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Predictive value of pupillography on intraoperative floppy iris syndrome in preoperative period

International Journal of Ophthalmology(English edition) 2021年第7期14卷 1018-1024页

作者： Gozde Sahin Vural mehmet Vural Department of Ophthalmology Balikesir University Medicine FacultyBalikesir 10100Turkey Department of Ophthalmology Balikesir Ataturk State HospitalBalikesir 10020Turkey

AIM: To present the frequency of intraoperative floppy iris syndrome(IFIS) in cataract patients who taking alpha 1-a receptor antagonist(ARA) drugs, and evaluate the predictive value of pupil diameter(PD) changes in IFIS ***: Male cataract patients who are under treatment with alpha-1 a-ARAs(alfuzosin, tamsulosin) intraoperatively were evaluated and were grouped as with/without IFIS. The preoperative PD values were compared with controls. Also, the intraoperative manipulations and early/late complications were ***: A total of 77 patients(77 eyes) of 94 benign prostate hyperplasia(BPH) patients have been defined as IFIS(81.91%) and 40 patients(40 eyes) were taking tamsulosin and 37 patients(37 eyes) were taking alfuzosin. During the cataract surgery, the rate of posterior capsular rupture(P=0.754), vitreous loss(P=0.585), iris tears(P=0.004), and iris catching(P=0.000) were higher in IFIS group, but the difference was significant only in the iris catching. At the postoperative first-month visit, persistent IOP rise and iris stromal tears were more frequent in IFIS group, but the difference was not significant(P=0.311, P=0.146;respectively). In contrast, Descemet membrane detachment was insignificantly more frequent in controls(P=0.311). In IFIS and control patients, PDs were 9.54±1.78 and 9.72±1.57 mm(P=0.255) under scotopic illumination, 8.54±1.43 and 8.74±1.25 mm(P=0.289) under mesopic illumination, 6.99±1.35 and 7.27±1.39 mm(P=0.662) under photopic illumination, respectively. However PDs were lower in IFIS under all illumination degrees, no significant difference was detected between ***: IFIS is a significant clinical syndrome with an increased intraoperative/postoperative complication ratio. The prediction of this syndrome is important because of prevention required precautions against possible complications. There is no association between IFIS and preoperative PD.

关键词： cataract intraoperative floppy iris syndrome pupillography alpha-1 adrenergic receptor antagonists

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Anatomic and functional results of idiopathic macular epiretinal membrane surgery

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 614-619页

作者： mehmet Ozgur Cubuk Erkan Unsal Department of Ophthalmology Istanbul Research and Education HospitalIstanbul 34025Turkey

AIM: To assess the impact of macular surgery on the functional and anatomic outcomes in patients with grade 2 epiretinal membrane(ERM), and the effect of internal limiting membrane(ILM) peeling on visual acuity and to analyze the long-term effect of pars plana vitrectomy(PPV) on intraocular pressure(IOP).METHODS: Pseudophakic eyes(62 eyes) diagnosed as idiopathic grade 2 ERM with at least 6 mo postoperative follow-up were included in this retrospective study. The fellow eye was nonvitrectomized. Patients were divided into two groups: group 1(29 eyes) treated with ERM and ILM peeling and group 2(33 eyes) with only ERM peeling. Preoperative and postoperative best corrected visual acuity(BCVA), slit-lamp, and a dilated fundus examination was performed. IOP was measured with Goldman applanation tonometer before, day 1 and first week and each visit after surgery. The incidence of significant IOP elevation was compared between vitrectomized eyes and nonvitrectomized fellow ***: Visual improvement was statistically significant and similar in both groups(P=0.008 in group 1, P=0.002 in group 2, P=0.09 inter-group). The amount of decrease in central macular thickness was statistically significant and similar in both groups(P=0.005 group 1, P=0.008 group 2, P=0.37 intergroup). At the final follow-up(14.1±9.6 mo) the incidence of significant IOP elevation was 4% in vitrectomized eyes(three eyes) and 3%(two eyes) in the nonvitrectomized fellow eyes(P=0.12). Four eyes(12.1%) had recurrent ERM after a mean follow-up of 8.6±1.1 mo in group 2, there was no recurrence in group 1(P=0.01).CONCLUSION: Recurrence of ERM may be decreased by ILM peeling during ERM surgery. However, it seems that ILM peeling do not affect the functional outcome and 23-gauge PPV alone do not have a significant effect on IOP.

关键词： epiretinal membrane internal limiting membrane peeling pars plana vitrectomy intraocular pressure

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Prediction of mine drainage generation potential and the prevention method of the groundwater pollution in the Gümüskoy(Kütahya)mineralization area,NW Turkey

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Journal of Mountain Science 2020年第10期17卷 2387-2404页

作者： Selcuk ALEMDAG Enver AKARYALI mehmet Ali GuCER Department of Geological Engineering Faculty of Engineering and Natural SciencesGumusşhane UniversityGumushane29100Turkey

One of the leading factors of seepage contamination is mine drainage,which creates serious ecological risks on the environment both during operation and post-mining *** this study,experimental processes have been carried out to determine the occurrence of mine drainage in the Gümüskoy(Kütahya)mineralization area(Northwest Turkey).The prevention method for potential mine drainage occurrence has been also *** enrichment was observed which are directly related to mineralization in trace element concentrations,especially in potentially toxic metals such as Ag,Cd,Mo,Ba,Bi,and *** on short-term tests,mine drainage formation has not been expected according to the p H(7.36-9.38),contact leaching,and acid-base accounting ***,in the long-term,acid generation potential has been expected because of weathering and oxidation in terms of rock type and mineralization in the ***,in order to prevent groundwater contamination in the event of a possible formation of mine drainage,the hydraulic conductivity of the stock area bedrock was evaluated by the in situ tests performed in the field and it was found to be moderately permeable(K=1.9×10^-6 m/s).In order to make the stock area bedrock impermeable,natural clay will be laid and compressed at the base of the stock *** the finite elements were modeled by seepage analysis,the seepage discharge to be formed on the base rock at a depth of 5 m was determined as 3.17×10^-19 m^3/*** the discharge value determined in the seepage analysis after modeling is very close to zero,contamination of possible ground and surface water will be prevented.

关键词： Ecological risks Environmental assessment Mine drainage Seepage analysis

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Transfemoral aortic valve implantation in the case of pre-existing mitral prosthesis and pure aortic regurgitation: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3549-3552页

作者： Aysun erdem Aycan Esen Zencirci Kivilcim Ozden Sait Terzi Department of Cardiology Dr Siyami Ersek Thoracic and Heart Surgery Education and Research Hospital

BACKGROUND Transcatheter aortic valve replacement(TAVR)is recommended in patients with severe aortic stenosis who have high surgical ***,in the pre-existing mechanical mitral valve prosthesis and natural pure aortic regurgitation,TAVR is relatively *** this report,we described one case of TAVR with native aortic regurgitation in the presence of mechanical mitral valve *** SUMMARY A 64-year-old man with a medical history of mitral valve replacement had severe dyspnea and was symptomatic even at rest for 3 *** echocardiography showed severe native pure aortic *** euroscore was 15.A TAVR procedure with an evolut R was planned.A 34 mm evolut R was placed by transesophageal *** mitral prosthesis was functioning normally,and mild-moderate paravalvular leakage was evident by transesophageal *** patient recovered without any *** 1 mo follow up,the patient was well,and no paravalvular leakage was *** TAVR for pure aortic regurgitation in the presence of prosthetic mitral valve can be a safe procedure.

关键词： Transcatheter aortic valve replacement Prosthetic Mitral stenosis Aortic regurgitation Case report

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A different view on the pathophysiology of Parkinson’s disease:a descendent neurochemical hypothesis?

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Neural Regeneration Research 2019年第10期14卷 1717-1718页

作者： Burak Yulug mehmet Ozansoy Seyda Cankaya Department of Neurology Alanya Alaaddin Keykubat UniversityAntalya/AlanyaTurkey Istanbul Medipol University Restorative and Regenerative Medicine CenterIstanbulTurkey Department of Physiology International School of MedicineIstanbul Medipol UniversityIstanbulTurkey

It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with slight non-motor findings such as olfactory dysfunction (Dickson et al., 2018). However, the potential biomarker role of olfactory dysfunction in PD has been a topic of great interest in the last years (Raskin et al., 1990;Dickson et al., 2018). The classical hypothesis of Braak suggests that PD begins as a synucleinopathy in the lower brainstem or in the olfactory bulb (OB) that progresses rostrally to the SN and amygdala to cause parkinsonism at a later stage of the disease (Burke et al., 2008).

关键词： Parkinson period cause has neu PD is

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Hydrogeochemistry and Water Quality Evaluation along the Flow Path in the Unconfined Aquifer of the Düzce Plain, North-western Turkey

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Acta Geologica Sinica(English Edition) 2010年第1期84卷 213-222页

作者： Nail üNSAL mehmet ELK Civil Engineering Department Gazi University Maltepe 06570 Ankara Turkey Department of Geol Eng. Faculty of Engineering Ankara University Tandgan 06100 Ankara Turkey

The Diizce Plain has a multi-aquifer system, which consists of a near surface unconfined aquifer, along with first and second deeper confined aquifers. Hydrochemical evolution and water quality are related to infiltration of the precipitation, recharge from the formations surrounding the plain, flow path of groundwater and the relationship between surface and groundwater. The groundwater in the unconfined aquifer flows towards the Efteni Lake and the Biiyiik Melen River. Surface waters are divided into two main hydrochemical facies in the study area：（a） Ca2＋-HCO3-; and （b） Ca2＋, Mg2＋-HCOc-, SO4^2-. The groundwater has generally three main hydrochemical facies：（a） Ca2＋-HCO3-; （b） Ca2＋, Mg2＋-HCO3-; and （c） Ca2＋, Mg2＋-HCO3-, Cl-. The hydrochemical facies ＂a＂ and ＂b＂ dominate within shallow depths in recharge areas under rapid flow conditions, while hydrochemical facies ＂c＂ characterizes shallow and mixed groundwater, which dominate intermediate or discharge areas （near Efteni Lake and Biiyiik Melen River） during low flow conditions and agricultural contamination. Calcium and bicarbonate ions, total hardness and electrical conductivity of total dissolved solids （EC-TDS） values increase along the groundwater flow path; but these parameters remain within the limits specified by the standards set for industrial and agricultural usages.

关键词： Duzce Plain groundwater flow path hydrochemical evaluation unconfined aquifer waterquality

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Comparison of brimonidine-timolol and dorzolamidetimolol in the management of intraocular pressure increase after phacoemulsification

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 945-949页

作者： Adem Turk Osman Melih Ceylan Gokcen Gokce mehmet Borazan mehmet Kola Department of Ophthalmology Faculty of MedicineKaradeniz Technical University Department of Ophthalmology Medical Park Hospital Department of Ophthalmology Kayseri Military Hospital Department of Ophthalmology Faculty of MedicineMevlana University

AIM: To compare the effectiveness of brimonidine/timolol fixed combination(BTFC) and dorzolamide/timolol fixed combination(DTFC) in the management of short-term intraocular pressure(IOP) increase after phacoemulsification surgery.·METHODS: Eighty eyes of 80 patients undergoing phacoemulsification and intraocular lens(IOL)implantation were randomly assigned into three *** 1 consisted of 28 eyes and represented the control group. Group 2 consisted of 25 eyes undergoing phacoemulsification surgery and BTFC was instilled at the end of surgery. Group 3 consisted of 27 eyes undergoing phacoemulsification surgery and DTFC was instilled at the end of surgery. IOP was measured preoperatively and 6, 24 h and 1wk postoperatively.·RESULTS: There was no statistically significant difference in preoperative baseline IOP among the three groups(P =0.84). However, IOP was significantly lower in groups 2 and 3 compared to the control group(P 25 mm Hg at 6h after surgery(P =0.008). However, IOP decreased and was >25 mm Hg in only one eye in each group at24 h after surgery.·CONCLUSION: BTFC and DTFC have similar effects in reducing increases in IOP after phacoemulsificationsurgery and can both be recommended for preventing IOP spikes after such surgery.

关键词： cataract brimonidine dorzolamide timolol intraocular pressure phacoemulsification postoperative complication

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Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level

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Neural Regeneration Research 2020年第5期15卷 824-827页

作者： mehmet Ilyas Cosacak Prabesh Bhattarai Caghan Kizil German Center for Neurodegenerative Diseases (DZNE) Dresden Helmholtz AssociationDresdenGermany Center for Molecular and Cellular Bioengineering (CMCB) CRTDTU DresdenDresdenGermany

Alzheimer’s disease cannot be cured as of *** current understanding on the causes of Alzheimer’s disease is *** develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are *** recent years,Alzheimer’s disease research underwent a paradigm *** to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the *** on every cell type adds an alternative approach and hope for the efforts towards the *** stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy ***,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for ***,this provocative idea requires further evidence and tools for ***,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s *** this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research.

关键词： Alzheimer's disease mouse neural regeneration neural stem cell neurogenesis neuron single cell sequencing zebrafish

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

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Frontiers of Medicine 2015年第3期9卷 368-373页

作者： Naci Topaloglu Adem Kucuk Sule Yildirm Mustafa Tekin Havva erdem Mustafa Deniz Canakkale Onsekiz Mart University Medical Faculty Department of Pediatrics Canakkale Turkey Diizce Atatiirk State Hospital Department of Pediatric Surgery Diizce Turkey Diizce University Medical Faculty Department of Pathology Diizce Turkey Canakkale Onsekiz Mart University Medical Faculty Department of Physiology Canakkale Turkey

Glucagon-like peptide-2 （GLP-2） has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion （I/R） injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups （n = 8）. The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion （HIR, vehicle saline-treated） group; and the third group was the GLP-2 pretreated I/R （GLP2-IR） group. Each rat in the third group was intraperitoneally administered 5 ~tg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the fiver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline- treated HIR group （P 〈 0.001）, whereas GLP-2 pretreatment significantly decreased their levels （P 〈 0.01）. Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.

关键词： ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase

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Absolute parameters of young stars:PU Pup

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Research in Astronomy and Astrophysics 2021年第10期21卷 151-163页

作者： Ahmet erdem Derya Surgit Timothy S.Banks Burcu Ozkardes Edwin Budding Canakkale Onsekiz Mart University Astrophysics Research Center and Ulupinar ObservatoryTR-17100CanakkaleTurkey Department of Physics Faculty of Arts and SciencesCanakkale Onsekiz Mart UniversityTerzioglu KampusuTR-17100CanakkaleTurkey Department of Space Sciences and Technologies Faculty of Arts and SciencesCanakkale Onsekiz Mart UniversityTerzioglu KampusuTR-17100CanakkaleTurkey Data Science Nielsen200 W JacksonChicagoIL 60606USA Physics&Astronomy Harper College1200 W Algonquin RdPalatineIL 60067USA Visiting astronomer Mt.John ObservatoryUniversity of CanterburyPrivate Bag 4800Christchurch 8140NZ Carter Observatory Wellington 6012New Zealand School of Chemical&Physical Sciences Victoria University of WellingtonWellington 6012New Zealand Variable Stars South RASNZPO Box 3181WellingtonNew Zealand

We present combined photometric and spectroscopic analyses of the southern binary star PU ***-resolution spectra of this system were taken at the University of Canterbury *** Observatory in the years 2008 and again in *** find the light contribution of the secondary component to be only 2%of the total light of the system in optical wavelengths,resulting in a single-lined spectroscopic *** TESS data revealed grazing eclipses within the light minima,though the tidal distortion,examined also from Hipparcos data,remains the predominating light curve *** model shows PU Pup to have the more massive primary relatively close to filling its Roche *** Pup is thus approaching the rare‘fast phase’of interactive(Case B)*** adopted absolute parameters are as follows:M_(1)=4.10(±0.20)M_(⊙),M_(2)=0.65(±0.05)M_(⊙),R_(1)=6.60(±0.30)R_(⊙),R_(2)=0.90(±0.10)R_(⊙);T_(1)=11500(±500)K,T_(2)=5000(±350)K;photometric distance=186(±20)pc,age=170(±20)*** less-massive secondary component is found to be significantly oversized and overluminous compared to standard main sequence *** discuss this discrepancy referring to heating from the reflection effect.

关键词： (stars:)binaries(including multiple):close stars:early-type stars:individual(PU Pup) Galaxy:stellar content

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