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The role of HBD-2,HBD-3,and calprotectin in the relationship between chronic periodontitis and atherosclerosis

BIOCELL 2020年第3期44卷 337-344页

作者： mehmet taspinar ALIHAN BOZOGLAN ABDULLAH SECKIN ERTUGRUL LEVENT ELMAS Faculty of Medicine Aksaray UniversityAksarayTurkey Faculty of Medicine Yuzuncu Yil UniversityVanTurkey Department of Periodontology Faculty of DentistryFırat UniversityElazığTurkey Department of Periodontology Faculty of DentistryYuzuncu Yil UniversityVanTurkey Department of Periodontology Faculty of Dentistryİzmir KatipÇelebi UniversityİzmirTurkey Faculty of Medicine Pamukkale UniversityDenizliTurkey

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins(HBD)HBD-2,HBD-3,and *** is the most frequently observed cardiovascular *** and periodontal infections are known to provide a considerable basis for atheroma plaque *** study group consists of a total number of 40 subjects,with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic *** periodontal and blood parameters and HBD-2,HBD-3,and calprotectin biomarkers in the gingival crevicular fluid were *** both groups,following clinical periodontal treatment,a statistically significant decrease in white blood cells(WBC),low-density lipoproteins(LDL),fibrinogen,creatinine,and platelets(PLT),a statistically significant increase in high-density lipoproteins(HDL)in blood samples,statistically meaningful decrease in HBD-2,HBD-3,and calprotectin in the gingival crevicular fluid were *** values and HBD-2,HBD-3,calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group.A positive correlation was observed between decreases in HBD-2,HBD-3,calprotectin,and clinical periodontal *** in systemic inflammation was observed after clinical periodontal *** is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

关键词： Atherosclerosis Periodontal Diseases HBD-2 HBD-3 Calprotectin

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