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Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

World Journal of Gastroenterology 2004年第17期10卷 2544-2546页

作者： mehdi nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian *** Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient *** cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan,and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium ***: We measured serum selenium in 300 healthy adults from ArdabU (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-MS) at the US Centers for Disease Control (Atlanta,Georgia).RESULTS: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, Mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (P<0.001). The results of linear regression showed that the Province variable, by itself,explained 76% of the variance in log selenium (r^2 = 0.76).The proportion of the populations with a serum selenium more than 90μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan,Kerman, and Mazandaran but only 29% in ***: Our findings suggest nat selenium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province.

关键词：生态研究免疫血清硒胃肠癌肿瘤伊朗消化系统

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