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Nomogram for predicting short-term response to anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration:An observational study

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World Journal of Radiology 2024年第9期16卷 418-428页

作者： Zhen-Huan Huang Xue-Zhao tu Qi Lin mei tu Guo-Cai Lin Kai-Ping Zhang Department of Radiology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Endocrinology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina Department of Ophthalmology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina

BACKGROUND Anti-vascular endothelial growth factor(anti-VEGF)therapy is critical for managing neovascular age-related macular degeneration(nAMD),but understanding factors influencing treatment efficacy is essential for optimizing patient *** To identify the risk factors affecting anti-VEGF treatment efficacy in nAMD and develop a predictive model for short-term *** In this study,65 eyes of exudative AMD patients after anti-VEGF treatment for≥1 mo were observed using optical coherence tomography *** were classified into non-responders(n=22)and responders(n=43).Logistic regression was used to determine independent risk factors for treatment response.A predictive model was created using the Akaike Information Criterion,and its performance was assessed with the area under the receiver operating characteristic curve,calibration curves,and decision curve analysis(DCA)with 500 bootstrap *** Multivariable logistic regression analysis identified the number of junction voxels[odds ratio=0.997,95%confidence interval(CI):0.993-0.999,P=0.010]as an independent predictor of positive anti-VEGF treatment *** predictive model incorporating the fractal dimension,number of junction voxels,and longest shortest path,achieved an area under the curve of 0.753(95%CI:0.622-0.873).Calibration curves confirmed a high agreement between predicted and actual outcomes,and DCA validated the model's clinical *** The predictive model effectively forecasts 1-mo therapeutic outcomes for nAMD patients undergoing anti-VEGF therapy,enhancing personalized treatment planning.

关键词： Vascular endothelial growth factor Macular degeneration Neovascularization Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Nomogram

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Effect analysis of applying high-quality service model to surgical nursing

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World Journal of Clinical Cases 2024年第19期12卷 3744-3751页

作者： Li Chen Qiu-mei tu Zhao-Di Guo Xiao-Wei Zhu Wei Wang Hui-Fang Xie Yuan Ye Hand Surgery The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Surgical care of the hand plays a crucial role in the medical field,as problems with the hand can profoundly affect a patient's quality of life and *** order to meet the needs of patients,improve patient satisfaction and improve treatment outcomes,high-quality service models have been introduced in the field of *** To explore the effect analysis of applying high-quality service model to surgical *** We conducted a retrospective study of patients who underwent hand surgery at our hospital between 2019 and 2022,using a quality service model that included improved patient education,pain management,care team collaboration,and effective *** group of patients received traditional care as a control *** compared postoperative recovery,satisfaction,complication rate,and length of hospital stay between the two *** statistics were used to compare the difference between the two groups by independent sample t test,Chi-square test and other methods to evaluate the effect of intervention *** Postoperative recovery time decreased from 17.8±2.3 d to 14.5±2.1 d,pain score decreased from 4.7±1.9 to 3.2±1.4,and hand function score increased from 78.4±7.1 to 88.5±*** terms of patient satisfaction,the quality service model group scored 87.3±5.6 points,which was significantly higher than that of the traditional care group(74.6±6.3 points).At the same time,patients'understanding of medical information also improved from 6.9±1.4 to 8.6±*** terms of postoperative complications,the application of the quality service model reduced the incidence of postoperative complications from 26%to 10%,the incidence of infection from 12%to 5%,and the incidence of bleeding from 10%to 3%.The reduction in these data indicates that the quality service model plays a positive role in reducing the risk of *** addition,the average hospital stay of patients in the quality service model group was shortened fr

关键词： Hand surgery nursing Quality service model Clinical outcomes Patient satisfaction Collaboration Pain management

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Laser light scattering technique for non-invasive in situ simultaneous measurements on elastic constants and viscosity coefficients of nematic liquid crystals

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Science China(Physics,Mechanics & Astronomy) 2004年第1期47卷 79-85页

作者： tu mei HUANG Yaoxiong Institute of Biomedical Engineering Jinan University Guangzhou 510632 China Institute of Biomedical Engineering Jinan University Guangzhou 510632 China

The laser light scattering technique for non-invasivein situ simultaneous measurements on elastic constants and viscosity coefficients of nematic liquid crystals is introduced. By measuring the autocorrelation function of the scattered light from nematic liquid crystals at different scattering angles, the splay and twist elastic constantsK 11 andK 22 are obtained from the amplitudes of the autocorrelation function, and the viscosity coefficients ofη Splay andη Twist are determined using the viscoelastic ratiosK 11/η Splay andK 22 η Twist from the telaxation parameters of the two modes.

关键词： dynamic light scattering, nematic liquid crystal, elastic constants, viscosity coefficients.

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Protein adsorption behaviors on chitosan/poly(ε-caprolactone) blend films studied by quartz crystal microbalance with dissipation monitoring(QCM-D)

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Science China(Technological Sciences) 2009年第8期52卷 2275-2279页

作者： ZENG Rong ZHANG Yi LIANG ZhiHong tu mei ZHOU ChangRen Department of Materials Science and Engineering College of Science and EngineeringJinan UniversityGuangzhou 510632China Engineering Research Center of Artificial Organs and Materials Ministry of EducationGuangzhou 510632China Experiment and Technology Center Jinan UniversityGuangzhou 510632China

Chitosan/poly(ε-caprolactone) (PCL) blend films in different mass ratios were prepared using the chitosan/PCL mixture solutions in 80 vol.-% acetic acid by spin coating. Their surface micromorphologies were assessed by atomic force microscopy (AFM). It was found that the micromorphology of chitosan/PCL blend films was in large extent related to the mass ratio of chitosan. 25 wt% chitosan/PCL blend film presented microphase separation. The protein adsorption of bovine serum albumin (BSA) onto chitosan/PCL blend films was investigated by using quartz crystal microbalance with dissipation monitoring (QCM-D) in real time. The results suggested that the amount of adsorbed BSA on the chitosan/PCL blend films decreased with the addition of chitosan, but the structure and viscoelastic properties of the adsorbed BSA layers were greatly affected by the surface micromorphology of chitosan/PCL blend films. BSA absorbed on the 25 wt% chitosan/PCL blend film with microphase separa- tion showed larger adsorption reversibility, and preferred to form a loose, dissipative layer in comparison with those on other chitosan/PCL blend films without microphase separation.

关键词： protein adsorption chitosan poly(ε-caprolactone) quartz crystal microbalance with dissipation monitoring(QCM-D) surface micromorphology

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Microwave-assisted Immobilization of Heparin onto Polyurethane Surface for Improving Blood Compatibility

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Journal of Wuhan University of Technology(Materials Science) 2014年第5期29卷 1071-1077页

作者：邱炳崧 MAI Weizhong 曾戎 tu mei ZHAO Jianhao ZHA Zhengang Department of Materials Science and Engineering College of Science and Engineering Jinan University Guangzhou Overseas Chinese Hospital the First Affiliated Hospital of Jinan University

Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol）（APEG） was rapidly grafted onto PU surface within 20 rain by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was eovalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy （XPS）, atomic force microscopy （AFM） and water contact angle measurements. The results revealed that hepadn-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time （CT） and prothrombin time （PT）. Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.

关键词： surface modification microwave irradiation heparin polyurethane blood compatibility

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探讨按病种分值付费背景下全面质量管理在住院病案首页质量改进中的应用效果分析

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中国当代医药 2024年第15期31卷 116-119页

作者：邹庞傅嘉婧刘芳萍涂梅福建省龙岩市第一医院质控科福建龙岩364000 福建省龙岩市第一医院妇幼保健科福建龙岩364000 福建省龙岩市第一医院内分泌科福建龙岩364000

目的探讨按病种分值付费(DIP)背景下全面质量管理在住院病案首页质量改进中的应用效果。方法选取2021—2022年福建省龙岩市第一医院在DIP背景下住院病案首页全面质量管理前后的住院病案各1346份作为研究对象,比较DIP背景下全面质量管理... 详细信息

目的探讨按病种分值付费(DIP)背景下全面质量管理在住院病案首页质量改进中的应用效果。方法选取2021—2022年福建省龙岩市第一医院在DIP背景下住院病案首页全面质量管理前后的住院病案各1346份作为研究对象,比较DIP背景下全面质量管理实施前后住院病案首页患者费用信息、诊疗信息、住院过程信息、基本信息缺陷的发生率及主要诊断、其他诊断、主要手术操作、其他手术操作填写及编码的合格率。结果DIP背景下全面质量管理后,病案首页费用信息、诊疗信息、住院过程信息及基本信息缺陷的发生率低于全面质量管理前,病案首页主要诊断、其他诊断、主要手术操作、其他手术操作填写及编码的合格率高于全面质量管理前,差异均有统计学意义(P<0.05)。结论在DIP背景下住院病案首页质量改进中应用全面质量管理,可有效降低患者病案首页信息缺陷的发生率,提高病案首页疾病诊断、手术操作填写及编码的合格率,值得临床推广应用。

关键词：住院病案首页按病种分值付费全面质量管理质量改进应用效果

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Superresolution measurement on the minute fluctuation of cell membrane

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Chinese Science Bulletin 2006年第2期51卷 143-147页

作者： LI ding HUANG Yaoxiong ZHAO Haiyan tu mei CHEN Wenxin Institute of Biomedical Engineering Ji Nan University Guangzhou 510632 China Department of Equipment Kunming General Hospital Kunming 650032 China Ophthalmic Center Sun Yat-sen University Guangzhou 510080 China

A novel method for measuring the min- ute fluctuation of cell membrane is developed by modifying the super-resolution theory, increasing dimension in Fourier space, enhancing brightness gradient and utilizing maximum adaptive weighted averaging filter (MAWA) in obstructing noise. The application of the method in studying aspergillus fla- vus cell (AFC) and red blood cell and the new find- ings from the study show that it is a useful tool.

关键词：细胞膜超分辨率测量动态数列图像平均值滤波器

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Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3950-3965页

作者： Linglong Deng Hannah Petrek mei-Juan tu Neelu Batra Ai-Xi Yu Ai-Ming Yu Department of Orthopaedic Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhan 430072China Department of Biochemistry and Molecular Medicine UC Davis School of MedicineSacramentoCA 95817USA

With the understanding of microRNA(miRNA or miR) functions in tumor initiation,progression,and metastasis,efforts are underway to develop new miRNA-based *** recently,we demonstrated effectiveness of a novel humanized bioengineered miR-124-3 p prodrug in controlling spontaneous lung metastasis in mouse *** study was to investigate the molecular and cellular mechanisms by which miR-124-3 p controls tumor *** study identified a set of proteins selectively and significantly downregulated by bioengineered miR-124-3 p in A549 cells,which were assembled into multiple cellular components critical for metastatic *** them,plectin(PLEC) was verified as a new direct target for miR-124-3 p that links cytoskeleton components and *** miR-124-3 p-treated lung cancer and osteosarcoma cells,protein levels of vimentin,talin 1(TLN1),integrin beta-1(ITGB1),IQ motif containing GTPase activating protein 1(IQGAP1),cadherin2 or N-cadherin(CDH2),and junctional adhesion molecule A(F11 R or JAMA or JAM1) decreased,causing remodeling of cytoskeletons and disruption of cell-cell ***,miR-124-3 p sharply suppressed the formation of focal adhesion plaques,leading to reduced cell adhesion ***,efficacy and safety of biologic miR-124-3 p therapy was established in an aggressive experimental metastasis mouse model in *** results connect miR-124-3 p-PLEC signaling to other elements in the control of cytoskeleton,cell junctions,and adhesion essential for cancer cell invasion and extravasation towards metastasis,and support the promise of miR-124 therapy.

关键词： RNA therapy MiR-124-3p Metastasis Proteomics Junctions Cell adhesion Bioengineer Imaging

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Construction of physical crosslink-based chitosan/liquid crystal composite hydrogel and evaluation on their cytocompatibility

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Regenerative Biomaterials 2017年第1期4卷 39-45页

作者： Lin Du Xiaohui Yang Wenqiang Li Xuhui Luo Hao Wu Jiaqing Zhang mei tu Department of Materials Science and Engineering Jinan UniversityGuangzhou 510632People’s Republic of China Engineering Research Center of Artificial Organs and Materials Ministry of EducationJinan UniversityGuangzhou 510632People’s Republic of China The First Affiliated Hospital Jinan UniversityGuangzhou 510632People’s Republic of China School of Medicine Jinan UniversityGuangzhou 510632People’s Republic of China

In order to provide a novel biomimetic composite substrate for tissue engineering and explore the interaction between cells and this type of material,we developed chitosan/liquid crystal(CS/LC)composite hydrogel with embedded LC phases by composing of cholesterol hydroxypropyl cellulose ester liquid crystalline material and *** micromorphology of CS/LC composite hydrogels exhibited‘islands-sea’phase separation structures similar to the‘fluid mosaic model’of *** vitro cell compatibility study suggested that 3T3 is fibroblasts exhibited better initial cell adhesions and higher proliferation rates on the composite hydrogel than on the polystyrene control plate and the pure LC *** novel CS/LC composite hydrogel provides more favorable interface for cell growth and proliferation and may serve as potentially active substrate for engineering interfaces to live cells.

关键词： chitosan liquid crystal composite hydrogels structure and morphology cell compatibility

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Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression

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Acta Pharmaceutica Sinica B 2019年第3期9卷 639-647页

作者： Xin Li Ye Tian mei-Juan tu Pui Yan Ho Neelu Batra Ai-Ming Yu Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou511436China Lab for Bone Metabolism Key Lab for Space Biosciences and BiotechnologySchool of Life SciencesNorthwestern PolytechnicalUniversityXi'an710072China Department of Biochemistry&Molecular Medicine UC Davis School of MedicineSacramentoCA95817USA

Drug-metabolizing enzymes, transporters, and nuclear receptors are essential for the absorption, distribution, metabolism, and excretion(ADME) of drugs and xenobiotics. MicroRNAs participate in the regulation of ADME gene expression via imperfect complementary Watson–Crick base pairings with target transcripts. We have previously reported that Cytochrome P450 3A4(CYP3A4) and ATP-binding cassette sub-family G member 2(ABCG2) are regulated by miR-27b-3p and miR-328-3p,respectively. Here we employed our newly established RNA bioengineering technology to produce bioengineered RNA agents(BERA), namely BERA/miR-27b-3p and BERA/miR-328-3p, via fermentation. When introduced into human cells, BERA/miR-27b-3p and BERA/miR-328-3p were selectively processed to target miRNAs and thus knock down CYP3A4 and ABCG2 mRNA and their protein levels,respectively, as compared to cells treated with vehicle or control RNA. Consequently, BERA/miR-27b-3p led to a lower midazolam 10-hydroxylase activity, indicating the reduction of CYP3A4 activity. Likewise,BERA/miR-328-3p treatment elevated the intracellular accumulation of anticancer drug mitoxantrone, a classic substrate of ABCG2, hence sensitized the cells to chemotherapy. The results indicate that biologic miRNA agents made by RNA biotechnology may be applied to research on miRNA functions in the regulation of drug metabolism and disposition that could provide insights into the development of more effective therapies.

关键词： Bioengineered RNA miR-27b miR-328 CYP3A4 ABCG2 Drug disposition

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