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Prenatal cytogenetic diagnosis study of 2782 cases of high-risk pregnant women

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Chinese Medical Journal 2010年第4期123卷 423-430页

作者： ZHANG Lin ZHANG Xiao-hong liang mei-ying REN mei-hong Prenatal Diagnosis Center Peking University People's Hospital Beijing 100044 China

Background Prenatal diagnoses are extremely advantageous for pregnant women with high-risk indicators and can help prevent the birth of malformed infants. However, no large-scale statistical study analyzing the correlation between fetal chromosome disorders and abnormal indicators during pregnancy has been done in China. The objectives of this study were to diagnose and analyze fetal chromosome abnormalities, determine the feasibility of the various prenatal test methods and establish diagnostic guidelines for the early, middle, and late trimesters. Methods From January 2004 to May 2009, 2782 pregnant women at high-risk underwent prenatal diagnoses. Categorized data expressed as either actual counts or percentages were analyzed by the chi-square or Fisher＇s exact test. Chorionic villus sampling was performed in the early-trimester （10-12 weeks of gestation）, amniocentesis in mid-trimester （16-28 weeks of gestation）, and umbilical cord blood collection in mid- or late-trimester （16-37 weeks of gestation）. In 51 cases either autopsy samples from intrauterine fetal deaths or placental tissues from aborted fetuses were tested. Results Chromosomal abnormalities were observed in 3.99% （111/2782） of the samples. Overall, the success rate of cytogenetic analysis for high-risk pregnancy groups was 98.17% （2731/2782）. It was significantly less successful when used to analyze data from the chorionic villus sampling compared with that from amniocentesis and umbilical cord blood （P=-0.000）. Abnormal chromosome carriers had the highest percentage of abnormal chromosomes （67.86%） when compared with chromosomal abnormalities in patients with ultra-sonographic ＂soft markers＂（11.81%）, advanced maternal age （4.51%） and those who had positive serum screening results （P=-0.000）. Conclusions Invasive prenatal diagnostic techniques are feasible tools for confirming fetal chromosomal abnormalities. Abnormal chromosomes detected in one of the parents carrying abnormal chromosome, ultrasoun

关键词： chorionic villus sampling amniocentesis umbilical cord blood collection chromosomal karyotype prenatal diagnosis

Synthesis ofα-D-GlcpNAc-(1→2)-[α-D-ManpNAc-(1→3)-]α-L-Rhap-(1→2)-α-L-Rhap-(1→3)-α-L-Rhap,the repeating unit of O10 antigen from Acinetobacter baumannii

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Chinese Chemical Letters 2008年第4期19卷 415-418页

作者： Jian Jun Zhang Guang Hui Zong Xiao mei liang Yun Qi Li Dao Quan Wang Fan Zuo Kong Key Lab of Pesticide Chemistry and Application Technology Department of Applied ChemistryChina Agricultural UniversityBeijing 100094China Research Center for Eco-Environmental Sciences Academia SinicaR.O.Box 2871Beijing 100085China

An efficient synthesis ofα-D-GlcpNAc-（1→2）-[α-D-ManpNAc-（1→3）-]α-L-Rhap-（1→2）-α-L-Rhap-（1→3）-α-L-Rhap（1）, the repeating unit of the O10 antigen from Acinetobacter baumannii was achieved via sequential assembly of the building blocks,p- methoxylphenyl 2,4-di-O-benzoyl-α-L-rhamnopyranoside（2）;2-O-allyloxycarbonyl-3,4-di-O-bcnzoyl-α-L-rhamnopyranosyl tri- chloroacetimidate（3）;4-methoxylphenyl 3-O-allyloxycarbonyl-4-O-benzoyl-α-L-rhanmopyranoside（4）;2-azido-3-O-benzoyl-2- deoxy-4,6-O-isopropylidene-α-D-mannopyranosyl trichloroacetirnidatc（5）;2-azido-3,4,6-tri-O-benzoyl-2-deoxy-α,β-D-glucopyr- ano syl trichloroacetimidatc（6）.The total yield of 1 from 4 was 4.7%.

关键词： Oligosaccharide Rharmnose Glucosamine Mannosamine

Highly efficient removal of allyloxycarbonyl(Alloc)function provides a practical orthogonal protective strategy for carbohydrates

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Chinese Chemical Letters 2009年第2期20卷 127-130页

作者： Guang Hui Zong Shi Qiang Yan Xiao mei liang Jian Jun Zhang Dao Quan Wang Fan Zuo Kong Key Lab of Pesticide Chemistry and Application Technology Department of Applied Chemistry China Agricultural University Beijing 100094 China Research Center for Eco-Environmental Sciences Academia Sinica Beijing 100085 China

Highly efficient removal of allyloxycarbonyl （Alloc） group was achieved in the presence of CH3COONH4, Pd[P（C6H5）3]4, and NaBH4 in MeOH-THF, within 5 min in almost quantitative yields （〉90%, isolated yield） with... 详细信息

关键词： Allyloxycarbonyl group Orthogonal protective strategy Carbohydretes

Three new species of imitator-group of the genus Macrophya(Hymenoptera,Tenthredinidae) from China

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Zoological Systematics 2015年第2期40卷 212-222页

作者： Meng-Meng Liu Xue-mei Heng Xiang-mei liang Yi-Hai Zhong Ze-Jian Li Lab of Insect Systematics and Evolutionary Biology Central South University of Forestry and Technology Henan Vocational College of Agriculture Lishui Baiyun Mountain Ecology Forest Farm Environment and Plant Protection Institute of Chinese Academy of Tropical Agriculture Danzhou Scientific Observing and Experimental Station of Agro-EnvironmentMinistry of Agriculture Lishui Academy of Forestry

Three species, Macrophya circulotibialis Li, Liu ＆ Heng, sp. nov., M. curvatitheca Li, Liu ＆ Heng, sp. nov. and M. changbaina Li, Liu ＆ Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom （Hymenoptera, Tenthredinidae） from China are described as new to science. A key to all known species of the imitator-group from China is provided. The specimens examined in this study, including all holotypes and paratypes of the new species, are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China, and the Department of Zoology, National Museum of Nature and Science, Amakubo, Tsukuba, Ibaraki, Japan.

关键词： Symphyta Tenthredinidae Macrophya taxonomy.

Interaction mechanisms between autophagy and ferroptosis:Potential role in colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1135-1148页

作者： Xin-Ya Zeng Xin-Ze Qiu Jiang-Ni Wu Sheng-mei liang Jie-An Huang Shi-Quan Liu Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Pathology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina

Colorectal cancer(CRC)is a common malignancy that has the second highest incidence and mortality *** there are many personalized treatment options for CRC,the therapeutic effects are ultimately limited by drug *** have aimed to block the initiation and progression of CRC by inducing cell death to overcome this *** evidence has indicated that both autophagy and ferroptosis play important regulatory roles in ***,a lysosome-dependent process by which cellular proteins and organelles are degraded,is the basic mechanism for maintaining cell *** duality and complexity of autophagy in cancer therapy is a hot topic of ***,a regulated cell death pathway,is associated with iron accumulationinduced lipid *** activation of ferroptosis can suppress CRC proliferation,invasion and drug ***,recent studies have suggested an interaction between autophagy and *** can selectively degrade certain cellular contents to provide raw materials for ferroptosis,ultimately achieving antitumor and anti-drug ***,exploring the interaction between autophagy and ferroptosis could reveal novel ideas for the treatment of *** this review,we describe the mechanisms of autophagy and ferroptosis,focusing on their roles in CRC and the crosstalk between them.

关键词： Ferroptosis Autophagy Cell death Colorectal cancer Iron Lipid peroxidation

Comparative study on the anti-tuberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiao He extract and JieHeWan

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Military Medical Research 2022年第2期9卷 164-183页

作者： Li-Yao Duan Yan liang Wen-Ping Gong Yong Xue Jie Mi Jie Wang Lan Wang Zai-Xing Jia Hong Lei Yu-mei liang Jun Liu Yue Zheng Xue-Qiong Wu Tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentTuberculosis Research Institutethe 8th Medical CenterChinese PLA General HospitalBeijing 100091China Hebei North University Zhangjiakou 075000HebeiChina Clinical Laboratory the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Pathology Department the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Guangdong Qifang Pharmaceutical Co. LtdGuangzhou 510075China

Background:The traditional Chinese medicine NiuBeiXiaoHe(NBXH)extract and Chinese medicine preparation JieHeWan(JHW)exhibit anti-tuberculosis(TB)*** anti-TB effect of NBXH was compared with that of JHW to elucidate the mechanism of action of ***:BALB/c mice aged 6-8 weeks were randomly divided into a normal control group,TB model group,JHW treatment group,and NBXH treatment *** 3 and 13 weeks of treatment,the therapeutic effect in each group was evaluated by comparing lung histopathology,lung and liver colony counts,the number of spots representing effector T cells secreting IFN-γin an enzyme-linked immunospot assay(ELISPOT),and the levels of Th1,Th2,and Th17 cytokines,which were measured by a cytometric bead array(CBA).Mouse RNA samples were subjected to transcriptome ***:After 13 weeks of treatment,the mean histopathological lesion area of the NBXH group was significantly smaller than that of the TB model group(P<0.05).Compared with those in the TB model group,the lung colony counts in the JHW and NBXH groups were significantly decreased(P<0.05),and the IL-2 and IL-4 levels in the NBXH group were significantly increased(P<0.05).NBXH partly restored significant changes in gene expression caused by Mycobacterium tuberculosis(***)*** to GO and KEGG analyses,the changes in biological process(BP),cell composition(CC)and molecular function(MF)terms and in signaling pathways caused by NBXH and JHW treatment were not completely consistent,but they were mainly related to the immune response and inflammatory response in the mouse TB ***:NBXH had therapeutic effects similar to those of JHW in improving lung histopathology,reducing lung colony counts,and regulating the levels of *** restored significant changes in gene expression and repaired cell damage caused by *** infection by regulating immune-related pathways,which clarified the mechanism of action of NBXH.

关键词： Traditional Chinese medicine Tuberculosis NiuBeiXiaoHe extract JieHeWan Therapeutic effect

Synthesis of 4″-benzyloxyimino-4″-deoxyavermectin Bla derivatives

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Chinese Chemical Letters 2007年第8期18卷 895-898页

作者： Yue mei Jia Xiao mei liang Xue Qin.Fang Jing Ping Wu Dao Quan Wang Chang Hui Rui Xian Lin Fan Hai Yan Zhao Yun Xia Wang Department of Applied Chemistry China Agricultural University Beijing 100094 China Institute of Plant Protection Chinese Academy of Agricultural Science Beijing 100094 China

Six new 4＂-benzyloxyimino-4＂-deoxyavermectin B la derivatives were synthesized from avermectin Bla by the selective protection of C-5-hydroxy group, oxidation of C-4＂-hydroxy group, and deprotection followed by reaction with O-substituted hydroxylamine hydrochlorides. Their structures were confirmed by IR, 1H NMR, 13C NMR and MS. Insecticidal activities of the derivatives against Phopalosiphum pseudobrassicae, Spodoptera exigua and Pluteua xylosteua were evaluated.

关键词： Avermectin Synthesis 4"-Benzyloxyimino,4"-deoxyavermectin B1a derivatives Insecticidal activity

Formation of Endohedral Complexes in Collisions of H_(2 ) and D_(2) with C_(60)

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Chinese Physics Letters 1996年第7期13卷 527-530页

作者： XING Yue-lin XIA Yue-yuan mei liang-mo Department of Physics Shandong UniversityJinan 250100

Formations of endohedral complexes in collisions of H_(2) and D_(2) with C_(60) molecules have been studied using a molecular dynamics simulation method.H@C_(60) complex is produced when a H_(2) molecule collides with a C_(60) molecule dong the direction from the center of a hexagonal ring into the center of the C_(60) at collision energy E0=40 *** the same collision condition,a D2 molecule colliding with a C_(60) molecule forms a D_(2)@C_(60) complex。

关键词： method collision hexagonal

Gene cloning and expression of aminopeptidase N and cadherin from midgut of the rice stem borer, Chilo suppressalis

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Insect Science 2010年第5期17卷 393-399页

作者： Hong-Kun Yu Hao Ghen Yong-Jun Zhang Kong-Ming Wu Ge-mei liang Ze-Wen Liu Yu-Yuan Guo State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects Ministry of Agriculture College of Plant Protection Nanjing Agricultural University Nanjing China

The rice stem borer, Chilo suppressalis Walker is one of the most important insect pests on rice in Asia, north Africa and southern Europe. Transgenic Bt rice has been developed in the laboratory with good resistance to this pest and other Lepidopteran insects, which will provide a possible alternative tool for this pest control. The full-length cDNAs encoding an aminopeptidase N （CsAPN） and a cadherin （CsCad） were cloned from C. suppressalis. CsAPN showed common features of, and high identities to, other insect APNs in its deduced amino acid sequence. Although a full-length cDNA encoding cadherin-like protein has been reported in GenBank, the newly isolated cadherin here （CsCad） showed some differences in its amino acid sequence, especially at the 7th cadherin repeat region （CR7）, which indicated the newly isolated CsCad might be another allele. CsAPN and CsCad were successfully expressed in insect Tn cells, and the blot analysis showed these two proteins could bind Bt toxin CrylAb. The results will provide valuable information for the studies of toxin mode of action and the possible toxin resistance mechanisms in this pest.

关键词： aminopeptidase N cadherin Chilo suppressalis heterologous expression,Tn cells