence based interaction prediction in the field of bioinformatics,most successful models adopt supervised learning methods,and there is a lack of research on interaction prediction with only a small number of labeled ***,this study aimed to develop a semi-supervised learning framework for predicting Lb St I using genomic data from 362 isolates(181per species).The framework consisted of a two-part model:a co-clustering prediction model(based on the Kyoto Encyclopedia of Genes and Genomes(KEGG)dataset)and a Laplacian regularized least squares prediction model(based on K-mer analysis and gene composition of all isolates datasets).To enhance accuracy,we integrated the separate outcomes produced by each component of the two-part model to generate the ultimate Lb St I prediction results,which were verified through milk fermentation *** through milk fermentation experiments confirmed a high precision rate of 85%(17/20;validated with 20 randomly selected combinations of expected interacting isolates).Our data suggest that the biosynthetic pathways of cysteine,riboflavin,teichoic acid,and exopolysaccharides,as well as the ATP-binding cassette transport systems,contribute to the mutualistic relationship between these starter bacteria during milk ***,this finding requires further experimental *** presented model and data are valuable resources for academics an

关键词： Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus interaction prediction semi-supervised learning dairy starter artificial intelligence milk fermentation

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-yu Jiang dan-dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-Chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts