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Effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions

国际眼科杂志 2024年第10期24卷 1515-1521页

作者： Ali Dal Onur Catak Murat Erdag mehmet Canleblebici Ebru Onalan Ilay Buran Department of Ophthalmology Faculty of MedicineFirat UniversityElazig 23119Turkey Department of Ophthalmology Ata Sokmen Faculty of MedicineMustafa Kemal UniversityHatay 31100Turkey Department of Ophthalmology Kayseri State HospitalKayseri 38200Turkey Department of Medical Biology Faculty of MedicineFirat UniversityElazig 23100Turkey

AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VEGF)expression in human retinal pigment epithelium(ARPE-19)cells using a hypoxic ***:In the first set of experiments,the optimal CoCl_(2) dose was determined by exposing ARPE-19 cell cultures to different *** evaluate the effect of ALCAR on cell viability,five groups of ARPE-19 cell culture were established that included a control group,a sham group(200μM CoCl_(2)),and groups that received 1,10 and 100 mM doses of ALCAR combined with 200μM CoCl_(2),*** cell viability was measured by MTT *** morphological characteristics of cells were observed by an inverted phase contrast *** levels of VEGF and HIF-1α secretion by ARPE-19 cells were detected by enzyme linked immunosorbent assay(ELISA)***:ARPE-19 cells were exposed to different doses of CoCl_(2) in order to create a hypoxia ***,when exposed to a concentration of 200μM CoCl_(2),a notable decrease in viability to 83% was *** was found to increase the cell viability at 1 mM and 10 mM concentrations,while the highest concentration(100 mM)did not have an added *** cell viability was found to be significantly higher in the groups treated with a concentration of 1 mM and 10 mM ALCAR compared to the Sham group(P=0.041,P=0.019,respectively).The cell viability and morphology remained unaffected by the greatest dose of ALCAR(100 mM).The administration of 10 mM ALCAR demonstrated a statistically significant reduction in the levels of VEGF and HIF-1α compared with the Sham group(P=0.013,P=0.033,respectively).CONCLUSION:The findings from the current study indicate that ALCAR could represent a viable therapeutic option with the potential to open up novel treatment pathways for retinal diseases,particular relevance for age-related macular degeneration(AMD).However,to fully elucidate ALCAR’s application

关键词： acetyl-L-carnitine(ALCAR) human retinal pigment epithelium(ARPE-19) vascular endothelial growth factor(VEGF) hypoxia-inducible factor 1(HIF-1α)

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群体饲养生命表:资料分析理论与转化为个体生命表的方法

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昆虫学报 2024年 2-17页

作者：马敏任芳旭王怡孔维娜魏明峰齐心 mehmet Salih ?ZG?K?E 马瑞燕山西农业大学植物保护学院农业有害生物综合治理山西省重点实验室山西农业大学棉花研究所山东农业大学植物保护学院福建农林大学应用生态研究所闽台作物有害生物生态防控国家重点实验室福建省农业科学院农业质量标准与检测技术研究所 Department of Plant Protection Faculty of AgricultureVan Yüzüncü Yil University

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。群体饲养生命表的记录实际上即年龄-龄期两性生命表的N矩阵,而每日所有雌虫的总繁殖记录即为Ftotal矩阵。利用N矩阵与Ftotal矩阵可以计算S矩阵、F矩阵及各种群参数... 详细信息

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。群体饲养生命表的记录实际上即年龄-龄期两性生命表的N矩阵,而每日所有雌虫的总繁殖记录即为Ftotal矩阵。利用N矩阵与Ftotal矩阵可以计算S矩阵、F矩阵及各种群参数。以桃蚜Myzus persicae和马铃薯块茎蛾Phthorimaea operculella为例,阐明群体饲养生命表分析的理论依据,证明群体饲养生命表得到的各项参数可靠,并介绍了一种将群体饲养生命表转化为个体生命表的方法。比较了群体饲养生命表和个体饲养生命表的特点。利用群体饲养研究昆虫生命表可以节省大量人力、时间与经费,群体饲养生命表可用于设计大量饲养生物防治天敌、鱼与鸟的饲料昆虫以及可供人类食用的昆虫。

关键词：年龄龄期两性生命表群体饲养电脑模拟种群预测生物防治

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群体饲养生命表:资料分析理论与转化为个体生命表的方法

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昆虫学报 2024年第8期67卷 1147-1162页

作者：马敏任芳旭王怡孔维娜魏明峰齐心 mehmet Salih ZG K E 马瑞燕山西农业大学植物保护学院农业有害生物综合治理山西省重点实验室太原030031 山西农业大学棉花研究所运城044000 山东农业大学植物保护学院泰安271018 福建农林大学应用生态研究所闽台作物有害生物生态防控国家重点实验室福州350002 福建省农业科学院农业质量标准与检测技术研究所福州350003 Department of Plant Protection Faculty of AgricultureVan YüzüncüY l UniversityVan 65080Türkiye

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。每日群体饲养生命表的记录实际上即年龄-龄期两性生命表的矩阵N,而每日所有雌虫的总繁殖力记录即为矩阵F total。利用矩阵N与矩阵F total可以计算年龄-龄期存活率矩... 详细信息

本文介绍群体饲养生命表的资料分析基本原理及转换为个体生命表的方法。每日群体饲养生命表的记录实际上即年龄-龄期两性生命表的矩阵N,而每日所有雌虫的总繁殖力记录即为矩阵F total。利用矩阵N与矩阵F total可以计算年龄-龄期存活率矩阵S、繁殖力矩阵F及各种群参数。以桃蚜Myzus persicae和马铃薯块茎蛾Phthorimaea operculella为例,阐明群体饲养生命表分析的理论依据,证明群体饲养生命表得到的各项参数可靠,并介绍了一种将群体饲养生命表转化为个体生命表的方法。比较了群体饲养生命表和个体饲养生命表的特点。利用群体饲养研究昆虫生命表可以节省大量人力、时间与经费,群体饲养生命表可用于设计大量饲养生物防治天敌、鱼与鸟的饲料昆虫以及可供人类食用的昆虫。

关键词：年龄-龄期两性生命表群体饲养电脑模拟种群预测生物防治

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Compensating the effects of DC bias lines on terahertz photomixer antennas using resistively loaded lines

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红外与毫米波学报 2015年第4期34卷 420-426页

作者： Adem Yilmaz mehmet Unlu Electrical and Electronics Engineering Department Yildirim Beyazit University Ankara Turkey Cankiri Caddesi Cicek Sokak No: 3 Ulus Ankara 06030 Turkey

This paper proposed a method,namely resistively loaded lines(RLL),to compensate the effects of the DC bias lines after investigating its effects on several types of antennas for terahertz *** RLL is formed by placing lumped resistances periodically on the DC bias line in order to cease the leakage current virtually,w hich cause a significant amount of distortion on the antenna *** simulation results of the dipole,folded dipole,log-periodic,and spiral antennas show that RLL almost removes the effects of the bias lines and improves the antenna radiation resistance and radiation pattern notably compared w ith that of the commonly used bias line types,such as coplanar stripline and photonic bandgap type bias lines.

关键词：红外技术毫米波技术光电技术应用

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Fuzzy rule based seismic risk assessment of one-story precast industrial buildings

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Earthquake Engineering and Engineering Vibration 2019年第3期18卷 631-648页

作者： mehmet Palanci Istanbul Arel University Department of Civil Engineering

Effi cient tools capable of using uncertain data to produce fast and approximate results are more practical in rapid decision-making applications when compared to conventional methods. From this point of view, this study introduces a risk assessment model for one-story precast industrial buildings by fuzzy logic which builds a bridge between uncertainty and precision. The input, output and relations of the fuzzy based risk assessment model (FBRAM) were determined by reference buildings. The Monte Carlo simulation method was used to handle uncertainties associated with the structural characteristics of the reference buildings. Section dimension, longitudinal reinforcement ratio, column height related to building elevation, confi nement ratio and seismic hazard are regarded as input and the plastic demand ratio is considered as the output parameter by the mathematical formulation of strength and deformation capacity of the buildings. The supervised learning method was used to determine the membership function of fuzzy sets. Fuzzy rules of FBRAM were constructed from Monte Carlo simulation by mapping of inputs and output. FBRAM was evaluated by a group of simulated buildings and two existing precast industrial buildings. Comparisons have shown signifi cant agreement with analytical model results in both cases. Consequently, it is anticipated that the proposed model can be used for the seismic risk mitigation of precast buildings.

关键词： fuzzy logic supervised learning precast buildings risk assessment Monte Carlo simulation

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Examination of Element Concentrations in Groundwater by ICP-MS for Monitoring of Pre-Earthquake Activities

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光谱学与光谱分析 2013年第1期33卷 1-6页

作者： mehmet Yaman Ahmet Sasmaz Firat University Sciences FacultyDepartment of ChemistryElazigTurkey Firat University Engineering FacultyDepartment of GeologyElazigTurkey

This study presents the results of hydrogeochemical studies carried out in Zeytun thermal springs in Kahramanmaras,located South Middle *** than 90thermal water samples were collected on a regular basis from 2006to 2008to measure element concentrations as a monitor of earthquake *** samples were analyzed using *** observed B,Ba,Br and Ge concentrations for 16months are in ranges of 79～422,103～167,28～93and 0.3～1.2 μ g.L-1,*** concentrations for these periods are in range of 7～*** data identify some element anomalies before *** anomalies are characterized by decreases up to 158%in Ba and Cl *** occurrence of these anomalies can be attributed to stress / strain induced pressure changes in the subsurface water *** can be suggested that the thermal springs in the fault line area are ideal sites for precursors of earthquakes.

关键词： Earthquake Groundwater Elements Precursory ICP-MS

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Use of Atomic Absorption Spectrometry in Assessment of Biomonitor Plants for Lead,Cadmium and Copper Pollution

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光谱学与光谱分析 2012年第1期32卷 229-234页

作者： Gokce Kaya mehmet Yaman Tunceli University Engineering Faculty Department of Food Sciences Tunceli-Turkey Firat University Sciences Faculty Department of Chemistry Elazig-Turkey

Eleven plant species were collected from the vicinity of lead-battery plant in the city of Gaziantep,***,cadmium and copper concentrations in the soil and leaves of plants were determined by atomic absorption ***,Cd and Cu concentrations in the soil samples taken from battery area were found to be in the ranges of 304～602,0.4～0.44 and 31～37 mg·kg-1,*** increased lead concentration up to 2 750 mg·kg-1 was found in the leaves of Eleagnus angustifolia *** lead concentrations in the other plant leaves taken from 50 m around battery factory followed the order Ailanthus altissima>Morus sp.>Juglans regia L.>Ficus carica L.>Cydonia oblonga Miller>Prunus x domestica *** plants,Populus nigra L.,Eleagnus angustifolia *** Salix *** found useful for Cd,and the plant,Eleagnus angustifolia *** Pb,to be considered as potential ***,leaves of trees and plants taken from the distance of 50 m from battery plant have relatively higher Pb ***,people who and animals which live in this area and benefit from these soil and plants have vital risks.

关键词： Atomic absorption Lead Cadmium Coper Biomonitor plants Pollution

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Effect of hydroxyapatite:zirconia volume fraction ratio on mechanical and corrosive properties of Ti-matrix composite scaffolds

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Transactions of Nonferrous Metals Society of China 2022年第3期32卷 882-894页

作者： mehmet TOPUZ Burak DIKICI mehmet GAVGALI Yasemin YILMAZER Department of Mechanical Engineering Van YüzüncüYıl UniversityVan 65080Turkey Department of Metallurgical and Materials Engineering Atatürk UniversityErzurum 25240Turkey Department of Mechanical Engineering Necmettin Erbakan UniversityKonya 42090Turkey Department of Molecular Biology and Genetics İstanbul Sabahattin Zaim Universityİstanbul 34303Turkey

Ti-based scaffolds reinforced with zirconia and hydroxyapatite were produced successfully by a hybrid method with an eco-friendliness and low cost to obtain low elastic modulus(E) with sufficient physical, electrochemical and biological properties. The effect of simultaneous modification of the volume fraction of hydroxyapatite(HA) and zirconia(ZrO_(2)) on scaffolds was investigated in terms of mechanical, corrosive, and antibacterial properties. Scanning electron microscopy with attached electron dispersive spectroscopy and X-ray diffraction were used for the characterization of scaffolds. Compression and electrochemical tests were performed to determine mechanical properties with detailed fracture mechanism and in-vitro corrosion susceptibility to simulated body fluid at 37 ℃,respectively. Antibacterial tests were carried out by comparing the inhibition areas of *** and *** bacteria. It was observed that the mechanical strength of the scaffolds decreased with increasing HA:ZrO_(2)volume fraction *** lowest E was achieved(6.61 GPa) in 6:4 HA:ZrO_(2)composite scaffolds. Corrosion current density(J_(corr)) values were calculated to be 21, 337, and 504 μ A/cm^(2) for unreinforced Ti, 3:2 and 6:4 HA:ZrO_(2)reinforced scaffolds,respectively. The inhibition capacity of the 6:4 reinforced composite scaffold was found to be more effective against *** bacteria than other scaffolds.

关键词： titanium biocomposite hydroxyapatite zirconia scaffold mechanical properties in-vitro corrosion

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Analytical and approximate solutions of(2+1)-dimensional time-fractional Burgers-Kadomtsev-Petviashvili equation

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Communications in Theoretical Physics 2020年第5期72卷 21-31页

作者： mehmet Senol Department of Mathematics Nevsehir Haci Bektas Veli UniversityNevsehirTurkey

In this paper,we applied the sub-equation method to obtain a new exact solution set for the extended version of the time-fractional Kadomtsev-Petviashvili equation,namely Burgers-Kadomtsev-Petviashvili equation(Burgers-K-P)that arises in shallow water ***,using the residual power series method(RPSM),approximate solutions of the equation were obtained with the help of the Mathematica symbolic computation *** also presented a few graphical illustrations for some *** fractional derivatives were considered in the conformable *** of the obtained solutions were replaced back in the governing equation to check and ensure the reliability of the *** numerical outcomes confirmed that both methods are simple,robust and effective to achieve exact and approximate solutions of nonlinear fractional differential equations.

关键词： fractional partial differential equations Burgers-Kadomtsev-Petviashvili equation conformable fractional derivative sub-equation method residual power series method

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Two-and three-dimensional stability analysis of underground storage caverns in soft rock(Cappadocia, Turkey) by finite element method

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Journal of Mountain Science 2022年第4期19卷 1182-1202页

作者： SARI mehmet Department of Mining Engineering Aksaray UniversityAksaray 68100Turkey

Engineering design in soft rocks and its stability analysis exerts many challenges to rock engineers. Many engineering works in Turkey’s Cappadocia region must face and tackle the existing sites covered by the soft rocks. This study is aimed to examine the stability condition of a typical underground storage cavern(USC) excavated in a soft rock in this region. For this purpose, two-and threedimensional stability analyses of the USCs were performed using the finite element method(FEM).Because of the inherent difficulty in characterizing soft/weak rock masses in the region using traditional classification systems, the stability of a typical USC was evaluated by representing the rock mass condition with two distinct scenarios in FEM *** these structures were unstable according to the 2D analysis conducted in RS2 software in the worstcase scenario, they were stable in the 3D analysis using RS3 software in both scenarios. Besides,feasible cover depths were examined to assess their possible effects on the factor of safety and deformation measurements. It was found that 15 m seems to be an optimal depth for excavating a typical USC in the soft rocks exposed in the region. The 3D FEM results provide valuable information to optimize the future planning and preliminary design of USCs.

关键词： Underground storage cavern Numerical modeling Soft rock FEM analysis Rock mass failure

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