检索结果-南通市图书馆

Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 687-696页

作者： Longqing Zhang Xi Tan Fanhe Song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang Liu Yaqun Zhou wei mei Department of Anesthesiology Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Healthand Wuhan Clinical Research Center for Geriatric AnesthesiaTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR39 attenuates neuropathic pain remains *** this study,we established a Sprague-Dawley rat model of spared nerve injury-induced neuropathic pain and found that GPR39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated *** injection of TC-G 1008,a specific agonist of GPR39,significantly alleviated mechanical allodynia in the rats with spared nerve injury,improved spinal cord mitochondrial biogenesis,and alleviated *** changes were abolished by GPR39 small interfering RNA(siRNA),Ex-527(SIRT1 inhibitor),and PGC-1α*** together,these findings show that GPR39 activation ameliorates mechanical allodynia by activating the SIRT1/PGC-1αpathway in rats with spared nerve injury.

关键词： G-protein-coupled receptor 39(GPR39) neuroinflammation neuropathic pain nuclear respiratory factor 1(NRF1) peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) sirtuin 1(SIRT1) spinal cord mitochondrial transcription factor A(TFAM)

Association between islet autoantibodies and the prevalence of autoimmune uveitis

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第11期13卷 1733-1738页

作者： Yun Zhang Ni Yan Ya Li wei-mei Ma Hong-Li Liu Jing-Ni Yu Le Ma Xi'an People's Hospital(Xi'an Fourth Hospital) Xi'an 710004Shaanxi ProvinceChina School of Public Health Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina

AIM:To evaluate the predictive value of islet autoantibodies for the diagnosis of autoimmune uveitis(AU),as well as to characterize the association bet ween islet autoantibodies and ***:Totally 97 patients with AU and 100 healthy persons without any autoimmune diseases as the control group were *** serum islet autoantibodies were measured using commercial enzyme-linked immunosorbent assay kits(ELISA).A supplementary questionnaire was used to complement the subject's demographics and clinical *** level of glucose concentrations and white blood cells were *** logistic regression was performed to estimate odds ratios(ORs),and 95%confidence intervals(CIs)of AU according to islet autoantibodies and to evaluate the predictive value of islet autoantibodies for AU *** subgroups and other variables were included into ***:In AU patients,the prevalence of detecting at least one of the autoantibodies was 31.9%(31/97).The most frequent autoantibody was ZnT8A(30.9%),followed by GADA(11.3%),IA-2A(4.1%),ICA(2.1%)and IAA(2.1%).Islet autoantibodies were found to be correlated positively with AU diagnosis[OR(95%CI):13.86(3.28,58.50),P<0.001].Moreover,Zn-T8A was remarkably correlated with AU diagnosis[OR(95%CI):6.13(1.96,19.17),P<0.001],In contrast,neither GADA nor other islet antibodies(IA-2A,ICA and IAA)showed any association with AU risk under an additive ***:The prevalence of islet antibodies,especially ZnT8A,in patients with AU is *** antibodies as well as novel biomarkers should be included in routine evaluation at AU and is a valuable biological marker to classify newly-diagnosed uveitis.

关键词： autoimmune uveitis islet autoantibody ZnT8A epidemiology

First record of Stigmatijanus wei(Hymenoptera: Cephidae) from South Korea with description of a new species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Systematics 2015年第1期40卷 103-106页

作者： mei-Cai wei Jin-Kyung Choi Jong-Wook Lee Key Laboratory of Cultivation and Protection for Non–Wood Forest Trees (Central South University of Forestry) and Technology Ministry of Education Department of Life Sciences Yeungnam University

The genus Stigmatijanus wei, 2007 is recorded from Korea for the first time. A diagnosis of the genus is briefly discussed. A new species, Stigmatijanus koreanus sp. nov., is described from Mt. Homyeong, Gyeonggi-do, ... 详细信息

关键词： Hartigiinae new species new record South Korea Prunus.

Linguistic Dimensions of Accentedness,Comprehensibility and Intelligibility:Exploring Listener Effects in American,Moroccan,Turkmen and Chinese Varieties of English

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Applied Linguistics 2021年第4期44卷 520-542,590页

作者： mei wei Tianjin Foreign Studies University

The present study examines accentedness, comprehensibility, and intelligibility of American English, Moroccan English, Turkmen English, and Chinese English, from the perspectives of three groups of listeners: native speakers of English and Chinese speakers of English with or without international experiences. Of the 145 listeners, 38 had face-to-face interviews. These listener groups were asked to listen to the recordings of the four English varieties and fill in a cloze *** indicated that the three listener groups differed significantly in rating comprehensibility of American English, Moroccan English and Chinese English but they did not give Turkmen English statistically different ratings;there were no significant differences in accentedness ratings except for Chinese English;and there were significant differences in the intelligibility scores of the four English varieties. In addition, with respect to seven linguistic variables-speed, clarity, intonation,smoothness and fluency, vocal intensity, pause, vocabulary and grammar, there were significant differences in three listener groups’ rating of six variables in American English except the one of“speed”. By contrast, Chinese English received significantly different ratings only in “proper speed”. No differences were found in the ratings for Moroccan English and Turkmen ***, unlike Chinese listeners without international experiences, native listeners and Chinese listeners with international experiences shared some similarities in correlations between the ratings of accentedness and comprehensibility and those of linguistic variables on Moroccan English,Turkmen English, and Chinese English. However, the results for American English from Chinese listeners without international experiences and native listeners seemed to be more alike. Linguistic variables correlating with accentedness and comprehensibility of American English showed a mixed profile. Qualitative data provided more variant elaborati

关键词： accentedness comprehensibility intelligibility English varieties linguistic variables

Prognostic Factors for Patients with FIGO Stage-IB Cervical Squamous Cell Carcinoma:Does the Tumor Size(≤4 cm or>4 cm)Really Matter?

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2007年第2期4卷 115-120页

作者： Ying Xiong Lizhi Liang Xiaoping Peng mei wei Yang Shen Department of Gynecologic Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

OBJECTIVE To investigate the factors that can accurately predict the prognosis for patients with FIGO stage-IB cervical squamous cell carcinoma treated with radical surgery. METHODS A retrospective analysis of clinical data from 174 cases of FIGO Stage-IB cervical squamous cell carcinoma treated in our institute was conducted. RESULTS The 5-year overall disease-free survival of the patients was 79.4% and the recurrence rate was 16.7%. Seventy-five percent of the 60 patients with a tumor 〉 4 cm and 28.1% of the 114 patients with a tumor ≤ 4 cm received preoperative radiotherapy, resuting in a significant difference between the two groups （P 〈 0.001）. The 5-year disease-free survival rate for the groups with a tumor ≤ 4 cm without and with preoperative radiotherapy, and with a tumor 〉 4 cm without and with preoperative radiation therapy were 80.5%, 85.2%, 69.3% and 77.1%, respectively. There was no significant difference between any of the groups （P 〉 0.05）. A univariate analysis showed that pelvic node metastasis, a positive parametrial surgical margin and postoperative adjuvant therapy were all significantly correlated with the 5-year disease-free survivals （P 〈 0.05）. Multivariate analysis revealed that pelvic node metastasis （P = 0.004） and a positive parametrial surgical margin （P = 0.040） were independent factors that influenced the prognosis. The 5-year disease-free survivals for the cases with a tumor ≤ 4 cm and 〉 4 cm were 57.4% and 44.7% respectively in the high-risk group （patients with pelvic lymphatic metastasis and/or positive parametrial surgical margin）（P=0.575） and the recurrence ratio was 7/18 and 6/14 for the cases of the two tumor sizes in the same risk group. There was no significant difference between the two groups （P=0.821）. The 5-year disease-free survivals for the cases with a tumor ≤ 4 cm and 〉 4 cm were 86.5% and 82.9% respectively in the low-risk group （patients without pelvic lymph-node metastasis and/or positive parametrial surgical

关键词： cervical neoplasm tumor size prognosis

A Switchable and Tunable Dual-Wavelength Actively Mode-Locked Fiber Laser Based on Dispersion Tuning

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2012年第12期29卷 93-96页

作者： mei Jia-wei XIAO Xiao-Sheng GUI Li-Li XU Ming-Rui YANG Chang-Xi State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua UniversityBeijing 100084

A switchable and tunable dual-wavelength actively mode-locked fiber laser based on a dispersion tuning technique is proposed and *** wavelength tuning of dual-wavelength operation with wavelength spacing of 22.9 nm can be achieved up to 23.2 nm by changing the modulation *** proposed laser can operate in dual-wavelength or single-wavelength by simple adjustment of the polarization ***,wavelength spacing can also be varied from 22 to 45 nm at the cost of a reduced tuning range by changing the harmonic order,which is determined by the modulation *** experimental observations agree well with the theoretical analysis.

关键词： tuning polarization spacing

One New Gray Differential Equation of GM（1,1） Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

信息工程期刊（中英文版） 2013年第6期3卷 104-110页

作者： mei Fan Yong wei College of Mathematics and Information China West Normal University Nanchong Sichuan 637002 China

Association between admission hemoglobin level and prognosis in patients with type 2 diabetes mellitus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第11期12卷 1917-1927页

作者： Hai-Ying Song Cui-mei wei Wen-Xiong Zhou Hao-Fei Hu Qi-Jun Wan Department of Nephrology The First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518035Guangdong ProvinceChina Department of Nephrology Shenzhen University Health Science CenterShenzhen 518035Guangdong ProvinceChina

BACKGROUND Anaemia is common in patients with chronic kidney disease(CKD)and is a major risk factor that contributes to mortality in such *** 2 diabetes mellitus(T2DM)is one of the leading causes of *** association between admission hemoglobin levels and renal damage in patients with T2DM remains *** To evaluate the relationship between admission hemoglobin levels and prognosis in patients with *** We performed a retrospective analysis of 265 consecutive patients presenting with T2DM between 2011 and *** composite endpoint was end-stage renal disease or a 50%reduction in the estimated glomerular filtration *** In multivariable-adjusted Cox proportional hazards models(adjusting for demographic factors,traditional risk factors,lipids),the adjusted hazard ratios(HRs)for the highest and middle tertiles compared to the lowest tertile of hemoglobin were 0.82(95%CI:0.11-6.26,P=0.8457)and 0.28(95%CI:0.09-0.85,P=0.0246),***,after further adjustment for glycaemia control,hemoglobin was positively related to the risk of the composite endpoint(HR:1.05,95%CI:0.14-8.09,P=0.9602)when the highest tertile was compared to the lowest tertile of *** found a U-shaped relationship between hemoglobin levels and the composite *** curve tended to reach the lowest level at an optimal hemoglobin *** Among patients with T2DM,a U-shaped relationship was observed between hemoglobin levels and renal damage.A lower admission hemoglobin level(hemoglobin<13.3 g/dL)is an independent predictor of renal damage.

关键词： Type 2 diabetes mellitus Hemoglobin Renal damage Prognosis

Controlling Bovine Serum Albumin Release From Biomimetic Calcium Phosphate Coatings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 28-35页

作者： Xiaohua Yu mei wei 不详

Biomimetic calcium phosphate (CaP) coating has been used successfully for protein delivery, but the release of protein from CaP coating is mainly dependent on the limited dissolution of the CaP coating and the passive diffusion of the protein in the CaP coating. In the present work, our aim is to improve the release behavior of protein from CaP coating and make it more controllable. By using bovine serum albumin (BSA) as a model protein, our strategy is to tailor BSA release profiles by controlling the distribution of BSA in CaP coatings. To achieve this aim, BSA was added to a modified simulated body fluid (m-SBF) at different stages of coating formation to obtain tailored BSA release profiles. Sustained BSA release was obtained when BSA was added to m-SBF at the initial stage of the coating where the BSA was incorporated into the lattice structure of the coating. In contrast, a relatively faster release was observed when BSA was added during the later stage of coating formation where BSA was mainly adsorbed to the coating surface. As a result, the BSA release efficiency could be tailored by adding BSA into m-SBF at different coating formation stages. More importantly, the coating composition was not altered with the change of BSA adding times and all the beneficial properties of the biomimetic coating were reserved. Therefore, the BSA release from CaP coatings can be tailored by adjusting its distribution in the coating to achieve a more satisfactory release profile.

关键词： Biomimetic Coating Apatite Controlled Release Release Efficiency